- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Elimination of Lymphatic Filariasis in India - Why morbidity management and disability prevention pillar lagging behind? (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2790;
MDA campaign was initiated with a single drug of diethylcarbamazine citrate (DEC), which was replaced with co-administration of DEC and albendazole since 2007...The financial assistance to patients is also suggested with suitable provision under the disability prevention act. Digital reporting of all such cases listed or managed will be helpful in documentation and facilitating while certifying at the stage of elimination.
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Impact of mass drug administration for elimination of lymphatic filariasis in Abuja Nigeria (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2657;
The Federal Capital Territory (FCT), an area endemic for LF, commenced mass drug administration (MDA) using ivermectin (IVM) and albendazole (ALB) in 2011...The results showed that the two Evaluation Units (EU) had achieved the LF Ag threshold required to stop MDA.ConclusionAlthough Abuja-FCT has made significant progress towards LF elimination with two Area Councils qualifying to stop treatment, two other area councils still require a further two years of mass drug administration with effective MDA coverage to qualify for impact assessment. This paper provides evidence of the impact of MDA on LF prevalence in Abuja.
- |||||||||| doxycycline / Generic mfg.
Effect of filarial lymphedema treatment with doxycycline on immune activation and exhaustion frequencies in blood (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2649;
Current treatment (200 µg/kg ivermectin (IVM) and 400 mg albendazole (ALB)) acts on microfilariae, the larval stage that is also responsible for transmission, but does not affect the adult worm...Interestingly, the opposite is observed in the Ghanaian samples when examining paired values from pre- and 6 months post-treatment. Clearer conclusions as to the nature of these differing results will be able to be drawn after unblinding of the study participants (anticipated July 2022).
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The impact of one vs. two doses of ivermectin mass drug administration on the prevalence and intensity of soil-transmitted helminth (STH) infections (Convention Center - Room 602/603/604 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2059;
Although WHO guidelines recommend albendazole preventive chemotherapy targeted to school-aged children for STH control, albendazole has limited efficacy against two major species, T. trichiura and S. stercoralis...Statistical analyses to investigate whether there are significant differences in prevalence and intensity of infection between timepoints and treatment arms are underway. This study will contribute to our understanding of the role of ivermectin preventive chemotherapy in the control of STH and may be used to optimise integrated neglected tropical disease control strategies locally in Solomons Islands and in other endemic settings, particularly in the context of scabies MDA programmes.
- |||||||||| Promoting sustainable access to quality-assured NTD products in low- and middle-income countries (Convention Center - Room 602/603/604 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2058;
To address these concerns, the Promoting the Quality of Medicines Plus (PQM+) program, funded by the U.S. Agency for International Development (USAID), conducted a study in sub-Saharan Africa and select Asian countries to assess local production of albendazole, mebendazole, azithromycin, diethylcarbamazine, ivermectin, tetracycline eye ointment, and praziquantel...The study identified several technical interventions to address these challenges and to ensure sustainable access to quality-assured NTD products. The primary interventions include strengthening the quality and supply of APIs, strengthening regulatory systems, and improving regional collaborations.
- |||||||||| ivermectin oral / Generic mfg.
1188- Abametapir - a promising single dose scabicide candidate with multiple targets (Convention Center - Room 615/616/617 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2024;
The commonly used oral ivermectin and topical permethrin are single target neuro-inhibitors and ineffective on the egg which is the “amplification” stage in the S. scabiei life cycle...Proteomic and zymography analyses indicated that abametapir interferes with several S. scabiei proteins and proteases, including multiple metalloproteases involved in a range of biological processes. Our results indicate abametapir as a promising single dose scabicide candidate with multiple targets and novel modes of action.
- |||||||||| ivermectin oral / Generic mfg.
Trachoma and Onchocerciasis: the Burden of Neglected Tropical Diseases in South Sudan (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1738;
These results highlight the burden of these neglected tropical diseases in the country, especially trachoma. South Sudan should conduct epidemiological studies to determine the prevalence of the diseases and invest in and expand the SAFE strategy and MDT in the regions affected to reduce and prevent long-term complications.
- |||||||||| ivermectin oral / Generic mfg.
Investigation into Possible Causes for Continued Onchocerciasis High Prevalence in the Wenchi Municipal of Ghana (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1704;
Suboptimal programmatic performance related to inexhaustive census and reach issues revealed by qualitative assessment might have been contributing to the ongoing transmission as well. These results have prompted the programme and the Ghana Onchocerciasis Expert Committee to call for further exploration to identify and characterise all other at-risk communities in the vicinity of Kwanware and Ottou in order to inform strategy adaption to address the situation.
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Towards Onchocerciasis Elimination: Promising trend on Epidemiological Evaluation Results in Tanzania (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1700;
Overall, 5 district councils were close to the elimination threshold, 19 district councils were on track but required more rounds of treatment, and in 4 district councils progress was unsatisfactory. Nine councils (4 with unsatisfactory progress and 5 which were on track) changed the modality from annual to bi-annual MDA to accelerate elimination.
- |||||||||| ivermectin oral / Generic mfg.
Onchocerca volvulus vectors Simulium spp.: perspectives on research, bionomics, and implications for elimination of onchocerciasis in Nigeria. (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1696;
Detailed analysis is ongoing, however preliminary results indicate that most studies reported the S. damnosum complex, focused on both adult/larvae blackfly stages, used human bait for adult fly collections, sampled for different durations across different seasons, and used both dissection/molecular methods to detect infection. When completed, this comprehensive information database will be an important resource and facilitate future research to assist the onchocerciasis elimination programme in Nigeria.
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Persistence of the prevalence and associated clinical manifestations of Lymphatic Filariasis in the Bono Region of Ghana (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1695;
This study demonstrated that most of the study communities are still hyperendemic for LF infection, with its associated clinical manifestations persisting despite more than a decade of LF control in the Bono Region of Ghana. The findings from this study underscore the need for further investigations into reasons for persistence of the disease in these communities and to regularly evaluate the LF control programme in the race to achieve the 2025 targets.
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A pharmacometric approach to evaluate drugs for potential repurposing as COVID-19 therapeutics (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1445;
However, this approach is challenging since many drug candidates show efficacy in in-vitro experiments, but fail to deliver effective treatment when evaluated in clinical trials (e.g. chloroquine/hydroxychloroquine)...This project evaluated potential drugs that might be of interest for repurposing in the treatment of patients with COVID-19 disease (i.e. chloroquine, mefloquine, amodiaquine, daclatasvir, sofosbuvir, favipiravir, nitazoxanide, ivermectin, atazanavir/ritonavir, and colchicine)...Half of the evaluated drugs showed simulated total plasma concentrations associated with effective inhibition of SARS-COV-2 in in-vitro systems. This provides a relatively unbiased and simple framework for prioritizing and de-risking the selection process of drugs to evaluate further in prospective randomized controlled clinical trials.
- |||||||||| ivermectin oral / Generic mfg.
The effect of sublethal doses of ivermectin on Anopheles gambiae midgut microbiota (Convention Center - Room 615/616/617 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1301;
However, a few bacteria genera were found to be present only in IVM-treated mosquitoes or only in controls. In the field, these modest changes due to IVM exposure may be amplified in certain mosquito populations which could impact their fitness, survival, or Plasmodium infection status.
- |||||||||| ivermectin oral / Generic mfg.
Evaluation of ivermectin as an antimalarial therapy against Plasmodium falciparum liver stage (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_500;
We have established a robust invitro liver assay to study the liver stage development of human malaria parasites in primary human hepatocytes that can be used to evaluate the potential impact of these metabolic differences on ivermectin’s anti-liver stage efficacy. This model can be used to evaluate the metabolism of ivermectin in hepatocytes from different donors and its efficacy against Plasmodium falciparum liver stages.
- |||||||||| ivermectin oral / Generic mfg.
Anti-viral activity of FDA-licensed drugs on Arboviral infection in vitro (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_430;
In this study, we investigated anti-viral activity of FDA-approved drugs including Favipiravir, Arbidol, Ivermectin B1a, Milbemycin oxime, Niclosamide, and Telmisartan on arboviral infection...Among all, we observed only two drugs had any inhibitory effect on ZIKV infection including Arbidol and Ivermectin B1a with IC50 values of 2.5 and 0.3 µg/ml, respectively. These data indicate a potential inhibitory effect of these drugs against CHIKV and ZIKV replications which and may be considered as candidates for testing in animal model and future clinical evaluation.
- |||||||||| ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
Insect Repellant or Insecticide? Efficacy, Safety, and Toxicity (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_320;
Combinations of permethrin-impregnated clothing and either topical DEET or picaridin are recommended for the best protection from mosquitoes and ticks. Topical and oral ivermectin preparations are recommended over lindane and malathion for treating lice and mite infections, including scabies.
- |||||||||| ivermectin oral / Generic mfg.
13 - Plenary Session II: Charles Franklin Craig Lecture (Convention Center - Room 6AB (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_272;
Garcia is interested in continuing with research in the areas of her core interests, promoting community participation in research, equity and involving the most vulnerable populations. She is interested in continuing working in moving research into policy in Peru and Latin America and sharing lessons learned beyond the Latin American region.
- |||||||||| ivermectin oral / Generic mfg.
Abametapir - a promising single dose scabicide candidate with multiple targets (Convention Center - Room 602/603/604 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_27;
The commonly used oral ivermectin and topical permethrin are single target neuro-inhibitors and ineffective on the egg which is the “amplification” stage in the S. scabiei life cycle...Proteomic and zymography analyses indicated that abametapir interferes with several S. scabiei proteins and proteases, including multiple metalloproteases involved in a range of biological processes. Our results indicate abametapir as a promising single dose scabicide candidate with multiple targets and novel modes of action.
- |||||||||| ivermectin oral / Generic mfg.
Review: Potential limitations in systematic review studies assessing the effect of the main intervention for treatment/therapy of COVID-19 patients: An overview. (Pubmed Central) - Oct 8, 2022
All systematic reviews investigated the effectiveness, efficacy, safety, and outcome of the main intervention (Favipiravir, Remdesivir, Hydroxychloroquine, Ivermectin, Lopinavir/Ritonavir, or Tocilizumab) for the treatment of COVID-19 patients and reported the potential limitations of the included studies...As a result, stronger studies with more reliable results will be reported and disseminated. Further research on COVID-19 SRs is essential to improve research quality and also, efficiency among scientists across the world.
- |||||||||| moxidectin / Generic mfg.
Trial primary completion date: Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) - Oct 6, 2022
P3, N=164, Active, not recruiting,
While it is not possible to establish a causal relationship from the evaluation of spontaneous reports, the present study confirms the presence of adverse reactions-some of them serious-involving drugs used to treat or prevent COVID-19. Trial primary completion date: Sep 2022 --> Sep 2023
- |||||||||| ivermectin oral / Generic mfg.
Observational data, Journal: Ivermectin-Induced Clinical Improvement and Alleviation of Significant Symptoms of COVID-19 Outpatients: A Cross-Sectional Study. (Pubmed Central) - Oct 4, 2022
The results of this study demonstrated a significant decrease in several COVID-19 disease symptoms, including fever, chills, dyspnea, headache, cough, fatigue, and myalgia in the group administered ivermectin compared to the control group. In addition, the odds ratio of the above symptoms was significantly lower in patients who received ivermectin than in patients who did not receive the drug (OR = 0.16, 95% CI = 0.09, 0.27).
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