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  • ||||||||||  ivermectin oral / Generic mfg.
    Ivermectin to reduce malaria transmission in Sub-Saharan Africa, The BOHEMIA cluster randomized trial in Kenya (Convention Center - Room 391/392 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3350;    
    P3
    The eligible population received a single 400 mcg/kg dose of ivermectin once a month for three months at the beginning of the short-rains season or albendazole 400 mg single dose with the same schedule as control...The incidence rate ratio for severe adverse events was 0.63 (95%CI 0.19-1.85). Three rounds of a single dose of ivermectin was a safe intervention and provided an additional 24% reduction in malaria infection incidence in children 5-15 living in an area with existing good bed net coverage and usage.
  • ||||||||||  emodepside (BAY 44-4400) / Bayer
    Emodepside: a drug to change the helminth world (Convention Center - Room 383/384/385 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3216;    
    Following treatment, an additional three stool samples will be collected to evaluate infection status. A dose-response curve and adverse events will be reviewed to assess the most efficacious and safe dose of emodepside.
  • ||||||||||  ivermectin oral / Generic mfg.
    Next Generation Ov16-based Rapid Tests: Field Data (Convention Center - Room 345 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2528;    
    In adult males in Nkwanta, the Mf prevalence was 4% (1.9-7.9) and the seroprevalence 44% (37-51). Despite proven transmission, both the Mf prevalence and seroprevalence was 0% in children under the age of 10, suggesting that children would be an inadequate sentinel group post-MDA.
  • ||||||||||  ivermectin oral / Generic mfg.
    A biomarker assay to detect people with high Loa loa microfilaria counts (Convention Center - Room 345 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2523;    
    Thus, this antigen assay appears to be highly sensitive for identifying people with high L. loa microfilarial counts who are at increased risk of serious adverse events after ivermectin. Optimization of this prototype assay and use of a rapid diagnostic platform could facilitate loiasis mapping and efforts to eliminate lymphatic filariasis and onchocerciasis in Central Africa.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg., azithromycin / Generic mfg.
    Acceptability of integrated neglected tropical diseases surveys and mass drug administration in Vanuatu (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2302;    
    To control and eliminate these diseases, the Vanuatu Ministry of Health implemented an integrated control program including mass drug administration (MDA) with albendazole, azithromycin and ivermectin...In conclusion, this study suggests that the integrated MDA was acceptable to the community. Strategies to engage local communities in both awareness creation and medicine distribution can further improve participation of the communities and MDA acceptability.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg., azithromycin / Generic mfg.
    Impact of Mass Drug Administration for Lymphatic Filariasis and Yaws Elimination on Attendances for Skin Disease in Rural Health Centers in West New Britain Province, Papua New Guinea (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2281;    
    Recently, PNG started mass drug administration (MDA) to eliminate lymphatic filariasis (LF) and yaws and control scabies and STH with ivermectin, diethylcarbamazine, albendazole (IDA), followed by azithromycin...These effects could increase treatment acceptability within the health system and help sustain the high drug coverage in the population necessary to achieve elimination targets for LF and yaws. We will continue to conduct active surveillance of skin-neglected tropical diseases in WNBP to see how long the reduction in HC visits persists after MDA and better evaluate participants' perceptions of the MDA program.
  • ||||||||||  ivermectin oral / Generic mfg.
    Rebound in prevalence and intensity of Onchocerca volvulus infection five years after cessation of alternative treatment strategies in the Massangam Health District, West Region, Cameroon: need for coordinated and sustained efforts (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2251;    
    To tackle onchocerciasis in hotspots and achieve elimination of transmission, several complementary/alternative strategies (biannual ivermectin, doxycycline-based test-and-treat and vector control) have been implemented in Massangam Health District (HD), and short-term impact evaluation showed significant reductions in the endemicity levels in three focal hotspot communities (Makouopsap, Makankoun, and Njinja-Njingouet)...The parasitological indicators significantly increased five years after the cessation of Alternative Treatment Strategies (ATS) in all three focal communities (?2 = 4.18; df = 2; p = 0.0409) compared with their baseline levels (end of ATS implementation). These findings indicate a rebound in onchocerciasis transmission and underscore the need for coordinated and sustained efforts, which can be implemented in a transmission zone as recommended by the WHO, to achieve the elimination goals outlined in the 2021-2030 roadmap to end the neglect and achieved SDGs.
  • ||||||||||  ivermectin oral / Generic mfg.
    Evaluation of the effect of one round of mass drug administration with IDA on human Brugia malayi infections in Belitung District, Indonesia (Convention Center - Room 343/344 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1777;    
    The district received mass drug administration (MDA) with DEC and albendazole (DA) from 2005-2010 and passed three transmission assessment surveys (TAS)...This is an additional risk for the elimination of LF in the area and high coverage MDA with intensified evaluation of MDA and post MDA surveillance is needed. Areas with zoonotic B. malayi infection may need to be declared by WHO to special intervention zones that need special attention.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    Moxidectin plus albendazole for lymphatic filariasis: effects through 36 months post-treatment (Convention Center - Room 343/344 (3rd Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1772;    
    Complete results adjusted for baseline characteristics and infection intensity for all participants will be presented at the meeting. Results from this trial suggest that mass drug administration with MoxA could accelerate LF and onchocerciasis elimination in Africa.
  • ||||||||||  ivermectin oral / Generic mfg.
    Application of qPCR to determine community prevalence of Strongyloides stercoralis in southern India (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1591;    
    While ecological niche models suggest that hookworm prevalence would be predictive of Strongyloides , our findings indicate a lower prevalence of Strongyloides by qPCR. A combination of molecular and serological diagnostic approaches may be needed to accurately estimate the burden of Strongyloides to help plan and prioritize appropriate interventions for control.
  • ||||||||||  ivermectin oral / Generic mfg.
    Pregnancy, Onchocerca volvulus infection and ivermectin use: a cross-sectional study (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1582;    
    We recommend that women should have access to IVM treatment post-partum in vaccination centers and that all women who inadvertently take IVM should be registered to further explore safety of IVM. In addition, a clinical trial evaluating the potential beneficial effect of treating O. volvulus infected pregnant women with IVM should be considered.
  • ||||||||||  ivermectin oral / Generic mfg.
    Evaluation of a novel biplex rapid diagnostic test for antibody responses to Loa loa and Onchocerca volvulus infections (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1571;    
    The diagnostic agreement between the two ARTs was poor, suggesting that IgG and IgG4 antibody responses should be interpreted differently. The assessment of the innovative IgG4-SXP-1 biplex test, designed for onchocerciasis and loiasis, shows encouraging sensitivity but underscores the necessity for further in vitro assessment.
  • ||||||||||  Viracept (nelfinavir) / ViiV Healthcare, Roche, emodepside (BAY 44-4400) / Bayer
    Elimination goals for onchocerciasis can be progressed faster by incorporating treatment with repurposed drugs that target various stages of filarial worms (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1570;    
    We demonstrated that, 1) Nelfinavir (anti-HIV drug that targets aspartic proteases) significantly inhibited motility of Brugia pahangi female worms in vitro and reduced survival of adult worms as well as their fecundity in vivo; 2) Niclosamide and Rottlerin (autophagy inducing drugs) significantly reduced Wolbachia levels in vitro and in vivo , as well as embryogenesis and fecundity in treated female B. pahangi worms in vivo; and 3) Emodepside (repurposed macrofilaricide under clinical development), when used as a prophylactic drug, inhibits molting and motility of O. volvulus and B. pahangi early stages of the parasite in vitro with IC 50 s in the nanomolar range. Our findings indicate that a major programmatic shift that incorporates integrated control strategies, aimed at reducing both the overall adult worm burden and transmission, is needed to achieve the 2030 WHO elimination of transmission goals for onchocerciasis.
  • ||||||||||  ivermectin oral / Generic mfg.
    Antiplasmodial and insecticidal activities of third generation ivermectin hybrids (Convention Center - Hall I-1 (1st Floor); In-Person-Only) -  Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1454;    
    We further assess, for the first time, the blood stage activity of the most potent hybrids in vivo , in a rodent model of Plasmodium infection. Collectively, our results provide key structure-activity relationships to guide the rational design of new molecules, supporting the subsequent pursuit of the clinical development of IVM hybrids as potential antiplasmodial drugs.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Deciphering Chemical Rules for Drug Penetration into Strongyloides. (Pubmed Central) -  Sep 29, 2024   
    These findings allow us to establish structural rules for parasite entry that could be of interest for future drug screening or drug development campaigns. These rules might also be applicable to other related parasites.
  • ||||||||||  Nucala (mepolizumab) / GSK
    PEDIATRIC HYPEREOSINOPHILIA (Monitor 12; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1127;    
    She was transitioned to mepolizumab following discharge...Prompt recognition and treatment are imperative to prevent end-organ damage, and noting such cases respond dramatically to systemic corticosteroids and anti IL-5 therapy. Absolute Eosinophil Trend Patient
  • ||||||||||  ivermectin oral / Generic mfg.
    WHAT THE ITCH? A CASE OF CUTANEOUS STRONGYLOIDIASIS (Monitor 15; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1013;    
    This case illustrates the importance of maintaining a high index of clinical suspicion for parasitic infection in returning travelers as laboratory testing has limitations. Cutaneous Manifestation of Strongyloidiasis Pink, pruritic coaslescing papules and plaques in a patient with cutaneous Strongyloidiasis 106 Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110
  • ||||||||||  ivermectin oral / Generic mfg.
    SECONDARY IMMUNODEFICIENCY RELATED TO STRONGYLOIDES INFECTION (Monitor 12; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_778;    
    He was treated for his Strongyloides infection with ivermectin/albendazole for 14 days and for meningitis/colitis...In this case, low complement levels may have reflected severely compromised synthetic function, contributing to immunodeficiency. Low pneumococcal titers also warrants further evaluation of vaccine responses.
  • ||||||||||  ivermectin oral / Generic mfg., doxycycline delayed-release / Generic mfg.
    Trial completion:  Trial of Combination Therapy to Treat COVID-19 Infection (clinicaltrials.gov) -  Sep 23, 2024   
    P1,  N=31, Completed, 
    Not yet recruiting --> Active, not recruiting Active, not recruiting --> Completed
  • ||||||||||  ivermectin oral / Generic mfg.
    132 - Mass Drug Administration of Ivermectin for Onchocerciasis Elimination: Can We Stop Sooner? (Convention Center - Room 357 (3rd Floor); In-Person-Only) -  Sep 15, 2024 - Abstract #ASTMH2024ASTMH_662;    
    In this symposium we will present the initial results from the countries involved and the diagnostic challenges encountered during the studies. The presentations will address sampling and laboratory methodologies, serology and entomology results, diagnostic challenges and solutions, and next steps.
  • ||||||||||  ivermectin oral / Generic mfg.
    115 - Evaluating the Case for Loiasis as a Neglected Tropical Disease (Convention Center - Room 388/389 (3rd Floor); In-Person-Only) -  Sep 15, 2024 - Abstract #ASTMH2024ASTMH_597;    
    Speakers for this symposium will be loiasis experts that live or have extensively worked in endemic areas. They will review the clinical and public health challenges caused by loiasis, advances in loiasis mapping and diagnostic strategies, and will make recommendations for or against recognition of loiasis as a NTD by WHO.
  • ||||||||||  atorvastatin / Generic mfg., ivermectin oral / Generic mfg.
    Journal:  Evaluation of muscular apoptotic changes and myogenin gene expression in experimental trichinosis after stem cells and atorvastatin added to ivermectin treatment. (Pubmed Central) -  Sep 10, 2024   
    The results revealed that mice that received ivermectin, atorvastatin, and stem cell triple therapies showed the maximum reduction in the adult worm and larvae burden, marked improvement in the underlying muscular degenerative changes (as was noticed by histopathological, ultrastructural, and histochemical Feulgen stain assessment), lower biochemical levels of serum NK-?B and tissue NO, and lower myogenin expression. Accordingly, the combination of stem cells, atorvastatin, and ivermectin affords a potential synergistic activity against trichinosis with considerable healing of the underlying degenerative sequel.
  • ||||||||||  ivermectin oral / Generic mfg.
    Preclinical, Journal:  Survival and growth of M. perstans larvae in a human colon carcinoma cell line-based in vitro culture. (Pubmed Central) -  Sep 10, 2024   
    We obtained that the 10% NCS culture condition was superior allowing long-term maintenance of M. perstans L3 for up to 100 days and boosted growth of the parasites for up to 5-folds compared to the initial size at culture inception. Although no moulting of the L3 into L4 or adult worms could be overserved, the human colon carcinoma cell-based in vitro culture provides an alternative platform to analyse M. perstans biology and screen for novel drugs against M. perstans.
  • ||||||||||  ivermectin oral / Generic mfg.
    Review, Journal:  Scabies, Bedbug, and Body Lice Infestations: A Review. (Pubmed Central) -  Sep 9, 2024   
    Permethrin cream and oral ivermectin are first-line treatments for adults, with similar clearance rates by week 2 (74% with permethrin vs 68% with ivermectin; relative risk, 0.91; 95% CI, 0.76-1.08)...First-line treatments include scabicides for patients with common scabies and their close contacts. Scabies, bedbug, and body lice infestations should be treated with decontamination measures.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Retrospective data, Journal:  Imported Loiasis at a Clinical Reference Center in Germany: A Retrospective Case Series. (Pubmed Central) -  Sep 4, 2024   
    In one patient, long-term follow-up indicated treatment failure after the first course of treatment. Another traveler was prescribed chemoprophylaxis with diethylcarbamazine after experiencing repeated infections due to long-term residence in a high-risk region in Cameroon.
  • ||||||||||  ivermectin oral / Generic mfg., ivermectin topical / Generic mfg.
    Journal, HEOR:  Investigation of the effect of oral ivermectin on systemic inflammatory response and quality of life in scabies patients. (Pubmed Central) -  Sep 3, 2024   
    In 119 patients (51 males) diagnosed with scabies, increases in ESR, CRP, and SII values and decreases in inflammatory cell counts and DLQI scores were observed one month after treatment with oral ivermectin. The results of the study showed that the use of oral ivermectin, a scabicidal agent, triggered the inflammatory response and improved the QoL of the patients.