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Journal: Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms. (Pubmed Central) - Jan 26, 2023 These in vitro assays identified several macrocyclic lactones (emamectin, milbemycin oxime, and the moxidectin metabolite 23-ketonemadectin) that caused contractile paralysis and lack of lactate production...Nevertheless, these data show the utility of a multiplexed in vitro screening platform to quantitatively assess drug action and exclude inactive compounds from a chemical series before proceeding to in vivo studies. While the prototypical macrocyclic lactone ivermectin displays minimal activity against adult Schistosoma mansoni, this family of compounds does contain schistocidal compounds which may serve as a starting point for development of new anti-flatworm chemotherapies.
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REQUESTS FOR IVERMECTIN AND HEALTHCARE DISTRUST IN THE RURAL SOUTH () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1493; Patients value the right to try ivermectin, this desire was fueled by distrust of government. If clinicians are perceived as aligned with the government, such alignment may void trust of clinicians.
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DISSEMINATED STRONGYLOIODES INFECTION AFTER CORTICOSTEROID USE () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1368; Strongyloides hyperinfection is an uncommon complication with a high mortality rate, with meningeal involvement often described post-mortem. Prophylactic anti-parasitic agents can be considered for patients identified as high risk for chronic strongyloidiasis who are about to undergo corticosteroid treatments, including COVID-19 associated regimens.
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