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- | moxidectin / Generic mfg., ivermectin / Generic mfg.
Journal: Questionnaire survey on helminth control practices in horse farms in Ireland. (Pubmed Central) - May 11, 2020
The majority of farms (81.4%) treated horses 4-5 times per year and 74.2% only estimated the weight of the horses visually. The findings of this study illustrates that many stud managers/owners do not follow best practice with regard to helminth control and more education is needed.
- |||| ivermectin / Generic mfg.
PK/PD data: I agree with @PaulSaxMD, but for a different reason. Even though this PK/PD model suggests some drugs (e.g., HCQ, ivermectin) are above the EC50 for SARS-CoV-2, up until now the negative studies of HCQ suggest PK/PD may not matter. https://t.co/KGc5gqXsej (Twitter) - May 11, 2020
- || ivermectin / Generic mfg.
Yup. Interestingly, last week Peru approved ivermectin to treat Covid (while acknowledging limited evidence). Several RCTs are going on now. (Twitter) - May 11, 2020
- || ivermectin / Generic mfg.
I don’t think @Dereklowe has covered ivermectin yet, but you might find these comments about that paper interesting https://t.co/Dq4GjvTOlQ (Twitter) - May 11, 2020
- || ivermectin / Generic mfg.
Is there a probability Ivermectin can be used for prophylaxis? Does Ivermectin interact with HCQ/Zinc if taken simultaneously? any answer at your convenience would be greatly appreciated. Thank you. (Twitter) - May 11, 2020
- || ivermectin / Generic mfg.
Dr. Patel, Any further update on Ivermectin? A lot of people see it as a big hope against this nasty virus. (Twitter) - May 11, 2020
- ||| ivermectin / Generic mfg.
Clinical: Would love to read more opinions (and studies!) on this as well, as Ivermectin has been included in Peru's latests MoH guidelines for mild and moderate cases https://t.co/I9CFwpQHv0 (Twitter) - May 10, 2020
- || ivermectin / Generic mfg.
Yes. I've discussed this with David Sullivan, parasitologist at Hopkins. He said there is a huge PK mismatch with ivermectin (Twitter) - May 10, 2020
- ||||| ivermectin / Generic mfg.
Cytokine storm: Ivermectin is an inhibitor of #p2RX7 which is an upstream activator of the #nlrp3 #inflammasome which mediates #IL1beta production which is likely important in #COVID19 #CytokineStorm. Not harmful. Maybe promising? (Twitter) - May 10, 2020
- |||| ivermectin / Generic mfg.
FDA event, Preclinical: The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro - @sciencedirect What do people think? @RMKGandhi @RWalensky @jeffrey_lennox @vmarconi2 @colleenfkelley @Armstrws https://t.co/UbNWcWytNy (Twitter) - May 10, 2020
- ||| ivermectin / Generic mfg.
Dear Dr Patel, when we can know more about the trials with ivermectin and Covid 19 ? Puerto Rico, Japón, argentina, Bolivia and Peru show hoping news ...rgds (Twitter) - May 10, 2020
- | ivermectin / Generic mfg.
How @FDAMedWatch refuses to report on Ivermectin? (Twitter) - May 10, 2020
- | ivermectin oral / Generic mfg.
New P3 trial: Study of the efficacy of ivermectin in the treatment and prevention of COVID-19 Estudio de la eficacia de ivermectina en el tratamiento y la prevenci (EUDRACT) - May 9, 2020
P3, N=266, Ongoing, Sponsor: Fundaci
- | ivermectin / Generic mfg.
Journal: The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus. (Pubmed Central) - May 9, 2020
To provide a practical example, we analysed two gene families of potential relevance to ivermectin drug resistance; the ABC transporters and the ligand-gated ion channels (LGICs)...This work illustrates the need to account for sequence polymorphism in differential expression analysis. It also demonstrates that a large number of genuine transcriptional differences can occur between H. contortus strains and these must be considered before associating the differential expression of specific genes with phenotypic differences between strains.
- | ivermectin / Generic mfg.
Journal: The distinct profiles of the inhibitory effects of fluensulfone, abamectin, aldicarb and fluopyram on Globodera pallida hatching. (Pubmed Central) - May 9, 2020
Fluensulfone is a potent inhibitor of hatching and impacts on the viability of the J2 s emerging from the cysts. This activity, and the previously described impaired motility and metabolism of hatched juveniles, show that fluensulfone's distinct mode of action among existing nematicides intersects at two pivotal steps of the parasitic life cycle.
- || ivermectin / Generic mfg., Alinia (nitazoxanide) / Lupin, Romark Lab
Testing Ivermectin (single dose) + Nitazoxanide 600mg (2×day) when symptoms begin. Won't see many studies... patent free... no big money to be made... I guess. (Twitter) - May 8, 2020
- || ivermectin / Generic mfg.
Kerala trying out Ivermectin for CoVID! @drharshvardhan @PMOIndia @narendramodi @AmitShah @BJP4India @ArvindKejriwal @AtishiAAP @msisodia @raghav_chadha @ProfBhargava @drkaushalk https://t.co/bqYQuEFj1j (Twitter) - May 8, 2020
- || ivermectin / Generic mfg.
Acompanhe o perfil do PHD @DoctorAmitPatel que está desenvolvendo uma pesquisa com a ivermectina. O artigo está está no perfil dele tbm (Twitter) - May 8, 2020
- ||| ivermectin / Generic mfg.
Clinical: Dr Ding, pulse-oxymeters catch the first sign of ARDS risk if hyper-potent COVID strain. To honor the inventor Takuo Aoyagi, we must USE 2 treatments proven BRD to prevent ARDS (& save hospitals) IF Rx'ed EARLY=outpatient. #ZelenkoProtocol & #Ivermectin. Harvard, wake up! (Twitter) - May 8, 2020
- || Skyrizi (risankizumab) / AbbVie, Boehringer Ingelheim
Clinical, Journal: Risankizumab-Aggravated Crusted Scabies in a Patient with Down Syndrome. (Pubmed Central) - May 8, 2020
The patient was hospitalized and successfully treated by local permethrine and systemic ivermectine. This case suggests that even though anti-IL23 antagonists display an excellent overall safety profile, a particular caution for infections should still be respected in patients with underlying risk factors.
- || ivermectin / Generic mfg.
Clinical, Journal: Risk factors for treatment failure in scabies: a cohort study. (Pubmed Central) - May 7, 2020
This case suggests that even though anti-IL23 antagonists display an excellent overall safety profile, a particular caution for infections should still be respected in patients with underlying risk factors. Use of topical BB alone and a single (versus two) intake of ivermectin are predictors of treatment failure.
- | ivermectin / Generic mfg.
Preclinical, Journal: Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum ammi on gastrointestinal nematodes in donkey (Equus asinus): An in vivo study. (Pubmed Central) - May 7, 2020
The present study indicated that both CP and CAE of T. ammi had the dose-dependent anthelmintic effects. Due to the development of drug resistance against synthetic anti-helminthics, T. ammi seems to be a promising alternative for the treatment and prevention of helminths in livestock.
- ||| ivermectin / Generic mfg.
Sorry but you're wrong. Even with a smaller dose, ivermectin enables the immunitar system to resist to COVID19 (Twitter) - May 7, 2020
- || Flagyl (metronidazole) / SLA, metronidazole topical / SLA Pharma, ivermectin / Generic mfg.
Clinical, Journal: Nodular Demodicosis in a Pregnant Woman Treated with Oral Ivermectin and Metronidazole. (Pubmed Central) - May 7, 2020
A Demodex preparation revealed numerous Demodex mites from each pustule that was sampled. Based on the clinical findings and the positive Demodex preparations, the woman was diagnosed with nodular demodicosis.
- | albendazole / Generic mfg.
Trial suspension, Combination therapy: DOLF IDA/Oncho: Safety and Efficacy of IDA for Onchocerciasis (clinicaltrials.gov) - May 6, 2020
P2, N=201, Suspended, Sponsor: Washington University School of Medicine
Based on the clinical findings and the positive Demodex preparations, the woman was diagnosed with nodular demodicosis. Enrolling by invitation --> Suspended
- | ivermectin / Generic mfg.
Journal: A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool. (Pubmed Central) - May 6, 2020
The roadmap covers various aspects, which include 1) the definition of optimal dosage/regimens for ivermectin MDA in both humans and livestock, 2) the risk of resistance to the drug and environmental impact, 3) ethical issues, 4) political and community engagement, 5) translation of evidence into policy, and 6) operational aspects of large-scale deployment of the drug, all in the context of a drug given as a prevention tool acting at the community level. The roadmap reflects the insights of a multidisciplinary group of global health experts who worked together to elucidate the path to inclusion of ivermectin in the toolbox against malaria, to address residual transmission, counteract insecticide resistance, and contribute to the end of this deadly disease.
- || ivermectin / Generic mfg.
Clinical, Journal: Ivermectin and Malaria-Putting an Elderly Drug to a New Test. (Pubmed Central) - May 6, 2020
The roadmap reflects the insights of a multidisciplinary group of global health experts who worked together to elucidate the path to inclusion of ivermectin in the toolbox against malaria, to address residual transmission, counteract insecticide resistance, and contribute to the end of this deadly disease. No abstract available
- | ivermectin / Generic mfg.
Journal: Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic. (Pubmed Central) - May 6, 2020
Our study shows that there is ongoing O. volvulus transmission in the Landja Mboko area. We recommend that the extent of this onchocerciasis focus should be mapped, and the introduction of ivermectin MDA should be considered in these communities.
- ||| ivermectin / Generic mfg.
BREAKING NEWS : Japan is coming to use the ivermectin as treatment to the COVID19 https://t.co/qM7uxmh9ah (Twitter) - May 6, 2020
- ||| ivermectin / Generic mfg.
Clinical: Ivermectin+favirpiravir+Vit C+ azithral - if this combination of drugs be given to all asymptomatic & mild CoVID cases without contraindication of each drug, maybe they recover sooner without getting critical.@PMOIndia @drharshvardhan @AmitShah @ProfBhargava @drkaushalk (Twitter) - May 3, 2020
- || ivermectin / Generic mfg., azithromycin / Generic mfg.
Clinical, Journal: Randomised trial of community treatment with azithromycin and ivermectin mass drug administration for control of scabies and impetigo. (Pubmed Central) - May 2, 2020
P4
There was a transient increase in the proportion of macrolide-resistant S. aureus strains following azithromycin MDA. Registered on clinicaltrials.gov (NCT02775617).
- || ivermectin / Generic mfg.
Ivermectin is showing promise. (Twitter) - May 2, 2020
- || ivermectin / Generic mfg.
I like this Ivermectin graph better. (Twitter) - May 2, 2020
- || ivermectin / Generic mfg.
Did you try ivermectin? (Twitter) - May 2, 2020
- ||| ivermectin / Generic mfg.
Clinical: Should have sent to NEJM "Of those requiring mechanical ventilation fewer patients died in the ivermectin group (7.3% versus 21.3%) and overall death rates were lower with ivermectin (1.4% versus 8.5% with a corresponding HR 0.20, CI 95% 0.11-0.37, p<0.0001)" Yeah, sure... (Twitter) - May 2, 2020
- || ivermectin / Generic mfg.
There are at least 4 ivermectin registered trials. (Twitter) - May 1, 2020
- || ivermectin / Generic mfg.
Any plans to further investigate the use of ivermectin based on this: https://t.co/lyUSDUUiY2 (Twitter) - May 1, 2020
- || doxycycline / Generic mfg.
Clinical, Journal: Implementation of test-and-treat with doxycycline and temephos ground larviciding as alternative strategies for accelerating onchocerciasis elimination in an area of loiasis co-endemicity: the COUNTDOWN consortium multi-disciplinary study protocol. (Pubmed Central) - Apr 30, 2020
Registered on clinicaltrials.gov (NCT02775617). Using a multidisciplinary approach, we aim to assess the effectiveness of TTd, alone or in combination with ground larviciding, following a single intervention round and scrutinise the acceptability and feasibility of implementing at scale in similar hotspots of onchocerciasis infection, to accelerate onchocerciasis elimination.
- ||| ivermectin / Generic mfg.
Clinical: Dr. Ban Truong (@WeightlessMWNM): R U confident that Quercetin is an effective substitute for HCQ in the dose U state? It would solve a huge crisis in states that restrict HCQ. Will U try Ivermectin in more difficult patients? Hope U follow Twitter more. https://t.co/gFrEtK58iB (Twitter) - Apr 30, 2020
- ||| ivermectin / Generic mfg.
Clinical: A patient asked me about this today by sheer coincidence and I said I wasn't aware of ivermectin being used in trials for Covid...clearly how wrong I was!! (Twitter) - Apr 30, 2020
- ||| ivermectin / Generic mfg.
Not a single word on #ivermectin proven to eliminate #SARS_COV_2 in 2 days! Sad. (Twitter) - Apr 30, 2020
- ivermectin / Generic mfg.
[VIRTUAL] Multiomics-based energy metabolism heterogeneity and its regulation by antiparasite drug ivermectin. () - Apr 29, 2020 - Abstract #ASCO2020ASCO_4597;
These findings provide more accurate understanding of molecular mechanisms of ovarian cancers and discovery of effective energy-metabolism-heterogeneity-based therapeutic drugs for ovarian cancers. Research Funding: This work was supported by the Xiangya Hospital Funds for Talent Introduction (to XZ), the Hunan Provincial Hundred Talent Plan (to XZ), the grants from China “863†Plan Project (Grant No.
- ||| ivermectin / Generic mfg.
Clinical: Y wait fr CoVID patients 2 b critical 2 treat wid antivirals/HCLQ&ivermectin?treat even asym &mild ones& see how soon they recover. Else they occupy hosp beds for long & if their case worsens,chance of death r higher! @drharshvardhan @AmitShah @PMOIndia @ProfBhargava @drkaushalk (Twitter) - Apr 29, 2020
- || ivermectin / Generic mfg.
Clinical, Journal: Low ivermectin use among 5- to 6-year-old children: observations from door-to-door surveys in onchocerciasis-endemic regions in Africa. (Pubmed Central) - Apr 29, 2020
The causes of the low ivermectin coverage observed among children 5-6 y of age need to be explored. Integrating ivermectin distribution into chemoprophylaxis strategies for other neglected diseases could increase coverage in a cost-effective manner.
- ||| ivermectin / Generic mfg.
Clinical, Adverse events: have to wage war agst CoVID& not b defensive! All asymptomatic patients shld be given trial drugs as long as no serious side effects- ivermectin, HCLQ &antivirals. All suspects, primary&secondary contacts also shld be given meds. @AmitShah @PMOIndia @drharshvardhan @ProfBhargava (Twitter) - Apr 28, 2020
- || ivermectin / Generic mfg.
Clinical, Journal: Determinants of community-led ivermectin treatment adherence for onchocerciasis control in Western Ethiopia: a case-control study. (Pubmed Central) - Apr 28, 2020
To improve intake of the drug and its adherence, the community should be empowered to make decisions, and counseling family members and sensitizing those living far from river sides is commendable. Health information about onchocerciasis should be strengthening to increase risk perception.
- || ivermectin / Generic mfg., Actemra IV (tocilizumab) / Roche, JW Pharma
Braking News ?? Ufff here in Dominican Republic is in use for a month. First use was in somes infected Doctor in critical condition . It’s incredible that we are saving more life ! Mortality here is low using different medications HZQ, ivermectine, Tocilizumab ect (Twitter) - Apr 27, 2020
- || ivermectin / Generic mfg.
How about this ivermectin registry? Still long road ahead. https://t.co/UWIW5m43Zl (Twitter) - Apr 27, 2020
- ivermectin / Generic mfg.
Strongyloides Screening in Heart Transplant Candidates () - Apr 26, 2020 - Abstract #ISHLT2020ISHLT_1272;
All with positive serologic screening were treated pre-transplant with ivermectin...Given the variability in diagnostic yield across commercially available serologic assays, these findings raise the possibility of false negative results and thus, bring into question the utility and reliability of using serologic testing alone, for screening of Strongyloides infection among HT candidates. Accordingly, a thoughtful assessment of epidemiologic risk is essential for appropriate risk stratification and management of Strongyloides in HT candidates and recipients.
- | ivermectin / Generic mfg.
Journal: Survey of husbandry practices for bovidae in zoos: the importance of parasite management for reintroduction programmes. (Pubmed Central) - Apr 26, 2020
The frequent use of concentrating flotation techniques as the sole method to evaluate the presence of parasite eggs in faecal samples is not recommended because it fails to detect trematode and lung nematode infections, so it would be better to use flotation techniques together with sedimentation procedures or serological and molecular tests. The results suggest that parasite control in zoological institutions can be complicated, indicating the need to implement a specific management schedule for institutions involved in reintroduction projects.