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Journal: Strongyloides Screening in Heart Transplant Candidates. (Pubmed Central) - May 30, 2020 Given the variability in diagnostic yield across commercially available serologic assays, these findings raise the possibility of false negative results and thus, bring into question the utility and reliability of using serologic testing alone, for screening of Strongyloides infection among HT candidates. Accordingly, a thoughtful assessment of epidemiologic risk is essential for appropriate risk stratification and management of Strongyloides in HT candidates and recipients.
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Clinical, Journal: Scabies therapy in Germany : Results of a nationwide survey with a special focus on the efficacy of first-line therapy with permethrin (Pubmed Central) - May 29, 2020 Ivermectin can inhibit cholangiocarcinoma cells proliferation in vivo and vitro via induction of ER-Stress and would be a promising drug therapy for cholangiocarcinoma, which provides novel treatment methods for CCA. Although there are localized reports of decreased effectiveness of permethrin therapy, results of this survey point towards a persisting high efficacy of first-line standard treatment of scabies with permethrin 5% cream in Germany.
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Journal: A single dose of ivermectin is sufficient for strongyloidiasis. (Pubmed Central) - May 28, 2020 Although there are localized reports of decreased effectiveness of permethrin therapy, results of this survey point towards a persisting high efficacy of first-line standard treatment of scabies with permethrin 5% cream in Germany. No abstract available
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Journal: Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform. (Pubmed Central) - May 27, 2020 Using a ubiquitin-dependent mitophagy inducer, the lactone ivermectin, we have combined genetic and imaging experiments to address these questions...Targeted ubiquitinated mitochondria are cradled by endoplasmic reticulum (ER) strands even without functional autophagy machinery and mitophagy adaptors. We propose that damaged mitochondria are ubiquitinated and dynamically encased in ER strands, providing platforms for formation of the mitophagosomes.
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Enrollment open, Combination therapy: DOLF IDA/Oncho: Safety and Efficacy of IDA for Onchocerciasis (clinicaltrials.gov) - May 22, 2020 P2, N=201, Enrolling by invitation, Referral to a specialised Infectious Risk Assessment consultation should be done promptly in order to review and address accordingly the risk of specific infections taking in to account the patients clinical and epidemiologic history. Suspended --> Enrolling by invitation
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