- |||||||||| ivermectin / Generic mfg.
Ivermectin? (Twitter) - Jun 14, 2020
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Journal: Genetic targeting and chemogenetic inhibition of new born neurons. (Pubmed Central) - Jun 12, 2020 Here, an approach is presented that combines the use of a transgenic mouse line, expressing cre recombinase under a nestin promoter, with lentiviral delivery of a floxed, ivermectin (IVM)-gated chloride channel construct to the dentate gyrus...Ivermectin treatment of cells expressing the chloride channel prevented gabazine-induced expression of the immediate early gene product EGR1, while cells expressing a control inactive channel or no channel retained their EGR1 response. We thus present a genetic strategy for targeting a specific neurogenic niche for transgene expression in the adult mouse brain and show proof of principle that it can be used in vitro as a method for silencing neuronal activity.
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Due to the absence of effective treatment or vaccines against COVID-19 so far, the precautionary measures according to WHO's strategic objectives are the only way to confront this crisis. Governments should adopt national medical care programs to reduce the risk of exposure to any future viral outbreaks especially to patients with pre-existing medical conditions.
- |||||||||| metformin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, sirolimus / Generic mfg.
Journal: Old wine in new bottles: Drug repurposing in oncology. (Pubmed Central) - Jun 4, 2020 In this review article we discuss the advantages of the repurposing strategy, and provide an overview of a number of promising candidates, such as aspirin, artesunate, cimetidine, doxycycline, ivermectin, metformin, rapamycin (sirolimus), and thalidomide, that have the potential to be repurposed as anticancer drugs both in cancer prevention and therapy. In addition, we highlight some of the studies regarding the signalling pathways and molecular targets altered by these drugs, and describe the biological mechanisms underlying their anticancer effects.
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Review, Journal: Novel 2019-coronavirus on new year's Eve. (Pubmed Central) - Jun 4, 2020 Preventive measures such as social distancing, quarantine, cough etiquettes, proper hand washing, cleaning and decontaminating the surfaces are the mainstay for curbing the transmission of this virus. The present review highlights the update of novel SARS-CoV-2 in context to the Indian scenario.
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