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Clinical, Journal: CME Dermatology 21: Scabies - Clinical Manifestation, Diagnosis and Therapy (Pubmed Central) - Jul 9, 2020 Additionally, written instructions on how to behave, decontaminate textiles and apply medications should be provided to suspected cases, and all the patient's close personal contacts should be treated simultaneously. As the disease can be sexually transmitted, screening for sexually transmitted diseases is recommended in sexually active patients.
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Enrollment change: Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19 (clinicaltrials.gov) - Jul 8, 2020 P=N/A, N=100, Active, not recruiting, Anthelmintic resistance was widespread on the sampled dairy calf to beef farms in Ireland with resistance to benzimidazole, levamisole, ivermectin and moxidectin detected. N=10 --> 100
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FDA event, Preclinical, Journal: The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. (Pubmed Central) - Jul 7, 2020 Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARS-CoV-2 able to effect ∼5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.
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Journal: Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. (Pubmed Central) - Jul 7, 2020 Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, including viruses. This paper proposes an alternative mechanism of action for this drug that makes it capable of having an antiviral action, also against the novel coronavirus, in addition to the processes already reported in literature.
- |||||||||| prednisone / Generic mfg., ivermectin / Generic mfg., albendazole / Generic mfg.
[VIRTUAL] Pulmonary Strongyloidiasis Complicating Acute Respiratory Distress Syndrome in an Immunocompromised Adult (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6827; Treatment includes ivermectin or albendazole, the reversal of immunosuppression and other modifiable risk factors, and supportive medical therapy. Mortality rates, however, remain as high as 60% due to complications of pneumonia, sepsis, immunosuppression, and ARDS.
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[VIRTUAL] An Unusual Case of Usual Interstitial Pneumonia (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4138; He was discharged on ivermectin as well as five antihypertensive agents...This case highlights UAPA as an underdiagnosed clinical entity and illustrates the importance of accurate radiographic evaluation to avoid potential unnecessary procedures. UAPA should be considered in the differential diagnosis of patients with chronic unilateral lung findings or unilateral lung hypoplasia.
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Journal: Genotypic and allelic frequencies of MDR1 gene in dogs in Italy. (Pubmed Central) - Jul 5, 2020 A mutation in the canine multidrug resistance MDR1 gene (also referred as ABCB1), encoding for the multidrug resistance (MDR) P-glycoprotein (P-gp) transponder, causes a pathological condition known as 'ivermectin toxicosis'...The breeds with the highest allelic mutation frequency are Smooth and Rough Collies with 75 per cent and 66 per cent of mutant MDR1 allele, respectively. The results support the usefulness of this genetic analysis to optimise medical care in dogs at risk of multidrug resistance and to create an objective basis in breeding programme definition and in the risk evaluation in different breeds.
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Journal: Disseminated Strongyloides stercoralis infection in a dog following long-term treatment with budesonide. (Pubmed Central) - Jul 4, 2020 Findings illustrated the importance of performing diagnostic testing, including routine fecal examination, to rule out infectious causes of diarrhea before beginning empirical treatment with glucocorticoids such as budesonide. Further, repeated fecal examinations, including Baermann tests, should be considered if a positive response to glucocorticoids is not observed.
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Journal: Apparent Digestibility of Nutrients, Blood Parameters and Body Development of Dewormed and Not Dewormed Weanlings. (Pubmed Central) - Jul 4, 2020 Group ND was infected mainly by small strongyles. There was no difference between groups (P > .05) for morphometric measurements, dry matter intake, and digestibility coefficients, except for apparent digestibility of calcium, which was higher (P < .05) in group D. Small strongyles infection in six- to nine-month-old weanlings fed high grain, nutrient-balanced rations apparently did not affect growth, blood parameters, and apparent digestibility of nutrients.
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Clinical, Review, Journal: Skin infections in Australian Aboriginal children: a narrative review. (Pubmed Central) - Jul 4, 2020 Addressing normalisation of skin infections and the social determinants of skin health are key challenges for the clinician. Research is underway on community-wide skin health programs and the role for mass drug administration which will guide future management of these common, treatable diseases.
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