- |||||||||| So Remdesivir,Dexamethasone,Hydroxychloroquine and chloroquine,Azithromycin,Convalescent plasma,Tocilizumab ( For DMARD), lopinavir/ritonavir, oseltamivir, favipiravir, colchicine & Ivermectin are being studied! We’re back to the drawing board,haggling for the wonder drug HCQ! (Twitter) - Jul 29, 2020
- |||||||||| Review, Journal: Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection. (Pubmed Central) - Jul 28, 2020
Natural products (carolacton, homoharringtonine, emetine, and cepharanthine) and natural product-inspired small molecules (ivermectin, GS-5734, EIDD-2801, and ebselen) are potential anti-SARS-CoV-2 agents that have attracted significant attention due to their broad-spectrum antiviral activities. Here, we review the research on potential landmark anti-SARS-CoV-2 agents, systematically discussing the importance of natural products and natural-product-inspired small molecules in the research and development of safe and effective antiviral agents.
- |||||||||| ivermectin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
Preclinical, Journal: Effects of combined drug treatments on Plasmodium falciparum: In vitro assays with doxycycline, ivermectin and efflux pump inhibitors. (Pubmed Central) - Jul 22, 2020 CI results showed synergistic effect of verapamil plus doxycycline, which is coherent with the starting hypothesis, i.e. that ABC transporters represent potential targets, worth of further investigations, towards the development of companion molecules useful to enhance the efficacy of antimalarial drugs. At the same time, the observed antagonistic effect of doxycycline in combination with ivermectin or elacridar highlighted the importance of drug testing, to avoid the de-facto generation of a sub-dosage, a condition that facilitates the development of drug resistance.
- |||||||||| ivermectin oral / Generic mfg.
Enrollment open: Efficacy of Ivermectin in Adult Patients With Early Stages of COVID-19 (EPIC Trial) (clinicaltrials.gov) - Jul 21, 2020 P2/3, N=400, Recruiting, At the same time, the observed antagonistic effect of doxycycline in combination with ivermectin or elacridar highlighted the importance of drug testing, to avoid the de-facto generation of a sub-dosage, a condition that facilitates the development of drug resistance. Not yet recruiting --> Recruiting
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