- |||||||||| ivermectin / Generic mfg., albendazole / Generic mfg.
Review, Journal: Anthelmintic drugs for treating ascariasis. (Pubmed Central) - Sep 1, 2020 The drugs appear to be safe to treat children and adults with confirmed Ascaris infection. There is little to choose between drugs and regimens in terms of cure or adverse events.
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Journal: Assessing Onchocerciasis Subcriticality from Pre-Intervention Cross-Sectional Surveys. (Pubmed Central) - Sep 1, 2020 Here, we assess the distribution of onchocerciasis prevalence taken from surveys across sub-Saharan Africa before the initiation of ivermectin in mass drug administrations...Even if the geometric distribution suggested pre-intervention subcriticality in more localized geographical areas, our model using pooled survey data of all geographic areas suggests that the pre-intervention prevalence does not fit a geometric distribution. Further work will be required to confirm the significance of a geometric distribution for onchocerciasis.
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Journal: Ivermectin: Potential Role as Repurposed Drug for COVID-19. (Pubmed Central) - Sep 1, 2020 In the meanwhile, the available practical approach is to repurpose existing therapeutic agents, with proven safety record as a rapid response measure for the current pandemic. Here we discuss the presently used repurposed drugs for COVID-19 and the potential for ivermectin (IVM) to be used as a therapeutic option in COVID-19.
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Trial completion date, Trial primary completion date: SAINT: Sars-CoV-2/COVID-19 Ivermectin Navarra-ISGlobal Trial (clinicaltrials.gov) - Aug 31, 2020 P2, N=24, Recruiting, Here we discuss the presently used repurposed drugs for COVID-19 and the potential for ivermectin (IVM) to be used as a therapeutic option in COVID-19. Trial completion date: Aug 2020 --> Dec 2020 | Trial primary completion date: Aug 2020 --> Nov 2020
- |||||||||| doxycycline / Generic mfg., Pierre Fabre
Journal: Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention. (Pubmed Central) - Aug 28, 2020 Initial candidate interventions include prophylaxis to augment epithelial defense (e.g., AT1 receptor blockade, type III and type I interferons, melatonin, calcitriol, camostat, and lopinavir) and to reduce viral load (e.g., remdesivir, ivermectin, emetine, Abelson kinase inhibitors, dopamine D2 antagonists, and selective estrogen receptor modulators). Additional interventions focus on tempering inflammatory signaling and injury (e.g., dexamethasone, doxycycline, Ang1-7, estradiol, alpha blockers, and DHA/EPA, pasireotide), as well as inhibitors targeted toward molecular mediators of the maladaptive COVID-19 immune response (e.g., IL-6, TNF-α, IL-17, JAK, and CDK9).
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Review, Journal: Treatment Options for COVID-19: A Review. (Pubmed Central) - Aug 28, 2020 Drug repurposing of available antiviral agents may provide a respite; moreover, a cocktail of antiviral agents may be helpful in treating this disease. Here, we have highlighted a few available antimicrobial agents that could be very effective in treating COVID-19; indeed, a number of trials are underway to detect and confirm the efficacy of these agents.
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Journal: The Role of IL-17 in Papulopustular Rosacea and Future Directions. (Pubmed Central) - Aug 27, 2020 We hypothesize that IL-17 inhibitors, currently used successfully in psoriasis and psoriatic arthritis, could perhaps be used to treat severe and treatment-resistant papulopustular rosacea in the future; however, clinical trials and case reports will be needed to dictate expanded indications of IL-17 inhibitors. Furthermore, the high cost of IL-17 inhibitors presently prevents their use in disease states other than psoriasis or psoriatic arthritis.
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Review, Journal: Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. (Pubmed Central) - Aug 27, 2020 Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.
- |||||||||| Review, Journal: Known drugs and small molecules in the battle for COVID-19 treatment. (Pubmed Central) - Aug 26, 2020
While nicotine and ivermectin may be blocking transport abilities of the virus or its components, famotidine, remdesivir and chloroquine in combination with zinc ions can deactivate important enzymes needed for the replication of the virus. While clinical trials for some of these drugs have already started, it is common knowledge that lack of organization between countries, institutes and hospitals might slow down the whole process for an official treatment based in wide, randomized, placebo controlled trials.
- |||||||||| Journal: Pandemic COVID-19: current status and challenges of antiviral therapies. (Pubmed Central) - Aug 26, 2020
Convalescent plasma (CP) therapy suggested its safety use in SARS-CoV-2 infection; but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human origin. Further research should be conducted to define the exact mechanism of SARS-CoV-2 pathogenesis, suitable animal models or ex vivo human lung tissues aid in studying replication, transmission and spread of the novel viruses, thereby facilitating highly effective therapies.
- |||||||||| moxidectin / Generic mfg., ivermectin / Generic mfg.
PK/PD data, Review, Journal: Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. (Pubmed Central) - Aug 24, 2020 Avermectin has unwanted effects or reactions, especially when administered indiscriminately, which include respiratory failure, hypotension, and coma. The current review examines the mechanism of actions, biosynthesis, safety, pharmacokinetics, biological toxicity and activities of avermectins.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Encephalopathy in a patient with loiasis treated with albendazole: A case report. (Pubmed Central) - Aug 23, 2020 The clinical and electroencephalographic similarities between Loa loa albendazole-related encephalopathy and immune-mediated encephalitis suggest the possibility of an underlying inflammation-based pathogenesis. Although corticosteroid administration is not recommended in Loa loa ivermectin-induced encephalopathy, in this case of Loa loa albendazole-induced encephalopathy it may have played a therapeutic role.
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Review, Journal: Ivermectin: repurposing a multipurpose drug for Venezuela's humanitarian crisis. (Pubmed Central) - Aug 22, 2020 IVM's versatile nature could serve as a powerful tool to tackle the multiple overlapping endemic and emergent diseases that affect Venezuela today. The repurposing of this multipurpose drug would be without a doubt a timely therapeutical approach to help mitigate the tremendous burden of NTDs nationwide.
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Ou ivermectina (Twitter) - Aug 22, 2020
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Journal: Acaricide resistance in Rhipicephalus microplus collected from selected districts of Madhya Pradesh, Uttar Pradesh and Punjab states of India. (Pubmed Central) - Aug 20, 2020 The isolates of Rhipicephalus microplus collected from Madhya Pradesh (MP), Punjab (PJB) and Uttar Pradesh (UP) states of India were characterized using laboratory standardized adult immersion test (AIT) against macrocyclic lactone (ivermectin), synthetic pyrethroids (cypermethrin and deltamethrin), organophosphates (coumaphos and diazinon) and phenylpyrazole compounds (fipronil)...The phenylpyrazole compound however was found effective, and none of the isolates could survive at a discriminating concentration. The possible strategy for the management of multi-acaricide-resistant ticks in the surveyed districts was discussed in the present study.
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