- |||||||||| ivermectin / Generic mfg.
Preclinical, Journal: Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models. (Pubmed Central) - Sep 16, 2020
Ivermectin directly binds this pocket to inhibit MAPKAP2-mediated HSP27 phosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and client-oncoprotein interactions. Ivermectin potentiated activity of anti-androgen receptor and anti-EGFR drugs in prostate and EGFR/HER2-driven tumor models, respectively, identifying a repurposing approach for cotargeting stress-adaptive responses to overcome resistance to inhibitors of oncogenic pathway signaling.
- |||||||||| prednisone / Generic mfg., ivermectin / Generic mfg.
[VIRTUAL] An Unusual Case of Nausea and Vomiting () - Sep 15, 2020 - Abstract #ACG2020ACG_3291;
Home medications include a recently prescribed prednisone taper for back pain...Patient was treated with ivermectin and made a complete recovery...Screening patients from endemic regions before immunosuppression or organ donation is recommended. It is important for providers to maintain a high index of suspicion for Strongyloides in immunosuppressed patients from endemic regions presenting with rash or GI symptoms.
- |||||||||| ivermectin / Generic mfg.
[VIRTUAL] Strongyloidiasis Hyperinfection in an Immunocompetent HIV Male () - Sep 15, 2020 - Abstract #ACG2020ACG_3236;
Patient was subsequently treated with an extended course of ivermectin...An extensive literature review revealed less than 20 cases of strongylodiasis hyperinfection in HIV positive patients in the continental United States. However, due to advances in diagnostic techniques and increased awareness of the disease process, the incidence is increasing in 3rd world nations where HIV is more prevalent.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] The First Documented Case of Strongyloides Liver Abscess With Superimposed Methicillin-Resistant Staph aureus Infection () - Sep 15, 2020 - Abstract #ACG2020ACG_2926;
He was initially treated with ivermectin and percutaneous drainage, but subsequently developed secondary Klebsiella pneumoniae, Bacteroides fragilis and Candida albicans infections, requiring intravenous (IV) ceftriaxone and fluconazole...Though IV vancomycin was initiated, the post-surgical course was complicated by MRSA bacteremia and meningitis...This case highlights the importance of reassessing a patient’s diagnosis when the patient does not improve with appropriate therapy. In this case, abscess cultures revealed a superimposed MRSA infection for which appropriate therapy was provided, resulting in the patient’s recovery.
- |||||||||| ivermectin / Generic mfg.
[VIRTUAL] Strongyloidiasis: A Fatal Mimicker of Inflammatory Bowel Disease () - Sep 15, 2020 - Abstract #ACG2020ACG_2291;
A simple regimen of Ivermectin (200mcg/kg per day for one or two days) and avoidance of immunosuppressive agents is curative of this disease. This case illustrates the importance of maintaining high cognizance of the striking similarities and subtle differences between Strongyloidiasis and Inflammatory Bowel Disease to avoid any fatal diagnostic error.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J
[VIRTUAL] Pulmonary Manifestations of Crohn’s Disease () - Sep 15, 2020 - Abstract #ACG2020ACG_2283;
As his symptoms, effusions, and lymphadenopathy all improved with infliximab, this suggests that the pulmonary manifestations were related to his inflammatory condition. We provide this case as the first description of CTEPH and pleural effusion as an EIM for CD.
- |||||||||| clarithromycin / Generic mfg., omeprazole / Generic mfg., amoxicillin / Generic mfg.
[VIRTUAL] Acute Upper Gastrointestinal Bleed Unmasks a Wormy Intruder in an Immunocompetent Patient - A Case of Chronic Strongyloides stercoralis () - Sep 15, 2020 - Abstract #ACG2020ACG_1982;
IVF hydration and Protonix drip was started...Patient was discharged with treatment for H. pylori with Amoxicillin, Clarithromycin and Omeprazole...Treatment is Ivermectin 200mcg/kg for 1-2 days in uncomplicated immunocompetent patient.6,7 This rare case of Strongyloides reminds us to think of a zebra diagnosis when looking into common gastroenterology symptoms. Image 1: Gastric mucosa of the patient showing inflammatory infiltration of lamina propria and eggs and rhabditiform larvae (red arrow) of Strongyloides stercoralis in the glands under light microscopy in a biopsy made by endoscopic procedure (H&E staining).
- |||||||||| bictegravir (GS-9883) / Gilead
[VIRTUAL] Diagnosis of Strongyloidiasis in the Antrum, Duodenum, and Colon by Endoscopy of a Patient With HIV () - Sep 15, 2020 - Abstract #ACG2020ACG_1832;
His CD4 count was 133/cumm (ref 494-1694/cumm) while on antiretroviral therapy with bictegravir, emtricitabine, and tenofovir...He was prescribed ivermectin, fluconazole, valganciclovir and discharged home...No change in eosinophils could be the result of immune dysregulation secondary to HIV. This case highlights the importance of endoscopic evaluation for infection causing gastrointestinal symptoms in an immunocompromised patient.
- |||||||||| Gazyva (obinutuzumab) / Roche, Biogen
[VIRTUAL] A Case of Strongyloides Hyperinfection Syndrome in an Immunocompromised Patient () - Sep 15, 2020 - Abstract #ACG2020ACG_1235;
Case Description/ A 67-year-old male with leukemia on ibrutinib and obinutuzumab presented with persistent non-productive cough and dyspnea unresponsive to methylprednisolone...He was treated for pneumonia, yet had worsening hypoxia with suspicion for Pneumocystis pneumonia, and was started on trimethoprim-sulfamethoxazole and prednisone with paradoxical worsening respiratory failure requiring intubation...He was treated with subcutaneous ivermectin and albendazole with persistent shock...This case highlights classic features of SHS including eosinophilia, cough with progressive respiratory failure, thumb-print purpuric rash, and gastrointestinal symptoms. Due to significant mortality, it is critical to maintain a high index of suspicion and carefully consider steroid use in immunocompromised patients with this constellation of symptoms.
- |||||||||| ivermectin / Generic mfg., PerFoam Five (permethrin) / Menlo Therap
Review, Journal: Part I - Ectoparasites: Scabies. (Pubmed Central) - Sep 13, 2020
With scabies now recognized as a neglected tropical disease by the World Health Organization, increased awareness and systematic efforts are addressing gaps in diagnosis and treatment that impede scabies control. This review summarizes available data and provides an update on scabies epidemiology, clinical features, diagnosis, management, and public health considerations.
- |||||||||| ivermectin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, salinomycin (HSB-1216) / Hillstream BioPharma
Review, Journal: Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs. (Pubmed Central) - Sep 11, 2020
To date, these agents have been used for the treatment of a broad-spectrum of bacterial and parasitic infectious diseases and are widely available, which is why they were selected. The data presented here clearly show that the antibiotics mentioned above should be recognised in the near future as novel agents able to eradicate cancer cells and cancer stem cells (CSCs) across several cancer types.
- |||||||||| ivermectin / Generic mfg.
Journal: Ivermectin-a drug and a tool. (Pubmed Central) - Sep 9, 2020
In addition, drug-drug interaction and safety concerns must be taken into account before the administration of the recommended drugs. No abstract available
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: Natural history of COVID-19 and current knowledge on treatment therapeutic options. (Pubmed Central) - Sep 9, 2020
These include different classes of drugs such as antiviral agents (chloroquine, ivermectin, nitazoxanide, hydroxychloroquine, lopinavir, remdesivir, tocilizumab), supporting agents (Vitamin C, Vitamin D, azithromycin, corticosteroids) and promising investigational vaccines. Considering the controversies and excessive number of compounds being tested and reported in the literature we hope that this review can provide useful and updated consolidated information on potential drugs used to prevent, control and treat COVID-19 patients worldwide.
- |||||||||| hydroxychloroquine / Generic mfg.
Enrollment open, Trial completion date: Comparative Study of Hydroxychloroquine and Ivermectin in COVID-19 Prophylaxis (clinicaltrials.gov) - Sep 8, 2020
P=N/A, N=400, Recruiting,
Considering the controversies and excessive number of compounds being tested and reported in the literature we hope that this review can provide useful and updated consolidated information on potential drugs used to prevent, control and treat COVID-19 patients worldwide. Not yet recruiting --> Recruiting | Trial completion date: Oct 2020 --> Apr 2021
- |||||||||| ivermectin / Generic mfg.
Ivermectin? (Twitter) - Sep 8, 2020
- |||||||||| ivermectin / Generic mfg.
Journal: Entomological Assessment of Onchocerca Species Transmission by Black Flies in Selected Communities in the West Region of Cameroon. (Pubmed Central) - Sep 6, 2020
The enormity of the public health burden of onchocerciasis motivated the creation of various large-scale control programs that have depended principally on mass treatment of endemic communities with ivermectin for the elimination of the disease...On the other hand, the frequency of infected flies was 0.8% in Makouopsap, 0.2% in Bankambe, 0.1% in Bayon, and 0.0% in Lemgo, Tsesse, Ndionzou, and Kouffen. These results provide entomologic evidence for continuous transmission of Onchocerca species in Makouopsap, risk of active transmission in Bankambe, and Bayon, and a suppressed transmission in the four other studied communities.
- |||||||||| ivermectin / Generic mfg.
Journal: White paper on Ivermectin as a potential therapy for COVID-19. (Pubmed Central) - Sep 5, 2020
The panel looked at Ivermectin, one of the old molecule and evaluated it's use in COVID 19 (Novel Coronavirus Disease 2019) management. After critical panel discussion, all the attending doctors came to a conclusion that Ivermectin can be a potential molecule for prophylaxis and treatment of people infected with Coronavirus, owing to its anti-viral properties coupled with effective cost, availability and good tolerability and safety.
- |||||||||| ivermectin / Generic mfg.
Journal: Orally Administrable Therapeutic Synthetic Nanoparticle for Zika Virus. (Pubmed Central) - Sep 4, 2020
Further, our preliminary in vitro studies documented that ivermectin crosses the placental barrier, thus making it unsafe for the pregnant ZIKV population, whereas the ivermectin-loaded nanoparticle did not show any significant placental barrier crossing, thus indicating its potential suitability for such population. We envision that this work will fill a great unmet need by developing safer and more effective therapies for the treatment of viral infections, including ZIKV.
- |||||||||| ivermectin / Generic mfg.
Journal: Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations. (Pubmed Central) - Sep 4, 2020
It was recently demonstrated that both ivermectin and chloroquine inhibit replication of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in vitro Further ivermectin and chloroquine trials in humans are warranted to evaluate their role in Plasmodium vivax control and as adjunctive therapies against COVID-19 infections. No abstract available
- |||||||||| ivermectin / Generic mfg.
Review, Journal: Where Are We With Human Lice? A Review of the Current State of Knowledge. (Pubmed Central) - Sep 2, 2020
For instance, ivermectin represents a relatively new and very promising pediculicide...Therefore, novel opportunities for pest control strategies are needed. Our objective here is to review the current state of knowledge on the biology, epidemiology, phylogeny, disease-vector and control of this fascinating and very intimate human parasite.
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