- |||||||||| moxidectin / Generic mfg., ivermectin / Generic mfg.
Journal: Impact on beef cattle productivity of infection with anthelmintic-resistant nematodes. (Pubmed Central) - Nov 19, 2020 In calves naturally infected with resistant nematodes, under the production system assessed here, weight gains were lower in calves treated with anthelmintics that were moderately or highly ineffective compared to those treated with highly effective anthelmintics. These results demonstrate to farmers and veterinarians the importance of a sustainable and effective nematode control under field conditions.
- |||||||||| ivermectin / Generic mfg.
Journal: Oral migration of Dirofilaria repens after creeping dermatitis. (Pubmed Central) - Nov 18, 2020 Ivermectin treatment was given prior to diagnosis, while taking into consideration the most common causes of creeping dermatitis, but treatment was ineffective. The oral form of dirofilariasis is uncommon and could lead to diagnostic wandering.
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Journal: Elimination of Simulium neavei-Transmitted Onchocerciasis in Wambabya-Rwamarongo Focus of Western Uganda. (Pubmed Central) - Nov 18, 2020 The approach for elimination was twice yearly treatment with ivermectin for every round, treating at least 90% of all the eligible population...In 2017, after the PTS period, all 3,079 young children examined were negative for OV16 (95% CI: 0-0.16). Therefore, entomological and serological results provided evidence that resulted in the reclassification of Wambabya-Rwamarongo focus from "transmission interrupted" to "transmission eliminated" with no possibility of recrudescence.
- |||||||||| moxidectin / Generic mfg., ivermectin / Generic mfg.
Retrospective data, Journal: Implications of Endectocide Residues on the Survival of Aphodiine Dung Beetles: A Meta-Analysis. (Pubmed Central) - Nov 12, 2020 It is often difficult to compare studies examining the effects of endectocides on dung fauna because of different experimental approaches, for example, active ingredients (eprinomectin, doramectin, ivermectin, moxidectin) and formulations (injectable, pour-on, spiked). Environ Toxicol Chem 2020;00:1-10.
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Trial completion date, Trial primary completion date: Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis (clinicaltrials.gov) - Nov 10, 2020 P3, N=1000, Not yet recruiting, The results of this study suggest that CDDs, who are present in about 200,000 communities in 31 Sub Saharan African countries where onchocerciasis is endemic, can be successfully used to assess epilepsy prevalence, and therefore map epilepsy in many African countries. Trial completion date: Nov 2023 --> Jul 2024 | Trial primary completion date: Nov 2023 --> Jul 2022
- |||||||||| Journal: Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating. (Pubmed Central) - Nov 6, 2020
Lithocholic acid allosterically modulates P2X2 and P2X4 receptor sensitivity to ATP, reduces the rate of P2X4 receptor desensitization and antagonizes the effect of ivermectin on P2X4 receptor deactivation...Lithocholic acid also inhibits ATP-evoked currents in pituitary gonadotrophs expressing native P2 × 2, and potentiates ATP currents in nonidentified pituitary cells expressing P2 × 4 receptors. These results indicate that lithocholic acid is a bioactive steroid that may help to further unveil the importance of the P2 × 2, and P2 × 4 receptors in many physiological processes.
- |||||||||| chloroquine phosphate / Generic mfg., dexamethasone / Generic mfg., ivermectin / Generic mfg.
Preclinical, Journal: What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results. (Pubmed Central) - Nov 6, 2020 Several clinical studies are being performed to test possible drugs in response to the COVID-19 outbreak; however, there is still no treatment that is completely effective. Our goal in this paper is to bring together the results of main studies carried out with different drugs in order to help spread the knowledge about possible treatments for COVID-19 that have been suggested so far.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Dificid (fidaxomicin) / Merck (MSD), Astellas
Journal: Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach. (Pubmed Central) - Nov 3, 2020 Furthermore, ADME analysis along with analysis of toxicity was also undertaken to check the pharmacokinetics and drug-likeness properties of the two compounds. Comparative structural analysis of protein-inhibitor complexes revealed that the amino acids Y32, K47, Y122, Y129, H133, N138, D140, T141, S709 and N781 are crucial for drug surface hotspot in the RdRp of SARS-CoV-2.
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