ivermectin oral / Generic mfg. 
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  • ||||||||||  ivermectin / Generic mfg.
    Journal:  Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine. (Pubmed Central) -  Nov 28, 2020   
    Our findings revealed that the Warburg and reverse Warburg effects coexisted in human ovarian cancer tissues, provided the first multiomics-based molecular alteration spectrum of ovarian cancer energy metabolism pathways (aerobic glycolysis, Kreb's cycle, oxidative phosphorylation, and lactate shuttle), and demonstrated that the antiparasite drug ivermectin effectively regulated these changed molecules in energy metabolism pathways and had strong capability to inhibit cell proliferation and cell cycle progression and promote cell apoptosis in ovarian cancer cells. The observed molecular changes in energy metabolism pathways bring benefits for an in-depth understanding of the molecular mechanisms of energy metabolism heterogeneity and the discovery of effective biomarkers for individualized patient stratification and predictive/prognostic assessment and therapeutic targets/drugs for personalized therapy of ovarian cancer patients.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date:  DOLF-LIBERIA: Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia (clinicaltrials.gov) -  Nov 27, 2020   
    P=N/A,  N=21862, Enrolling by invitation, 
    The observed molecular changes in energy metabolism pathways bring benefits for an in-depth understanding of the molecular mechanisms of energy metabolism heterogeneity and the discovery of effective biomarkers for individualized patient stratification and predictive/prognostic assessment and therapeutic targets/drugs for personalized therapy of ovarian cancer patients. Trial completion date: Jul 2020 --> Jul 2021
  • ||||||||||  ivermectin / Generic mfg.
    Use ivermectin (Twitter) -  Nov 26, 2020   
  • ||||||||||  ivermectin / Generic mfg.
    Journal:  Inhibition of human adenovirus replication by the importin α/β1 nuclear import inhibitor ivermectin. (Pubmed Central) -  Nov 26, 2020   
    This study expands our mechanistic knowledge of ivermectin by showing that ivermectin targets the ability of Imp-α to recognize nuclear localization sequences, without effecting the Imp-α/β1 interaction. These data also exemplify the applicability of targeting host factors upon which viruses rely as a viable antiviral strategy.
  • ||||||||||  meropenem / Generic mfg.
    [VIRTUAL] CASE REPORT: INVASIVE ASPERGILOSIS AND COVID-19 IN A PATIENT WITH MYELODYSPLASIA () -  Nov 26, 2020 - Abstract #HEMO2020HEMO_933;    
    A tracheal aspirate culture was performed, which showed the presence of Aspergillus fumigatus, and Voriconazole was started... Intensive care and early diagnosis are essential to provide a favorable outcome to the numerous clinical complications of hematological diseases.
  • ||||||||||  ceftriaxone / Generic mfg.
    [VIRTUAL] IMMUNE THROMBOCYTOPENIC PURPLE SECONDARY TO COVID-19 INFECTION () -  Nov 26, 2020 - Abstract #HEMO2020HEMO_928;    
    The report confirms the possibility of PTI's association with SARS-CoV-2, consistent with other publications. Finally, despite the pathophysiology of COVID-19 hypercoagulability, management does not differ in relation to other causes of acute ITP, with attention to hemorrhagic or thrombotic complications.
  • ||||||||||  ivermectin / Generic mfg.
    [VIRTUAL] Broaden Your Rosacea Therapy Approach () -  Nov 26, 2020 - Abstract #FCPANP2020FCPANP_44;    
    Newer studies are showing that ivermectin might play a larger role in controlling inflammation than previously thought that may even eclipse any effect it may have on Demodex folliculorum...Best of all, topical formulations of agents such as topical minocycline foam and gel have limited systemic absorption (thus limiting adverse effects such as vestibular disturbances, drug reactions, and concerns with antibiotic resistance) but significantly improved concentration at target sites in the dermis and epidermis. This talk highlighted the evolution of rosacea therapy as it adapts and keeps apace of our understanding of the pathophysiology.
  • ||||||||||  ivermectin / Generic mfg.
    Now do ivermectin (Twitter) -  Nov 25, 2020   
  • ||||||||||  ivermectin / Generic mfg.
    Journal:  Use of Ov16-Based Serology for Post-Elimination Surveillance of Onchocerciasis in Ecuador. (Pubmed Central) -  Nov 25, 2020   
    Onchocerciasis has been targeted for regional elimination based on annual and semiannual mass drug administration (MDA) with ivermectin in endemic communities over several years...All samples were negative, indicating no evidence of transmission since MDA was stopped. Ov16-based serology offers an economic and practical alternative for measuring vector infectivity for post-certification surveillance in formerly endemic countries where expertise and capacity to reliably measure fly infectivity rates are costly to maintain.
  • ||||||||||  doxycycline / Generic mfg., Pierre Fabre, favipiravir / Generic mfg.
    Journal:  Favipiravir and the Need for Early Ambulatory Treatment of SARS-CoV2 Infection (COVID-19). (Pubmed Central) -  Nov 25, 2020   
    These data support the concept that favipiravir could be paired with at least one more off-target antiviral agent (doxycycline, azithromycin, ivermectin) followed by corticosteroids and antithrombotics to prevent COVID-19 hospitalization and death in those over age 50 an or those with one or more comorbidities. Clinical trials and advanced practice should immediately pivot to combination/sequential drug therapy for ambulatory COVID-19 illness.
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment open, Trial completion date, Trial primary completion date:  GALECRUSTED: Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies (clinicaltrials.gov) -  Nov 23, 2020   
    P3,  N=130, Recruiting, 
    Clinical trials and advanced practice should immediately pivot to combination/sequential drug therapy for ambulatory COVID-19 illness. Not yet recruiting --> Recruiting | Trial completion date: Mar 2019 --> May 2021 | Trial primary completion date: Mar 2019 --> Apr 2021
  • ||||||||||  Clinical, Journal:  Crusted scabies in a Pediatric Renal transplant recipient on immunosuppressants. (Pubmed Central) -  Nov 22, 2020   
    This case is the first documented report of CS in a pediatric renal transplant patient. Our management highlights that classic formularies of magistral drugs are still effective treatment options and can be used especially when standard therapies cannot be tolerated or when optimum treatments are not available.
  • ||||||||||  ivermectin / Generic mfg.
    Preclinical, Journal:  In Vitro Efficacy of Aqueous and Methanol Extract of Cassia siamea Against the Motility of Caenorhabditis elegans. (Pubmed Central) -  Nov 22, 2020   
    The methanol extracts inhibited the motility of C. elegans Bristol N2 by 86.7% as well as DA1316 up to 84.9% at 2.0 mg mL after 48 h. The methanol extract was more efficient than aqueous extract (P < 0.05) against the motility of both strains of C. elegans. Cassia siamea may be used as a natural source of lead compounds for the development of alternative anthelmintic against parasitic nematodes as well ivermectin resistant strains of nematodes.
  • ||||||||||  Fasenra (benralizumab) / AstraZeneca
    [VIRTUAL] MARKED HYPEREOSINOPHILIA, ENDOMYOCARDITIS, ACUTE HEART FAILURE, AND BRAIN MICROINFARCTS IN A 16-YEAR-OLD MALE () -  Nov 21, 2020 - Abstract #ACAAI2020ACAAI_797;    
    A repeat bone marrow revealed 5% blasts consistent with a rare pre-B cell ALL involving IGH and IL3 (3).Discussion Although evaluation of pediatric hypereosinophilia cases may be considered broad (2), those that present acutely may not be as well described. The challenge was his acute presentation with thrombotic complications and worsening heart condition that required emergent management, eosinophil lowering measures, thorough work-up, and specific hematologic reevaluation.
  • ||||||||||  prednisone / Generic mfg., ivermectin / Generic mfg.
    [VIRTUAL] IS IT MULTICENTRIC CASTLEMAN’S DISEASE, IGG4 RELATED LYMPHADENOPATHY, OR AN OVERLAP? () -  Nov 21, 2020 - Abstract #ACAAI2020ACAAI_752;    
    Ivermectin was given empirically without response...Prednisone 40 mg qd was given...However, he has features of MCD such as constitutional symptoms, elevated CRP, and anemia. Overlapping features of these rare diseases challenges allergist immunologists.