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Journal: Biomagnification and body distribution of ivermectin in dung beetles. (Pubmed Central) - Dec 16, 2020 The results of this study highlight that the biomagnification of ivermectin should be investigated from a global dung-based food web perspective and that the use of these antiparasitic substances should be monitored and controlled on a precautionary basis. Thus, we suggest that an additional effort be made in the development of standardised regulatory recommendations to guide biomagnification studies in terrestrial organisms, but also that it is necessary to adapt existing methods to assess the effects of such veterinary medical products.
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Journal: Acaricidal Activity of Artemisia nilagirica Leaves Against Rhipicephalus (Boophilus) annulatus Ticks. (Pubmed Central) - Dec 16, 2020 Chemical acaricides such as organophosphates, synthetic pyrethroids, amitraz, and ivermectin are commonly used in tick control...Biochemical quantification, fluorescence analysis, and primary phytochemical analysis are already reported for the ethanolic extract and its fractions of areal parts of A. nilagirica. Phytochemical characterization of ethanolic extract of A. nilagirica from Kerala, India was shown to have the presence of terpenoids, flavonoids, steroids, saponins, fixed oils and fats, tannins, and glycosides.
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Ivermectin (Twitter) - Dec 16, 2020
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Enrollment change, Combination therapy: Trial of Combination Therapy to Treat COVID-19 Infection (clinicaltrials.gov) - Dec 16, 2020 P2, N=30, Recruiting, Phytochemical characterization of ethanolic extract of A. nilagirica from Kerala, India was shown to have the presence of terpenoids, flavonoids, steroids, saponins, fixed oils and fats, tannins, and glycosides. N=300 --> 30
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Retrospective data, Review, Journal: Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis. (Pubmed Central) - Dec 15, 2020 Similarly, the random effect model revealed that adding ivermectin led to significant clinical improvement compared to usual therapy (OR=1.98, 95% CI: 1.11 to 3.53, P=0.02). However, this should be inferred cautiously as the quality of evidence is very low. Currently, many clinical trials are on-going, and definitive evidence for repurposing this drug for COVID-19 patients will emerge only in the future.
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