AT-777 / Atea Pharma 
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  • ||||||||||  AT-777 / Atea Pharma
    Journal:  A water-soluble luminescent tris(2,4,6-trichlorophenyl)methyl radical-carbazole dyad. (Pubmed Central) -  Jun 24, 2024   
    The water-soluble TTM radical aqueous solution showed fluorescence at 777 nm and the ability to shorten the longitudinal relaxation time (T1) of water. The concept of water-soluble luminescent radicals is expected to be used to develop a potential fluorescence and MR dual-use imaging moiety.
  • ||||||||||  AT-777 / Atea Pharma
    Journal:  Analysis of Blue Corona Discharges at the Top of Tropical Thunderstorm Clouds in Different Phases of Convection. (Pubmed Central) -  Jul 24, 2022   
    We report on observations of corona discharges at the uppermost region of clouds characterized by emissions in a blue band of nitrogen molecules at 337 nm, with little activity in the red band of lightning leaders at 777.4 nm...The discharges are observed in both environments. The observations suggest that a range of storm environments may generate corona discharges and that they may be common in convective surges.
  • ||||||||||  bemnifosbuvir (AT-527) / Atea Pharma, AT-777 / Atea Pharma
    Enrollment change, Trial withdrawal, Combination therapy:  Study of AT-777 in Healthy Subjects and AT-777 in Combination With AT-527 in HCV-Infected Subjects (clinicaltrials.gov) -  Jun 8, 2022   
    P1/2,  N=0, Withdrawn, 
    The observations suggest that a range of storm environments may generate corona discharges and that they may be common in convective surges. N=26 --> 0 | Suspended --> Withdrawn
  • ||||||||||  AT-777 / Atea Pharma
    Journal:  Optical emissions associated with narrow bipolar events from thunderstorm clouds penetrating into the stratosphere. (Pubmed Central) -  Nov 21, 2021   
    We found that both polarities NBEs are associated with emissions at 337 nm with weak or no detectable emissions at 777.4 nm, suggesting that NBEs are associated with streamer breakdown...For negative NBEs, the emission strength is almost linearly correlated with the peak current of the associated NBEs. Our findings suggest that ground-based observations of radio signals provide a new means to measure the occurrences and strength of cloud-top discharges near the tropopause.
  • ||||||||||  AT-777 / Atea Pharma
    Journal:  Laser induced breakdown spectroscopy for monitoring the molten phase desulfurization process of blister copper. (Pubmed Central) -  Sep 7, 2021   
    Using ST-LIBS the relative emission intensities of Cu(I) at 351.06 nm, O at 777.34 nm and S at 921.29 nm in both molten and gaseous phase were considered simultaneously during the process...These results were validated with differential optical absorption spectroscopy (DOAS) as gold standard method. The analytical information obtained by LIBS can precisely determine the critical end-point of the desulfurization where the removal of sulfur is finished, and copper started to oxidize.
  • ||||||||||  AT-777 / Atea Pharma
    Journal:  Collisional excitation kinetics for O(3s^{5}S^{o}) and O(3p^{5}P_{3}) states using laser absorption spectroscopy in shock-heated weakly ionized O_{2}-Ar mixture. (Pubmed Central) -  Jul 18, 2021   
    Collisional excitation kinetics for atomic oxygen is studied behind reflected shock waves in 1%O_{2}/Ar mixtures over 10 000-11 000K using laser absorption spectroscopy of the O(3s^{5}S^{o}) to O(3p^{5}P_{3}) transition at 777 nm and the O(3p^{5}P_{3}) to O(3d ^{5}D_{2,3,4}^{o}) transitions at 926 nm...The four measured time histories are used to optimize the 12 collisional rate constants in the CR model using a stochastic gradient descent (SGD) algorithm. The time-history results, diagnostic methods, and collisional-radiative model presented in the current study are potentially useful in studies of high-enthalpy air, plasma processing, or other applications involving weakly ionized oxygen.
  • ||||||||||  bemnifosbuvir (AT-527) / Atea Pharma, AT-777 / Atea Pharma
    Trial completion date, Trial suspension, Trial primary completion date, Combination therapy:  Study of AT-777 in Healthy Subjects and AT-777 in Combination With AT-527 in HCV-Infected Subjects (clinicaltrials.gov) -  Apr 29, 2021   
    P1/2,  N=26, Suspended, 
    The time-history results, diagnostic methods, and collisional-radiative model presented in the current study are potentially useful in studies of high-enthalpy air, plasma processing, or other applications involving weakly ionized oxygen. Trial completion date: Feb 2021 --> Sep 2022 | Recruiting --> Suspended | Trial primary completion date: Nov 2020 --> Jun 2022
  • ||||||||||  AT-777 / Atea Pharma
    Journal:  Two-Temperature Collisional-Radiative Modeling of Partially Ionized O-Ar Mixtures over 8000-10000K behind Reflected Shock Waves. (Pubmed Central) -  Apr 21, 2020   
    The time-evolution of the atomic oxygen population in the 3s S state was monitored by laser absorption at 777.2 nm...The electron impact excitation rate constant of oxygen, the electron impact and the heavy particle impact ionization rate constants of Argon were modified in the model to match the experimental population time histories. The modified rate parameters are also reported for the temperature range explored in the current study.