- |||||||||| live horsepox virus vaccine (TNX-801) / Tonix
Preclinical, Journal: Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in both in vitro and in vivo models. (Pubmed Central) - Dec 19, 2024
The two FDA-approved vaccines, ACAM-2000 and JYNNEOS, have important advantages and disadvantages...Here, we show that TNX-801 is >10- to 1,000-fold attenuated in in vitro and in vivo models including human primary cells and immunocompromised murine models than vaccine strains utilized in smallpox eradication. The natural attenuation of TNX-801 and its ability to induce protective immunity via a single vaccination are promising and warrants further development.
- |||||||||| Review, Journal: Treatment and Vaccination for Smallpox and Monkeypox. (Pubmed Central) - May 27, 2024
In conclusion, further research for treatment and prevention of orthopox infections is needed and is already in progress. After a brief introduction, this chapter presents the smallpox and mpox disease and thereafter full overviews on antiviral treatment and vaccination including the passive immunization with vaccinia immunoglobulins.
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