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- |||| JYNNEOS (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Important guidance regarding #monkeypox & #psoriasis Key point: #JYNNEOS vax ok for those w weakened immune system or an exfoliative skin dz such as psoriasis. #ACAM2000 vax contraindicated for many psoriasis pts. #dermtwitter #epitwitter @AADmember https://t.co/zTbNO0nFKp (Twitter) - Aug 24, 2022
- | Journal: MONKEYPOX AND PREGNANCY: FORECASTING THE RISKS. (Pubmed Central) - Aug 21, 2022
Obstetric concerns relating to antiviral therapy with tecovirimat and vaccinia immune globulin, including the risks of QTc prolongation, erroneous blood glucose monitoring and venous thromboembolism, are highlighted. Finally, we discuss the possibility of monkeypox vaccine hesitancy during pregnancy, offer strategies to mitigate these risks and propose research priorities to address knowledge gaps about the impact of monkeypox infection on maternal, fetal, and neonatal health.
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Benefit-risk assessment: Fair, but doesn't account for our stockpile of ACAM2000. Tougher risk-benefit analysis in this case, but at the moment I'd bet on the benefits outweighing the risks for administering ACAM2000 to the MSM population. What are your thoughts? (Twitter) - Aug 18, 2022
- |||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: does that count as severely immunocompromised e.g. requiring isolation? if not, then i am pretty sure thats not what the letter is referring to. see the package insert of the acam2000 vaccine. (Twitter) - Aug 15, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: I haven't heard of a shortage of Acam2000. Jynneos vaccine has been available since 2019. (Twitter) - Aug 15, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Lymphopenia: @US_FDA is ACAM2000 safe to use post-COVID-19 with respect to post viral lymphopenia? Thank you. (Twitter) - Aug 14, 2022
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: #Monkeypox is spreading be prepared there is a #Vaccine. #ACAM2000 #Jynneos @SNHDinfo @ClevelandClinic @KizzyPhD @NIH @CDCDirector @HHSGov @NIHDirector @MayoClinic @AFANLV @CDC_NCEZID https://t.co/tXa49JLwQN (Twitter) - Aug 12, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: 1) what’s the thoughts on reinfection? Once people recover are they safe to resume normal activities? 2) any cases of asymptomatic transmission? 3) will the 1/5th dose of the vaccine the FDA is proposing decrease efficacy? 4) should we release the ACAM2000 supplies? (Twitter) - Aug 10, 2022
- || ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Hello Dr What do you think about getting ACAM2000 as a second dose after Jeynneos first dose? Would you support offering ACAM as a second dose for those who don’t want 1/5 dose? Wouldn’t this also create more hybrid immunity that might be more robust? Thank you (Twitter) - Aug 10, 2022
- || ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Does this include ACAM 2000? (Twitter) - Aug 9, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Starting to get questions about #monkeypoxvaccine from immunosuppressed patients. What is your take? One of them (ACAM2000) seems to be contraindicated (live vaccine). The other one (attenuated MVA) could be safe, but very little guidance. @UAB_ID @UABRheum @RADoctor (Twitter) - Aug 9, 2022
- ||||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: #Monkeypox is spreading be prepared there is a #Vaccine. #ACAM2000 #Jynneos @snhd @ClevelandClinic @KizzyPhD @NIH @CDCDirector @HHSGov @NIHDirector @MayoClinic @AFANLV @CDC_NCEZID https://t.co/tXa49JLwQN (Twitter) - Aug 8, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: ACAM2000 vaccine it’s not safe for general population and specially for immune compromised because some of them can get cowpox from the jab. Only in hypothetical scenario of terrible small pox outbreak the benefits cope the dangers (Twitter) - Aug 8, 2022
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Fear makes people do strange things. Most don't know we have alternatives. MVA or Jynneos vax. would be my choice. ACAM2000 is out there. Think of the panic there would be if a live smallpox was loosed. Make Covid and MPX a cakewalk. @waitus48 FYI @WesElyMD @drdagly @silentanb (Twitter) - Aug 6, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Using a bifurcated needed to administer the ACAM2000 Chapter 2, Part B: Vaccine Administration https://t.co/Bfx0mlJv98 via @YouTube (Twitter) - Aug 5, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Would expect Jynneos being an inactivated vaccine should be ok, while the ACAM2000 being live inactivated smallpox, I’d be very hesitant to use in an immunosuppressive pt… slides from CDC. https://t.co/v3IV1sWUti (Twitter) - Aug 4, 2022
- || ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
ACAM2000 - whatever it's Ve for MPXV - should be immediately on the table for use in selected populations (perhaps like healthcare workers seeking an added layer of protection). /1 (Twitter) - Aug 4, 2022
- || Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Agree with all comments. It’s important to note that jurisdictions can request ACAM2000 from HHS. ~One month ago, 800 doses of ACAM2000 had been requested from the SNS, compared to 11.5K doses of Jynneos. https://t.co/R2Wgg4s6ll (Twitter) - Aug 2, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: i know this article is from mid June, but is anyone actually receiving ACAM2000? from my understanding, i & others received Jynneos which is a pretty standard, non-“gnarly” vaccine. i imagine a global vaccination push would look at expanding production of MVA rather than ACAM2000 (Twitter) - Aug 1, 2022
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Agreed, just make sure if used that they are getting Jynneos which is replication deficient. Eventually we might use the live Viral ACAM2000 which would not be appropriate for Immunocompromised transplant patients. Agreed, no data, assume some decreased vaccine efficacy. (Twitter) - Aug 1, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: "I know health officials that don't want to give out ACAM2000 because they're concerned it could cause further vaccine hesitancy." @ddiamond. "The immunocompromised can't use this vaccine." @celinegounder. https://t.co/CYLSnEQsSO (Twitter) - Aug 1, 2022
- || ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
What angers me is FDA/states are withholding ACAM2000, but expect the at risk population to "modify behavior" & wait 9 months. What if this is school/church going population & tell them not going to school/church while vax is available immediately? What would they react? (Twitter) - Aug 1, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: Not everyone has monkeypox right now. But everyone who gets vaccinated with ACAM2000 - or is in close contact with them - will be at risk for its side effects. This is the challenge, and the Jynneos vaccine basically solves it, we just have to get more of it more quickly. (Twitter) - Jul 31, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Fair points. I do agree that if someone wants acam2000 and understands the risks/peculiarities involved with it, they should be able to get it (and find a provider who knows how to give it). From a mass-vaccination standpoint though, I think we are screwed at this point IMO (Twitter) - Jul 31, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: For those with high-risk behavior they can’t or don’t want to change, I think it could be an individual decision. But I’d be against a broader ACAM2000 vaccination campaign at this point in US — people really need to understand the side effects to make an informed decision. (Twitter) - Jul 31, 2022
- |||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: ACAM2000 has a meaningful level of side effects and may be harmful for people with uncontrolled HIV. We now have MUCH better vaccines and the risk of using ACAM2000 now is that the site effects would reduce uptake of the new vaccines once production capacity are increaed. (Twitter) - Jul 31, 2022
- |||| Clinical: Medical countermeasures for treatment of monkeypox from @CDCgov 💉 Vaccines JYNNEOS ACAM2000 💊 Treatment Tecovirimat Vaccinia Immune Globulin Intravenous (VIGIV) 💉 Cidofovir Brincidofovir https://t.co/1DP3X2quMI (Twitter) - Jul 29, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: It’s certainly a lot better than ACAM2000 for side effects. As a sidenote I was vaccinated probably with the related DryVax against smallpox in 1968 in the UK. So in the old days we used to give replicating vaccina vaccine to children. BN will be safer than that. (Twitter) - Jul 28, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Adverse events: My instinct would be that if the Ab's from the Jynneos "work" in reducing the severity of the actual disease then it should also recognize the attenuated virus in ACAM2000, making the side effects less gnarly (Twitter) - Jul 28, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: I'm not talking about giving everyone ACAM2000 Joseph. Calm down and think about this rationally and not emotionally for a moment. A safer vaccine could be funded and developed. Orthopox vaccines offer cross-protection (Twitter) - Jul 27, 2022
- ||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Denise the tweet said “decades ago” Are you arguing for the use of ACAM2000 because thats the only vaccine that could be currently used at population scale (and it kills 1 in a million who receive it) (Twitter) - Jul 27, 2022
- ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
ACAM2000 Should Be a First-Line Vaccine in the Current Monkeypox Outbreak: Pro/Con (207 AB) - Jul 23, 2022 - Abstract #IDWeek2022IDWEEK_344;
- ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
177 - Clinical Controversies (207 AB) - Jul 23, 2022 - Abstract #IDWeek2022IDWEEK_342;
Finally, we discuss the possibility of monkeypox vaccine hesitancy during pregnancy, offer strategies to mitigate these risks and propose research priorities to address knowledge gaps about the impact of monkeypox infection on maternal, fetal, and neonatal health. CME Credits : Maximum of 1.25 hours of AMA PRA Category 1 Credit™ MOC Credits : Maximum of 1.25 hours of MOC Credit CNE Credits : Maximum of 1.25 hours of ANCC Credit No CPE Credit Offered Learning Objectives: At the conclusion of this session, participants will be able to: discuss the ethical issues surrounding COVID-19 vaccine requirements for SOT candidates describe the risk/benefit considerations of the use of ACAM2000 in potentially immune compromised recipients in an ongoing outbreak
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: Jabs vs monkeypox are smallpox jabs. ACAM2000 is live virus and fully able to replicate!! JYNNEOS is live too - but is less efficient at replicating. Plenty of contra-indicated warnings! Neither have ANY EFFICACY DATA!! Check side effects (from 2007) 🤔 https://t.co/9MB3D8F3ON (Twitter) - Jul 21, 2022
- || Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
ACAM2000 would still requires that weird scarification process (which many providers never learned how to do) even if used as a 2nd dose after Jynneos. (Twitter) - Jul 20, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Adverse events: I'd be curious to know if the side effects of ACAM2000 aren't as bad if one leads with Jynneos (Twitter) - Jul 19, 2022
- | Journal: Prevention and Treatment of Monkeypox. (Pubmed Central) - Jul 16, 2022
Antivirals can be considered in severe disease, immunocompromised patients, pediatrics, pregnant and breastfeeding women, complicated lesions, and when lesions appear near the mouth, eyes, and genitals. The purpose of this short review is to describe each of these countermeasures.
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: 6/ Antibody responses 4 weeks after 1 dose of Jynneos vaccine were similar to antibody responses 4 weeks after 1 dose of ACAM2000. Data from Africa suggests that the smallpox vaccine is at least 85% effective in preventing monkeypox. (Twitter) - Jul 15, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: 5/ Jynneos (MVA) & ACAM2000 (smallpox) vaccine were compared on the basis of antibody responses. Participants were given 2 doses of Jynneos followed by 1 dose of ACAM2000 (the MVA group) OR 1 dose of ACAM2000 (the ACAM2000-only group) (Twitter) - Jul 15, 2022
- || Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
2/ We could at least be sharing ACAM2000 with endemic countries in West/Central Africa if we don't want to share our limited Jynneos supply. We could also be looking into ways to expand production of Jynneos, both in the US & endemic regions so that they can be self-sufficient. (Twitter) - Jul 13, 2022
- |||| ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: 1/ @pritikrishtel's comments at @aspenideas were about COVID vaccines, but we're seeing the same thing all over again with #monkeypox vaccine. We're hoarding MPX vaccine, including ACAM2000, which we aren't using in the US. (Twitter) - Jul 13, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
2) ACAM2000 replication-competent vaccinia virus -risk of inadvertent inoculation or auto-inoculation - two doses >100 million doses - not safe for immunosuppressed individiuals. Studies in HIV where with JYNNEOS. @CrohnsColitisFn (Twitter) - Jul 11, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Preclinical: 1) There are two Monkey pox vaccines both of which are live attenuated vaccines. JYNNEOS and ACAM 2000. They are not same and have important differences. JYNNEOS attenuated replication deficient modified vaccinia. -No risk of inoculation -1 dose -Limited supply. (Twitter) - Jul 11, 2022
- | ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
ACAM2000 has significant risks and many contraindications that limit its use (Twitter) - Jul 4, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: #monkeypox spokesperson, leader, #vaccine #JYNNEOS ACAM2000 (Twitter) - Jun 30, 2022
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: .@CDCDirector Walensky: #Monkeypox JYNNEOS vaccine currently has some limitations on supply so administration's strategy is prioritize to make it available to those who need it most urgently & for whom ACAM2000 is unable to be used, like immunocompromised, such as people with HIV (Twitter) - Jun 28, 2022
- |||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: 8/ 🔹The Jynneos is thought to be much less likely to cause myocarditis 🔹Jynneos is safer for use in immunocompromised persons & people with severe skin diseases. 🔹The virus in the Jynneos can't spread from vaccinated people to others, unlike the ACAM2000 vaccine. (Twitter) - Jun 28, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: 7/ The ACAM 2000 vaccine will be made available upon request. But it's important to not that: 🔹ACAM2000 is a REPLICATING virus vaccine. 🔹Jynneos is a NON-replicating virus vaccine. 🔹Jynneos has much milder side-effects. (Twitter) - Jun 28, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical: Breaking: HHS will expand access to JYNNEOS, a vaccine that protects against monkeypox. ACAM2000 vaccine also available. New policy to bring hundreds of thousands of doses to high-risk areas and those with risks (expanding definition of that...) Progress! (Twitter) - Jun 28, 2022
- ||| Imvanex (live modified vaccinia virus ankara) / Bavarian Nordic, ACAM2000 (smallpox (vaccinia) live vaccine) / Emergent Biosolutions
Clinical, Adverse events: 14/ We have two effective vaccines for monkeypox: the Jynneos vaccine and the ACAM2000 vaccine. The US is currently using only the Jynneos vaccine because it’s a safer vaccine & has fewer side effects. But supplies are limited: https://t.co/cXTb27gbya (Twitter) - Jun 27, 2022