| Metvixia (methyl aminolevulinate hydrochloride 16.8% cream) / Galderma |
2004-000063-10: A comparison of Metvix PDT with simple excision surgery in subjects with superficial Basal cell Carcinoma (sBCC) |
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| Ongoing | 4 | 198 | Europe | Metvix 160 mg/g cream, P-1202, Cream, Metvix 160 mg/g cream | Galderma R&D | Superficial Basal Cell Carcinomas, occurring mostly on trunk and extremities (4,5), are progressively spreading, slow growing cancers. They can be difficult to diagnose and often mistaken for other skin conditions such as eczema or psoriasis. sBCCs are red, with a slightly raised, sometimes ulcerated or crusted surface, often bordered with pearly, threadlike formations. Larger and older tumours may thicken, developing into nodular types of BCC. | | | | |
2010-020933-25: Fraktioneret CO2 laser-assisteret fotodynamisk terapi versus keratolytisk behandling af terapiresistente fodvorter |
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| Ongoing | 4 | 60 | Europe | Metvix, Verucid gel, 32850, Cream, Gel, Metvix creme 16%, Verucid gel | Bispebjerg Hospital | recalcitrant plantar viral warts | | | | |
2012-002233-11: Photodynamic therapy with topical methyl aminolevulinate for solar keratosis in organ transplant recipients: Ways to improve treatment Fotodynamisk terapi med topikal methyl-aminolevulinat til solkeratoser hos organtransplanterede patienter: Metoder til at forbedre behandlingen |
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| Ongoing | 4 | 15 | Europe | Metvix creme, Metvix cream, na, Cream, Metvix Creme, Metvix cream | Bispebjerg Hospital, Bispebjerg Hospital | actinic keratosis, solar keratosis due to sun exposure, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2011-005809-77: Superficiel basal cell carcinoma treatment with topical photodynamic therapy with fractionated 5-aminolevulinic acid 20% versus two stage methylaminolevulate Behandeling van het superficieel basaalcelcarcinoom middels topicale fotodynamische therapie met gefractioneerd 5-aminolevulinezuur 20% versus methylaminolevulaat in twee behandelingen |
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| Ongoing | 4 | 162 | Europe | Metvix 160 mg/g creme, 5-aminolevulinic acid hydrochloride 20% gel, Cream, Metvix 160 mg/g creme | Maastricht University Medical Centre, Maastricht University Medical Centre, Erasmus Medical Centre Rotterdam, VieCuri Medical Centre | Superficial basal cell carcinoma Superficieel basaalcelcarcinoom, Skin cancer Huidkanker, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2014-005235-13: Therapy-treatment (PDT) on Acne, a study to optimize the number of treatments, the right light-dose and the right pre-treatment in order to obtain a longterm remission-time |
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| Ongoing | 4 | 46 | Europe | Metvix, Cream, Metvix cream | Sahlgrenska University hospital of gothenburg Department of dermatology, Sahlgrenska University hospital of gothenburg Department of dermatology | Acne, Acne, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2005-004262-16: A trial comparing Metvix® photodynamic therapy (PDT) followed by Mohs micrographic surgery with Mohs micrographic surgery alone for the treatment of basal cell carcinoma (BCC) |
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| Ongoing | 4 | 20 | Europe | Metvix, Metvix® PDT, Metvix® PDT | Guy\'s & St Thomas\' NHS Foundation Trust, Guy's & St Thomas' NHS Foundation Trust | Basal cell carcinoma | | | | |
2005-005769-12: FLUORESCENT DETECTION WITH METHYL AMINOLEVULINATE OF BASAL CELL CARCINOMA: TO ASSESS THE ACCURACY OF THIS TECHNIQUE BY COMPARISON WITH RESECTION MARGIN LEFT BY MOH’S MICROGRAPHIC SURGERY AFTER DIFFERENT APPLICATION TIMES OF THE METHYL AMINOLEVULINATE |
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| Ongoing | 4 | 45 | Europe | Metvix 160mg/g cream, P-1202, Metvix 160mg/g cream, Metvix 160mg/g cream | Galderma R&D | Basal Cell Carcinoma | | | | |
2009-015640-42: Etude de l’efficacité thérapeutique de la photothérapie dynamique (PDT) dans le lichen scléreux génital et les dysplasies génitales résistantes aux traitements conventionnels. |
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| Ongoing | 4 | 4 | Europe | metvix, PL10590/0048, dynamic phototherapy with methyl aminolevulinate, dynamic phototherapy with methyl aminolevulinate | | lichen sclerosusgenital dysplasia | | | | |
2014-002756-11: Photodynamic therapy with varying application times for treatment of precursors of skin cancer |
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| Ongoing | 4 | 25 | Europe | Metvix, Metvix | Department of Dermatology D92, Bispebjerg Hospital, Department of Dermatology, D92, Bispebjerg Hospital | Actinic keratosis | | | | |
2008-006863-35: Prophylactic photodynamic therapy for organ transplant patients. Profylaktisk fotodynamisk terapi för organtransplanterade patienter. |
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| Ongoing | 4 | 25 | Europe | Metvix, Metvix creme, Metvix creme | Bispebjerg Hospital, Bispebjerg Hospital | Development of actinic keratoses and skin cancer in kidney transplant patients - a randomised, intra-individual trial with blinded outcome evaluation. Utveckling av aktiniska keratoser och hudcancer hos njurtransplanterade patienter en randomiserad, intra individuell studie med blindad effektutvärdering. | | | | |
| Ongoing | 4 | 50 | Europe | Cream, Metvix | Department of Dermatology D92, Bispebjerg Hospital, Department of Dermatology D92, Bispebjerg Hospital | Basal cell carcinoma, Skin cancer, Diseases [C] - Cancer [C04] | | | | |
2016-000490-20: Daylight photodynamic therapy (DL-PDT) in the treatment of actinic keratosis on the face and scalp carried out with two different skin preparation modalities Terapia fotodinamica daylight per il trattamento delle cheratosi attiniche del viso e del cuoio capelluto in seguito a due differenti modalit¿ di preparazione della cute |
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| Not yet recruiting | 4 | 40 | Europe | metil aminolevulinato, MAL, Cream, METVIX - TUBO DA 2 DI CREMA 160 MG/G | A.O.U. Università degli Studi della Campania "Luigi Vanvitelli", Galderma | actinic keratosis Cheratosi attiniche, Prevention of Skin Cancers Prevenzione tumori della cute, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2014-005121-13: Clinical study comparing daylight photodynamic therapy with cryosurgery for the treatment and prophylaxis of actinic keratoses in photodamaged skin of the face Klinische Studie zur Tageslicht-PDT im Vergleich zur Kryochirurgie für die Behandlung und Prophylaxe von aktinischen Keratosen bei lichtgeschädigter Haut im Gesicht |
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| Not yet recruiting | 4 | 58 | Europe | Cream, Metvix | University Hospital Regensburg, Galderma Laboratorium GmbH | Actinic keratoses and photoaged skin Aktinische Keratosen und lichtgeschädigte Haut, Actinic keratoses and photoaged skin Aktinische Keratosen und lichtgeschädigte Haut, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2018-004685-33: Comparing surgical excision with photodynamic therapy and 5-Fluorouracil in treatment of Bowen'disease. Vergelijking van operatieve verwijdering met photodynamische therapie (PDT) en 5-Fluorouracil crème (Efudix) als behandeling van de ziekte van Bowen |
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| Ongoing | 4 | 168 | Europe | Cream, Efudix, Metvix 160 mg/g crème | azM, azM, zonMW | Bowens's disease Morbus Bowen, Bowen's disease is a superficial form of skincancer. De ziekte van Bowen is een oppervlakkige vorm van huidkanker., Diseases [C] - Cancer [C04] | | | | |
BOWTIE, NCT03909646: Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease |
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| Recruiting | 4 | 250 | Europe | Methyl Aminolevulinate (Mal) for Topical Administration, 16.8%, 1 Gram, Metvix, 5Fluorouracil, Efudix, Surgical excision | Maastricht University Medical Center | Bowen's Disease | 12/21 | 12/25 | | |
2015-002663-42: STUDY TO ASSESS IF THE DAYLIGHT PHOTODYNAMIC THERAPY WITH METHYL AMINOLEVULINATE CREAM (METVIX?), (MAL-PDT) IS USEFUL TO PREVENT PRECANCEROUS CUTANEOUS LESIONS AND NON MELANOMA SKIN CANCER IN TRANSPLANT PATIENTS ESTUDIO PARA VALORAR SI LA TERAPIA FOTODINÁMICA CON CREMA DE METIL- AMINOLEVULINATO (METVIX?), (MAL-TFD) CON LUZ DE DÍA ES ÚTIL PARA PREVENIR LA APARICIÓN DE LESIONES CUTÁNEAS PRECANCEROSAS Y CÁNCER CUTÁNEO NO MELANOMA EN PACIENTES TRASPLANTADOS |
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| Ongoing | 3 | 22 | Europe | Metvix (metil-aminolevulinato), Cream, Metvix | Clínica Universidad de Navarra/Universidad de Navarra, Galderma | Actinic Keratosis (AK) are histologically characterized by the proliferation of keratinocytes with atypical cytology in the epidermis. One of the main risk factors for its occurrence is immunosuppression. Las Queratosis Actínica (QA) se caracterizan histológicamente por la proliferación de queratinocitos con citología atípica en la epidermis. Uno de los principales factores de riesgo en su aparición es la inmunosupresión., Actinic keratosis are premalignant lesions that occur as red, scaly patches on the face and scalp (in areas not covered by hair). Las queratosis actínicas son lesiones premalignas que se manifiestan como manchas rojas con descamación en cara y también en el cuero cabelludo (en zonas no cubiertas por pelo)., Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2004-003015-23: Estudio de la eficacia y seguridad de la Terapia Fotodinámica con Metil Aminolevulinato en crema (Metvix®) en pacientes de alto riesgo con Carcinoma Basocelular Superficial (CBCs). |
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| Ongoing | 3 | 30 | Europe | Metvix (metil aminolevulinato), Metvix 160 mg/g cream, Metvix 160 mg/g cream | Laboratorios Galderma S.A. | Carcinoma Basocelular Superficial (CBCs) | | | | |
2007-002776-33: Treatment of superficial basal cell carcinoma by three non-invasive modalities: PDT vs. imiquimod vs. 5-fluorouracil |
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| Ongoing | 3 | 300 | Europe | Imiquimod, Efudix, Metvix, EU/1/98/080/001, RVG06292, RVG31130, Imiquimod, Efudix, Metvix creme, Imiquimod, Efudix, Metvix creme | Academic hospital Maastricht | superficial basal cell carcinoma | | | | |
2012-003416-31: Multicenter, randomized, open clinical trial to establish the effectiveness of of methyl-aminolevulinate 16% (Metivix®) photodynamic therapy to treat fungal infections of the nails. Ensayo clínico abierto, aleatorizado y multicéntrico para averiguar si la terapia fotodinámica con metil-aminolevulinato 16% (Metvix ®) en el tratamiento de las infecciones fúngicas de las uñas. |
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| Ongoing | 3 | 60 | Europe | methyl-aminolevulinate, Metvix, Metvix | Fundación Academia Española de Dermatología y Venereología, Galderma | onychomycosis fungal infections of the nails | | | | |
2009-016748-38: Prospective, randomized, placebo-controlled, monocentric, two-armed, observer-blinded and within-patient study for Photodynamic Therapy (PDT) with MAL in the treatment of actinic keratoses (AK) and photodamage on the back of the hands using Intense Pulsed Light (IPL) devices |
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| Ongoing | 3 | 35 | Europe | Metvix, Metvix | Free State of Bavaria rep. by the Univ. of Regensburg, rep. by the Regensburg Univ. Hospital | actinic keratoses and photoaged skin | | | | |
2018-000545-39: MAL DL-PDT and Calcitriol for AK treatment of the upper extremities MAL DL-PDT e Calcitriolo per le AK degli arti superiori |
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| Ongoing | 3 | 36 | Europe | SILKIS, METVIX, [NA], Ointment, Cream, SILKIS - 1 TUBO AL DA 30 G DI POMATA, METVIX - TUBO DA 2 DI CREMA 160 MG/G | ASL 1 AVEZZANO-SULMONA-L'AQUILA, Galderma R&D | Actinic Keratosis Cheratosi attinica, Actinic keratosis are skin lesions that represent the first phase of cutaneous malignant tumour. Le cheratosi attiniche sono lesioni della pelle che rappresentano la fase iniziale di un tumore maligno cutaneo., Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2007-004085-41: Photodynamic Therapy for Basal Cell Carcinoma of the Eyelid and Periocular Skin with methyl aminolevulinate |
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| Ongoing | 2/3 | 15 | Europe | Metvix, Metvix | The Royal Wolverhampton Hospitals NHS Trust | Periocular basal cell carcinoma | | | | |
2013-005438-39: Treatment of precursors to skin cancer with photodynamic therapy using a halogen lamp Lys-terapi med halogenlampe til behandling af forstadier til hudkræft |
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| Ongoing | 2 | 28 | Europe | Metvix, Metvix | Department of Dermatology D92, Bispebjerg Hospital, Dermatologcial department D92, Bispebjerg Hospital | Actinic keratoses Aktiniske keratoser | | | | |
2017-000746-22: Blood vessel changes in regular skin cancer undergoing either electrochemotherapy or conventional topical treatment assessed with optical coherence tomography Ændringer i blodkar i almindelig hudkræft under enten elektrokemoterapi eller konventionel behandling vurderet med optisk kohærens tomografi. |
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| Ongoing | 2 | 75 | Europe | Powder for solution for injection/infusion, Cream, Bleomycin "Baxter", Aldara®, Orifarm A/S, DK, Metvix® | Department of Dermatology, Zealand University Hospital, Roskilde, Department of Dermatology, Zealand University Hospital, Roskilde, LEO fondet | Basal cell carcinoma in adults Basalcellekræft hos voksne, Regular skin cancer also called basal cell carcinoma Almindelig hudkræft, også kaldet basalcellekræft, Diseases [C] - Cancer [C04] | | | | |
2021-001586-21: Does 4% 5-fluorouracil pre-treatment improve the efficacy of daylight photodynamic therapy for actinic keratoses – a randomized controlled study |
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| Not yet recruiting | 2 | 60 | Europe | Cream, Tolak, Metvix | Bispebjerg Hospital, Department of Dermatology, German Medical Engineering | Actinic keratosis, Premalignant skin lesions - actinic keratosis, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
PhotodiVIN, NCT05104099: Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia |
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| Recruiting | 2 | 17 | Europe | Metvixia Topical Cream | Institut de Cancérologie de Lorraine | Vulvar Intraepithelial Neoplasia, Vulvar High Grade Squamous Intraepithelial Lesion, Differentiated Vulvar Intraepithelial Neoplasia | 12/24 | 12/24 | | |
NCT02367547 / 2014-002746-50: Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitizers: HAL and BF-200 ALA Versus MAL |
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| Active, not recruiting | 1/2 | 117 | Europe | Hexylaminolevulinate cream, HAL, Hexvix, Photocure, Aminolevulinic Acid Nano Emulsion, Ameluz, Biofrontera, L01XD04, BF-200 ALA, Methylaminolevulinate cream, Metvix, Galderma, L01X D03, MAL | Joint Authority for Päijät-Häme Social and Health Care, Tampere University, University of Jyvaskyla | Neoplasms, Basal Cell, Carcinoma, Basal Cell, Photochemotherapy, Photosensitizing Agents | 09/18 | 12/25 | | |
NCT00535080: Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease |
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| No Longer Available | N/A | | NA | Metvix (methyl aminolevulinate) | Galderma R&D | Field Actinic Keratoses, Basal Cell Carcinoma, Bowen's Disease | | | | |
Dermaris-35, NCT05522036: Clinical Evaluation of a Short Illumination Duration (35 Minutes) When Performing PDT of AK Using the Dermaris ® |
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| Completed | N/A | 25 | Europe | Metvix + Dermaris | Centre Dermatologique du Roy | Actinic Keratoses | 06/23 | 06/23 | | |
NCT05725213: ADL-PDT Under Routine Clinical Conditions in Patients With Actinic Keratosis |
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| Completed | N/A | 224 | Europe | Metvix® 160 mg/g Creme, Methyl-5-aminolevulinate | Galderma Laboratorium GmbH | Actinic Keratoses | 10/23 | 10/23 | | |
NCT05456334: New Treatments for Actinic Keratoses of the Scalp |
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| Active, not recruiting | N/A | 120 | NA | Pulsed-dye laser, Fractional CO2-laser, Metvix cream | Helsinki University Central Hospital | Photodamaged Skin, Actinic Keratoses | 12/23 | 12/24 | | |
