- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
An Unusual Case of High-Renin Hypertension (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3872;
The results are consistent with the in vivo metabolism of brotizolam, a medically used benzodiazepine and a chloro-phenyl analog of flubrotizolam. Introduction: We present an unusual case in which negative sodium balance was the etiology of high renin hypertensionCase Description: A 75-year-old woman consulted us due to high blood pressure.PMH: LBP, history of excessive NSAIDS use, s/p partial colectomyMeds : amlodipine, zolpidem, bisacodyl, pregabalin, , acetaminophen tramadol, brotizolam, atorvastatin, ezetimibe, esomeprazoleBP- 150/84mmHgLabs - 24 hour urine collection
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim, Belsomra (suvorexant) / Merck (MSD)
Journal: Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan. (Pubmed Central) - Nov 10, 2023
The likelihood of the reporting of glaucoma varied among the drugs, which should be used carefully in clinical practice to avoid it. The characteristics and success factors in relation to drug reduction in patients with multiple prescriptions of hypnotic drugs identified in this study may contribute to solving the problem of multiple prescriptions of hypnotic drugs.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim, Belsomra (suvorexant) / Merck (MSD)
Preclinical, Journal: Effects of Blindness on Sleep/Wakefulness States in Mice. (Pubmed Central) - Aug 2, 2023
In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J mice. These results suggest that blindness impairs sleep quality.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Talking to nobody () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_2505;
Usual treatment: Chlorthalidone, omeprazole, manidipine.He came to our emergency department referred by his spouse due to the presence of marked temporal-spatial disorientation not previously evidenced, with slow and partial recovery, starting when he woke up; Added to this picture, he refers visual hallucinations (inanimate objects and people), with a tendency to talk with them, disorientation and subsequent amnesia of the episode...The wife reports having started Brotizolam 3 days before the onset of symptoms, at a dose of 0.25mg per day...Sleep disturbances are very frequent in this pathology (40-60%), and special care must be taken both in the choice of the active ingredient and its dosage to avoid undesirable adverse effects or overdosing, and individualize its prescription. In patients with these characteristics, the drug of choice is clonazepam.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Talking to nobody () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_2504;
Usual treatment: Chlorthalidone, omeprazole, manidipine.He came to our emergency department referred by his spouse due to the presence of marked temporal-spatial disorientation not previously evidenced, with slow and partial recovery, starting when he woke up; Added to this picture, he refers visual hallucinations (inanimate objects and people), with a tendency to talk with them, disorientation and subsequent amnesia of the episode...The wife reports having started Brotizolam 3 days before the onset of symptoms, at a dose of 0.25mg per day...Sleep disturbances are very frequent in this pathology (40-60%), and special care must be taken both in the choice of the active ingredient and its dosage to avoid undesirable adverse effects or overdosing, and individualize its prescription. In patients with these characteristics, the drug of choice is clonazepam.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Talking to nobody () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_2503;
Usual treatment: Chlorthalidone, omeprazole, manidipine.He came to our emergency department referred by his spouse due to the presence of marked temporal-spatial disorientation not previously evidenced, with slow and partial recovery, starting when he woke up; Added to this picture, he refers visual hallucinations (inanimate objects and people), with a tendency to talk with them, disorientation and subsequent amnesia of the episode...The wife reports having started Brotizolam 3 days before the onset of symptoms, at a dose of 0.25mg per day...Sleep disturbances are very frequent in this pathology (40-60%), and special care must be taken both in the choice of the active ingredient and its dosage to avoid undesirable adverse effects or overdosing, and individualize its prescription. In patients with these characteristics, the drug of choice is clonazepam.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Talking to nobody () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_2502;
Usual treatment: Chlorthalidone, omeprazole, manidipine.He came to our emergency department referred by his spouse due to the presence of marked temporal-spatial disorientation not previously evidenced, with slow and partial recovery, starting when he woke up; Added to this picture, he refers visual hallucinations (inanimate objects and people), with a tendency to talk with them, disorientation and subsequent amnesia of the episode...The wife reports having started Brotizolam 3 days before the onset of symptoms, at a dose of 0.25mg per day...Sleep disturbances are very frequent in this pathology (40-60%), and special care must be taken both in the choice of the active ingredient and its dosage to avoid undesirable adverse effects or overdosing, and individualize its prescription. In patients with these characteristics, the drug of choice is clonazepam.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Journal: In silico studies on recreational drugs: 3D-QSAR prediction of classified and de novo designer benzodiazepines. (Pubmed Central) - Jul 16, 2022
The scaffold hopping studies strongly suggests that replacement of the pendant phenyl moiety with a five-membered ring could increase biological activity and highlight the existence of a still unexplored chemical space for DBZDs. QSAR could be of use as a preliminary risk assessment model for (newly) identified DBZDs, as well as scaffold hopping for the creation of computational libraries that could be used by regulatory bodies as support tools for scheduling procedures.
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Clinical, Journal: Relationship between use of sleep medication and accidental falls during hospitalization. (Pubmed Central) - Feb 8, 2022
Zolpidem (25%, n=63), a non-benzodiazepine, was the most frequently used sleep medication, followed by brotizolam (16%, n=41) and etizolam (13%, n=32), which are both benzodiazepines...Taking multiple sleeping pills makes it easier to fall, and even drugs with a short half-life, which are considered to be safe, can cause falls at night in elderly patients. The results of this study show that careful selection of sleep medications is required to prevent fall in elderly patients.
- |||||||||| isoflurane / Generic mfg.
Preclinical, Journal: Influence of light-dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice. (Pubmed Central) - Sep 12, 2021
In blind mice, delayed recovery induced by brotizolam was identical in both periods, while suvorexant did not influence recovery from isoflurane anesthesia. These results suggest that the effects of hypnotics on isoflurane anesthesia are altered by the circadian rhythm and that daily light-dark stimuli may be required for the chronopharmacological effects of hypnotics.
- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Benzodiazepine Concentrations in the Breast milk and Plasma of Nursing Mothers: Estimation of Relative Infant Dose. (Pubmed Central) - Aug 18, 2021
The target benzodiazepines were alprazolam, brotizolam, clonazepam, clotiazepam, etizolam, ethyl loflazepate, flunitrazepam, and lorazepam. The RID results of this study suggest that drug exposure through breast milk is small; thus, maternal drug treatment and breastfeeding are compatible.
- |||||||||| Nitredon (nitrazepam) / Remedica, Lendormin (brotizolam) / Boehringer Ingelheim, Ozalin (midazolam) / Primex Pharma, Sintetica
Benzodiazepine: Alprazolam, Bromazepam, Brotizolam, Clobazam, Clonazepam, Clorazepat, Diazepam, Flunitrazepam, Flurazepam, Lorazepam, Lormetazepam, Medazepam, Midazolam, Nitrazepam, Oxazepam, Prazepam, Temazepam und Triazolam (Twitter) - Mar 24, 2021
- |||||||||| Preclinical, Journal: A simple method using anesthetics to test effects of sleep-inducing substances in mice. (Pubmed Central) - Jul 25, 2020
The orexin receptor antagonist suvorexant delayed recovery from anesthesia only in the case of MMB, while the sleep-promoting supplement glycine only delayed recovery in the case of isoflurane. These results suggest that the simple comparison method is applicable for testing substances expected to exert sleep-inducing effects.
- |||||||||| amitriptyline / Generic mfg., paroxetine / Generic mfg., quetiapine / Generic mfg.
Preclinical, Journal: Stability of ten psychotropic drugs in formalin-fixed porcine liver homogenates. (Pubmed Central) - Feb 21, 2020
These data suggest that the concentrations of drugs in PLHs measured after formalin fixation decreased to varying degrees compared with their initial concentrations. These time-dependent changes in drug concentration were due to degradation during preservation in formalin solution and metabolism by hepatic microsomal enzymes.
- |||||||||| Enrollment change, Trial termination, Trial primary completion date, Adverse events: Pharmacovigilance in Gerontopsychiatric Patients (clinicaltrials.gov) - Oct 19, 2017
P3, N=407, Terminated,
These time-dependent changes in drug concentration were due to degradation during preservation in formalin solution and metabolism by hepatic microsomal enzymes. N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
Trial initiation date, Surgery: Treatment With Benzodiazepine After Cardiac Surgery (clinicaltrials.gov) - Nov 10, 2016
P3, N=200, Not yet recruiting,
N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017 Initiation date: May 2016 --> Dec 2016
- |||||||||| Lendormin (brotizolam) / Boehringer Ingelheim
New P4 trial: Lendormin D (clinicaltrials.gov) - Aug 22, 2014
P4, N=485, Completed,
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