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Clinical, PK/PD data, Journal: Pharmacokinetics of extended-release ivermectin microspheres after oral administration to healthy pigs. (Pubmed Central) - Jun 3, 2021
Moreover, the AUC of the microcapsule groups was increased from 1,129.76 ± 245.62 to 1,607.33 ± 343.35 hr ng/ml compared with the premix groups, and the relative bioavailability increased by an average of 17.53% after oral administration with ivermectin microspheres. Multiple-dose administration also indicated pigs fed with ivermectin microspheres can get a higher minimum steady-state concentration and a longer maintenance time than ivermectin premix.
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