fluticasone / Generic mfg. 
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  • ||||||||||  vilanterol (GW642444H) / GSK, Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
    Trial completion, Enrollment change, Head-to-Head:  Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults (clinicaltrials.gov) -  Mar 31, 2023   
    P2/3,  N=18, Completed, 
    Recruiting --> Completed | N=130 --> 18
  • ||||||||||  fluticasone / Generic mfg.
    FeNO, Biomarkers of High Th2 Immunity, and Response to Inhaled Corticosteroids in African American Children With Asthma (Walter E. Washington Convention Center, West Salon G-I (Street Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_3875;    
    All participants completed a six-week course of inhaled fluticasone MDI at age-appropriate doses... In this prospective study of African American children with asthma, a biomarker of high Th2 immunity incorporating data for allergen-specific IgEs, total IgE, and eosinophil count was better at predicting ICS responsiveness than a high FeNO.
  • ||||||||||  How Harmful Is Cocaine? A Case of Cocaine Induced Constrictive Bronchiolitis (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_3522;    
    Although immunosuppression with corticosteroids is a potential treatment option it typically does not prevent progression of the underlying disease. Further exploration into novel therapeutic options is warranted.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
    Journal:  Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. (Pubmed Central) -  Feb 27, 2023   
    Dexamethasone protected several cell types against the cholesterol-dependent cytolysin, pyolysin, from Trueperella pyogenes...Hydrocortisone and fluticasone also protected against pyolysin-induced cell damage...However, cytoprotection was dependent on the glucocorticoid receptor and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR). Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Dupilumab-associated Angioedema in an Adult. (Convention Center, Lobby Level, Hall 2) -  Feb 4, 2023 - Abstract #AAAAI2023AAAAI_1937;    
    Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins. Prednisone was administered, and resolution of angioedema observed...Dupilumab was discontinued, and the patient
  • ||||||||||  fluticasone / Generic mfg.
    Journal, Monotherapy:  Effect of MP-AzeFlu compared to monotherapy on COX-2, PGE , and EP2 gene expression in upper airway mucosa. (Pubmed Central) -  Jan 28, 2023   
    MP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which MP-AzeFlu produces this improved clinical effect has not yet been fully explained...MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. This downregulation of COX-2 and PGE coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells. (Pubmed Central) -  Dec 19, 2022   
    Isolated CD34 HSC from UCB were exposed to the synthetic glucocorticoids betamethasone and fluticasone for 20 h, and cell phenotype was determined before transplantation...Interestingly, betamethasone-exposed cells showed enhanced engraftment in 1 Gy-irradiated NSG mice, with a trend to increase regulatory T cell percentage when compared to control. Betamethasone induces alterations in CD34 HSCs and improve the engraftment, leading to a faster immune system recovery, which will contribute to engrafted cells survival.
  • ||||||||||  azelastine intranasal / Generic mfg., fluticasone / Generic mfg.
    Trial completion date, Trial primary completion date:  Efficacy and Safety of On-demand and Continuous Administration of Nasal Spray in the Treatment of Allergic Rhinitis (clinicaltrials.gov) -  Dec 6, 2022   
    P4,  N=150, Not yet recruiting, 
    Betamethasone induces alterations in CD34 HSCs and improve the engraftment, leading to a faster immune system recovery, which will contribute to engrafted cells survival. Trial completion date: Nov 2022 --> Jun 2024 | Trial primary completion date: Sep 2022 --> May 2024
  • ||||||||||  fluticasone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  Respiratory questionnaire-based analysis of awareness of COPD in a large multicenter rural population-based study in India. (Pubmed Central) -  Nov 25, 2022   
    Total 42% cases received oral treatment as theophylline in 16% cases, salbutamol in 7% cases, oral steroids in 19% cases (p < 0.0001). "Doctor-patient-drug trio" discordance clubbed as "difficult doctor, difficult patient, and difficult treatment" is a very crucial issue observed during diagnosis and management of COPD in peripheral settings in India.
  • ||||||||||  clarithromycin / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
    Clinical, Journal, Combination therapy:  Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. (Pubmed Central) -  Nov 19, 2022   
    However, post-intervention, LM scores reduced considerably in both groups, but the change was significantly higher in the azithromycin group (P<0.001). In combination with conventional therapies for CRS in adults, a four-week course of treatment with azithromycin is more effective than clarithromycin.Trial Registration Number: IRCT20201209049661N1.
  • ||||||||||  fluticasone / Generic mfg.
    Airways oscillometry in asthma diagnosis in treatment naive but symptomatic adults (Westminster, 4th floor) -  Nov 15, 2022 - Abstract #BTSWM2022BTS_WM_249;    
    Assessment included clinical history, examination, lung physiology (spirometry, reversibility, FeNO, PEFv and bronchial challenge), skin prick testing, serum eosinophils before and after 6–8 weeks of inhaled fluticasone (250µg BD)...However,% predicted values R5 and R20 were both significantly higher in asthma compared to not asthma.View this table:View inline P22 Table 1 Table of results 110 adults from RADicA study diagnosed with ‘asthma’ or ‘not asthma’ with Airways Oscillometry% predicted values for R5, R20 and fres, (geometric mean and 95% CI)Conclusion Our findings suggest that R5 and R20 AO results (as% predicted) were higher amongst symptomatic adults who were subsequently diagnosed with asthma, compared to those with symptoms that were not asthma. Further research is needed to evaluate the role of AO in asthma diagnosis, in particular, thresholds.
  • ||||||||||  fluticasone / Generic mfg.
    Tracking Asthma Medication Use in Children After an Emergency Department Visit with a Smart Inhaler and Connected Mobile Application (Anaheim Convention Center, Hall A, Board # 027) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1456;    
    Our study is a successful proof of concept, demonstrating moderate feasibility of real-time tracking of pediatric inhaled asthma medication using a “smart” inhaler device after an ED visit. Further studies are in development to construct an asthma risk profile by connecting medication use events and environmental data as a predictive tool to prevent future asthma exacerbations.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Porokeratotic Variant of Lichen Planus. (Pubmed Central) -  Nov 1, 2022   
    The patient was counseled and started on topical steroids (fluticasone)...(SKINmed. 2022;20:377-378).
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Porokeratotic Variant of Lichen Planus. (Pubmed Central) -  Nov 1, 2022   
    The patient was counseled and started on topical steroids (fluticasone). She is on regular follow-up.
  • ||||||||||  fluticasone / Generic mfg.
    Clinical, Journal:  A TRIAL OF INTRANASAL CORTICOSTEROIDS TO TREAT THE CHILDHOOD OBSTRUCTIVE SLEEP APNEA SYNDROME. (Pubmed Central) -  Oct 12, 2022   
    P3
    In children with OSAS, treatment with INCS did not result in significant polysomnography, neurobehavioral, or symptom changes at 3 and 12 months of treatment. Twelve months of INCS treatment resulted in a statistically significant but not clinically relevant OAHI reduction.
  • ||||||||||  cetirizine oral / Generic mfg., diphenhydramine / Generic mfg., fluticasone / Generic mfg.
    Delayed, Persistent Anaphylaxis After An Allergy Injection (Exhibit Hall (Upper Concourse); Monitor 02) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_843;    
    Twelve hours after his first allergy injection, he developed pruritus, took a diphenhydramine and went to sleep...It is important to educate our immunotherapy patients on the signs of anaphylaxis as well as the possibility that though rare, symptoms can be delayed. In addition, it is important to emphasize the need for prompt medical attention in such situations.
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis
    A Sympathetic Case of Multiple Inhaler Intolerances (Exhibit Hall (Upper Concourse); Monitor 01) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_818;    
    He tolerated inhaled fluticasone and cromolyn for several days before having the same symptoms following each use...Drug challenge with budesonide, omalizumab, and albuterol revealed intense flushing, hypertension, and sense of doom within 30 mins...Dexamethasone suppression test was normal...Pseudopheochromocytoma is a rare but important cause of drug reactions that present with paroxysms of hypertension, headache, palpitations, lightheadedness, flushing, and diaphoresis due to somatic sympathetic surges. Treatment includes antidepressants and biofeedback therapy.
  • ||||||||||  aspirin / Generic mfg.
    Possible Anaphylaxis to Aspirin in a Pediatric Patient (Exhibit Hall (Upper Concourse); Monitor 01) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_811;    
    Case Description A 6-year-old boy with history of allergic rhinitis and asthma received oral ibuprofen for fever and within 1 hour developed isolated eye and lip swelling, which persisted for several days despite taking diphenhydramine...He initially received his daily inhaled corticosteroid (fluticasone) and nasal corticosteroid (fluticasone), as well as albuterol, with partial improvement in cough...That night, he developed upper eyelid swelling, treated with diphenhydramine, followed by lower eyelid swelling and nasal congestion the next day, for which he was started on twice-daily cetirizine 10 mg...Discussion Although IgE mediated anaphylaxis to aspirin has not been reported, this patient experienced symptoms suggestive of anaphylaxis after a graded oral challenge to aspirin. Alternatively, symptoms may represent a blended non-IgE mediated reaction.
  • ||||||||||  doxycycline / Generic mfg., fluticasone / Generic mfg., itraconazole / Generic mfg.
    Journal:  The efficacy of itraconazole, fluticasone and doxycycline in chronic rhinosinusitis. (Pubmed Central) -  Sep 29, 2022   
    Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines. There were no significant differences between the clinical condition of patients receiving intranasal fluticasone, intranasal fluticasone in combination with doxycycline or itraconazole.