fluticasone / Generic mfg. 
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  • ||||||||||  Humira (adalimumab) / AbbVie
    Lichen Planus: A Rare Cause of Dysphagia in a Young Man (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3823;    
    Both MTX and subsequent adalimumab were discontinued as they were ineffective for his cutaneous lesions...Biopsies again revealed intraepithelial lymphocytosis and he was started on oral topical fluticasone...Accurate diagnosis of esophageal lichen planus is crucial given its therapeutic and prognostic implications. A high index of suspicion is necessary especially when the patient does not fit classic demographics.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Refractory Adult Fibrostenotic Phenotype Eosinophilic Esophagitis Treated With Dupilumab (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3811;    
    Our case suggests that Dupilumab can be a promising therapy for adult patients with fibrostenotic EoE refractory to repeated dilations. Figure: Endoscopic contrast opacification of esophageal stricture prior to index dilation
  • ||||||||||  fluticasone / Generic mfg.
    Esophageal Leukoplakia: A Rare Cause of Esophageal Stricture (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3807;    
    Pt was started on topical swallowed fluticasone and scheduled for repeat EGD for dilation...Currently, there are no established guidelines for post-ablation surveillance in cases of leukoplakia. Figure: Patchy white plaques seen in esophagus on EGD examination consistent with esophageal leukoplakia
  • ||||||||||  Unveiling the Uncommon: Lichenoid Esophagitis Secondary to Steven Johnson Syndrome (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3792;    
    In this report, we describe the case of a 47-year-old female who developed LE due to Steven Johnson syndrome (SJS) as a result of sulfasalazine (SSZ) therapy...Soon after due to poor tolerance to hydroxychloroquine and methotrexate, her rheumatologist started her on SSZ...During the last 2 EGDs, intralesional corticosteroid injections in addition to oral fluticasone were trailed which the patient responded to well and showed improvement of her dysphagia...Further research is needed to better understand the pathogenesis and optimal treatment of this rare condition. Figure: Fig illustrates acute esophagitis and a severe benign intrinsic stenosis that measures 1 cm in length.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    An Unusual Case of Esophageal Thickening (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3779;    
    His home medications included omeprazole and cetirizine...The patient was started on prednisone taper which was later switched to swallowed fluticasone...Treatment options include elimination diets, PPI, topical glucocorticoids, and dupilumab, which was recently approved by the FDA...Diseases of the Esophagus 2016;29:681-683. Figure: Figure 1: (A) At presentation, endoscopic ultrasound (EUS) from the distal esophagus showing thickened esophageal wall (10 mm), specifically layer 3 (submucosa), and (B) follow-up EUS after initiation of treatment showing improvement in esophageal wall thickness.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Double Trouble: Eosinophilic Esophagitis and Barrett (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_2399;    
    She was started on omeprazole 40 by mouth twice daily but reported poor symptomatic response prompting transition to fluticasone 440mcg swallowed twice daily and once daily omeprazole...Patient was transitioned to dupilumab 300mg subcutaneously once weekly and continued omeprazole for chemoprophylaxis with plans for a repeat EGD...Repeat EGD with proximal esophageal stricture and expected treatment effect (mucosal rent) after dilation with standard gastroscope. Barrett
  • ||||||||||  budesonide / Generic mfg., fluticasone / Generic mfg.
    Topical Steroids: An Effective Treatment Option for Lymphocytic Esophagitis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_2395;    
    She took budesonide for 3 months; while she endorsed improvement in dysphagia, repeat EGD showed persistent LE...She received one month of inhaled fluticasone without improvement in symptoms; however, repeat EGD showed resolution of LE...Figure: Figure 1. Histologic sections show stratified epithelium with numerous intraepithelial lymphocytes and intraepithelial edema (spongiosis) with occasional dyskeratotic cells.
  • ||||||||||  Cinqair (reslizumab) / Merck (MSD), UCB, Teva, Dupixent (dupilumab) / Sanofi, Regeneron
    Comparative Efficacy of Pharmacotherapy in Eosinophilic Esophagitis: A Network Meta-Analysis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_2325;    
    Our search yielded a total of 20 RCTs with 19 discrete interventions and 1430 patients randomized. Compared to placebo, the following interventions improved histology (based on study definitions): Dupilumab weekly (RD: 0.56, CI 0.38-0.74), Dupilumab q2weekly (RD: 0.56, CI: 0.28-0.83), Esomeprazole (RD: 0.67, CI: 0.33-1.00), Oral viscous budesonide (OVB) medium dose (RD: 0.54, CI: 0.33-0.75), OVB high dose (RD: 0.68, CI: 0.51
  • ||||||||||  fluticasone / Generic mfg.
    Nonadherence in Pediatric Eosinophilic Esophagitis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_1653;    
    The median age at first visit was 10.5 years and the majority of patients were white and male. The median length of follow up was 3 years (IQR 1.1-5.8) with 6 clinic visits (IQR 3-10).
  • ||||||||||  fluticasone / Generic mfg.
    Maternal and Fetal Outcomes in Patients With Eosinophilic Esophagitis on Steroids (West Ballroom B) -  Jul 29, 2023 - Abstract #ACG2023ACG_189;    
    Of those, 76.5% (n=836) were not on any active treatment with steroids, and 23.5% (n=257) were on steroids. The pre-PSM data suggest that patients on steroids had on average the same age (34.3 +/- 6.0 vs 34.3 +/- 6.2, P=0.951), gestational age (16.3 +/- 0.5 vs 15.2 +/- 1.9, P=0.125), and key comorbidities such as diabetes mellitus (3.9% vs 5.0%, P=0.456), and hypertension (12.5% vs 11.7%, P=0.752), compared to patients not on steroids.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  A steroid-resistant cockroach allergen model is associated with lung and cecal microbiome changes. (Pubmed Central) -  Jul 9, 2023   
    We utilized a steroid-resistant chronic model of cockroach antigen-induced (CRA) asthma with corticosteroid (fluticasone) treatment to examine lung and gut microbiome during disease...Finally, a functional analysis of cecal microbiome metabolites using PiCRUSt showed several biosynthetic pathways were significantly enriched in the Flut-treated group, with tryptophan pathway verified by ELISA with increased kynurenine in homogenized cecum samples. While the implications of these data are unclear, they may suggest a significant impact of steroid treatment on future disease pathogenesis through microbiome and associated metabolite pathway changes.
  • ||||||||||  ritonavir / Generic mfg., fluticasone / Generic mfg.
    Matters of the HAART - Ritonavir Induced CYP3A4 Inhibition of Intranasal Fluticasone Leading to Cushing's Syndrome (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_830;    
    Medications included emtricitabine-tenofovir-alafenamide and ritonavir at stable doses for several years. Educating patients on ritonavir about steroids being a component of many OTC medications/supplements, and a careful medication history and drug-drug interaction assessment is important in preventing steroid related adverse effects.
  • ||||||||||  tranexamic acid oral / Generic mfg., fluticasone / Generic mfg., hydroquinone / Generic mfg.
    Cosmetic issues and its nuances in dark skin (Level 3 - Nicoll 1) -  Apr 24, 2023 - Abstract #WCD2023WCD_1621;    
    KEY MESSAGE: In overall treatment of pigmentary disorders, various combinations of oral vitamin C, tranexamic acid, glutathione can be incorporated into daily regime along with sunscreens, topical agents containing combinations of kojic acid, arbutin, vitamin C, niacinamide, glycolic acid and lactic acid. As a multipronged approach 1064 Nano, Pico Nd:Yag, Erbium Yag laser will further reduce the intensity of hyper pigmentation in skin of color
  • ||||||||||  vilanterol (GW642444H) / GSK, Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
    Trial completion, Enrollment change, Head-to-Head:  Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults (clinicaltrials.gov) -  Mar 31, 2023   
    P2/3,  N=18, Completed, 
    EudraCT 2012-003728-19 (Study 1) and 2013-000045-39 (Study 2). Recruiting --> Completed | N=130 --> 18
  • ||||||||||  fluticasone / Generic mfg.
    FeNO, Biomarkers of High Th2 Immunity, and Response to Inhaled Corticosteroids in African American Children With Asthma (Walter E. Washington Convention Center, West Salon G-I (Street Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_3875;    
    All participants completed a six-week course of inhaled fluticasone MDI at age-appropriate doses... In this prospective study of African American children with asthma, a biomarker of high Th2 immunity incorporating data for allergen-specific IgEs, total IgE, and eosinophil count was better at predicting ICS responsiveness than a high FeNO.
  • ||||||||||  How Harmful Is Cocaine? A Case of Cocaine Induced Constrictive Bronchiolitis (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_3522;    
    Although immunosuppression with corticosteroids is a potential treatment option it typically does not prevent progression of the underlying disease. Further exploration into novel therapeutic options is warranted.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
    Journal:  Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. (Pubmed Central) -  Feb 27, 2023   
    Dexamethasone protected several cell types against the cholesterol-dependent cytolysin, pyolysin, from Trueperella pyogenes...Hydrocortisone and fluticasone also protected against pyolysin-induced cell damage...However, cytoprotection was dependent on the glucocorticoid receptor and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR). Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Dupilumab-associated Angioedema in an Adult. (Convention Center, Lobby Level, Hall 2) -  Feb 4, 2023 - Abstract #AAAAI2023AAAAI_1937;    
    Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins. Prednisone was administered, and resolution of angioedema observed...Dupilumab was discontinued, and the patient
  • ||||||||||  fluticasone / Generic mfg.
    Journal, Monotherapy:  Effect of MP-AzeFlu compared to monotherapy on COX-2, PGE , and EP2 gene expression in upper airway mucosa. (Pubmed Central) -  Jan 28, 2023   
    MP-AzeFlu (intranasal fluticasone and azelastine) has been widely studied and has demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which MP-AzeFlu produces this improved clinical effect has not yet been fully explained...MP-AzeFlu and FP both upregulated EP2 mRNA expression, though neither upregulated EP2 protein expression. This downregulation of COX-2 and PGE coupled with upregulation of EP2 receptor expression reinforces the anti-inflammatory effect of MP-AzeFlu in upper airway inflammation.