- |||||||||| fluticasone / Generic mfg.
Review, Journal, Adverse events: Systemic side effects of locally administered corticosteroids (Pubmed Central) - Oct 9, 2024
Certain agents, such as fluticasone inhaler or budesonide nasal spray, have an increased risk of systemic side effects. By switching to an alternative, if the case permits it, the risk of systemic side effects can be reduced.
- |||||||||| fluticasone / Generic mfg.
Journal: Redundancy of Pharmacologic Ingredients in Over-the-Counter Nasal Sprays. (Pubmed Central) - Oct 2, 2024
The active ingredients included in our analysis were oxymetazoline, phenylephrine, fluticasone, triamcinolone, budesonide, azelastine, cromolyn sodium, and mometasone...These findings suggest that there are widespread redundancies in the OTC nasal spray market. Clinician should be aware of the redundancy in OTC formulations and encourage patients to read the labels in order to make informed decisions regarding their use of OTC medications.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
CLINICAL MANAGEMENT OF EOSINOPHILIC ESOPHAGITIS (EOE) BY ALLERGIST- IS THERE A CONSENSUS? (Monitor 32; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_766;
While (10.9%) never prescribed medications, the rest considered PPI (97.1%), swallowed budesonide (79.6%) and fluticasone (69.5%)...Dupilumab was preferred biologic (90%)... EoE is a complex disease limited by reliable marker of disease control and prognosis leading to variability in clinical management.
- |||||||||| Fabhalta (iptacopan) / Novartis, Tai'ai (telitacicept) / Rongchang Pharma, atacicept (VT-001) / Vera Therap
Comparative Efficacy and Safety of New Therapies for IgA Nephropathy: A Systematic Review and Network Meta-Analysis (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3160;
Baseline characteristics in patients receiving and not receiving medium-/high-dose ICS Medium-/high-dose of ICS was defined as ?250mg/day fluticasone equivalent. This systematic review and network meta-analysis indicate Mycophenolate and Telitacicept are most effective in reducing UPCR and improving eGFR, suggesting these as preferable treatments for IgAN patients.
- |||||||||| Ultibro (glycopyrronium/indacaterol) / Novartis
18 ADMISSIONS WEREN () - Aug 27, 2024 - Abstract #MTS2024MTS_233;
Despite comprehensive treatment with Ultibro Breezehaler and Fluticasone, his symptoms remained uncontrolled. This case report underscores the challenges involved in diagnosing and managing ACOS, particularly in the context of a patient with a history of COPD and persistent peripheral blood eosinophilia which emphasises the need for heightened clinical awareness and a deep understanding of ACOS to provide optimal care for patients with overlapping respiratory disorders.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
When Eosinophils Invade: A Case of Eosinophilic Esophagitis and Gastroenteritis With Differential Responses to Therapy (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5446;
His dysphagia did not improve with pantoprazole, topical budesonide, or inhaled fluticasone but resolved completely with systemic steroids...He was treated with dupilumab with improvement in his symptoms...The presence of thickening and ascites suggests the presence of inflammation in all three layers of the bowel. Control of EOE does not necessarily predict control of non-EOE EGID in patients that have both, and more advanced disease monitoring and systemic therapy may be necessary.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Varied Endoscopic Presentations of Eosinophilic Esophagitis in Cancer Patients: A Case Series (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2788;
Case 2: A 40-year-old Caucasian female with a history of thyroid cancer reported 5 years of intermittent solid food dysphagia and heartburn unresponsive to PPIs and topical fluticasone...While studies show improvements in histological, symptomatic, and endoscopic features of EoE with dupilumab, little is known about the safety of dupilumab in patients with concomitant malignancy...Figure 4B. Superficial mucosal tear in the upper to middle third of the esophagus.
- |||||||||| omeprazole / Generic mfg., fluticasone / Generic mfg.
Lymphocytic Esophagitis Presenting in a Lichenoid Pattern (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1083;
Due to its rarity, no clear treatment guidelines have been established, though many providers have extrapolated from other esophagitis treatments and utilize PPI, topical steroids and endoscopic dilatation as treatment options. Figure: Figures A and B: Intrinsic strictures within the upper and middle esophageal lumen Figure C: White exudates present in lower third of esophagus Figure D: Histopathology with arrow highlighting many intraepithelial lymphocytes
- |||||||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
Journal: Cohort Profile Update: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS). (Pubmed Central) - Aug 15, 2024
Figure: Figures A and B: Intrinsic strictures within the upper and middle esophageal lumen Figure C: White exudates present in lower third of esophagus Figure D: Histopathology with arrow highlighting many intraepithelial lymphocytes At inclusion, 686 (95.8%) of EoE patients were on ongoing treatment (orodispersible budesonide tablet [Jorveza
- |||||||||| azithromycin / Generic mfg.
RETROSPECTIVE REVIEW OF AZITHROMYCIN-BASED REGIMENS FOR BRONCHIOLITIS OBLITERANS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION (Convention Center Exhibit Hall: Poster Area 4) - Jul 31, 2024 - Abstract #CHEST2024CHEST_3995;
Patients treated with FAM had similar rates of BOS disease progression compared to non-FAM regimens, though patients with severe BOS overwhelmingly received FAM, potentially confounding lung function results. CLINICAL IMPLICATIONS: Though azithromycin use for BOS appears safe, efficacy of FAM treatment is questionable and will need further evaluation before being recommended for routine use for all BOS patients following SCT.
- |||||||||| Incruse Ellipta (umeclidinium) / GSK, Xolair (omalizumab) / Roche, Novartis
THE ASTHMATIC SPECTRUM: ABPA TO CHRONIC PULMONARY ASPERGILLOSIS IN ADULTS (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1676;
He had previously been stable on a regimen of prednisone, fluticasone, umeclidinium, and omalizumab along with Mucinex and albuterol as needed...Treatment with voriconazole, levofloxacin, inhaled tiotropium, and budesonide led to remarkable recovery, and the patient currently remains stable with follow-up... Preventing further lung damage involves starting antifungal therapy and minimizing corticosteroid use, as increased corticosteroid treatment may compromise the immune response and promote Aspergillus growth.
- |||||||||| Anoro Ellipta (umeclidinium/vilanterol) / Innoviva, GSK, Nucala (mepolizumab) / GSK
THE PERENNIAL PNEUMONIA: A CASE REPORT OF ORGANIZING PNEUMONIA SECONDARY TO CHRONIC ASPIRATION FOLLOWING ROUX-EN-Y GASTRIC BYPASS (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1497;
Her home medications included fluticasone, umeclidinium, and vilanterol inhalers, prednisone 2.5 mg daily, and mepolizumab injections...At this point, antibiotics were discontinued, and she was started on methylprednisolone 1g daily for three days with trimethoprim-sulfamethoxazole for pneumocystis jiroveci pneumonia prophylaxis... In summary, recurrent aspiration following RYGB represents a unique presentation of secondary OP where definitive treatment is pivotal for the avoidance of redundant courses of antibiotic and corticosteroid therapy which may further heighten symptom burden.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
SERUM SICKNESS-LIKE REACTION SECONDARY TO OMALIZUMAB (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1083;
Serum-sickness like reactions are hypersensitivity reactions which can be seen with biologic therapies. Physicians should have a high index of suspicion when patients have arthralgias and constitutional symptoms temporally associated with exposure to these medications.
- |||||||||| tofacitinib / Generic mfg.
tofacitinib in alopecia totalis (Poster Area) - Jul 18, 2024 - Abstract #EADV2024EADV_1472;
However, emerging therapies such as tofacitinib, a Janus kinase (JAK) inhibitor, have shown promising results and gives potential treatment resulting in promoting hair regrowth n some patients with alopecia totalis. Tofacitinib is an off-label treatment option that requires careful consideration of the potential risks and benefits, as well as the challenges associated with insurance coverage and monitoring.
- |||||||||| fluticasone / Generic mfg.
COHORT PROFILE UPDATE: THE SWISS EOSINOPHILIC EESOPHAGITIS COHORT STUDY (SEECS) (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1085;
At inclusion, 694 (96.9%) of EoE patients have an ongoing treatment [orodispersible budesonide tablet: 290 patients (41.8%); budesonide/fluticasone syrup: 281 patients (40.5%); PPI: 162 patients (23.3%); elimination diets: 103 patients (14.8%); esophageal dilation at last visit: 166 patients (23.9%)]... Our findings are in line with the available literature on EoE
- |||||||||| Journal: Patterns of paternal medication dispensation around the time of conception. (Pubmed Central) - Jul 1, 2024
Our case highlights the need to promote the awareness of such serious side effect of prolonged use of topical corticosteroids among healthcare providers, even if administered through a metered inhaler. More than a third of fathers filled at least one prescription medication in the preconception period, and several of them are known to be embryotoxic, emphasizing the necessity for further investigation into the potential teratogenicity of paternal exposure.
- |||||||||| fluticasone / Generic mfg.
Journal: Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis. (Pubmed Central) - Jun 23, 2024
For example, the abundance of Oscillibacter was strongly correlated with gut microflora-related metabolites (Icosenoic acid, Lysosulfatide, and fluticasone) and liver differential genes (Grin3b, Lifr, and Spta1). Together, IMI exposure resulted in significant changes in microbial composition, along with alterations in certain metabolites and genes associated with metabolic process, which may promote gestational hyperglycemia.
- |||||||||| fluticasone / Generic mfg.
Delayed diagnosis of foreign body aspiration in children: complications and treatment (PS-20; Poster board no. 13) - May 31, 2024 - Abstract #ERS2024ERS_675;
Before FBA was diagnosed, frequent complaints were persistent cough (n=9), recurrent respiratory infections (n=7) and fever (n=6); patients were treated with short-acting beta-agonists (n=7), antibiotics (n=6) and fluticasone metered dose inhalation (n=3)...Our experiences emphasize the utility of a prolonged course of steroids and antibiotics as a preparatory measure for FB removal in case of a delayed diagnosis. The accumulation of additional cases will contribute to best practices in managing FBA in children.
- |||||||||| Cinqair (reslizumab) / Merck (MSD), UCB, Teva, cendakimab (CC-93538) / AbbVie, BMS, Dupixent (dupilumab) / Sanofi, Regeneron
Retrospective data, Journal: Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials. (Pubmed Central) - May 3, 2024
An important limitation of this study is absence of clinical efficacy data due to insufficient data. Other limitations include heterogeneity of operator, population, and outcome analysis.
- |||||||||| Rezurock (belumosudil) / Romeck Pharma, Sanofi, Jakafi (ruxolitinib) / Incyte, Imbruvica (ibrutinib) / AbbVie, J&J
Clinical guideline, Journal: ERS/EBMT clinical practice guideline on treatment of pulmonary chronic graft-versus-host disease in adults. (Pubmed Central) - Apr 1, 2024
Following the ERS standardised methodology, we conducted systematic reviews to address these questions and used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to develop recommendations.The resulting guideline addresses common therapeutic options (inhalation therapy, fluticasone-azithromycin-montelukast, imatinib, ibrutinib, ruxolitinib, belumosudil, extracorporeal photopheresis and lung transplantation), as well as other aspects of general management, such as lung functional and radiological follow-up and pulmonary rehabilitation, for adults with pulmonary cGvHD phenotype bronchiolitis obliterans syndrome. These recommendations include important advancements that could be incorporated in the management of adults with pulmonary cGvHD, primarily aimed at improving and standardising treatment and improving outcomes.
- |||||||||| Review, Journal: Allergic Rhinitis: A Review. (Pubmed Central) - Mar 16, 2024
Patients with allergic rhinitis should be instructed to avoid inciting allergens. Therapies include second-generation H1 antihistamines (eg, cetirizine, fexofenadine, desloratadine, loratadine), intranasal antihistamines (eg, azelastine, olopatadine), and intranasal corticosteroids (eg, fluticasone, triamcinolone, budesonide, mometasone) and should be selected based on the severity and frequency of symptoms and patient preference.
- |||||||||| fluticasone / Generic mfg.
DAILY OR TWICE DAILY TREATMENT WITH TOPICAL STEROIDS RESULTS IN SIMILAR RESPONSE IN EOSINOPHILIC ESOPHAGITIS (Hall A, Poster Hall - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_908;
Patients on twice daily dosing were more frequently prescribed fluticasone (36% vs. 18%; p trend < 0.001) and had a higher mean daily steroid dose (1706 mcg vs. 1519 mcg; p = 0.01) (Table 2)...These results can help patients and providers decide how to best take a tCS and to be assured that either regimen is effective. Moreover, given comparable efficacy, a once daily total dose, rather than divided dose, could be considered to increase adherence while reducing the risk for candidal esophagitis.
- |||||||||| montelukast / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
Try, Try Again: The Importance of Expanded Genetic Evaluation in Patients With Bronchiectasis of Unclear Etiology (San Diego Convention Center, Room 28C-E (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7803;
Broad testing many years later revealed the diagnosis of TRAF3-related immune dysregulation, which has resulted in changes in care and management for the entire family. Therefore, reexamination of previous genetic testing and broadening the scope of genetic testing are key when familial disease and an underlying genetic cause are suspected.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Vitamin D Supplementation Modifies the Estimated Effects of PM2.5 Exposure on Severe Asthma Exacerbations in Children With Low Vitamin D Levels (San Diego Convention Center, Room 11A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7287;
Before randomization, all participants completed a four-week run-in period in which they demonstrated ?75% adherence to a low-dose inhaled corticosteroid (Fluticasone MDI), which was continued throughout the trial... Among youth with mild asthma and low vitamin D levels treated with ICS, vitamin D supplementation may protect against pollution-induced SAEs through antioxidant effects and/or enhancement of corticosteroid responsiveness.
- |||||||||| cetirizine oral / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
Intracranial Hypertension as an Initial Sign of Adrenal Insufficiency Secondary to Inhaled Corticosteroids in a Child With Asthma (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6526;
9 mL daily, and cetirizine 10 mg daily...She gradually improved and was successfully extubated on day 4 and discharged home on a 2-week hydrocortisone taper...Unfortunately, there is more systemic absorption than originally understood. It is important to increase awareness of the risk and emphasize the importance of utilizing the minimal effective dose of ICS.
- |||||||||| fluticasone / Generic mfg.
Unmasking the Cause of Dyspnea: Partial Anomalous Pulmonary Venous Return in an Adult (San Diego Convention Center, Area I (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6427;
She was started on a fluticasone inhaler while awaiting further imaging with no resolution of symptoms and increased to a combo long-acting muscarinic antagonist (LAMA), long-acting beta-agonist (LABA), and inhaled corticosteroid (ICS) inhaler with again no resolution...If not revealed in childhood, many patients with PAPVR will remain asymptomatic until they progress to significant pulmonary hypertension. Increased awareness can lead to earlier detection and possibly prevent progression to worse sequelae, including worsening of pulmonary hypertension.
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