- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Tirosint (levothyroxine) / IBSA Institute Biochemical SA
[VIRTUAL] Myxedema Madness: A Rare Case of Severe Hypothyroidism Presenting as Psychosis () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_2038;
In this patient’s case, it is likely that her myxedema madness was precipitated by long-term nonadherence with her thyroid replacement therapy, as the patient had no prior psychiatric history. Additionally, her rapid reversal of symptoms after the administration of levothyroxine supports the diagnosis of hypothyroid-induced myxedema madness.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Clinical characteristics and epilepsy in genomic imprinting disorders: Angelman syndrome and Prader-Willi syndrome. (Pubmed Central) - Apr 11, 2020
Notably, carbamazepine, oxcarbazepine, and vigabatrin should be avoided, since these may induce nonconvulsive status epilepticus...Early diagnosis and teamwork intervention, including geneticists, neurologists, rehabilitation physicians, and pulmonologists, are important. Epilepsy is common in patients with AS, and after proper treatment, seizures could be effectively controlled in late childhood or early adulthood for both AS and PWS patients.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] Epilepsy and pediatric multiple sclerosis (Room Amsterdam) - Apr 9, 2020 - Abstract #EAN2020EAN_2287;
As epilepsy started before the MS onset and before DMT using in some patients, so seizures can be one of the clinical disease manifestations. Epilepsy in MS is focal and well treatable.
- |||||||||| amitriptyline / Generic mfg., carbamazepine / Generic mfg.
[VIRTUAL] Treating chronic SUNCT with a nerve blockade in an anticoagulated patient (Room: Screen B5) - Apr 9, 2020 - Abstract #EAN2020EAN_1968;
SON blockade may be an effective treatment for SUNCT and may even be considered in anticoagulated patients. The presence of migrainous features may predict a better outcome of peripheral blockades for SUNCT.
- |||||||||| venlafaxine / Generic mfg., ceftriaxone / Generic mfg., quetiapine / Generic mfg.
Non-resolving Pneumonia in a Woman with Sicca Syndrome and a History of Collagenous Colitis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area H) - Mar 15, 2020 - Abstract #ATS2020ATS_9204;
Our case is the first known case of an association between AFOP, MRSA and collagenous colitis. We add to the emerging body of literature of success with combined immunomodulatory and antimicrobial therapy in the management of patients with AFOP.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Lamotrigine as a mood stabilizer: insights from the pre-clinical evidence. (Pubmed Central) - Mar 4, 2020
Significant methodological differences concerning time and dose of LTG treatment, administration route, animal strains, and behavioral paradigms also hamper the reproducibility of the findings, leading to contradictory conclusions. Moreover, the role of other mechanisms (e.g. inositol phosphate and GSK3β pathways) implicated in the mode of action of different mood-stabilizers must also be consolidated with LTG.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles. (Pubmed Central) - Mar 3, 2020
For Tc-LTG-PLGA-NPs via intra-nasal route, drug targeting efficiency (DTE%) was found to be 129.81% and drug target organ transport (DTP%) to be 22.81% in brain with C of 3.82%/g within T 1.5 h. Thus, the developed PLGA nanoparticles for intra-nasal delivery provide a possible alternative for existing available drug formulation for neuropathic pain management.
- |||||||||| [VIRTUAL] Electroconvulsive therapy for agitation in Lewy Bodies Dementia (Station 04) - Feb 20, 2020 - Abstract #EPA2020EPA_400;
Medication trials including donepezil, memantine, lamotrigine, sertraline, quetiapine, risperidone and melatonine, all failed to manage his depressive, psychotic and behavorial disturbances. This case suggests that ECT has an impact in the treatment of agitation in DLB patients, although further investigation is needed.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
Journal: Management of epilepsy in brain tumors. (Pubmed Central) - Feb 8, 2020
Management of seizures in patients with BTE should be multidisciplinary. The panel evidenced conflicting or lacking data regarding the role of EEG, the choice of therapeutic strategy, and timing to withdraw AEDs and recommended high-quality long-term studies to standardize BTE care.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Tirosint (levothyroxine) / IBSA Institute Biochemical SA
Myxedema Madness: A Rare Case of Severe Hypothyroidism Presenting as Psychosis (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_1839;
In this patient's case, it is likely that her myxedema madness was precipitated by long-term nonadherence with her thyroid replacement therapy, as the patient had no prior psychiatric history. Additionally, her rapid reversal of symptoms after the administration of levothyroxine supports the diagnosis of hypothyroid-induced myxedema madness.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
The Phenotypic Spectrum of Epilepsy in Desanto-Shinawi Syndrome () - Jan 21, 2020 - Abstract #AAN2020AAN_2011;
The findings in this small cohort of patients suggest that the course of epilepsy in Desanto-Shinawi syndrome is often relatively benign. Seizure onset may occur from infancy to adolescence.
- |||||||||| Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Real-world Study of Brivaracetam in the US: an Interim Analysis () - Jan 21, 2020 - Abstract #AAN2020AAN_1230;
Determine whether BRV retention is associated with lifetime levetiracetam (LEV), lamotrigine (LTG), oxcarbazepine (OXC), or carbamazepine (CBZ) failure. This interim analysis indicates that BRV retention (a measure of effectiveness) at 3 and 6 months is similar between patients that previously failed LEV, LTG, OXC, and CBZ.
- |||||||||| lamotrigine oral suspension (ET-105) / Eton Pharma, lamotrigine liquid oral suspension / OWP Pharma
Administration of Lamotrigine Formulation for Oral Suspension (ET-105) Through Gastrostomy Feeding Tubes () - Jan 21, 2020 - Abstract #AAN2020AAN_1060;
This interim analysis indicates that BRV retention (a measure of effectiveness) at 3 and 6 months is similar between patients that previously failed LEV, LTG, OXC, and CBZ. ET-105, lamotrigine for oral suspension, can be delivered accurately through g-tubes down to at least a minimum diameter of 0.8 cm/12 Fr.
- |||||||||| lamotrigine oral suspension (ET-105) / Eton Pharma, lamotrigine liquid oral suspension / OWP Pharma
Safety, Tolerability, and Pharmacokinetics of ET-105, Lamotrigine for Oral Suspension, Under Fasting and Fed Conditions () - Jan 21, 2020 - Abstract #AAN2020AAN_1059;
ET-105, lamotrigine for oral suspension, can be delivered accurately through g-tubes down to at least a minimum diameter of 0.8 cm/12 Fr. The administration of ET-105, lamotrigine for oral suspension, was safe and well tolerated in healthy subjects under fasting and fed conditions and is bioequivalent to reference lamotrigine tablets.
- |||||||||| pregabalin / Generic mfg., clobazam / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Efficacy of clobazam as an add-on therapy in brain tumor-related epilepsy. () - Jan 21, 2020 - Abstract #AAN2020AAN_889;
Our analysis shows clobazam to be an effective agent in BTRE. A comparative study between clobazam and other anti-epileptics in BTRE could be considered in the future.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Behavioral Complications from Levetiracetam in the Epilepsy Monitoring Unit () - Jan 21, 2020 - Abstract #AAN2020AAN_887;
LEV was transitioned mostly commonly to lamotrigine (43.2%) in our population. We recommend counseling patients regarding behavioral side effects and prompt follow-up when side effects are noted.
- |||||||||| Treatment Strategies for Ultra-Resistant Schizophrenias (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_934;
Electroconvulsive therapy seems to be the only non-pharmacological technique with enough data to support its efficacy in ultra-resistant cases of schizophrenia. Other neuromodulatory techniques, like tDCS, are still in early phase of investigation, and psychotherapy does not have enough evidence to support its efficacy.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Teratogenicity of antiepileptic drugs. (Pubmed Central) - Jan 13, 2020
Although for MCMs the risk is primarily associated with the first trimester of gestation, influences on cognitive and behavioral development could extend throughout pregnancy. Available information now permits a more rational AED selection in women of childbearing potential, and evidence-based counseling on optimization of AED treatment before conception.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Brain targeting stealth lipomers of combined antiepileptic-anti-inflammatory drugs as alternative therapy for conventional anti-Parkinson's. (Pubmed Central) - Jan 12, 2020
Consequently; brain targeting Tween®80-coated pegylated lipomers were tailored for intravenous administration (IV) of L-Dopa, and two drugs of reported neuroprotective effect: lamotrigine (LTG) and tenoxicam (TX)...Thus; offering a safe, targeted, and therapeutically efficient sustained dosage form, capable of mitigating PD risk and treating it though weekly administration. Hence; presenting a novel promising anti-neurodegenerative strategy; on employing various mechanisms that were previously achieved through additional therapeutic supplements.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
Clinical, Journal: Hormonal contraception in patients with epilepsy. (Pubmed Central) - Jan 11, 2020
As interaction between OC and AEDs are common, nonhormonal, highly effective methods, such as IUDs, may be ideal for women with epilepsy. The results of the study indicate the need for closer cooperation between neurologist and gynecologist caring for women with epilepsy.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Hemophagocytic lymphohistiocytosis associated with the use of lamotrigine. (Pubmed Central) - Dec 23, 2019
Lamotrigine is associated with immune-related adverse reactions including HLH. HLH is a potentially fatal event; prompt recognition and early therapeutic intervention to mitigate the event is important in improving patient outcomes.
- |||||||||| topiramate / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma, Zarontin (ethosuximide) / Pfizer
Behavioural and Electroencephalographic Consequences of Partial cacna1a Loss-of-Function in Larval Zebrafish (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1562;
Herein, all used drugs were equally potent. Conclustions Although the cacna1aa partial loss-of-function in larval zebrafish might mimic some symptoms of human CACNA1A deficiency, further validation with broad range of AEDs combined with an analysis of underlying changes in the larval brain is warranted to state if it may be a useful animal model of seizures.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Trileptal (oxcarbazepine) / Novartis
Multinodular and Vacuolating Neuronal Tumors of the Temporal Lobe (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1516;
She has rare breakthrough seizures on zonisamide...Also, it is unclear whether lesionectomy is sufficient, or if these patients require 2-step epilepsy surgery with invasive monitoring to define epileptic zone margins beyond radiographic margins. Larger multi-center case series would help to answer these questions.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Awareness of Seizures: Patient Report and RNS Record (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1515;
It can also be challenging to differentiate focal seizures without awareness from non-epileptic hypervigilant behaviors by patients’ descriptions. RNS ECog recordings provide further objective electrophysiological evidence, and therefore could be helpful in the diagnosis and treatment.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Ictal Forced Mouth Opening in a Patient with Refractory Focal Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1373;
In 2017 the seizures recurred and oxcarbazepine was added but she continued to have nightly seizures...Conclustions Ictal forced mouth opening be considered as a rare automatism seen in epileptic seizures and can be a semiologic sign of a right frontal convexity epilepsy. This rare ictal manifestation should be recognized as epileptic to avoid misdiagnosis and treatment failure.
- |||||||||| clobazam / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
GAD-65 Antibodies in Epilepsy Patients Without Autoimmune Encephalitis (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1364;
Prior brain injury may be a risk factor for GAD-65 antibody associated epilepsy. This small group of GAD-65 positive epilepsy patients merit further investigation.
- |||||||||| lacosamide / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
Ultra Long-Term EEG as an Improvement over Seizure Diary When Optimizing AED Treatment (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_746;
It is a minimally invasive method, which accommodates the possibility of unobtrusive recordings in the every-day life of epilepsy patients. Further, based on this case-study, it is likely that ultra long-term EEG increases the power of clinical trials in epilepsy due to a more correct seizure count than has previously been available.
- |||||||||| carbamazepine / Generic mfg.
Antiseizure Drug Response of Outbred Versus Inbred Mice in Pharmacoresistant Acute and Chronic Seizure Models (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_678;
Conclustions This work highlights strain-related differences in the potency of acutely administered ASDs in common mouse seizure models; both inbred (C57Bl/6) and outbred (CF-1) mouse strains are frequently used in the development of novel ASDs. It also highlights the dose-dependent impacts that pharmacologically-equivalent doses of ASDs can have upon quantifiable locomotor behavior beyond the TD50 alone.
- |||||||||| Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Real-World Study of Brivaracetam in the US: An Interim Analysis (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_653;
Three patients died during the study, but none were judged to be drug-related. Conclustions This interim analysis indicates that retention on BRV (a measure of effectiveness) at 3 and 6 months is similar between patients that had previously failed LEV, LTG, OXC, and CBZ.
- |||||||||| Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Effect of Concomitant Anti-Seizure Drugs During Adjunctive Perampanel Treatment in Pediatric Patients (Aged 4 to <12 Years): Post Hoc Analysis of Study 311 (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_647;
P3
For the most common concomitant ASDs these were: levetiracetam: 48.9% (22/45) and 55.6% (5/9); valproic acid: 39.6% (19/48) and 75.0% (3/4); clobazam: 52.5% (21/40) and 66.7% (4/6); lamotrigine: 42.9% (15/35) and 77.8% (7/9); topiramate: 54.5% (12/22) and 40.0% (2/5); and carbamazepine: 42.3% (11/26) and 0.0% (0/0), respectively. Conclustions These data suggest adjunctive perampanel is generally well tolerated and efficacious in pediatric patients (aged 4 to ˂12 years) with POS (with/without SGS) or PGTCS, irrespective of baseline ASD use.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Behavioral Complications from Levetiracetam in the Epilepsy Monitoring Unit (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_608;
We recommend at minimum discussion with patients regarding risk of behavioral side effects when initiating LEV and follow up specifically regarding side effects after the patient has been on maintenance LEV. When necessary, transition to an AED with a lower incidence of adverse mood effects should be considered.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Prevalence of Concurrent Prescriptions for Oral Anticoagulants and Antiepileptic Drugs Among People with Epilepsy Between 2010-2016 (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_341;
The OACs included warfarin, as well as those DOACs that received regulatory approval during the study time frame (dabigatran, rivaroxaban, apixaban, and edoxaban)...These findings highlight the clinical significance of advancing understanding of interactions between EI-AEDs and OACs, given their potential impact on as much as 7.17% of PWE. In particular, further research into proposed interactions with DOACs appears warranted in light of rapid uptake of this form of anticoagulation within the population with epilepsy.
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