- |||||||||| Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
[VIRTUAL] Reasons for Clinical Trial Failure in Bipolar Disorder () - Apr 13, 2021 - Abstract #ASCP2021ASCP_225;
Other factors that may contribute to failed trials in bipolar depression include poor choice of primary outcome ratings scales, as suggested by use of the Hamilton rather than Montgomery-Asberg Rating Scales for depression in an initial large industry trial of lamotrigine for acute bipolar depression...Finally, and arguably most challenging of all, involves the need for study designs that adequately account for differences due to treatment versus the natural course of illness, as exemplified in the failed STEP-BD randomized trials of antidepressants (bupropion or paroxetine) versus placebo augmentation of antimanic drugs in bipolar depression...To recognize differences between, and examples of, failed versus randomized trials across all phases of bipolar disorder 2. To describe the impact on detecting drug-placebo differences when clinical trials utilize add-on therapy designs, fail to enrich samples for acute responsivity before entering maintenance therapy phases, ignore discontinuation effects of pre-enrollment medications, and fail to balance randomization for key moderators of outcome such as baseline severity, rapid cycling, predominant polarity proneness, and degree of treatment resistance.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Contraceptive vaginal ring reduces lamotrigine levels. (Pubmed Central) - Mar 17, 2021
The findings support that the vaginal ring contraceptive method decreases lamotrigine concentrations during the active phase of treatment. This has important implications for contraceptive counseling and maintaining therapeutic levels in women of childbearing age with epilepsy.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Observational data, Journal: Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients. (Pubmed Central) - Mar 16, 2021
In addition to phenytoin, also lamotrigine, oxcarbazepine, and phenobarbital were associated with increased prevalence of gingival overgrowth. In the management of epileptic patients, dentists should take into account different drugs as possible causes for gingival overgrowth and warn for possible alternatives.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Modulation of the Powder Properties of Lamotrigine by Crystal Forms. (Pubmed Central) - Mar 2, 2021
The two drug-drug crystals of LAM with nicotinamide and valproic acid demonstrate superior flowability and tabletability over LAM. The improved powder properties are rationalised by structure analysis using energy framework, scanning electron microscopy, and Heckel analysis.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: The Treatment of Vestibular Migraine: A Narrative Review. (Pubmed Central) - Feb 25, 2021
Also, vestibular rehabilitation (VR) treatment should be considered for all VM. Meanwhile, we also propose to establish a culture of prevention which is essential for reducing the personal, social and economic burden of VM.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Contraception in epileptic women (Pubmed Central) - Feb 23, 2021
Family planning counseling at the first visit has been shown to influence the choice of the contraceptive method and the early initiation of folic acid in the search for fertility. In conclusion, the different therapeutic options should be analyzed together with the epileptic patients in order to achieve and optimize the best goal for each one.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Preparation and characterization of lamotrigine containing nanocapsules for nasal administration. (Pubmed Central) - Feb 10, 2021
The results indicate that the formulation could be a promising alternative of lamotrigine (LAM) as the NCs were around 305 nm size with high encapsulation efficiency (58.44 %). Moreover, the LAM showed rapid and high release from the NCs in vitro and considerable penetration to the brain tissues was observed during the in vivo study.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie
[VIRTUAL] Bilateral hemimasticatory spasm: Report of a 4-year follow-up case treated with botulinum toxin () - Jan 29, 2021 - Abstract #TOXINS2021TOXINS_76;
Trials of carbamazepine and lamotrigine were unsuccessful. HMS is a very rare disorder characterized by paroxysmal involuntary contraction of the jaw-closing muscles, typically unilaterally.1,2 Since the original description by Gowers in 1897, few cases have been described in the literature, and no case of bilateral involvement to the authors’ knowledge.3,4 Botulinum toxin type A injection is the most effective treatment available.4,5
- |||||||||| donepezil / Generic mfg.
[VIRTUAL] TREATMENT OPTIONS FOR SLEEP-RELATED EPILEPTIC SPIKING IN EARLY ALZHEIMER’S DISEASE () - Dec 24, 2020 - Abstract #ADPD2021ADPD_1050;
We will test the standard ADdrugs donepezil and memantine, anti-epileptic drugs levetiracetam and lamotrigine, gamma-secretase inhibitor semagacestat and an anti-inflammatory tetracycline derivative minocycline at doses with no overt motor manifestations. Sleep-related epileptic spiking in AD is treatable with clinically approved drugs.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] A Case of Ictal Asystole in Temporal Lobe Epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_945;
Left TLE in particular is associated with autonomic-induced cardiorespiratory phenomena such as ictal bradycardia and ictal central apnea, due to the role of the left insular region in parasympathetic regulation demonstrated through cortical stimulation and lesional studies. 2, 3.
- |||||||||| XEN1101 / Xenon, lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Cortical oscillations to measure anti-epileptic drug activity in clinical trials () - Nov 28, 2020 - Abstract #AES2020AES_680;
Spectral fingerprints should be further investigated to provide robust and objective biomarkers of target engagement in human clinical trials. Funding: This study represents an independent research supported by the National Institute for Health Research (NIHR)-Well come King’s Clinical Research Facility and the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Sunflower syndrome in two pairs of monozygotic twins () - Nov 28, 2020 - Abstract #AES2020AES_545;
Both pairs were concordant in epilepsy syndrome and had seizure onset within a short time of each other, consistent with published data on age of seizure onset as a familial trait, and epilepsy syndrome concordance rates in monozygotic twins. Overlapping but distinct ranges of seizure semiologies were seen within pairs.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Tectin (tetrodotoxin) / WEX, Miostat (carbachol) / Novartis
Journal: Constitutively active HCN channels constrain detrusor excitability and modulate evoked contractions of human bladder. (Pubmed Central) - Nov 27, 2020
Overall, HCN channels immunolocalized in mucosa, smooth muscle, gap junctions and nerve fibers exert a tonic constraint on detrusor excitability, enable spatio-temporal integration of evoked contractions and constrain the release of neurotransmitters, respectively. In contrast to the pacemaker role in other organs, findings argue for a non-pacemaking role of HCN channels in human bladder.
- |||||||||| Review, Journal: Chronic Pain Treatment Strategies in Parkinson's Disease. (Pubmed Central) - Nov 23, 2020
Anticonvulsants such as gabapentin, pregabalin, lamotrigine, carbamazepine and tricyclic antidepressants (TCAs) can be trialed when attempting to manage chronic pain in PD...A treatment plan can be devised that may include dopaminergic agents, acetaminophen, NSAIDs, opioids, antidepressants, physical therapies, DBS and other options discussed in this review. A thorough assessment of patient history and physical examination should be made in patients with PD so chronic pain may be managed effectively.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Clinical, Journal: Bidirectional interaction between oral contraception and lamotrigine in women with epilepsy - Role of progestins. (Pubmed Central) - Nov 19, 2020
The findings suggest that drospirenon and levonorgestrel but not gestoden seem to reduce LTG serum concentrations when being co-administered in WWE which might be of importance concerning seizure risk. Vice versa, no effect of LTG on several progestins could be demonstrated, arguing against a potential loss of contraception safety with LTG.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Factors associated with obsessive-compulsive symptoms in people with epilepsy. (Pubmed Central) - Nov 4, 2020
Obsessive-compulsive symptoms are common in persons with epilepsy and are associated with severe epilepsy, temporal lobe seizures, and the use of topiramate and lamotrigine. Specifically, the use of lamotrigine may aggravate OCS, whereas the use of topiramate may have beneficial effects on OCS.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, ethosuximide / Generic mfg.
Journal: The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. (Pubmed Central) - Sep 13, 2020
It was revealed that the disease-modifying effects were accompanied by the prevention of neuronal loss and astrogliosis. ESM was devoid of antiepileptogenic and its accompanying histological effects in this TLE model, in contrast to the antiepileptogenic effects found in the genetic absence epilepsy models, suggesting that different mechanisms are involved in the different models for epileptogenesis and antiepileptogenesis.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Effects of lamotrigine on learning and memory processes in Wistar rats (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_818;
In step-down passive avoidance test the higher dose of Lamotrigine markedly improves acquisition and memory consolidation. Lamotrigine at a dose of 20 mg/kg in pregnant rats did not affect cognitive functions of offspring in passive and active avoidance tests [3] supports our conclusion that Lamotrigine does not impair learning and memory in rats.
- |||||||||| [VIRTUAL] Comparative effectiveness of antipsychotics for risk of attempted or completed suicide among persons with schizophrenia (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_814;
In addition, adjunctive pharmacotherapies including antidepressants, mood stabilisers (carbamazepine, valproic acid, lamotrigine, lithium), benzodiazepines and Z-drugs were investigated...The results from two large nationwide cohorts provide the first evidence on comparative real-world effectiveness of specific antipsychotics in the prevention of severe suicidal behavior. Clozapine was the only pharmacological treatment associated with a substantially decreased risk of attempted or completed suicide and should be considered as first-line treatment for patients with suicidal ideation or behavior.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, alprazolam / Generic mfg.
Journal: The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability after traumatic brain injury. (Pubmed Central) - Jul 16, 2020
KRM-II-81 also decreased convulsions in rats undergoing amygdala kindling in the presence of lamotrigine (lamotrigine-insensitive model) (ED = 19 mg/kg, i.p.)...Molecular modeling studies were conducted: docking in the binding site of the α1β3γ2L GABA receptor showed that replacing the C8 chlorine atom of alprazolam with the acetylene of KRM-II-81 led to loss of the key interaction with α1His102, providing a structural rationale for its low affinity for α1-containing GABA receptors compared with benzodiazepines such as alprazolam...In silico docking experiments begin to describe the structural basis for the relative lack of motor-impairment induced by KRM-II-81. KRM-II-81 has unique structural and anticonvulsant effects predicting its potential as an improved antiepileptic drug and novel therapy for posttraumatic epilepsy.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Sphenopalatine Ganglion Block for the Treatment of SUNCT Syndrome in a Geriatric Patient () - Jul 15, 2020 - Abstract #AHS2020AHS_262;
Patients with SUNCT can often be refractory to standard headache medications, and side effects from medications, drug interactions, and tolerability can be a limiting factor in the choice of oral treatments for elderly patients. SPG block is a safe, office-based, and non-invasive procedure that can be considered for treatment of pain in elderly patients with SUNCT.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential. (Pubmed Central) - Jul 4, 2020
Alternatives have emerged, especially lamotrigine and levetiracetam, but also topiramate, zonisamide, and recently perampanel, but none of these AEDs can be considered fully safe in the context of pregnancy...Carbamazepine, oxcarbazepine and phenytoin must be avoided...The consequences of a lifetime of poorly controlled epilepsy need to be balanced against the teratogenic risks of valproate during limited times in a woman's life. The management of JME in WWE should include lifestyle interventions, with avoidance of sleep deprivation, and planned pregnancy.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Observational data, Journal: Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study. (Pubmed Central) - Jun 29, 2020
Therefore, further research will be required to delineate the potential risks to learning and memory functions in children exposed to carbamazepine, lamotrigine, and phenytoin in monotherapy during pregnancy. Additional research employing larger prospective studies will be required to confirm the long-term cognitive and behavioral risks to children of mothers who are prescribed these four AEDs during pregnancy as well as to delineate any potential risks of newer AEDs and to understand the underlying mechanisms of adverse AED effects on the immature brain.
- |||||||||| carbamazepine / Generic mfg.
Journal: Developmental outcomes at age four following maternal antiepileptic drug use. (Pubmed Central) - Jun 29, 2020
Prenatal exposure to sodium valproate and lamotrigine is associated with an increased risk of concerns about emotional and behavioral development being reported by parents in a neurodevelopmental screening program. Additional investigation is required into why significant differences between AEDs were not seen in this study.
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