- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Neurologic and Obstetrical Outcomes in Pregnant Women with Epilepsy After Craniotomy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1781;
The cesarian section rate of 48% is higher than the national average of 31.9%, though in this study over half of cesarian sections were planned due to previous cesarian sections or due to craniotomy history. Women who delivered vaginally had no acute neurologic complications.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
A Data-driven Approach to Reconstructing Disease Trajectories in syngap1-related Disorder (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1541;
We utilized a novel data-driven approach to assess phenotypic patterns, identify clinically significant genotype-phenotype correlations, and demonstrate the dynamic pattern of seizures and drug response in individuals with SYNGAP1-related disorder. Elucidating the full clinical spectrum in SYNGAP1-related disorder will be critically important for understanding the disease mechanism, developing disease-specific outcome measures and guiding future precision medicine efforts.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1286;
Our findings demonstrate the role of HCN1 mutations in causing seizures, and suggest a potential contribution of interneuronal dysfunction in HCN1-linked epilepsy, with consequent alterations in the antiseizure drug response profile. The availability of strong preclinical models, such as the Hcn1G380D/+ and Hcn1M142I/+ mouse lines presented here, overall provides an ideal platform for investigating the mechanisms underlying epileptic encephalopathies as well as testing new therapeutic approaches.
- |||||||||| Fycompa (perampanel) / Eisai
Efficacy and Safety of Perampanel as First or Only Adjunctive Therapy in Patients with Focal-onset Seizures (FOS) or Generalized Tonic-clonic Seizures (GTCS) in Studies 412, 501, 410, and 509 (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1195;
P, P=N/A,
Based on the available data from these studies, perampanel as a first or only adjunctive ASM was found to be efficacious and generally well tolerated. These data support the use of perampanel as an early-line treatment option for patients with various seizure types (FOS, FBTCS, and GTCS).
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Actigraphic Correlates of Psychiatric Disability in Patients with Focal Epilepsy () - Oct 17, 2022 - Abstract #ANA2022ANA_419;
Can we achieve similar therapeutic effects by instituting behavioral modifications that reshape a subject’s RAR? In ongoing stud ies, we are characterizing RAR structure in PWE with broader comorbidities, including intellectual disability, lim ited/no verbal abilities and/or static motor impairments (e.g., quadriparesis).
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Case Series of Manic Symptoms Following Concussion () - Oct 17, 2022 - Abstract #ANA2022ANA_373;
Case 1: Manic Episode Provoked by Concussion A 65-year-old male with recurrent major depressive disor der presented following acute concussion in a car accident. One month later, he reported symptoms of irritable mood, increased talkativeness, distractibility, and racing thoughts.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Lamotrigine Causing Drug-Induced Acute Interstitial Nephritis With Granulomas (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3527;
1-3 Interstitial nephritis with granulomas on biopsy should prompt a thorough review of a patient's medications, as this pattern of injury is usually due to a drug-related AIN. 4 In patients with new-onset renal failure in the setting of lamotrigine use, AIN should be considered so that early and appropriate intervention can be initiated.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Enbrel (etanercept) / Pfizer, Amgen
Retrospective data, Review, Journal: Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Aug 30, 2022
Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP. Pamidronate and prednisone showed better effect than other pharmacotherapies, which warrants further investigation.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review. (Pubmed Central) - Aug 26, 2022
Monitoring for medication-induced obsessive compulsions or tics should be undertaken when prescribing antiseizure medication for treatment of mood disorders or epilepsy. Further research identifying the causal relationship between antiseizure medication and de novo onset of obsessive-compulsive symptoms, obsessive-compulsive disorder and tic disorder is required.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Preclinical, Journal: Effects of treatment with clinically relevant valproate, carbamazepine, oxcarbazepine, topiramate, lamotrigine and levetiracetam on ovarian folliculogenesis in young rats. (Pubmed Central) - Jul 15, 2022
In addition to the classic action on sodium channels, CBZ has also antagonistic effects on calcium channels, as documented in several experimental models in vitro. Exposure to VPA, CBZ, OXC, TPM, LTG and LEV caused different levels of impaired folliculogenesis in young rats.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: NEXMIF mutations in intellectual disability and epilepsy: A report of 2 cases and literature review. (Pubmed Central) - May 18, 2022
She took the medicine of levetiracetam and lamotrigine, and the seizures were under control...He was given topiramate and adrenocorticotrophic hormone (ACTH)...During the follow-up period, the seizures were reduced with vigabatrin...Most of the variants reported so far were loss-of-function resulted in the reduced protein expression of NEXMIF. The degree of NEXMIF loss appears to correlate with the severity of the phenotype.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Clinical guideline, Journal: Borderline Personality Disorder: Clinical Guidelines for Treatment. (Pubmed Central) - May 6, 2022
Where the history suggests a genetic link to bipolar disorder, a mood stabilizer such as lithium or lamotrigine, even in modest doses, may be particularly beneficial, more so than conventional antidepressants...As for the psychotherapeutic component, the patient's cognitive style and capacity for introspection will help determine whether a primarily expressive (psychoanalytically oriented) technique is preferable or a primarily cognitive-behavioral technique. Flexibility is necessary, since during emotional crises, supportive and limit-setting interventions will be needed, along with psychotropic medications, and where necessary, programs to help combat substance abuse (which is common among patients with BPD).
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Psychiatric Comorbidities Associated With Postural Tachycardia Syndrome (POTS): Case Report and Literature Review () - May 5, 2022 - Abstract #APA2022APA_608;
She was on Escitalopram, Bupropion, and Lamotrigine...Duloxetine and Venlafaxine are preferred due to dual action on serotonin and norepinephrine...The case highlights difficulties in choosing psychotropic medications for depression and anxiety, as these medications can lead to worsening of falls and syncope. However, certain combinations of medications and therapy can improve of quality of life.
- |||||||||| buspirone/melatonin (BCI-952) / BrainCells, lamotrigine liquid oral suspension / OWP Pharma
Medroxyprogesterone for Refractory Agitation in TBI and Parkinson’s Disease () - May 5, 2022 - Abstract #APA2022APA_549;
Psychiatric course of treatment included adequate trials of Quetiapine, Olanzapine, Buspirone, Melatonin, Valproic Acid, Trazodone, and varying levels of benzodiazepines...Due to severity of his Parkinson''s, Neurology was reluctant to make changes to Carbidopa-Levodopa 25-100 mg four times daily due to the overall motor benefit he experienced...As in the prior case, he was started on medroxyprogesterone IM 150 mg weekly and found benefit at 300 mg weekly, which allowed for discharge to memory care unit. While dopamine and D2-like receptor families have been associated with impulsive personality traits, these cases illustrate the potential for Medroxyprogesterone to target an alternative mechanism when agitation appears refractory to treatment, and changes to dopamine may be unable to be made.
- |||||||||| levetiracetam / Generic mfg.
Journal: A Case of Possible Levetiracetam Induced Aseptic Meningitis vs Viral Meningitis. (Pubmed Central) - May 5, 2022
Applying the Naranjo Scale yields a score of 4, which indicates possible levetiracetam-induced meningitis in this adult patient. Providers should be cognizant when prescribing antiepileptics to assess and monitor for aseptic meningitis that may appear with atypical symptoms.
- |||||||||| carbamazepine / Generic mfg.
Journal: Evaluation of family planning methods in married women with epilepsy. (Pubmed Central) - Apr 6, 2022
Because of high consumption of valproate in women of childbearing age in our study and concerning issue about its fetal malformation, it is recommended to reduce the administration of valproate in this population. Moreover, regarding the low consumption of folic acid, especially for women of childbearing age and pregnant WWE who are taking AED, the necessary recommendations should be made by our physicians.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, lamotrigine liquid oral suspension / OWP Pharma
Preclinical, Journal: Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. (Pubmed Central) - Mar 25, 2022
The matrix effect was within 91%-105%, and the recovery was better than 88%. The established UPLC-MS/MS method was successfully applied to the pharmacokinetic study of lamotrigine, oxcarbazepine, lacosamide, and topiramate in rats.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Clinical, Journal: Abdominal epilepsia partialis continua in a patient with astrocytoma treated with Lacosamide - value of repetitive EEG recordings. (Pubmed Central) - Mar 24, 2022
The independent spikes in her frontal and parietal regions suggested the presence of a large epileptogenic zone generating independent epileptiform activities in the pre-central motor cortex and the post-central sensory cortex as the pathophysiologic phenomena in persistent abdominal EPC. To the best of our knowledge, this is the first report presenting a patient experiencing an abdominal EPC due to a cerebral mass resolved with lacosamide suggesting this drug is a promising treatment option in resistant EPC.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Epilepsy and Pregnancy. (Pubmed Central) - Mar 3, 2022
Practitioners should discuss the risks of various obstetric complications; potential anatomic teratogenicity and neurodevelopmental dysfunction related to fetal antiseizure medication exposure; and a plan of care during pregnancy, delivery, and postpartum. Women with epilepsy should also be reassured that the majority of pregnancies are uneventful.
- |||||||||| dextroamphetamine immediate release / Generic mfg.
Journal: Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. (Pubmed Central) - Feb 1, 2022
Low doses of diazepam partially reduced the hyperlocomotion and fully recovered the immobility time during tail suspension...Inputs inhibiting VTA neurons intensify wakefulness (increased activity, enhanced alertness and motivation), qualities useful for acute survival. In the extreme, however, decreased or failed inhibition from VTA neurons produces mania-like qualities (hyperactivity, hedonia, decreased sleep).
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Preclinical, Journal: Developing precision treatments for epilepsy using patient and animal models. (Pubmed Central) - Feb 1, 2022
There are also recommendations from experimental epileptology on synergistic AED combinations for patients with drug-resistant seizures. The clinical evidence on this issue is scarce and favors a combined treatment with valproate + lamotrigine.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Seizures in Fragile X Syndrome: Associations and Longitudinal Analysis of a Large Clinic-Based Cohort. (Pubmed Central) - Jan 18, 2022
Overall, this study confirms previous reports of seizures in FXS and extends previous findings by further defining the cognitive and behavioral phenotype of those with epilepsy in FXS. Future studies should further investigate the natural history of seizures in FXS and the characteristics of seizures in FXS in adulthood.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Post-stroke epilepsy and antiepileptic drug use in men and women. (Pubmed Central) - Dec 30, 2021
Choice of AED, oral anticoagulant use and percutaneous endoscopic gastrostomy (PEG) showed an association with the persistence to therapy. We conclude that in both men and women with PSE, levetiracetam was the most used AED for initiation of treatment and also had the highest persistence.
- |||||||||| gabapentin / Generic mfg.
Clinical, Journal: SUNCT/SUNA: Case series presenting in an orofacial pain clinic. (Pubmed Central) - Dec 21, 2021
Differentiating between SUNCT/SUNA does not appear to be clinically relevant. Presenting symptoms were consistent with those published, except 5/6 patients describing intraoral pain and two patients describing paresthesia.
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