Nyxol (phentolamine mesylate ophthalmic solution 1%) / Ocuphire Pharma 
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3 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Nyxol (phentolamine mesylate ophthalmic solution 1%) / Ocuphire Pharma
VEGA-2, NCT05646719: Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia

Completed
3
333
US
Phentolamine Opthalmic Solution 0.75%, Nyxol, Placebo, Phentolamine Ophthalmic Solution Vehicle, Low dose pilocarpine, Pilocarpine, LDP, Low dose pilocarpine vehicle
Ocuphire Pharma, Inc.
Presbyopia
10/23
10/23
LYNX-2, NCT06349759: Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects with Post-refractive Surgery Visual Disturbances

Active, not recruiting
3
200
US
phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist, Nyxol, Placebo, phentolamine ophthalmic solution vehicle
Ocuphire Pharma, Inc., Viatris Inc.
Mesopic Vision, Night Vision Loss
09/25
11/25
VEGA-3, NCT06542497: Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia

Active, not recruiting
3
545
US
0.75% phentolamine ophthalmic solution, Nyxol, Placebo, phentolamine ophthalmic solution vehicle
Ocuphire Pharma, Inc.
Presbyopia
10/25
05/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Nyxol (phentolamine mesylate ophthalmic solution 1%) / Ocuphire Pharma
VEGA-2, NCT05646719: Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia

Completed
3
333
US
Phentolamine Opthalmic Solution 0.75%, Nyxol, Placebo, Phentolamine Ophthalmic Solution Vehicle, Low dose pilocarpine, Pilocarpine, LDP, Low dose pilocarpine vehicle
Ocuphire Pharma, Inc.
Presbyopia
10/23
10/23
LYNX-2, NCT06349759: Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects with Post-refractive Surgery Visual Disturbances

Active, not recruiting
3
200
US
phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist, Nyxol, Placebo, phentolamine ophthalmic solution vehicle
Ocuphire Pharma, Inc., Viatris Inc.
Mesopic Vision, Night Vision Loss
09/25
11/25
VEGA-3, NCT06542497: Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia

Active, not recruiting
3
545
US
0.75% phentolamine ophthalmic solution, Nyxol, Placebo, phentolamine ophthalmic solution vehicle
Ocuphire Pharma, Inc.
Presbyopia
10/25
05/26

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