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- KM023 / Kainos Medicine
Predicting drug?drug interactions between ainuovirine and rifampicin plus isoniazid using PBPK modelling (Virtual) - Oct 26, 2024 - Abstract #HIVGlasgow2024HIV_Glasgow_342;
The developed PBPK model characterized the opposite effect-mediated DDIs between RFP and INH on metabolisms of ANV, accurately predicting a narrowed therapeutic window when ANV 150 mg daily was co-administered with RFP plus INH. A change in ANV dosing regimen from 150 to 225 mg was predicted to mitigate the effect of the DDIs on the Cmax and Ctrough of ANV, maintaining plasma concentration levels above the therapeutic threshold but well below the safety margin.
- fluconazole oral / Generic mfg.
Effect of fluconazole on the pharmacokinetics of ainuovirine in healthy adults (Virtual) - Oct 26, 2024 - Abstract #HIVGlasgow2024HIV_Glasgow_339;
Co-administration of ainuovirine with fluconazole significantly increased ainuovirine systemic exposure, whereas ainuovirine did not appear to affect fluconazole exposure. Therefore, it is recommended that the ainuovirine dose be halved (i.e. 75 mg) when co-administered with strong CYP2C19 inhibitors, including fluconazole.
- | KM023 / Kainos Medicine
Journal: The function of the cytoplasmic dynein light chain PTKM23 in the transport of PTSMAD2 during spermatogenesis in Portunus trituberculatus. (Pubmed Central) - Jun 20, 2024
KM23 belongs to the dynein light chain family...These results indicate that PTKM23 is involved in the assembly of cytoplasmic dynein and microtubules during spermatogenesis and that PTKM23 mediates the participation of cytoplasmic dynein in the transport of PTSMAD2 during spermatogenesis. This study provides a theoretical molecular biological basis for the breeding of P. trituberculatus.
- | KM023 / Kainos Medicine
Journal: Hydroxy(phenyl)pyruvic acid reductase in Actaea racemosa L.: a putative enzyme in cimicifugic and fukinolic acid biosynthesis. (Pubmed Central) - Apr 2, 2024
This study provides a theoretical molecular biological basis for the breeding of P. trituberculatus. NADPH is the preferred cosubstrate (Km 23?
- | KM023 / Kainos Medicine
Journal: No Meaningful Drug-Drug Interactions Are Associated with the Coadministration of ACC007, Lamivudine, and Tenofovir Disoproxil Fumarate. (Pubmed Central) - May 3, 2023
ACC007 combined with 3TC-TDF was generally well tolerated during daily dosing for 17?days with no serious adverse events. Overall, ACC007 and 3TC-TDF had no significant or meaningful interactions and a favorable safety profile, which supports the use of the combination regimen.
- | KM023 / Kainos Medicine
Preclinical, Journal: The New NNRTI ACC007 Combined with Lamivudine and Tenofovir Disoproxil Fumarate Show Synergy Anti-HIV Activity In Vitro. (Pubmed Central) - Sep 29, 2021
Overall, ACC007 and 3TC-TDF had no significant or meaningful interactions and a favorable safety profile, which supports the use of the combination regimen. ACC007 exhibits potent antiviral activity alone or with 3TC and TDF, and exerts synergistic effect against all HIV strains used in our investigation in vitro.
- ||| KM023 / Kainos Medicine
Trial completion: Single Ascending Dose (SAD)/Multiple Ascending Dose(MAD) Safety/Pharmacokinetic (PK) Study of KM-023 (clinicaltrials.gov) - Jul 23, 2012
P1, N=83, Completed, Sponsor: Kainos Medicine Inc.
ACC007 exhibits potent antiviral activity alone or with 3TC and TDF, and exerts synergistic effect against all HIV strains used in our investigation in vitro. Active, not recruiting --> Completed