||||||||||AB022 / Bayer, Aronora Journal: Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species. (Pubmed Central) - Nov 16, 2023 Therefore, this study aimed to extract and elucidate antimicrobial metabolites from the following myxobacteria: Myxococcus xanthus CA010 and AB022; Corallococcus exiguus DSM 14696; Myxococcus stipitatus DSM 14675; and Corallococcus aberystwythensis AB050A...With previously confirmed bioactivity of compound A, it is suggested that these DKP compounds are contributing to the antimicrobial activity observed. Furthermore, many compounds could not be identified and so these unknowns present further potential for novel bioactive compounds.
||||||||||AB022 / Bayer, Aronora Preclinical, Journal: BauA and Omp34 surface loops trigger protective antibodies against Acinetobacter baumannii in a murine sepsis model. (Pubmed Central) - Jun 22, 2022 The mice were challenged with a clinical isolate of A. baumannii (ABI022)...Histopathological findings in the immunized mice showed bronchioles clear from inflammatory cells and normal texture of the spleen and liver. The findings support the use of a multivalent vaccine to induce broadly reactive antibody responses against heterologous A. baumannii strains.