sisunatovir (PF-07923568) Trials

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

sisunatovir (PF-07923568) / LianBio

NCT06079320: A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection

Terminated

2/3

Canada, Japan, US, RoW

Sisunatovir, Placebo

Pfizer

Respiratory Syncytial Virus Infection

09/24

2017-001282-24: A clinical trial of RV521 in healthy volunteers

Not yet recruiting

Europe

RV521 50mg, RV521 100mg, RV521, 200mg, RV521, Capsule

ReViral Ltd, ReViral Ltd

Respiratory Syncytial Virus Infection, RSV is a common virus that can cause severe chest infections in small children, adults with heart, lung and immune system conditions and elderly people., Diseases [C] - Virus Diseases [C02]

2019-003746-33: Study of RV521 for the treatment of adults who have received a blood cell transplant and that have a respiratory infection caused by the virus RSV

Not yet recruiting

200

Europe

RV521, Capsule

ReViral Ltd., ReViral

Symptomatic RSV infection (upper airway involvement only) in subjects who have undergone HCT transplantation within 1 year of Randomization and who are moderately to severely immunocompromised., respiratory infection, Diseases [C] - Respiratory Tract Diseases [C08]

REVIRAL 1, NCT04225897: A Study to Learn About the Effects of Sisunatovir in Infants With Respiratory Syncytial Virus Lower Respiratory Tract Infection.

Terminated

Europe, Canada, RoW

RV521, sisunatovir, Placebo

Pfizer

Respiratory Syncytial Virus (RSV), Lower Resp Tract Infection

12/22

2018-001010-15: A phase 2a Study in Infants with RSV lower respiratory tract infection, to evaluate the safety, tolerability, pharmacokinetics and antiviral effect of RV521.

Not yet recruiting

184

Europe

Sisunatovir, RV521, Powder for oral solution

ReViral Ltd., ReViral Ltd.

Respiratory Syncytial Virus Infection, Respiratory Syncytial Virus Infection, Diseases [C] - Respiratory Tract Diseases [C08]

NCT05873764: A Study to Learn About Effect of Sisunatovir in Healthy Adult Male Participants

Completed

200 mg RV521/78 µCi [ 14C]-RV521.

Pfizer

Respiratory Syncytial Virus Infections

07/22

NCT05712460: A Study to Assess the Safety, Effects and Palatability of Sisunatovir in Healthy Adult Participants

Completed

Europe

sisunatovir, Placebo

Pfizer

Respiratory Syncytial Viruses

04/23

NCT06003829: A Study to Learn About the Tastes of Different Suspensions With the Study Medicine (PF-07923568) in Healthy Adult Participants.

Completed

Europe

Sinsunatovir, Bitrex

Pfizer

Healthy

09/23

NCT05878522: A Study to Investigate the Effects of Sisunatovir on QTc Interval in Healthy Adult Participants.

Completed

sisunatovir, PF-07923568, placebo, moxifloxacin

Pfizer

Healthy

10/23

NCT05994963: A Study to Compare Different Preparations of Sisunatovir in Healthy Adult Participants.

Completed

Europe

sisunatovir, PF-07923568, RV521

Pfizer

Healthy

02/24

NCT05857644: A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.

Completed

PF-07923568, Sisunatovir

Pfizer

Liver Diseases, Hepatic Impairment

02/24

NCT06105983: A Study to Learn How a Medicine That Reduces Stomach Acid Affects the Level of Sisunatovir in the Blood of Healthy Adults.

Completed

Europe

Sisunatovir, Rabeprazole 40 mg, Sisunatovir suspension, Rabeprazole 20 mg

Pfizer

Healthy

07/24

NCT05987072: A Study to Learn How the Study Medicine Called Sisunatovir is Tolerated and Acts in the Bodies of Chinese Healthy Adults.

Completed

RoW

Sisunatovir

Pfizer

Respiratory Syncytial Virus Infection

12/23

NCT06037031: A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Completed

Drug: PF-07923568, Sisunatovir

Pfizer

Renal Impairment

07/24

NCT06102174: A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV

Terminated

Canada, Japan, US, RoW

Placebo, Active, PF-07923568, RV521

Pfizer

Respiratory Syncytial Virus Infections

09/24

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

sisunatovir (PF-07923568) / LianBio

NCT06079320: A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection

Terminated

2/3

Canada, Japan, US, RoW

Sisunatovir, Placebo

Pfizer

Respiratory Syncytial Virus Infection

09/24

2017-001282-24: A clinical trial of RV521 in healthy volunteers

Not yet recruiting

Europe

RV521 50mg, RV521 100mg, RV521, 200mg, RV521, Capsule

ReViral Ltd, ReViral Ltd

2019-003746-33: Study of RV521 for the treatment of adults who have received a blood cell transplant and that have a respiratory infection caused by the virus RSV

Not yet recruiting

200

Europe

RV521, Capsule

ReViral Ltd., ReViral

REVIRAL 1, NCT04225897: A Study to Learn About the Effects of Sisunatovir in Infants With Respiratory Syncytial Virus Lower Respiratory Tract Infection.

Terminated

Europe, Canada, RoW

RV521, sisunatovir, Placebo

Pfizer

Respiratory Syncytial Virus (RSV), Lower Resp Tract Infection

12/22

2018-001010-15: A phase 2a Study in Infants with RSV lower respiratory tract infection, to evaluate the safety, tolerability, pharmacokinetics and antiviral effect of RV521.

Not yet recruiting

184

Europe

Sisunatovir, RV521, Powder for oral solution

ReViral Ltd., ReViral Ltd.

Respiratory Syncytial Virus Infection, Respiratory Syncytial Virus Infection, Diseases [C] - Respiratory Tract Diseases [C08]

NCT05873764: A Study to Learn About Effect of Sisunatovir in Healthy Adult Male Participants

Completed

200 mg RV521/78 µCi [ 14C]-RV521.

Pfizer

Respiratory Syncytial Virus Infections

07/22

NCT05712460: A Study to Assess the Safety, Effects and Palatability of Sisunatovir in Healthy Adult Participants

Completed

Europe

sisunatovir, Placebo

Pfizer

Respiratory Syncytial Viruses

04/23

NCT06003829: A Study to Learn About the Tastes of Different Suspensions With the Study Medicine (PF-07923568) in Healthy Adult Participants.

Completed

Europe

Sinsunatovir, Bitrex

Pfizer

Healthy

09/23

NCT05878522: A Study to Investigate the Effects of Sisunatovir on QTc Interval in Healthy Adult Participants.

Completed

sisunatovir, PF-07923568, placebo, moxifloxacin

Pfizer

Healthy

10/23

NCT05994963: A Study to Compare Different Preparations of Sisunatovir in Healthy Adult Participants.

Completed

Europe

sisunatovir, PF-07923568, RV521

Pfizer

Healthy

02/24

NCT05857644: A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.

Completed

PF-07923568, Sisunatovir

Pfizer

Liver Diseases, Hepatic Impairment

02/24

NCT06105983: A Study to Learn How a Medicine That Reduces Stomach Acid Affects the Level of Sisunatovir in the Blood of Healthy Adults.

Completed

Europe

Sisunatovir, Rabeprazole 40 mg, Sisunatovir suspension, Rabeprazole 20 mg

Pfizer

Healthy

07/24

NCT05987072: A Study to Learn How the Study Medicine Called Sisunatovir is Tolerated and Acts in the Bodies of Chinese Healthy Adults.

Completed

RoW

Sisunatovir

Pfizer

Respiratory Syncytial Virus Infection

12/23

NCT06037031: A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Completed

Drug: PF-07923568, Sisunatovir

Pfizer

Renal Impairment

07/24

NCT06102174: A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV

Terminated

Canada, Japan, US, RoW

Placebo, Active, PF-07923568, RV521

Pfizer

Respiratory Syncytial Virus Infections

09/24



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