R-554 / Salzman Group 
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  • ||||||||||  R-554 / Salzman Group
    Journal:  Preferential allosteric modulation of Otop1 channels by small molecule compounds. (Pubmed Central) -  Feb 27, 2025   
    MFaN activates Otop1 while preserving its core biophysical and pharmacological properties by associating with key residues on the channel's S5-6 and S11-12 loops, including a crucial arginine (R554) essential for Zn2+ and alkali activation. This study identifies important Otop1 modulators and structural elements underlying its gating, paving the way for further exploration of this ion channel.
  • ||||||||||  R-554 / Radikal Therap
    Journal:  Vertebrate OTOP1 is also an alkali-activated channel. (Pubmed Central) -  Jan 4, 2023   
    Mutations of K221 and R554 at the S5-S6 and S11-S12 linkers significantly reduced alkali affinity without affecting acid activation, suggesting that different domains are responsible for acid- and alkali-activation of OTOP1...Given that the alkali-activation of OTOP1 and the required key residues were conserved in the six representative vertebrates, we cautiously propose that OTOP1 participates in alkaline sensation in vertebrates. Thus, our study identified OTOP1 as an alkali-activated channel.