| CNM-Au8 / Clene |
| Completed | 2/3 | 161 | US | CNM-Au8, Matching Placebo | Merit E. Cudkowicz, MD, Clene Nanomedicine | Amyotrophic Lateral Sclerosis | 04/22 | 03/23 | | |
VISIONMS-LTE, NCT04626921: A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis |
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| Completed | 2/3 | 55 | RoW | CNM-Au8 | Clene Nanomedicine, George Clinical | Relapsing Multiple Sclerosis | 05/23 | 09/23 | | |
| Active, not recruiting | 2/3 | 1500 | US | Zilucoplan, Verdiperstat, CNM-Au8, Pridopidine, SLS-005 Trehalose, ABBV-CLS-7262, DNL343 | Merit E. Cudkowicz, MD, Massachusetts General Hospital | Amyotrophic Lateral Sclerosis | 07/25 | 04/26 | | |
NCT05299658: An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS |
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| Active, not recruiting | 2 | 40 | RoW | CNMAu8 | Clene Nanomedicine | Amyotrophic Lateral Sclerosis | 11/24 | 12/24 | | |
REPAIR-MS, NCT03993171: 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis. |
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| Recruiting | 2 | 30 | US | gold nanocrystals, CNM-Au8 | Clene Nanomedicine, University of Texas Southwestern Medical Center | Multiple Sclerosis | 12/24 | 12/24 | | |
NCT06408727: Intermediate Expanded Access Protocol CNMAu8.EAP04 |
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| Available | N/A | | US | CNM-Au8 | Clene Nanomedicine, National Institute of Neurological Disorders and Stroke (NINDS) | ALS, Amyotrophic Lateral Sclerosis, PALS | | | | |
NCT04081714: Intermediate Expanded Access Protocol CNMAu8.EAP03 |
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| Available | N/A | | US | CNM-Au8, Nanocrystalline gold | Clene Nanomedicine, University of Texas, Southwestern Medical Center at Dallas | Multiple Sclerosis | | | | |
| Available | N/A | | US | CNM-Au8, Nanocrystalline gold | Clene Nanomedicine | Amyotrophic Lateral Sclerosis | | | | |
