moxidectin / Generic mfg. 
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  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  New drugs for small animals in 2019 (Pubmed Central) -  May 11, 2021   
    One substance was authorized for an additional species: The antidiabetic protamine zinc insulin of human origin (ProZinc) is now additionally authorized for dogs. Additionally, one veterinary drug with a new combination of active ingredients (fluralaner + moxidectin), 5 agents in a novel pharmaceutical formulation (acepromazine, chloramphenicol, dexamethasone, metronidazole, torasemide), one drug (lidocaine) with a new route of administration, as well as one agent (apomorphine) in a new primary packaging with extended opening stability have been launched on the market for small animals.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  False positive antigen test for Dirofilaria immitis after heat treatment of the blood sample in a microfilaremic dog infected with Acanthocheilonema dracunculoides. (Pubmed Central) -  May 7, 2021   
    Additionally, one veterinary drug with a new combination of active ingredients (fluralaner + moxidectin), 5 agents in a novel pharmaceutical formulation (acepromazine, chloramphenicol, dexamethasone, metronidazole, torasemide), one drug (lidocaine) with a new route of administration, as well as one agent (apomorphine) in a new primary packaging with extended opening stability have been launched on the market for small animals. We conclude that heat treatment of initially negative blood samples for D. immitis could lead to false positive antigen test results if the dog is infected with A. dracunculoides.
  • ||||||||||  Review, Journal:  Natural Products That Changed Society. (Pubmed Central) -  May 1, 2021   
    The use of synthetic analogues such as chloroquine or semisynthetic drugs such as artemether or artesunate further improved the possibilities for healing malaria...These possibilities have been elaborated through preparation of semisynthetic analogues. Today vincristine and vinblastine and semisynthetic analogues are powerful weapons against cancer diseases.
  • ||||||||||  moxidectin / Generic mfg., azithromycin / Generic mfg., erythromycin / Generic mfg.
    Journal:  Inhibition of TMEM16A Ca-activated Cl- channels by avermectins is essential for their anticancer effects. (Pubmed Central) -  Apr 23, 2021   
    The IC and E values for TMEM16A inhibition of five tested avermectins (avermectin B, ivermectin, doramectin, selamectin, and moxidectin) were 0.15-1.32 μM and 65-87 %, respectively...Eprinomectin (4"-(acetylamino)-4"-deoxy-avermectin B) and two other important macrolides (erythromycin and azithromycin), which have minimal or no TMEM16A inhibitory effects, were used as negative control drugs...These data demonstrate that avermectins are novel TMEM16A inhibitors and are potentially useful in specific cancer therapies. These findings also provide a new opportunity to develop TMEM16A modulators.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Moxidectin: an oral treatment for human onchocerciasis. (Pubmed Central) -  Apr 16, 2021   
    If donated, moxidectin could mitigate the additional programmatic costs of biannual ivermectin distribution because, unlike other alternatives, it can use the existing community-directed treatment infrastructure. A pediatric indication (for children <12 years) and determination of its usefulness in onchocerciasis-loiasis co-endemic areas will greatly help fulfill the potential of moxidectin for the treatment and elimination of onchocerciasis.
  • ||||||||||  moxidectin / Generic mfg.
    Review, Journal:  Recent advances in understanding and treating scabies. (Pubmed Central) -  Apr 7, 2021   
    Advances over the past 5 years indicate that mass drug administration is an effective strategy to treat scabies. This review will outline advances in the mite biology, epidemiological understanding, diagnosis, and treatment of scabies.
  • ||||||||||  moxidectin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
    Clinical, Journal:  Non-Arsenical heartworm adulticidal therapy using topical moxidectin-imidacloprid and doxycycline: A prospective case series. (Pubmed Central) -  Mar 25, 2021   
    Nonaresenical-adulticide therapy may result in pneumonitis and heartworm-pulmonary thromboembolism at unpredictable times, potentially months after initiation of macrocyclic lactone therapy and exercise restriction should be considered when using a nonarsenical protocol. Although not currently recommended by the American Heartworm Society (AHS), non-arsenical strategies are in use and the goal of this study was to evaluate the efficacy, duration of therapy, and safety of an accelerated dosing protocol of M/I with doxycycline.
  • ||||||||||  moxidectin / Generic mfg.
    Clinical, Journal:  Usual or unusual presentations of Dirofilaria repens in two sibling dogs: a case report. (Pubmed Central) -  Mar 13, 2021   
    The treatment with moxidectin 2.5% and imidacloprid 10%/kg was effective in eliminating microfilariae after just one application, as demonstrated by negative modified Knott's tests and PCR analyses of blood samples...Moreover, in the case of circulating eosinophilia or pyotraumatic dermatitis, investigations should include modified Knott's test and PCR to ensure that D. repens is not the cause of these alterations. Rapid and sensitive tests for the early detection of infected animals would help to prevent or limit the spread of this zoonosis.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Eficacy of ivermectin, moxidectin and febendazole in equine in Brazil. (Pubmed Central) -  Mar 10, 2021   
    The highest prevalence of Strongylus vulgaris occurred on farms where the intervals between deworming were long. The questionnaire applied showed that ivermectin was the drug most used among these farmers.
  • ||||||||||  Journal:  Anthelmintic resistance and common worm control practices in sheep farms in Flanders, Belgium. (Pubmed Central) -  Mar 10, 2021   
    Results indicated widespread resistance against benzimidazoles (albendazole, fenbendazole and mebendazole), with treatment failure on all 8 farms investigated...Resistance against macrocyclic lactones (ivermectin, doramectin and moxidectin) was recorded on 7 out of 20 flocks, mainly in H. contortus and T. circumcincta...Only few sheep farmers (9%) regularly used faecal egg counts to monitor worm infections. Despite the FECRT showing otherwise, most of the farmers perceived the efficacy of anthelmintics as very good (30%) or good (54%).
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion date, Trial primary completion date:  A Pharmacokinetic and Safety Study of Moxidectin to Identify an Optimal Dose for Treatment of Children 4 to 11 Years (clinicaltrials.gov) -  Mar 3, 2021   
    P1,  N=27, Not yet recruiting, 
    Our results demonstrate the role of active drug ingestion by nematodes for susceptibility and provide functional evidence for the contribution of P-glycoproteins to ML resistance in a tissue-specific manner. Trial completion date: Dec 2021 --> Mar 2022 | Trial primary completion date: Jul 2021 --> Dec 2021
  • ||||||||||  moxidectin / Generic mfg., levamisole / Generic mfg.
    Retrospective data, Journal:  Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database. (Pubmed Central) -  Feb 27, 2021   
    For GIN and particularly F. hepatica, there was a bias towards preferential sampling of individual farms with suspected AR, and research effort was biased towards Western Europe and particularly the United Kingdom. Ongoing capture of future results in the live database, efforts to avoid bias in farm recruitment, more accurate tests for AR, and stronger appreciation of the importance of AR among the agricultural industry and policy makers, will support more sophisticated analyses of factors contributing to AR and effective strategies to slow its spread.
  • ||||||||||  moxidectin / Generic mfg.
    Clinical, Journal:  Ocular thelaziosis in a dog in Germany - an autochthonous case? (Pubmed Central) -  Feb 17, 2021   
    Treatment consisted of manual collection of the adult worms and the administration of moxidectin/imidacloprid as spot on (Advocate, Bayer)...Except for a one-week stay in the Netherlands 11 months before the symptoms began, it had never traveled abroad. Considering the prepatency of T. callipaeda, an autochthonous transmission in this case is highly probable.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    New P3 trial:  Efficacy and Safety of MOX/ALB Co-administration (clinicaltrials.gov) -  Jan 26, 2021   
    P3,  N=282, Not yet recruiting, 
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis. (Pubmed Central) -  Nov 28, 2020   
    Interestingly, overexpression of milE resulted in increased transcriptional levels of milbemycin biosynthetic genes and production of total milbemycins, which implied that the insufficient function of MilE was a limiting factor to milbemycin biosynthesis. Our research not only provides an efficient engineering strategy to improve the production of a commercially important product milbemycins, but also offers the clues for future study about transcriptional regulation of milbemycin biosynthesis.
  • ||||||||||  moxidectin / Generic mfg.
    FDA event, Journal:  FDA-Approved Antiparasitic Drugs in the 21st Century: A Success for Helminthiasis? (Pubmed Central) -  Nov 28, 2020   
    Diseases caused by helminth infections affect more than a quarter of the population of the world, but the therapeutic arsenal is limited. The approval of moxidectin in 2018 and triclabendazole in 2019 by the FDA marked an important moment in the fight against diseases of poverty, such as helminthiases.
  • ||||||||||  moxidectin / Generic mfg., ivermectin / Generic mfg.
    Journal:  Impact on beef cattle productivity of infection with anthelmintic-resistant nematodes. (Pubmed Central) -  Nov 19, 2020   
    In calves naturally infected with resistant nematodes, under the production system assessed here, weight gains were lower in calves treated with anthelmintics that were moderately or highly ineffective compared to those treated with highly effective anthelmintics. These results demonstrate to farmers and veterinarians the importance of a sustainable and effective nematode control under field conditions.
  • ||||||||||  moxidectin / Generic mfg., ivermectin / Generic mfg.
    Retrospective data, Journal:  Implications of Endectocide Residues on the Survival of Aphodiine Dung Beetles: A Meta-Analysis. (Pubmed Central) -  Nov 12, 2020   
    It is often difficult to compare studies examining the effects of endectocides on dung fauna because of different experimental approaches, for example, active ingredients (eprinomectin, doramectin, ivermectin, moxidectin) and formulations (injectable, pour-on, spiked). Environ Toxicol Chem 2020;00:1-10.
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion date, Trial primary completion date:  Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis (clinicaltrials.gov) -  Nov 10, 2020   
    P3,  N=1000, Not yet recruiting, 
    Trial primary completion date: Mar 2021 --> Jul 2021 Trial completion date: Nov 2023 --> Jul 2024 | Trial primary completion date: Nov 2023 --> Jul 2022
  • ||||||||||  moxidectin / Generic mfg.
    Clinical, Journal:  Gut microbial signatures associated with moxidectin treatment efficacy of Haemonchus contortus in infected goats. (Pubmed Central) -  Oct 21, 2020   
    A signature or balance represented by the log ratio of the abundance of Verrucomicrobiaceae and Camplyobacteraceae had a strong correlation with EPG (r = 0.80). These novel insights into the interactions between H. contortus and gut microbiome in the caprine host and the consequence of a partial anthelmintic clearance on animal health and well-being may facilitate the design of more effective next-generation anthelmintics.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins. (Pubmed Central) -  Oct 7, 2020   
    This study consisted of a field study and two computer simulations to evaluate the efficacy of a moxidectin-oxibendazole (MOX-OBZ) combination against the same cyathostomin population...The second set of simulations identified combination treatments used with selective therapy to be the most effective at delaying MOX resistance. Overall, this study supports the use of combination treatment against drug-resistant cyathostomins, when one of the actives exhibits high efficacy, and demonstrates benefits of this approach despite substantially lowered efficacy of the other active ingredient.
  • ||||||||||  moxidectin / Generic mfg.
    Enrollment status:  Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) -  Oct 5, 2020   
    P3,  N=250, Enrolling by invitation, 
    Overall, this study supports the use of combination treatment against drug-resistant cyathostomins, when one of the actives exhibits high efficacy, and demonstrates benefits of this approach despite substantially lowered efficacy of the other active ingredient. Recruiting --> Enrolling by invitation
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Short communication: A practical farm-based trial to compare ewe nematode control strategies in peri-parturient ewes. (Pubmed Central) -  Oct 3, 2020   
    The use of long-acting moxidectin may be helpful as part of a parasite control programme by reducing the worm burdens of ewes and their lambs, decreasing the number of anthelmintic treatments required in that year and by reducing pasture contamination for those sheep which will graze the pasture in the next year. However, like all anthelmintics, its use should be judicious to avoid selection for resistance.