moxidectin / Generic mfg. 
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  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
    Journal:  Signs of multiple anthelmintic resistance in sheep gastrointestinal nematodes in Sweden. (Pubmed Central) -  Nov 28, 2022   
    Thus, there is a need for a truly randomized study to get an update on the extent of the situation of anthelmintic resistance at a national level, as well as to identify risk factors involved in the resistance selection. Research is also required to establish the optimal intervals for sampling post-treatment.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species. (Pubmed Central) -  Nov 22, 2022   
    With respect to germination percentage, G. mollugo was more sensitive to formulated moxidectin at the warmest temperature regime, whereas P. lanceolata showed the highest sensitivity at the coldest regime. This study shows that it is important to consider temperature dependencies of the effects of pharmaceuticals on seed germination when conducting standardised germination experiments.
  • ||||||||||  moxidectin / Generic mfg.
    Review, Journal:  Anthelmintic resistance in equine nematodes: Current status and emerging trends. (Pubmed Central) -  Nov 8, 2022   
    Two recent studies have documented resistance to the larvicidal regimen of fenbendazole, whereas the larvicidal efficacy of moxidectin is variable, but with no evidence of a reduction from historic levels...In conclusion, multi-drug resistance is becoming the norm in managed cyathostomin populations around the world, and a similar pattern may be emerging in Parascaris spp. More work is required to understand the mechanisms behind the shortened ERPs, and researchers and veterinarians around the world are encouraged to routinely monitor anthelmintic efficacy against equine nematodes.
  • ||||||||||  Review, Journal:  Anthelmintic intoxication in goats and sheep: A systematic review. (Pubmed Central) -  Nov 2, 2022   
    The most prevalent symptoms of anthelmintic intoxication reported were showed involvement of the nervous, locomotor, and renal systems, as well as teratogenic influences. Data from this review underscore the need of the care required in the control of parasitic infections through the safe use of antiparasitic drugs to avoid cases of intoxication.
  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Journal:  Current pharmacotherapeutic strategies for Strongyloidiasis and the complications in its treatment. (Pubmed Central) -  Oct 28, 2022   
    Moxidectin might be a valid alternative to ivermectin, with the advantage of being a dose-independent formulation...In pregnant or lactating women, studies have not identified increased risk with ivermectin use. However, with limited available data, a risk-benefit assessment should be considered for each case.
  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg.
    Review, Journal:  Strongyloides stercoralis: A Neglected but Fatal Parasite. (Pubmed Central) -  Oct 27, 2022   
    In contrast, treatment is simple: administration of single dosage ivermectin or moxidectin, a recent anthelmintic drug...Thus, disease manifestation awareness among clinicians is crucial. Furthermore, active surveillance and advanced diagnostic tests are essential for fundamental management.
  • ||||||||||  moxidectin / Generic mfg.
    Population Pharmacokinetics of Moxidectin in Patients with Lymphatic Filariasis (Convention Center - Hall 4A (4th Floor); In-Person-Only) -  Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2645;    
    The MOX population PK model was suitable for predicting drug exposure in LF patients and can be used for future dose-informing studies by simulating different dosing regimens and comparing the drug exposures resulting from those regimens to fixed dosing. Additional studies evaluating covariates that may account for high variability are warranted to better understand MOX PK in LF patients.
  • ||||||||||  moxidectin / Generic mfg.
    Pharmacokinetics of Moxidectin and Ivermectin in Combination Treatments for Bancroftian Filariasis (Convention Center - Hall 4A (4th Floor); In-Person-Only) -  Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2644;    
    The geometric mean ratio for Cmax, AUC0-t, and AUC0-∞ were within the no drug interaction range of 80 - 125% for all drugs. This indicates that the addition of MOX to ALB or ALB plus DEC for LF therapy did not result in alterations in drug exposure of co-administered drugs.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Moxidectin induces autophagy arrest in colorectal cancer. (Pubmed Central) -  Oct 7, 2022   
    It was found that MOX can induce autophagy arrest, promote autophagy initiation, inhibit autophagic flux and cell proliferation, simultaneously PI3K-Akt-mTOR signaling pathway and microtubule acetylation. Furthermore, MOX suppressed the growth of xenograft tumors, which was consistent with the in vitro results.
  • ||||||||||  moxidectin / Generic mfg.
    Trial primary completion date:  Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) -  Oct 6, 2022   
    P3,  N=164, Active, not recruiting, 
    Furthermore, MOX suppressed the growth of xenograft tumors, which was consistent with the in vitro results. Trial primary completion date: Sep 2022 --> Sep 2023
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  MilR3, a unique SARP family pleiotropic regulator in Streptomyces bingchenggensis. (Pubmed Central) -  Sep 28, 2022   
    However, a lack of understanding of the regulatory network of milbemycin biosynthesis limited the development of high-producing strains using a regulatory rewiring strategy...This study first illustrated the co-regulatory role of this unique SARP regulator. This greatly enriches our understanding of SARPs and lay a solid foundation for milbemycin yield enhancement in the near future.
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion, Trial completion date, Head-to-Head:  StrongMoxi_KH: Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis (clinicaltrials.gov) -  Sep 27, 2022   
    P3,  N=332, Completed, 
    This greatly enriches our understanding of SARPs and lay a solid foundation for milbemycin yield enhancement in the near future. Enrolling by invitation --> Completed | Trial completion date: Dec 2022 --> Jul 2022
  • ||||||||||  moxidectin / Generic mfg.
    Observational data, Journal:  The compliance and revenue benefits of ProHeart Vs monthly heartworm disease preventives in the US. (Pubmed Central) -  Aug 22, 2022   
    The aim of the current study was to understand how the canine heartworm disease preventive ProHeart® 12 (extended-release injectable moxidectin, PH 12), impacts heartworm preventive purchase compliance and veterinary practice revenue over time compared to monthly heartworm disease preventives...PH 12 was single-handedly responsible for all growth in patients compliant for more than 6 months in this study. Growth in protection of canine patients with PH 12 proves a helpful tool where mitigation strategies have thus far failed to curb increasing canine heartworm disease prevalence in the US.
  • ||||||||||  moxidectin / Generic mfg.
    Review, Journal:  Epidemic Scabies: New Treatment Challenges in an Ancient Disease. (Pubmed Central) -  Aug 14, 2022   
    In refractory cases, the prescriber should prioritize oral medication, indicate a higher dose, combine treatments, or evaluate the use of off-label treatments in certain populations. The availability of new medications - such as spinosad or, especially, moxidectin - offer hope for bringing this disease under control.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Application of Moxidectin and Ultrasound-Aided Injection of Melarsomine During the American Heartworm Society Recommended Treatment Protocol in Dirofilaria immitis Infected Dogs. (Pubmed Central) -  Jul 20, 2022   
    The American Heartworm Society (AHS) recommends the three-dose alternate melarsomine therapeutic regimen, together with a macrocyclic lactone (ML) to reduce new infections and eliminate susceptible larvae and doxycycline against Wolbachia bacteria...Microfilaremic dogs were pretreated with prednisolone and clopidogrel for 1 week before the first moxidectin application...On the first day, dexamethasone and chloropyramine were used to avoid potential adverse effects caused by the destroyed microfilariae...From the 60th day, dalteparin was applied for 10 days to decrease the chance of pulmonary thromboembolism...All dogs recovered clinically by the 120th day and no microfilaremia was seen that time. An antigen test performed in 37/44 animals on the 271st day was also negative in all cases.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
    Journal:  Susceptibility of Angiostrongylus cantonensis Larvae to Anthelmintic Drugs. (Pubmed Central) -  Jul 10, 2022   
    Collectively, our study revealed that macrocyclic lactones, levamisole, pyrantel pamoate, and albendazole are important anthelmintic agents against A. cantonensis. The results of this in vitro study also suggest that A. cantonensis L1 may be a particularly sensitive and useful model for anthelmintic studies.
  • ||||||||||  monepantel (PAA1) / Pharmaust
    Journal:  Effectiveness of Anthelmintic Treatments in Small Ruminants in Germany. (Pubmed Central) -  Jun 25, 2022   
    Thus, a nationwide field study was undertaken to assess the effectiveness of 253 treatments performed in 223 small ruminant flocks by faecal egg count reduction test (FECRT) using pooled samples and a modified McMaster method...Reduced effectiveness was observed for treatments with all examined anthelmintic classes, but treatments with benzimidazoles and moxidectin showed significantly poorer results than monepantel, a closantel and mebendazole combination, and levamisole...Unsuccessful treatments were frequently associated with the survival of H. contortus, but this was also observed for non-Haemonchus genera. The results are highly concerning, and sustainable approaches to parasite control are urgently needed to prevent further deterioration of this situation.
  • ||||||||||  moxidectin / Generic mfg.
    Enrollment status, Head-to-Head:  StrongMoxi_KH: Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis (clinicaltrials.gov) -  Jun 13, 2022   
    P3,  N=350, Enrolling by invitation, 
    Results of this study suggest that successful elimination of microfilariae by doxycycline is associated with complete clearance of Wolbachia DNA in D. immitis-naturally infected dogs. Recruiting --> Enrolling by invitation
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces. (Pubmed Central) -  May 30, 2022   
    The sspH overexpression inhibited milbemycin production by repressing the expression of milbemycin biosynthetic genes...Moreover, cross-overexpression experiments showed that SspH and its orthologs, SCO1241 from Streptomyces coelicolor and SAVERM_07097 from Streptomyces avermitilis, shared identical functionality, and all exerted a positive effect on actinorhodin production but a negative effect on avermectin production, indicating that SspH-mediated differential control of antibiotic biosynthesis may be widespread in Streptomyces. This study extended our understanding of the regulatory network of antibiotic biosynthesis and provided effective targets for future antibiotic discovery and overproduction.
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion:  Dose-finding Study of Moxidectin for Treatment of Scabies (clinicaltrials.gov) -  May 24, 2022   
    P2,  N=22, Completed, 
    Recruiting --> Active, not recruiting Active, not recruiting --> Completed
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  Strongyloides stercoralis infection in dogs in Austria: two case reports. (Pubmed Central) -  May 24, 2022   
    More attention should be paid to this nematode because although it appears to be rare in Austria, it is easily overlooked on standard coproscopy unless a Baermann funnel technique is used, and even then, it can be missed. Moxidectin is not always successful in eliminating the infection, and treatment with ivermectin should be considered in cases of infection.