moxidectin / Generic mfg. 
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  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg., levamisole / Generic mfg.
    Journal:  Efficacy of levamisole, ivermectin and moxidectin against Capillaria spp. in European hedgehogs (Erinaceus europaeus). (Pubmed Central) -  Dec 18, 2023   
    striatum often appeared refractory to treatment, and managing these infections requires additional anthelmintic therapy. Based on the formulations and dosages trialled, moxidectin is not recommended for treating capillariosis in European hedgehogs, whereas levamisole given orally for two consecutive days at 25-35 mg/kg is suggested as the treatment of choice.
  • ||||||||||  moxidectin / Generic mfg.
    Preclinical, Journal:  Syringe immersion test as in vitro bioassay against Rhipicephalus microplus: Macrocyclic lactones dose-response relationship. (Pubmed Central) -  Dec 3, 2023   
    Log-logistic dose-response model for Ivermectin (IVM), Doramectin (DRM), and Moxidectin (MOX) were performed using concentrations ranging from 0.01 to 20.0 ppm (n = 6, 3 replicates per level on each drug)...DRM had a different slope compared to IVM and MOX (p 0.05). This study allowed us to standardize the technique for larvae immersion for each ML, granting a new tool for in vitro test as a screening technique for tick sensitivity.
  • ||||||||||  ivermectin oral / Generic mfg.
    Journal:  First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches. (Pubmed Central) -  Oct 28, 2023   
    The results reported here should also encourage future work that examines different scenarios of infection with S. stercoralis in dogs and humans with the aim of integrating clinical management, diagnosis, treatment and follow-up strategies in the quest for new approaches for the treatment of this disease in animals and humans. The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis.
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion date, Trial primary completion date:  Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) -  Oct 27, 2023   
    P3,  N=164, Active, not recruiting, 
    The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis. Trial completion date: Sep 2023 --> Sep 2024 | Trial primary completion date: Sep 2023 --> Sep 2024
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Procedure for Handling and Storage of Onchocerca volvulus Microfilariae Obtained from Skin Snips for Downstream Genetic Work. (Pubmed Central) -  Sep 27, 2023   
    Based on our experience with microfilariae obtained from different collaborators, we developed a microfilariae transfer procedure for large-scale studies in the Democratic Republic of Congo (DRC) comparing safety and efficacy of ivermectin, the mainstay of current onchocerciasis elimination strategies, and moxidectin, a new drug...Among the 576 microfilariae from DRC, 16.0% and 16.7% failed these assays, respectively. This difference may not only be related to the microfilariae transfer procedure but also to other factors, notably the ethanol concentration in the tubes in which microfilariae were stored (64% vs. ?75%).
  • ||||||||||  moxidectin / Generic mfg.
    Trial completion date:  Efficacy and Safety Study of Moxidectin in Adults with Scabies (clinicaltrials.gov) -  Sep 21, 2023   
    P2,  N=200, Recruiting, 
    This difference may not only be related to the microfilariae transfer procedure but also to other factors, notably the ethanol concentration in the tubes in which microfilariae were stored (64% vs. ?75%). Trial completion date: Mar 2024 --> Jul 2024
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Effects of macrocyclic lactone anthelmintics on seed germination of temperate grassland species. (Pubmed Central) -  Sep 13, 2023   
    We used four commonly applied macrocyclic lactones to assess their effects on germination: moxidectin, ivermectin, abamectin and doramectin as pure substances; moxidectin and ivermectin also in formulated form...Although effect size and sign varied between species, our study shows that non-target effects of macrocyclic lactones commonly occur in terrestrial plants. This may impede successful seed exchange between habitats via sheep, and even translate into profound changes to grazed ecosystems.
  • ||||||||||  moxidectin / Generic mfg.
    Enrollment open:  Efficacy and Safety Study of Moxidectin in Adults with Scabies (clinicaltrials.gov) -  Aug 7, 2023   
    P2,  N=200, Recruiting, 
    Clinical Trial Registration: NCT04410406, https://clinicaltrials.gov/. Not yet recruiting --> Recruiting
  • ||||||||||  moxidectin / Generic mfg., praziquantel / Generic mfg.
    Journal:  Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds. (Pubmed Central) -  Jul 23, 2023   
    Although the combination of MI/PFP improved the anthelmintic efficacy, the FECR remained below 90%. Future studies are indicated to evaluate further the epidemiology of persistent hookworm infections in dogs in the US and to identify more effective treatment protocols as they pose a significant health risk to canine and human health.
  • ||||||||||  moxidectin / Generic mfg.
    Enrollment closed, Enrollment change, Trial primary completion date:  EOLoa: Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients (clinicaltrials.gov) -  Jul 12, 2023   
    P2,  N=72, Active, not recruiting, 
    The systemic use of moxidectin for tick management in critical reproductive hosts has the potential to be effective in an areawide capacity while also permitting human consumption of treated venison. Recruiting --> Active, not recruiting | N=220 --> 72 | Trial primary completion date: Feb 2023 --> Aug 2023
  • ||||||||||  AWZ1066S / Eisai, Liverpool School of Tropical Medicine, University of Liverpool
    Preclinical, Journal:  Dirofilariasis mouse models for heartworm preclinical research. (Pubmed Central) -  Jul 10, 2023   
    We validated NSG and NXG D. immitis mouse models as a filaricide screen by in vivo treatments with single injections of moxidectin, which mediated a 60%-88% reduction in L4 larvae at 14-28 days. Future adoption of these mouse models will benefit end-user laboratories conducting research and development of novel heartworm preventatives via increased access, rapid turnaround, and reduced costs and may simultaneously decrease the need for experimental cat or dog use.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Shortened strongylid egg reappearance periods in horses following macrocyclic lactone administration - The impact on parasite dynamics. (Pubmed Central) -  Jun 23, 2023   
    The ERPs of ivermectin and moxidectin were originally reported in the 8-10 and 12-16 week ranges, respectively, but several recent studies have found them to be around 4-5 weeks for both actives...This is the first study to evaluate consequences of shortened ERPs in horses and demonstrated a substantial loss in anthelmintic performance resulting from this development. The results illustrate that anthelmintic efficacy is more than the percent reduction of fecal egg counts at 14 days post treatment, and that substantial anthelmintic performance can be lost despite FECRTs remaining at 100%.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  The first report of macrocyclic lactone resistant cyathostomins in the UK. (Pubmed Central) -  Mar 21, 2023   
    In recent years, resistance to the benzimidazole (BZ) and tetrahydropyrimidine (PYR) anthelmintics in global cyathostomin populations, has led to reliance on the macrocyclic lactone drugs (ML-of which ivermectin and moxidectin are licensed in horses) to control these parasites...Resistance to MLs was not found in yearlings or mares on studs B, C or D with FECR after MOX OR IVM treatment ranging from 99.8 to 99.9% (95.4-100); although yearlings on studs B, C and D all had an egg reappearance period (ERP) of six weeks for MOX and stud C had a four-week ERP for IVM. This study describes the first confirmed case of resistance to both licensed ML drugs on a UK Thoroughbred stud and highlights the urgent need for a) increased awareness of the threat of ML resistant parasites infecting horses, and b) extensive surveillance of ML efficacy against cyathostomin populations in the UK, to gauge the extent of the problem.
  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg.
    Review, Journal:  Ivermectin and moxidectin against soil-transmitted helminth infections. (Pubmed Central) -  Mar 20, 2023   
    This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Insecticidal activity of Simparica and Simparica Trio against Aedes aegypti in dogs. (Pubmed Central) -  Mar 10, 2023   
    We also highlight the reports of resistance of S. scabiei to acaricides, including clinical and in vitro observations. Both studies demonstrated that a single oral dose of Simparica or Simparica Trio provides high efficacy against mosquitoes in dogs within 24-72
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Synergism of macrocyclic lactones against Haemonchus contortus. (Pubmed Central) -  Mar 9, 2023   
    After estimating the half maximal effective concentration of abamectin (ABA), eprinomectin, (EPR), ivermectin (IVM), and moxidectin (MOX) for both isolates, combinations were delineated by a simplex-centroid mixture experiment, and the mixture regression analysis was applied to the special cubic model...For the resistant isolate, inhibition greater than that of the reference mixture was found with higher proportions of IVM as well as lower proportions of the other drugs. The synergistic and antagonistic effects were dependent on the following: (a) parasite drug resistance profile, (b) the composition of the combination, and (c) the proportions used, with EPR and IVM exerting a greater impact on these effects.
  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg.
    Journal:  Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms. (Pubmed Central) -  Jan 26, 2023   
    These in vitro assays identified several macrocyclic lactones (emamectin, milbemycin oxime, and the moxidectin metabolite 23-ketonemadectin) that caused contractile paralysis and lack of lactate production...Nevertheless, these data show the utility of a multiplexed in vitro screening platform to quantitatively assess drug action and exclude inactive compounds from a chemical series before proceeding to in vivo studies. While the prototypical macrocyclic lactone ivermectin displays minimal activity against adult Schistosoma mansoni, this family of compounds does contain schistocidal compounds which may serve as a starting point for development of new anti-flatworm chemotherapies.
  • ||||||||||  moxidectin / Generic mfg., cyclosporin A microemulsion / Generic mfg.
    Journal:  Effect of cyclosporin A on the toxicity of ivermectin, eprinomectin and moxidectin in populations of Rhipicephalus microplus. (Pubmed Central) -  Dec 25, 2022   
    There was statistically significant synergism (p < 0.05) between CsA and ivermectin in all populations; between CsA and eprinomectin in only one population; and between CsA and moxidectin in two populations. It was concluded that, despite the involvement of ABCts in the mechanisms of resistance to ivermectin, metabolic detoxification does not seem to be the mechanism predominantly involved in resistance to eprinomectin and moxidectin in the populations of R. microplus evaluated.
  • ||||||||||  moxidectin / Generic mfg.
    Review, Journal:  Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited. (Pubmed Central) -  Dec 22, 2022   
    Reports of shortened ERP for moxidectin and ivermectin are frequent: 20 studies that used comparable ERP definitions reported shortened moxidectin and ivermectin ERPs of 35 and 28 days, respectively...Future research in horses is required to understand the mechanism(s) behind the shortening of ERP for cyathostomins. Based on this systematic review, we propose recommendations for future ERP studies.
  • ||||||||||  moxidectin / Generic mfg.
    Review, Journal:  Epidemic Scabies: New Treatment Challenges in an Ancient Disease. (Pubmed Central) -  Dec 4, 2022   
    In refractory cases, the prescriber should prioritize oral medication, indicate a higher dose, combine treatments, or evaluate the use of off-label treatments in certain populations. The availability of new medications - such as spinosad or, especially, moxidectin - offer hope for bringing this disease under control.