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- || Hyruan Plus (sodium hyaluronate) / LG Chem
Clinical, Journal: Effects and Safety of Intra-Articular Sodium Hyaluronate Injection for the Treatment of Ankle Osteoarthritis: A Prospective Clinical Trial. (Pubmed Central) - Mar 16, 2022
3 weekly hyaluronate injections (2 mL Hyruan Plus®) were administered...This study suggests that 3 weekly intra-articular hyaluronate injections can be performed safely to reduce pain and improve function without serious complications in patients with early or intermediate-grade ankle osteoarthritis when patients inadequately respond to medication. Larger controlled studies are needed to clarify the effects of hyaluronate injection and identify patients who can benefit most from hyaluronate injection.
- ||| DA-5202 - Dong / A
Trial completion: Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee (clinicaltrials.gov) - Apr 14, 2021
P2, N=115, Completed, Sponsor: Dong-A ST Co., Ltd.
Larger controlled studies are needed to clarify the effects of hyaluronate injection and identify patients who can benefit most from hyaluronate injection. Recruiting --> Completed
- || Hyruan Plus (sodium hyaluronate) / LG Chem
Clinical, Journal: Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. (Pubmed Central) - Apr 7, 2021
In this pilot study, we aimed to compare polynucleotide sodium (Conjuran) with sodium hyaluronate (Hyruan Plus) and 1,4-butanediol diglycidyl ether-crosslinked sodium hyaluronate (Synovian) in terms of analgesic efficacy after intraarticular injection in patients with knee osteoarthritis...No adverse events occurred. In conclusion, polynucleotide sodium could effectively reduce weight-bearing pain in the patients with knee osteoarthritis compared to standard hyaluronic acid viscosupplementation.
- ||||| DA-5202 - Dong / A
New P2 trial: Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee (clinicaltrials.gov) - Sep 18, 2015
P2, N=120, Recruiting, Sponsor: Dong-A ST Co., Ltd.
- ||||||| Hyruan Plus (sodium hyaluronate) / LG Chem
Trial completion: Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis (clinicaltrials.gov) - Jan 15, 2013
P3, N=287, Completed, Sponsor: LG Life Sciences
In conclusion, polynucleotide sodium could effectively reduce weight-bearing pain in the patients with knee osteoarthritis compared to standard hyaluronic acid viscosupplementation. Active, not recruiting --> Completed
- |||||||||| Hyruan Plus (sodium hyaluronate) / LG Chem
New P3 trial: Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis (clinicaltrials.gov) - Jan 12, 2012
P3, N=287, Completed, Sponsor: LG Life Sciences