| lithium carbonate ER / Generic mfg. |
2008-006891-31: A randomised placebo-controlled trial of Lithium carbonate in Amyotrophic Lateral Sclerosis (LiCALS) |
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| Ongoing | 4 | 220 | Europe | Lithium Carbonate, Lithium Citrate, Lithium Apogepha, Lithium Carbonate, Lithium Citrate, Lithium Apogepha, Lithium Carbonate, Lithium Citrate | King\'s College London | Amyotrophic Lateral Sclerosis (ALS) | | | | |
2008-008342-20: This is a trial to look at the treatment of Downs Syndrome patients with Lithium Carbonate versus placebo |
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| Ongoing | 4 | 34 | Europe | CAMCOLIT 250mg Lithium Carbonate, NO5AN01, Camcolit 250, Camcolit 250 | King\'s College London, Baily Thomas Charitable Fund | Down\'s Syndrome | | | | |
2009-011409-17: Randomized evaluation of the effectiveness of lithium in subjects with treatment-resistant depression and suicide risk. An independent, pragmatic, multicentre, parallel-group, superiority trial. |
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| Ongoing | 4 | 230 | Europe | CARBOLITHIUM, CARBOLITHIUM | AZIENDA OSPEDALIERA ISTITUTI OSPITALIERI DI VERONA | Treatment-resistant depression and suicide risk. | | | | |
ChiCTR-TRC-13003463: To evaluate the efficacy and safety of lithium carbonate and methimazole in Graves' disease |
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| Recruiting | 4 | 180 | | lithium carbonate ;methimazole ;lithium carbonate combination with methimazole | Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine ; Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Science and technology infrastructure construction program of Jiangsu province (BM2012064) | Graves' disease (Hyperthyroidism) | | | | |
2012-000778-46: Investigation of the drug Lithium with Brain Imaging in people with Bipolar Disorder Bildgebung des Gehirns zur Erforschung des Medikaments Lithium bei manisch-depressiven Menschen |
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| Ongoing | 4 | 80 | Europe | Quilonum retard 450 mg Retard Tablets, Quilonum retard 450 mg Retard Tablets | Forschungszentrum Jülich GmbH, Forschungszentrum Jülich GmbH | Healthy volunteersBipolar patients type 1 Gesunde ProbandenBipolare Patienten Typ 1 | | | | |
2016-001637-27: Lithium versus Quetiapine in Treatment Resistant Depression. |
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| Ongoing | 4 | 276 | Europe | Lithium carbonate, Quetiapine, Lithium citrate, Tablet, Syrup | South London and Maudsley NHS Foundation Trust, King's College London, National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme | Treatment resistant major depressive disorder (single episode or recurrent). Treatment resistant depression, defined as failure to respond to two or more adequate doses of antidepressant in the current episode, Treatment resistant depression: where the person with depression has not responded adequately to two or more antidepressants given in the current episode of depression., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR1900021798: Lithium Carbona in contrast-induced acute kidney injury: a prospective, randomized, controlled study |
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| Not yet recruiting | 4 | 200 | | Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ Lithium carbonate sustained release tablets 300mg/600mg qd oral for 3 days ;Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ placebo qd oral for 3 days | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Self-supporting | Contrast induced acute kidney injury | | | | |
| Recruiting | 4 | 276 | Europe | Quetiapine, Lithium | King's College London, University of Oxford, Newcastle University, Oxford Health NHS Foundation Trust, Northumberland, Tyne and Wear NHS Foundation Trust, South London and Maudsley NHS Foundation Trust, Tees, Esk and Wear Valleys NHS Foundation Trust, Sussex Partnership NHS Foundation Trust, Avon and Wiltshire Mental Health Partnership NHS Trust | Depressive Disorder, Treatment-Resistant | 04/21 | 08/21 | | |
| Recruiting | 4 | 189 | RoW | Perospirone hydrochloride tablets, Lithium carbonate + perospirone hydrochloride, Lithium Carbonate Pill | Shanghai Mental Health Center, University of Leipzig, Department of Psychiatry | Depressive Disorder | 06/21 | 06/21 | | |
2021-006706-69: Lithium versus cariprazine in the treatment of bipolar depression |
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| Not yet recruiting | 4 | 122 | Europe | Cariprazine, lithium citrate, Capsule, hard, Tablet, Reagila, Litarex | Psychiatry – Aalborg University Hospital, Unit for Psychiatric Research, Danske Regioner, Region Nordjylland | Bipolar disorder, current depressive episode. -Bipolar affektiv lidelse, aktuel depressiv episode, Patients with a diagnoses of bipolar disorder who have a depressive episode, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR2000038166: Lithium carbonate and lamotrigine monotherapy or combination therapy as maintenance treatment for childbearing women with bipolar disorder in remission: a randomized controlled study. |
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| Recruiting | 4 | 110 | | Lithium carbonate combined with Lamotrigine ;Lamotrigine | Beijing Anding Hospital Affiliated to Capital Medical University; Beijing Anding Hospital Affiliated to Capital Medical University, Capital health development research project | Bipolar disorder | | | | |
Li2CO3, NCT01669369: Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma |
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| Recruiting | 4 | 400 | RoW | Lithium Carbonate, Lithobid, Placebo, PLACEBO TREATMENT | Sun Yat-sen University, Qilu Hospital of Shandong University, Nanfang Hospital of Southern Medical University, Shenzhen Second People's Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Shanghai 6th People's Hospital | Osteosarcoma | 12/23 | 12/23 | | |
| Active, not recruiting | 4 | 148 | Europe | Anhydrous Amiloride Hydrochloride, Placebo | Assistance Publique - Hôpitaux de Paris, Ministère de la Santé, PHRC national, 2019 | Bipolar Disorder | 03/25 | 01/26 | | |
| Completed | 4 | 87 | Canada, US | Aripiprazole Augmentation, Abilify, Bupropion Augmentation, Wellbutrin, Switch to bupropion, Lithium Augmentation, Lithium carbonate, Eskalith, Switch to nortriptyline, Pamelor | Centre for Addiction and Mental Health, National Institute of Mental Health (NIMH) | Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression, Geriatric Depression | 07/24 | 07/24 | | |
| Recruiting | 4 | 200 | Europe | Lithium Carbonate, lithium citrate, Lamotrigine | Mental Health Services in the Capital Region, Denmark | Bipolar II Disorder | 12/27 | 12/27 | | |
| Completed | 4 | 80 | US | Lithium Carbonate, Placebo oral capsule | Ariel Gildengers, MD, National Institute on Aging (NIA) | Mild Cognitive Impairment | 08/24 | 08/24 | | |
NCT06861842: Bioequivalence Study of Lithium Carbonate 300 mg Tablets. Actilitio® in Healthy Subjects |
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| Active, not recruiting | 4 | 24 | RoW | Theralite®, lithium carbonate, Actilitio® | Centro de Atencion e Investigacion Medica | Healthy, Healthy Donors | 04/25 | 04/25 | | |
| Recruiting | 4 | 122 | Europe | Lithium, Litarex, ATC; N05AN01, Cariprazine, Reagila, ATC: N05AX15 | Aalborg University Hospital, Mental Health Center, Glostrup, Mental Health Center North Zealand, Mental Health Department Odense, University Clinic, Psychiatric Center Copenhagen, Rigshospitalet | Depression, Bipolar | 09/24 | 09/24 | | |
NCT05593627: Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass |
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| Recruiting | 4 | 62 | RoW | Lithium Carbonate 250 MG Oral Tablet, Calcium Carbonate 500 MG Oral Tablet | China Medical University, China | Heart Valve Surgery | 12/25 | 07/26 | | |
2008-004182-26: Antidepressive efficacy, safety, tolerability and genetic response predictors of lithium augmentation in Escitalopram-treated patients with major depression |
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| Ongoing | 3 | 50 | Europe | Escitalopram, Lithiumcarbonat, Capsule, hard | Charité - Universitätsmedizin Berlin | 30-40% of depressed patients do not respond to the first course of drug treatment chosen. Over 50% of nonresponders to the first treatment also do not respond to a second, different treatment . Of those who do respond to the initial antidepressant, up to 50% do not reach full remission but rather display residual symptoms. Therefore, treatment optimization strategies should be considered at critical decision points early in the treatment progress to avoid prolonged treatment-resistant courses. | | | | |
2018-002749-12: Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression |
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| Not yet recruiting | 3 | 514 | Europe | ITI-007, Capsule | Intra-Cellular Therapies, Inc. (ITI), Intra-Cellular Therapies, Inc. (ITI) | Major depressive episodes associated with bipolar I or bipolar II disorder (bipolar depression), Bipolar Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2020-000579-19: An international multi-center clinical trial to investigate the efficacy of multiple drug compounds in patients with Amyotrophic Lateral Sclrerosis (ALS). |
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| Not yet recruiting | 3 | 171 | Europe | Lithium Carbonate, Capsule, hard | Stichting TRICALS Foundation, Stichting ALS Nederland, Fight MND, FWO, MNDA, Thierry Latran Foundation, Ulla-Carin Lindquist Foundation | Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS) / Motor Neurone Disease / Lou Gehrig's Disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05126238: A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction |
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| Recruiting | 3 | 500 | RoW | Lithium Carbonate, Placebo | Negovsky Reanimatology Research Institute, Demikhov Municipal Clinical Hospital 68 | Carotid Artery Diseases, Carotid Artery Stenosis | 12/25 | 11/26 | | |
Lisphem, NCT04623398: Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency) |
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| Active, not recruiting | 3 | 22 | Europe | Lithium Carbonate, Placebo | Assistance Publique - Hôpitaux de Paris | Autism Spectrum Disorder | 02/25 | 02/25 | | |
| Recruiting | 3 | 171 | Europe, RoW | Lithium Carbonate 400 MG | Stichting TRICALS Foundation, Stichting ALS Nederland, Fight MND, Research Foundation Flanders, MNDA, Thierry Latran Foundation, Ulla-Carin Lindquist Foundation, Luzon Foundation, Alan Davidson Foundation, My name'5 Doddie Foundation | Amyotrophic Lateral Sclerosis | 06/26 | 06/26 | | |
2012-001209-26: Efficacy of Tranylcypromine (TCP) in daily doses up to 60mg and the combination of lithium and antidepressants (Li.-Aug.) in the acute treatmet of therapy-resistant Depression. In this study the assignment to the treatment groups (TCP or Li.-Aug.) is made by chance. Physicians and participants know which treatment is applicated. If a planned interim-analysis reveals no superiority of TCP the study will be terminated previously. Wirksamkeit von Tranylcypromin (TCP) (bis 60mg/Tag) und der Kombination von Lithium und Antidepressiva (Li.-Aug.) in der Behandlung der unipolaren Depression. Die Zuordnung zu den Behandlungsgruppen (TCP oder Li.-Aug.) erfolgt zufällig wobei Arzt und Patient über diese Zuordnung informiert sind. Die Studie wird vorzeitig beendet, wenn sich in einer geplanten Zwischenauswertung keine Überlegenheit von TCP zeigt. |
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| Ongoing | 2/3 | 71 | Europe | Jatrosom N, Quilonum retard, Jatrosom N (10 and 20mg Tablets will be used in the trial), Quilonum retard, Jatrosom N (10 and 20mg Tablets will be used in the trial), Quilonum retard | Charité Universitätsmedizin Berlin, ARISTO Pharma GmbH | Major Depression ICD10: F 32.1, F 32.2, F32.3, F33.1, F33.2, F33.3 Klassifikationscode MedDRA : 10012378 unipolare Depression Klassifikationscodes ICD10: F 32.1, F 32.2, F32.3, F33.1, F33.2, F33.3 Klassifikationscode MedDRA : 10012378 | | | | |
NCT06789783: Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment |
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| Recruiting | 2/3 | 34 | Europe | Lithium Carbonate Capsule | University of Milan | Cornelia De Lange Syndrome | 09/25 | 12/26 | | |
| Not yet recruiting | 2 | 50 | | Lithium carbonate ;calcium carbonate | The Third Affiliated Hospital of Zhengzhou University; The Third Affiliated Hospital of Zhengzhou University, Department of Science and Technology of Henan Province and Horizontal special project of Zhengzhou University | Autism spectrum disorder | | | | |
| Not yet recruiting | 2 | 10 | Europe | AMILORIDE, Tablet, MODAMIDE 5 mg | Assistance Publique – Hôpitaux de Paris (AP-HP), Ministère de la Santé, PHRC national, 2019 | NA Patients traités par lithium et présentant un diabète insipide néphrogénique après 2 mois de traitement, NA Diabète insipide néphrogénique, Diseases [C] - Hormonal diseases [C19] | | | | |
2022-000240-30: The effect of Lithium on the inhibition of the formation of polyps in patients with familial adenomatous polyposis Het effect van het onderzoeksgeneesmiddel (Lithium) op de remming van poliepvorming in patiënten met Familiale Adenomateuze Polyposis. |
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| Ongoing | 2 | 12 | Europe | Lithiumcarbonate, 55991, Tablet, Lithiumcarbonate | Center for Experimental and Molecular Medicine, G2 (AMC) | Familial adenomatous polyposis Familiaire adenomateuze polyposis, Familial adenomatous polyposis Familiaire adenomateuze polyposis, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT02999022: Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) |
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| Recruiting | 2 | 160 | Canada | Lithium Carbonate, Lithium, Lactose Placebo, placebo | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR) | Fractures | 12/24 | 06/25 | | |
| Completed | 2 | 12 | Europe | Lithium Carbonate | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Familial Adenomatous Polyposis | 09/24 | 09/24 | | |
ESALIT, NCT06776848: A Placebo-controlled Evaluation of Low Dose Lithium Carbonate in Patients with TBR1-related Neurocognitive Disorders |
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| Not yet recruiting | 1/2 | 12 | Europe | Observation phase, Lithium treatment, biological monitoring | Centre Hospitalier Universitaire Dijon | Proven Pathogenic or Probably Pathogenic TBR1 Variant | 02/27 | 02/27 | | |
STAMD, NCT05814640: Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) |
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| Recruiting | 1/2 | 520 | RoW | Fluoxetine, Sertraline, Vortioxetine, Duloxetine, Aripiprazole, Lithium Carbonate, Olanzapine, GCBT | First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Children's Hospital of Chongqing Medical University, Southwest Hospital, China, Central South University | Depression, Sequestra | 12/25 | 07/27 | | |
NCT06719544: A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034) |
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| Completed | 1 | 16 | US | lithium carbonate, lithium, enlicitide, enlicitide decanoate, MK-0616/sodium caprate | Merck Sharp & Dohme LLC | Healthy | 01/25 | 02/25 | | |
| Active, not recruiting | 1 | 20 | RoW | Lithium, Lithicarb | Melbourne Health | Depressive Disorder | 05/25 | 06/25 | | |
| Recruiting | N/A | 80 | | taken lithium carbonate orally ;taken sodium carbonate orally ;taken sodium carbonate orally ;taken sodium carbonated orlly | The Third Affilited Hospital of Zhengzhou University; The Third Affilited Hospital of Zhengzhou University, self-financing | Metal retardation | | | | |
| Active, not recruiting | N/A | 109 | Europe | Lithium | Universiteit Antwerpen | Major Depressive Disorder (MDD) | 09/24 | 04/25 | | |
ChiCTR1900021088: A cohort study for sex hormone levels in child-bearing age women with bipolar mania |
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| Not yet recruiting | N/A | 240 | | oral lithium carbonate therapy ;Oral lithium carbonate treatment ;Oral valproic acid therapy ;No treatment | Zhengzhou Eighth People's Hospital (Zhengzhou Mental Health Center); Zhengzhou Eighth People's Hospital (Zhengzhou Mental Health Center), Henan Medical Science and Technology Research Program (No. 2018020866) | Bipolar Disorder | | | | |
| Recruiting | N/A | 80 | Europe | Lithium MR imaging | Leiden University Medical Center, PsyQ, GGZ Rivierduinen | Bipolar Disorder I or II | 03/27 | 03/28 | | |
NCT06424613: Effects of Lithium on Suicide Prevention in Adolescents and Young Adults With Bipolar Disorder in China |
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| Recruiting | N/A | 600 | RoW | Lithium Carbonate, Non-lithium medication | Peking University, Jiangsu Nhwa Pharmaceutical Co., Ltd. | Bipolar Disorder, Suicidal Ideation, Suicide, Attempted, Nonsuicidal Self Injury | 12/24 | 12/24 | | |
NCT03336918: Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder |
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| Recruiting | N/A | 120 | US | Lithium, Lithium carbonate or citrate or Lithium extended release | Brigham and Women's Hospital | Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode | 08/25 | 12/25 | | |
ChiCTR2100053117: Comparative study on clinical characteristics, biomarkers and treatment outcome of mixed major depressive disorder and bipolar II disorder |
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| Recruiting | N/A | 120 | | Sertraline+lithium carbonate ;Sertraline+lithium carbonate | Huzhou Third People's Hospital; Huzhou Third People's Hospital, Self-raised | Affective disorder | | | | |
ChiCTR2200066412: Efficacy and safety of mood stabilizers versus antidepressants for youth depression: a randomised, open-label, pilot study |
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| Not yet recruiting | N/A | 40 | | Lamotrigine and Lithium Carbonate Sustained-release ;Sertraline | Wuhan Mental Health Center; Wuhan Mental Health Center, Pivot Subjects in Wuhan Mental Health Center | Depression | | | | |
| Recruiting | N/A | 60 | Europe | urine collection, Level of Proteins, Level of mRNA and miRNA, Level of plasmatic and intraerythrocytic lithium | Assistance Publique - Hôpitaux de Paris | Bipolar Disorder I | 07/25 | 07/25 | | |
