- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Valproate (VPA) Decreases the Expression of Glucose Transporters as a Potential Mechanism of Inositol Depletion and Therapeutic Mechanism (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_348;
VPA and structurally dissimilar mood stabilizers lithium and carbamazepine, which inhibit inositol monophosphatase and inositol transporter SMIT1, respectively, have been shown to cause inositol depletion, supporting this biochemical outcome as a potential therapeutic mechanism... Overall, our results show that VPA decreases glucose transporters and that could be the mechanism of inositol reduction, and the therapeutic mechanism of VPA
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Therapeutic Challenges in Case of Dual Diagnosis - Cannabis Use Disorder and Bipolar Disorder (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_344;
The pharmacological management of patients presenting both CUD and BD should be explored in more good-quality clinical trials. Based on existing data, gabapentin, quetiapine XR, and the combination of lithium and divalproex can be efficient in these patients.
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Growth and Recovery in the Aftermath of Psychosis (Regency Ballroom D) - Jun 15, 2023 - Abstract #ISBD2023ISBD_286;
An author, speaker, and mental health advocate, he lives with his wife in Cocoa Beach, Florida. For more information, visit www.generalgreggmartin.com
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DNA Methylation of Lithium Use in Bipolar Disorder (Crystal Ballroom C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_249;
Wnt signaling has consistently been associated with lithium, but our work shows that epigenetics is involved in this process. Further work is required to understand the epigenetic role of lithium in BD treatment.
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A Systematic Review of Interventions in the Early Course of Bipolar Disorders (Regency Ballroom D) - Jun 15, 2023 - Abstract #ISBD2023ISBD_232;
Available evidence suggested that in the early course of illness, lithium use was associated with lower recurrence risk compared with other mood stabilizers. The certainty of this evidence was assessed to be low.
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The Focused Integrated Team-Based Treatment Program for Bipolar Disorder (FITT-BD): A One Year Update (Crystal Ballroom C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_224;
1 We believe that sharing ongoing lessons learned in our FITT-BD program is important, including the successes and challenges of our program, as we continually focus our efforts on improving treatment programs for people with bipolar disorder. Overall, FITT-BD has key implications for future clinical practice in bipolar disorder, potentially suggesting a new path for treating patients with bipolar disorder that is based on a flexible, comprehensive, and collaborative treatment model.
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Factors Impacting Lithium Use and Dosing: A Focus on Racial Disparities (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_204;
The factors that impact the use of lithium for treatment of bipolar disorder are complex, but understanding them is paramount for the proper treatment of patient populations. These findings have implications for precision psychiatry and demonstrate opportunities for improved clinical practice.
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Long-Term Lumateperone Treatment in Bipolar Disorder: Six-Month Open-Label Extension Study (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_186;
P3
In bipolar depression, long-term lumateperone treatment was generally well tolerated with low risk of extrapyramidal symptoms, weight gain, and cardiometabolic effects. These data further support the use of lumateperone in patients with bipolar depression.
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Does Low-Dose Lithium Raise TSH? Implications for Dementia Prevention (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_184;
This has broad public health implications: for an increasing population at risk of dementia, lithium prophylaxis will be widely considered, if current RCTs support earlier results. Monitoring TSH will be necessary, but risk of inducing hypothyroidism appears to be smaller than with standard lithium doses.
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The Neuropsychiatric Effects of Low-Dose Lithium Interventions (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_175;
Monitoring TSH will be necessary, but risk of inducing hypothyroidism appears to be smaller than with standard lithium doses. Despite the paucity and heterogeneity of studies, LDL
- |||||||||| lithium carbonate ER / Generic mfg.
Patterns of Pharmacotherapy for Bipolar Disorder: A Global Bipolar Cohort Survey (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_156;
Significant differences exist in the prescription practices across different geographic regions, especially the underutilization of Lithium in North American cohorts and higher utilization of first-generation antipsychotics in the European cohorts. There is a need to conduct future longitudinal studies to further explore these differences and their impact on outcomes, and to inform and implement evidence-based guidelines to help improve treatment practices in BD.
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Lithium in the Frontolimbic System: A Structured Review of Neuro Imaging Studies (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_142;
Longitudinal data in larger sample sizes may provide more substantial data. Furthermore, heterogeneity within BD has potentially tempered results so far, which may be addressed by profiling in future studies.
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Bipolar General: My Forever War with Mental Illness (Crystal Ballroom AB) - Jun 15, 2023 - Abstract #ISBD2023ISBD_24;
He has become an ardent mental health advocate, writing, speaking and conferring on BD and other mental health issues. His story offers hope, inspiration and knowledge to the millions of Americans and billions of people around the world who are afflicted and/or affected by BD and other mental illnesses.
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ISBD Regional Chapters: Stories of Resilience, Evolution and Impact (Crystal Ballroom C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_5;
The Dutch Chapter is also building capacity in EMCR, initiating a highly successful Young Investigators Network in BD. They also spearheaded an important national discussion on the values of disorder-specific mental health care and are the national certifier for specialized BD outpatient clinics.
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Essential Guide to Lithium Treatment in Mood Disorders: A Practical Course (Crystal Ballroom AB) - Jun 15, 2023 - Abstract #ISBD2023ISBD_3;
The major questions are who is getting lithium, at which point, and what algorithm can be offered in case a patients fails to first/second and further options, monotherapy vs. combination therapy. These questions will be addressed in this course which is a practical guide for all health care professionals, patients and their caregivers with up-to-date information about the correct use of lithium in various indications, essential knowledge they will require in short and long-term treatment.
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Lithium responsiveness in hyperexcitable neurons derived from bipolar patient iPSCs (Montreal Bonaventure Hotel (CAN meeting headquarters)) - Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_760;
Our results corroborate the literature discerning a hyperexcitability phenotype of young neurons, reversible by lithium in neurons derived from patients who clinically responded to lithium treatment. In this study, we combined cell imaging, electrophysiology, transcriptomic, phosphoproteomic, calcium imaging and pharmacological treatments to provide a molecular signature of disease, lithium responsiveness and alternative potential therapeutic candidates.
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Review, Journal: Mood and behavior regulation: interaction of lithium and dopaminergic system. (Pubmed Central) - Jun 8, 2023
It was suggested that lithium has various mechanisms affecting dopaminergic signaling and mood, and that many molecular factors can be involved, including brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), ?-catenin, protein kinase B (Akt), and glycogen synthase kinase-3 beta (GSK-3?). Thus, molecular effects of lithium can be the most important mechanisms of lithium that also alter neural transmissions including dopaminergic signaling in mesolimbic and mesocortical pathways.
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Review, Journal: Regulation of COX-2 expression by selected trace elements and heavy metals: Health implications, and changes in neuronal plasticity. A review. (Pubmed Central) - May 31, 2023
Calcium (Ca), zinc (Zn), cadmium (Cd), vanadium (V), nickel (Ni), copper (Cu), and iron (Fe) can potentially increase COX-2 expression, inducing neuroinflammation and Glu excitotoxicity; while magnesium (Mg), lithium (Li), and selenium (Se) can potentially decrease COX-2 expression. The associated mechanisms are described in the article.
- |||||||||| Review, Journal: Mood Stabilizers of First and Second Generation. (Pubmed Central) - May 27, 2023
The article presents clinical experiences with mood stabilizers of the first and second generations and with "insufficient" ones. Further, current suggestions for their use in preventing recurrences of bipolar mood disorder are provided.
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Journal: Association of Bipolar Disorder Diagnosis With Suicide Mortality Rates in Adolescents in Sweden. (Pubmed Central) - May 24, 2023
In this cross-sectional study, lower suicide death rates in adolescent males was robustly associated with regional diagnosis rates of bipolar disorder at an estimated magnitude of approximately 4.7% of the mean national suicide death rate. The associations could be due to treatment efficacy, early diagnosis and management, or other factors not accounted for.
- |||||||||| Journal: Mood Stabilizers: An Overview (Pubmed Central) - May 21, 2023
Classically, lithium carbonate and valproate are the most commonly used medications; however, in addition to lamotrigine, atypical antipsychotics including aripiprazole, quetiapine, and lurasidone are being used in recent years. Theoretically, patients are administered monotherapy; however, it is not uncommon to use combination treatment in clinical practice.
- |||||||||| lithium carbonate ER / Generic mfg., clozapine / Generic mfg.
Retrospective data, Review, Journal: Pharmacological and Somatic Treatment Effects on Suicide in Adults: A Systematic Review and Meta-Analysis. (Pubmed Central) - May 18, 2023
There were insufficient studies to meta-analyze associations of suicide risk with vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy, or transcranial direct current stimulation. Lithium and clozapine have consistent data supporting protective effects against suicide in certain clinical contexts.Reprinted from Depress Anxiety 2022; 39:100-112, with permission from John Wiley and Sons.
- |||||||||| Review, Journal: Pharmacologic Approaches to Suicide Prevention. (Pubmed Central) - May 18, 2023
For patients with chronic suicidality, clozapine remains the only U.S. Food and Drug Administration (FDA) approved antisuicidal medication, and its use is predominantly for patients with schizophrenia and schizoaffective disorder...Treatment guidelines focus on the importance of optimizing treatment of the psychiatric conditions known to be associated with suicide risk. For patients with these conditions, the authors recommend focusing on suicide as an independent treatment target and using an enhanced medication management strategy that includes maintaining a supportive, nonjudgmental therapeutic relationship; flexibility; collaboration; measurement-based care; consideration of combining medications with nonpharmacologic, evidence-based strategies; and ongoing safety planning.
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Treatment of Bipolar Depression (Room 205, Moscone South Room Level: Second Level) - May 17, 2023 - Abstract #APA2023APA_1560;
For the subset of bipolar patients who respond to antidepressants, prescribing them long term is a reasonable option. Finally, electroconvulsive therapy (ECT) is as effective in treating bipolar depression as in unipolar depression.Learning Objectives Objective One: 1) Know the ratio of depressive vs. manic times in bipolar disorder Objective Two: 2) Be aware of the efficacy of second generation antipsychotics in bipolar depression Objective Three: 3) Be knowledgeable about the data regarding treatment emergent affective switches in association with antidepressants in bipolar depression Objective Four: Objective Five:
- |||||||||| ECT as Innovative Life-Saving Treatment and Rehospitalization Prevention: A Case of Suicidal Ideation Via Enucleation (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1414;
Prior to this hospitalization, S had undergone extensive psychiatric treatment including four hospitalizations at the present institution, multiple hospitalizations at other institutions, partial hospitalization programs and intensive outpatient programs, and various medication trials (including hydroxyzine, lithium, olanzapine, sertraline, aripiprazole, and fluoxetine) to minimal effect...Although the utility of ECT has been widely studied in adults, it is not a familiar method of treatment among child and adolescent psychiatrists (3). While ECT therapy remains controversial for use in children and adolescents and requires court approval in the state of California, this poster demonstrates potential life-saving utility of using ECT as an innovative treatment in a unique case of treatment resistant depression with enucleation, leading to prevention of rehospitalization and improved outcomes.
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Silent: A Syndrome of Irreversible Lithium Effectuated Neurotoxicity (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1384;
While ECT therapy remains controversial for use in children and adolescents and requires court approval in the state of California, this poster demonstrates potential life-saving utility of using ECT as an innovative treatment in a unique case of treatment resistant depression with enucleation, leading to prevention of rehospitalization and improved outcomes. The patient
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Individual Patient Data Meta Analysis of Antidepressants Versus Lithium for Bipolar II Disorder (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1362;
Conclusion - Recommendations drawn from this IPD meta-analysis of prospective bipolar II depression trials suggest a divergence from current recommendations of evidence-based guidelines for treating bipolar II depression (i.e., use of combined therapy with mood stabilizer plus antidepressant). Antidepressant monotherapy may provide superior short-term benefit for bipolar II depression, without clinically meaningful, treatment-emergent hypomanic symptoms, relative to lithium.
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Epigenetic Markers in Peripheral Blood and Lithium Response in Patients With Bipolar Disorders (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1136;
Our results show DNA methylation differences in peripheral blood between Ex-Rp and non-Rp BD patients pointing to the importance of considering epigenetic markers when studying LR. These results should be further studied for a better understanding of LR and ultimately move towards a more effective and personalized treatment.
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Psilocybin in Treatment for Bipolar Disorder: A Systematic Review and Call to Action (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_939;
These results should be further studied for a better understanding of LR and ultimately move towards a more effective and personalized treatment. Further research is necessary to determine if psilocybin can be used safely with bipolar patients and if the same antidepressant effect is conferred in bipolar depression as has been demonstrated in unipolar depression.
- |||||||||| Mail Order Mania: An Induction of Mania While Seeking Gender Affirming Care Online (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_846;
While inpatient his psychiatric symptoms initially improved without medications (likely due to the cessation of exogenous supplement use) but then plateaued, requiring a 9-day hospitalization on a regimen of lithium, risperidone and mirtazapine for full stabilization...Thus, his treatment plan was adjusted to bolster his support network and delineate clear and available treatment options for his transitional needs. In this poster we explore the challenges and importance of gender affirming care and its impact on mental health in the setting of ever-growing restrictions.
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Lithium Key When First and Second Generation Antipsychotics Fail in the Treatment of Postpartum Psychosis (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_845;
During her previous hospitalization, the patient presented less than a week after delivery for suicidal ideation and thoughts about harming her baby and was discharged a month later on haloperidol and valproic acid...On day 5 of her second inpatient psychiatric stay, she was switched from olanzapine to aripiprazole, and lithium was started as it has been shown to be effective in achieving remission in up to 98.4% of patients diagnosed with postpartum psychosis as monotherapy or dual therapy...The goal of this poster is to motivate governments and organizations to recognize the importance of funding further research, modifying existing ways of classifying this illness, and changing laws and access to resources to improve outcomes for families affected by postpartum psychosis. This poster will highlight the diagnostic features of postpartum psychosis and aims to provide further evidence for the first line use of lithium as the treatment for postpartum psychosis.
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