- |||||||||| lithium carbonate ER / Generic mfg.
Use of the Wnt/?-catenin Activator Lithium Is Associated With Less Emphysema (San Diego Convention Center, Area I (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6307;
Participants who self-report using lithium for neuropsychiatric indications have decreased radiographic emphysema compared to users of other neuropsychiatric medications in adjusted multivariate and propensity-matched models. This study underscores the potential to clinically translate our data from animal models where administering lithium to activate Wnt/?-catenin signaling protects against emphysema.
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Hemodialysis Reversed Bradyarrhythmia and Sinus Nodal Dysfunction From Acute Lithium Toxicity (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6002;
Regular medications included levothyroxine, lisinopril, lithium carbonate, and furosemide...Renal function recovered and lithium was switched to cariprazine per psychiatry consultation...The most common manifestations include sinus nodal abnormalities and profound bradycardia. The available literature described the reversibility of bradyarrhythmia and restoration of nodal function with lithium levels normalization post-dialysis, as demonstrated in our case, although temporary (and rarely permanent) cardiac pacing was warranted in some patients.
- |||||||||| lithium carbonate ER / Generic mfg., prednisone / Generic mfg.
When Abdominal Pain and Pseudo-stemi Unleash Paroxysmal Granulomatosis (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1645;
Prednisone therapy was initiated and he was clinically asymptomatic with normal serum calcium at 1 month follow up...Increased PTHrP expression in bone marrow granulomas has been reported in few cases of sarcoidosis and other granulomatous diseases. Furthermore, his EKG showed ST elevation prompting escalation to ICU but was ultimately thought to be electrolyte mediated pseudo-STEMI.
- |||||||||| lithium carbonate ER / Generic mfg.
Trial termination, HEOR: Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies (clinicaltrials.gov) - Feb 15, 2024
P=N/A, N=1037352, Terminated,
Furthermore, his EKG showed ST elevation prompting escalation to ICU but was ultimately thought to be electrolyte mediated pseudo-STEMI. Completed --> Terminated; Per PI, this study is not a clinical trial and was inadvertently entered in the system
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Journal: Chronic Lithium Toxicity in Old Age Patients Taking Angiotensin Receptor Blocker: A Case Report. (Pubmed Central) - Feb 3, 2024
She had been under lithium therapy for bipolar type 1 disorder for 15 years before experiencing these symptoms, which emerged shortly after the addition of telmisartan (angiotensinogen receptor blocker) for hypertension. angiotensin receptor blocker; bipolar disorder; case reports; lithium; telmisartan.
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Journal: What Came First, Mania or Depression? Polarity at Onset in Bipolar I and II: Temperament and Clinical Course. (Pubmed Central) - Jan 22, 2024
Only BD-II and age at first depressive episode were predictors of D-PO, whereas BD-I, age at first manic/hypomanic episode, and hyperthymic temperament were predictors of M-PO (p < 0.01). (4) Our findings point to the importance of carefully assessing temperament and PO in patients with BD, to better predict the clinical course and tailor therapeutic interventions to individual patients' needs.
- |||||||||| lithium carbonate ER / Generic mfg.
Preclinical, Journal: Patterns of ingestion of rats during chronic oral administration of lithium chloride. (Pubmed Central) - Jan 22, 2024
The avoidance of LiCl was likely a combination of toxic effects of ingested LiCl and rapid acquisition of a learned aversion to the taste of LiCl, as shown by an extinguishable generalized aversion to NaCl solution during subsequent NaCl test days. The marked effect of chronic oral LiCl on ingestion may impact the oral dosing of lithium as well as the rat's metabolic status.
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Journal: Characterization of Psychiatric Inpatients: The Role of Gender Differences in Clinical and Pharmacological Patterns. (Pubmed Central) - Jan 20, 2024
Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations. Our real-world results highlighted gender differences among patients with severe mental disorders admitted to psychiatric units, and suggest further investigations that may help in understanding trajectories accompanying disabling clinical conditions.
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Journal: Bipolar Disorder. (Pubmed Central) - Jan 19, 2024
These studies support previous work that implicates dysregulation of neurodevelopment, mitochondria, and calcium homeostasis, while also allowing for investigation into the underlying mechanisms of individual responsivity to lithium. Sleep and circadian rhythms have also been heavily implicated in BD, from disruptions in activity patterns to molecular abnormalities.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Current Status and Treatment of Rapid Cycling Bipolar Disorder. (Pubmed Central) - Jan 17, 2024
Rapid cycling is prevalent among BD patients but seems to vary in risk over time without evidence of progressive worsening. Treatment of acute episodes in RC-BD patients and effective long-term preventive management require much more intensive investigation.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Estimating Lithium Concentrations in Groundwater Used as Drinking Water for the Conterminous United States. (Pubmed Central) - Jan 17, 2024
Model predictions were mapped at a spatial resolution of 1 km and represent well depths associated with public- and private-supply wells. This model was developed by hydrologists and public-health researchers to estimate Li exposure from drinking water and compare to national-scale human-health data for a better understanding of dose-response to low (<30 ?g/L) concentrations of Li.
- |||||||||| Viibryd (vilazodone) / AbbVie
And This is What Makes Liver Pathology Fun - Guy (BCC Room 339) - Jan 9, 2024 - Abstract #USCAP2024USCAP_426;
Her medications include Valium (diazepam), lithium, Zyprexa (olanzapine), propranolol, and Viibryd (vilazodone)...She was prescribed Zofran and discharged...Figure 9: Click to view full size Figure 9 Caption: Liver biopsy, trichrome, high power view. Figure 9 Virtual Slide: Liver biopsy, trichrome, high power view.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Drugs for depressionr. (Pubmed Central) - Dec 26, 2023
No abstract available No abstract available
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Review, Journal: The Novel Antipsychotic Lumateperone (Iti-007) in the Treatment of Schizophrenia: A Systematic Review. (Pubmed Central) - Dec 23, 2023
The evaluation of safety indicators in the reviewed studies indicates that lumateperone is deemed to be a well-tolerated and safe antipsychotic. Additional research is warranted to explore lumateperone's efficacy in managing major depressive disorders, behavioral issues in Alzheimer's disease and dementia, sleep maintenance insomnia, bipolar disorders, and personality disorders.
- |||||||||| Retrospective data, Journal: Use of Psychotropic Drugs during the COVID-19 pandemic in Minas Gerais, Brazil. (Pubmed Central) - Dec 17, 2023
Old age and comorbid substance use disorder do not appear to be major deterrents for clinicians to initiate Li therapy. The change in the psychotropic drug dispensation profile during the COVID-19 pandemic highlights the need to produce more studies to complete, confirm or rule out this profile and monitor the use of psychotropic drugs by the population in the post-pandemic context.
- |||||||||| Spravato (esketamine intranasal) / J&J
Review, Journal: Overcoming the myths of esketamine administration: different and not difficult. (Pubmed Central) - Dec 11, 2023
The administration of intranasal esketamine is considered as safe during the application itself and long-lasting or severe adverse events during long-term treatment are very rare. Since this is a new approach for treatment application psychiatrists face new different but not difficult treatment procedures compared to prescribing only a medication.
- |||||||||| lithium carbonate ER / Generic mfg., clozapine / Generic mfg.
Journal: Inflammation and damage-associated molecular patterns in major psychiatric disorders. (Pubmed Central) - Dec 4, 2023
Medications such as lithium and clozapine were associated with lower HSP70 levels in BD and SCZ groups, respectively. Therefore, it is worth mentioning that all participants were medicated and many psychotropic drugs exert an anti-inflammatory effect, possibly reducing the signs of inflammation.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Taste Disorder and Tongue Numbness After Lithium Overdose. (Pubmed Central) - Nov 30, 2023
This case brings attention to taste disorders induced by lithium and suggests potential mechanisms that could contribute to taste alterations. It underscores the importance of conducting thorough assessments in patients experiencing gustatory symptoms, particularly during the ongoing pandemic.
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Journal: Lithium carbonate-promoted mixed rare earth oxides as a generalized strategy for oxidative coupling of methane with exceptional yields. (Pubmed Central) - Nov 28, 2023
In-situ characterizations and quantum chemistry calculations provide insights into the distinct roles of the mixed oxide core and LiCO shell, as well as the interplay between the Pr oxidation state and active peroxide formation upon LiCO coating. Furthermore, we establish a generalized correlation between Pr content in the mixed lanthanide oxide and hydrocarbons yield, offering a valuable optimization strategy for this class of oxidative coupling of methane redox catalysts.
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Journal: Childhood trauma and self-harm in youths with bipolar disorders. (Pubmed Central) - Nov 27, 2023
Furthermore, we establish a generalized correlation between Pr content in the mixed lanthanide oxide and hydrocarbons yield, offering a valuable optimization strategy for this class of oxidative coupling of methane redox catalysts. Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Bipolar Disorders in the Emergency Department. (Pubmed Central) - Nov 22, 2023
Patients with bipolar disorder have high recurrence of acute symptoms, and on average spend 20% of their life in exacerbations characterized by mania, depression, or psychosis. Given the increased morbidity and mortality associated with bipolar disorders, it is imperative that the emergency physician remain vigilant when these patients seek emergency care.
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Review, Journal: Key questions on the long term renal effects of lithium: a review of pertinent data. (Pubmed Central) - Nov 17, 2023
Should the eGFR fall rapidly or below 60 ml/minute, patients should consider a consultation with a nephrologist. A decision as to whether lithium should be discontinued due to progressive renal insufficiency should be made using a risk/benefit analysis that takes into account other potential etiologies of renal dysfunction, current renal function, and the efficacy of lithium in that individual patient.
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Retrospective data, Journal: Causes, clinical characteristics, and outcomes of high lithium levels and intoxications: Retrospective analysis of patient records. (Pubmed Central) - Nov 15, 2023
Patients and medical doctors should be aware of the increased risk of lithium intoxication already within the high therapeutic range and should consider alternative medications without relative contraindications for concurrent lithium use. Involving psychiatrists during or after an intoxication event is associated with more frequent adjustment of the maintenance lithium dose and should be considered in most cases.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: A Conversation With ChatGPT About the Usage of Lithium in Pregnancy for Bipolar Disorder. (Pubmed Central) - Nov 7, 2023
However, it is essential to note that ChatGPT's responses lack specific references, raising concerns about the reliability of the information provided. Further research is needed to quantify the correctness and dependability of ChatGPT-generated answers in the healthcare context.
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Review, Journal: Diagnosis and Treatment of Bipolar Disorder: A Review. (Pubmed Central) - Nov 3, 2023
Bipolar disorder affects approximately 8 million adults in the US. First-line therapy includes mood stabilizers, such as lithium, anticonvulsants, such as valproate and lamotrigine, and atypical antipsychotic drugs, such as quetiapine, aripiprazole, asenapine, lurasidone, and cariprazine.
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