- |||||||||| lithium carbonate ER / Generic mfg.
Trial completion date, Trial primary completion date: LiLa-Bipolar: Lithium Versus Lamotrigine in Bipolar Disorder, Type II (clinicaltrials.gov) - Apr 18, 2024
P4, N=200, Not yet recruiting,
However, severe ADEs also occurred with other mood stabilisers and other psychotropic drugs. Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Dec 2026 --> Dec 2027
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Catalytic pyrolysis and in situ carbonization of walnut shells: poly-generation and enhanced electrochemical performance of carbons. (Pubmed Central) - Apr 17, 2024
In this study, walnut shell (WS) was used as feedstock, incorporating lithium carbonate (LC), sodium carbonate (SC), potassium carbonate (PC), and potassium hydroxide (PH) as pyrolysis catalysts and carbonization activators...Even after 5000 charge and discharge cycles at a current density of 2 A g-1, the capacitance retention rate remained at 98.16%. This method effectively enhances the quality of the biomass pyrolysis oil, gas, and char, contributing to the efficient and clean utilization of biomass in industrial applications.
- |||||||||| lithium carbonate ER / Generic mfg.
Retrospective data, Journal: Effect of antipsychotics and mood stabilisers on metabolism in (Pubmed Central) - Apr 15, 2024
This method effectively enhances the quality of the biomass pyrolysis oil, gas, and char, contributing to the efficient and clean utilization of biomass in industrial applications. After eliminating possible sensitivity, risperidone ranked 1st in elevating fasting serum glucose (SUCRA
- |||||||||| lithium carbonate ER / Generic mfg.
The Global Bipolar Cohort (GBC) () - Apr 14, 2024 - Abstract #SOBP2024SOBP_924;
Leveraging datasets from GBC members lays a critical foundation for comprehending the current strengths and limitations in the field, informing the establishment of prospective longitudinal cohorts to further explore the impact of pharmacological treatments on BD patient outcomes. Amidst these findings, the challenges of data harmonization, disparities between cross-sectional and longitudinal approaches, diverse patient populations, discrepancies in clinical practices and the need for Data Use Agreements to critically examine individualized datasets, remain.
- |||||||||| lithium carbonate ER / Generic mfg.
The Relationship between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study across 16 Enigma-Bipolar Sites (Lone Star Ballroom B) - Apr 14, 2024 - Abstract #SOBP2024SOBP_632;
Amidst these findings, the challenges of data harmonization, disparities between cross-sectional and longitudinal approaches, diverse patient populations, discrepancies in clinical practices and the need for Data Use Agreements to critically examine individualized datasets, remain. Here we present the largest multisite brain connectivity analysis of BD, showing how illness duration and severity impacts the brain in BD and highlighting the importance of modeling polypharmaceutical effects to better understand BD brain signatures.
- |||||||||| lithium carbonate ER / Generic mfg.
GrimAge and DunedinPACE in Bipolar Disorder: Exploring Suicide Attempt and Lithium Use (Griffin Hall) - Apr 14, 2024 - Abstract #SOBP2024SOBP_428;
Lithium, which is known for its suicide-protective effects, was not associated with epigenetic aging. These findings are consistent with those from early generation epigenetic clocks and lithium use, indicating that any suicide-protective effects and anti-aging effects may not be detectable in the periphery.
- |||||||||| ebselen (SPI-1005) / Sound Pharma
The Effects of Ebselen on Brain Neurochemistry in Depressed Patients on Antidepressants (Griffin Hall) - Apr 14, 2024 - Abstract #SOBP2024SOBP_376;
These findings are consistent with those from early generation epigenetic clocks and lithium use, indicating that any suicide-protective effects and anti-aging effects may not be detectable in the periphery. In patients with treatment-resistant depression, as in healthy volunteers, ebselen reduces inositol and glx levels potentially via inositol monophosphatase and glutaminase inhibition, respectively.
- |||||||||| lithium carbonate ER / Generic mfg.
Insulin Receptor Substrate in Bipolar 1 and 2 Disorder (Griffin Hall) - Apr 14, 2024 - Abstract #SOBP2024SOBP_194;
The cohort included 7,411 patients (Female n=4,293, 58.4%, mean age=41.22 The finding of an increased insulin receptor substrate in brain-enriched exosomes in bipolar 2 disorder compared to bipolar 1 disorder might provide a clue to understanding the difference in the biologic mechanism between bipolar 1 and 2 disorders.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Role of the Cerebellum in Bipolar Disorder: A Systematic Literature Review. (Pubmed Central) - Apr 12, 2024
The effects of lamotrigine and lithium on cerebellar volume and abnormalities are also discussed in this paper. The present systematic literature review illustrates the emerging involvement of the cerebellum in bipolar disorder and its affective symptoms and paves the way for future research and a better understanding of bipolar disorder.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Drugs for bipolar disorder. (Pubmed Central) - Apr 9, 2024
The present systematic literature review illustrates the emerging involvement of the cerebellum in bipolar disorder and its affective symptoms and paves the way for future research and a better understanding of bipolar disorder. No abstract available
- |||||||||| lithium carbonate ER / Generic mfg.
REAL-DMC: Review of Effect After Lithium Drug Manufacturer Change () - Apr 9, 2024 - Abstract #AMCP2024AMCP_102;
Differences in lithium levels occurred after a drug manufacturer change; however, levels above what is considered toxic (level equal to or greater than 1.3 mEq/L) were infrequently observed within the cohort. Further in- vestigation is needed to understand whether obtaining lithium levels after a drug manufacturer change is required.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: An Artificial LiSiOx Nociceptor with Neural Blockade and Self-Protection Abilities. (Pubmed Central) - Apr 9, 2024
The conducting channel ruptured partially under sequential potentiation, thus achieving nociceptive blockade, besides basic functions in one single nociceptor, which was rarely reported. These results provided important guidelines for constructing high-performance memristor-based artificial nociceptors and opened up an alternative approach to the realization of bioelectronic systems for artificial intelligence.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Insight into the Growth Mechanism of Low-Temperature Synthesis of High-Purity Lithium Slag-Based Zeolite A. (Pubmed Central) - Apr 9, 2024
These results provided important guidelines for constructing high-performance memristor-based artificial nociceptors and opened up an alternative approach to the realization of bioelectronic systems for artificial intelligence. The utilization of lithium slag (LS), a solid waste generated during the production of lithium carbonate, poses challenges due to its high sulfur content...High-purity and crystalline zeolite A was successfully obtained under hydrothermal conditions of 60
- |||||||||| lithium carbonate ER / Generic mfg.
Trial completion date, Trial primary completion date: Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder (clinicaltrials.gov) - Apr 7, 2024
P=N/A, N=120, Recruiting,
The utilization of lithium slag (LS), a solid waste generated during the production of lithium carbonate, poses challenges due to its high sulfur content...High-purity and crystalline zeolite A was successfully obtained under hydrothermal conditions of 60 Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Aug 2025
- |||||||||| Cerebrolysin (porcine brain-derived proteolytic peptide fraction) / Novartis, EVER Pharma
Preclinical, Journal: Cerebrolysin potentiates the antidepressant effect of lithium in a rat model of depression. (Pubmed Central) - Apr 1, 2024
our LiFT platform sends the test results to the patient's smartphone, which subsequently could be shared with the patient's healthcare provider to expedite diagnosis and prevention of acute lithium The augmentation of lithium with cerebrolysin showed a clear beneficial effect in the present model of depression suggesting the use of cerebrolysin as an adjuvant in antidepressant treatment.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: How the Food and Drug Administration Drug Approval Process Relates to the Potential Approval of Intravenous Racemic Ketamine for Treatment-resistant Major Depression. (Pubmed Central) - Mar 29, 2024
This column focuses specifically on whether generally small-scale studies done in academic centers are sufficient for drug approval, and it briefly reviews lithium and clozapine as examples of psychiatric medications that had such academic research in the literature, as well as clinical use in other countries...While safety concerns were specifically addressed in the registration trials for esketamine, comparable research remains to be done for intravenous racemic ketamine. Understanding how the FDA's drug approval process works is important for prescribers, their patients, and the public.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: A case of pregnancy with severe polyhydramnios related to long-term use of lithium. (Pubmed Central) - Mar 26, 2024
This case report contributes to the limited literature on the subject and gives doctors practical advice that may help them make a better risk-benefit analysis. Further research is warranted in order to refine risk assessment protocols and management strategies in this complex clinical scenario.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: High lithium serum level as maintenance treatment of rapid cycling bipolar disorder (Pubmed Central) - Mar 25, 2024
Only after lithium was introduced as a maintenance treatment at a level of around 1.20 mmol/l, a long-term stabilization of mood developed which also persisted. A literature review was performed which concluded that maintenance treatment with lithium at levels above 1.0 mmol/l in patients with rapid cycling bipolar disorder has not been adequately studied.
- |||||||||| lithium carbonate ER / Generic mfg., desmopressin / Generic mfg.
A Case of Diabetes Insipidus Masked by Severe Hyponatremia () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_571;
Hyponatremia is not typically seen in patients with DI. DI should be considered in any patient on lithium, regardless of sodium levels.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Exacerbation of Darier disease with lithium therapy. (Pubmed Central) - Mar 17, 2024
In consultation with the patient's psychiatrist, lithium was tapered, leading to rapid improvement in her skin. This case highlights the potential for lithium to complicate management of Darier disease and underscores the need for dermatologists to collaborate with psychiatrists to optimize both cutaneous and mental health in patients.
- |||||||||| lithium carbonate ER / Generic mfg., carbimazole / Generic mfg.
APATHETIC THYROTOXICOSIS DUE TO GRAVE'S DISEASE AND MULTI NODULAR GOITER PRESENTING WITH HYPERCALCEMIA () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_657;
Due to the apathetic nature of thyrotoxicosis and associated non PTH mediated hypercalcemia, extensive malignancy screening was performed to rule out hypercalcemia of malignancy. Normalization of calcium level with euthyroidism confirmed thyrotoxicosis as the cause of hypercalcemia.
- |||||||||| lithium carbonate ER / Generic mfg.
Trends in Service Utilization Among Youth Within the Child Welfare System (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_3390;
The number of MH diagnoses increased from 38.1% to 53.7%. We found significant increases in common disorders including ADHD, autism, adjustment disorders, communication and learning disorders, depression, intellectual disability, and specifically anxiety diagnoses which surged from 4.0% to 13.6%.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Effectiveness of ultra-long-term lithium treatment: relevant factors and case series. (Pubmed Central) - Mar 15, 2024
The authors of the paper reckon that in the case of good response, lithium can be given indefinitely. Given the appropriate candidates for such therapy and successful management of the adverse effects, ultra-long term lithium therapy is possible and beneficial for such patients.
- |||||||||| lithium carbonate ER / Generic mfg.
Enrollment open: BLISS: The Bipolar Lithium Imaging Scan Study. (clinicaltrials.gov) - Mar 13, 2024
P=N/A, N=80, Recruiting,
Given the appropriate candidates for such therapy and successful management of the adverse effects, ultra-long term lithium therapy is possible and beneficial for such patients. Not yet recruiting --> Recruiting
- |||||||||| lithium carbonate ER / Generic mfg.
Progress towards the development of a lithium ion selective nanosensor (Hybrid; Room 239 (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_2479;
To address this gap the creation of home monitoring devices is highly desirable so patients and their care takers can monitor levels more closely and frequently. This work reports on the progress in the development of a Li + selective iron oxide nanoparticle coated electrode to measure Li + concentrations with a potentiostat.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Prevention of suicidal behavior with lithium treatment in patients with recurrent mood disorders. (Pubmed Central) - Mar 9, 2024
We summarize results of a growing number of randomized, controlled studies of lithium treatment for suicide prevention including comparisons with placebos or alternative treatments, and comment on the severe challenges of such trials. The basis of a proposed protective effect of lithium against suicidal behaviors remains uncertain but may include protective effects against recurrences of depressive phases of mood disorders, especially with mixed features or agitation, and possibly through beneficial effects on impulsivity, agitation and dysphoric mood.
- |||||||||| lithium carbonate ER / Generic mfg., cinacalcet HCl / Generic mfg.
CASE REPORT: SUCCESSFUL TREATMENT OF LITHIUM-INDUCED HYPERPARATHYROIDISM (LIH) THROUGH THE USE OF CINACALCET (SUN-338; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1880;
It should be taken into account when diagnosing that the spectrum of LIH is broad and includes cases of obvious hyperparathyroidism, as well as forms with isolated hypercalcemia and without elevated PTH levels, or elevated PTH without hipercalcemia and hypocalciura. The reported case shows the effectiveness of pharmacological therapy based on the known modulating effects of calcimimetic drugs on the calcium sensing receptor, being of importance in patients without the possibility of reducing or definitive interreuption of lithium treatment.
|
