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Review, Journal: Intracellular Effects of Lithium in Aging Neurons. (Pubmed Central) - Jul 21, 2024
has also been established. The purpose of this review is to summarize some of the intracellular mechanisms related to lithium activity and how, through them, neuronal aging could be controlled.
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Journal, Adherence: Treatment of bipolar depression: clinical practice vs. adherence to guidelines-data from a Bavarian drug surveillance project. (Pubmed Central) - Jul 17, 2024
Of the patients, 38% were not administered any drug explicitly recommended for treatment of BPD, that is, quetiapine, lamotrigine, carbamazepine, or olanzapine...Prescription rates of venlafaxine (21% to 14%) and tricyclic antidepressants (9% to 6%) decreased significantly from the first (2014-2016) to the last (2020-2022) observed time period...Only two patients were administered a combination of olanzapine and fluoxetine...Increase in lithium prescription is an encouraging development due to its unique efficacy in maintenance treatment. To improve the quality of clinical practice guideline implementation, more randomized controlled trials should
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Journal: Iloperidone (Fanapt) - a new indication for bipolar disorder. (Pubmed Central) - Jul 15, 2024
To improve the quality of clinical practice guideline implementation, more randomized controlled trials should No abstract available
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Journal: Hydrocarbon Formation from Syngas with In-Operando Monitoring of Cobalt- and Manganese-Based (pre)Catalysts Using X-ray Diffraction. (Pubmed Central) - Jul 15, 2024
Reaction with syngas resulted in the generation of carbon, cobalt carbide, and lithium carbonate, in addition to the metallic cobalt phases...The best conversions were observed for the LiCoO2 precursor catalyst, with generally a low olefin-to-paraffin ratio. While the conversions for the cobalt-doped birnessite precatalyst were generally lower, with lower chain lengths (up to C5), these catalysts gave a strikingly high olefin-to-paraffin ratio: in the best case, greater than 20:1.
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Journal: New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (Pubmed Central) - Jul 10, 2024
Although the definitive causal link cannot be established, this case report suggests an increased seizure risk with combination of LSD and lithium, even at subtherapeutic serum lithium levels. This case emphasizes the need for further research, careful clinical practice, and patient education regarding the potential dangers of using psychedelic substances with psychopharmacological treatment.
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Journal: Lithium Induced Amenorrhea: A First Case Report. (Pubmed Central) - Jul 9, 2024
Clinicians should be aware of this potential side effect and monitor patients accordingly. Further studies are needed to confirm and understand this potential link.
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Journal: The 'LSVEC problem' for the Vienna Peedee belemnite carbon isotope-delta scale. (Pubmed Central) - Jun 26, 2024
Since 2016 there have been intense discussions within several established communities and networks regarding the consequences of the withdrawal of the LSVEC lithium carbonate reference material for carbon isotope-delta measurement calibration...The information herein was used as a foundation for discussions at the 2024 IAEA Consultancy Meetings on the Development of IAEA Stable Isotope Reference Materials and Related Products and on the Definition and Realisation of the Isotopic Delta Scales for Light Elements (22-26 January 2024, Vienna, Austria). A summary of those 2024 meetings and associated outcomes can be found elsewhere.
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Review, Journal: Bipolar disorder and Lewy body dementia: case report and literature review. (Pubmed Central) - Jun 19, 2024
Moreover, patients with BD have been suggested to have an elevated risk of developing Parkinson's disease (PD), and the pathophysiological relationship between BD and PD may be attributed to dopamine dysregulation resulting from multiple relapses. Future research is imperative to identify strategies for preventing dementia in patients with BD and to develop interventions for the comorbidities of BD and DLB.
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Journal: Lithium versus anticonvulsants and the risk of physical disorders - Results from a comprehensive long-term nation-wide population-based study emulating a target trial. (Pubmed Central) - Jun 17, 2024
In both Cohorts 1 and 2, there were no systematic statistically significant differences in associations between sustained use of lithium versus lamotrigine and valproate, respectively, and any physical disorder, including subtypes of disorders, except myxedema, for which exposure to lithium increased the absolute risk of myxedema with 7-10 % compared with lamotrigine or valproate. In conclusion, these analyses emulating a target trial of "real world" observational register-based data show that lithium does not increase the risk of developing any kind of physical disorders, except myxedema, which may be a result of detection bias.
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Journal: Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder. (Pubmed Central) - Jun 16, 2024
The lower RORs for suicide attempt with ketamine and esketamine is noted but cannot, given the limitations of the database, be interpreted as a direct therapeutic effect. These results suggest potential for new treatment strategies in BD, such as Akt activators in LR cases, and the use of AMPK activators for LNR patients with BD.
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Journal: Exploring the genetics of lithium response in bipolar disorders. (Pubmed Central) - Jun 12, 2024
Lithium attenuates neuroinflammation and neuronal toxicity as well as protects the brain from edema, hippocampal neurodegeneration, loss of hemispheric tissues, and enhanced memory as well as spatial learning after TBI. Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.
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Enrollment open: LiLa-Bipolar: Lithium Versus Lamotrigine in Bipolar Disorder, Type II (clinicaltrials.gov) - Jun 6, 2024
P4, N=200, Recruiting,
Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II. Not yet recruiting --> Recruiting
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Journal: Catatonia Due to Lithium Neurotoxicity: A Case Report. (Pubmed Central) - Jun 6, 2024
If lithium neurotoxicity is suspected, rapid and appropriate intervention is required to prevent permanent neurological damage. Keywords: Lithium, Neurotoxicity, Catatonia.
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Journal: Human brain 7Li-MRI following low-dose lithium dietary supplementation in healthy participants. (Pubmed Central) - May 30, 2024
7Li-MRI performed using a clinical 3T scanner demonstrated detection of lithium in the brain at very low concentration, in the range of approximately 10-60?mM. The methods are suited to studies assessing low dose lithium administration in psychiatric and neurodegenerative disorders, and permit the comparison of different lithium salt preparations at a time of emerging interest in the field.
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Journal: Adolescent and Adult Transitions From Major Depressive Disorder to Bipolar Disorder. (Pubmed Central) - May 29, 2024
These findings suggest that adolescents may experience delayed BD progression and that diagnosis substantially reduced inpatient care in all age groups, which coincided with a reduction in the use of antidepressants. These findings may inform pharmacologic strategies in patients with first-episode MDD at risk for BD.
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Review, Journal: Depression: Managing Resistance and Partial Response to Treatment. (Pubmed Central) - May 28, 2024
Ketamine and esketamine can also be used as augmentation for treatment-resistant depression and may help reduce suicidal ideation...Pharmacogenetic testing has limited evidence and is not recommended. Nonpharmacologic therapies include psychotherapy, exercise, and focused dietary changes.
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Enrollment closed, Trial completion date, Trial primary completion date: Lisphem: Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency) (clinicaltrials.gov) - May 28, 2024
P3, N=22, Active, not recruiting,
Nonpharmacologic therapies include psychotherapy, exercise, and focused dietary changes. Recruiting --> Active, not recruiting | Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025
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Journal: Mortality risk and mood stabilizers in bipolar disorder: a propensity-score-weighted population-based cohort study in 2002-2018. (Pubmed Central) - May 23, 2024
Our data showed that olanzapine and risperidone were associated with higher mortality risk than lithium, and further supported the clinical guidelines recommending lithium as the first-line mood-stabilizer for BD. Future research is required to further clarify comparative mortality risk associated with individual SGA agents to facilitate risk-benefit evaluation of alternative mood-stabilizers to minimize avoidable premature mortality in BD.
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Journal: Optical Coherence Tomography Findings in Bipolar Disorder Patients and the Related Factors. (Pubmed Central) - May 20, 2024
As a result of the study, it was established that neurodegenerative processes play a role in the pathophysiology of BD and the usage of Li is protective against the neurodegeneration of RNFL. Retinal changes measured with SD-OCT can be used for the diagnosis and prognosis of BD and for evaluating responses to mood stabilizers.
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Observational data, Journal: The influence of chronic inflammation on the illnesscourse of bipolar disorder: A longitudinal study. (Pubmed Central) - May 17, 2024
Individuals who were exposed to a higher level of inflammation over time suffered from more manic symptoms in this period. These findings underline the hypothesis that inflammatory processes have an accumulative influence on the illness course of BD, especially concerning manic symptoms and episodes.
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Journal: Analysis of Trace Impurities in Lithium Carbonate. (Pubmed Central) - May 13, 2024
In conclusion, the precision of the new ICP-OES methodology renders it suitable for identifying and characterizing Li2CO3 impurities. It can effectively complement solid-state techniques such as XRD, SEM-EDX, and XPS.
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Trial completion date, Trial primary completion date: LATTICE: Lithium As a Treatment to Prevent Impairment of Cognition in Elders (clinicaltrials.gov) - May 9, 2024
P4, N=80, Active, not recruiting,
It can effectively complement solid-state techniques such as XRD, SEM-EDX, and XPS. Trial completion date: May 2024 --> Aug 2024 | Trial primary completion date: May 2024 --> Aug 2024
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Journal: Impaired neural stress resistance and loss of REST in bipolar disorder. (Pubmed Central) - May 8, 2024
Thus, an impaired cellular stress response in BD cerebral organoids leads to altered neural development and transcriptional dysregulation associated with downregulation of REST. These findings provide a new model and conceptual framework for exploring the molecular basis of BD.
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Journal: Investigating light sensitivity in bipolar disorder (HELIOS-BD). (Pubmed Central) - May 8, 2024
Further, we will assess whether individuals with bipolar disorder who are being treated with lithium have less pronounced light responses and attenuated retinal changes compared to individuals with bipolar disorder not being treated with lithium. This study represents a comprehensive investigation of visual and non-visual light responses in a large bipolar disorder population, with great translational potential for patient stratification and treatment innovation.
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Journal: Structure and dynamics of Li1.24K0.76CO3 molten carbonate electrolyte from molecular simulations with explicit polarization. (Pubmed Central) - May 7, 2024
Utilizing molecular dynamics with explicit polarization, we demonstrate that the structure of this molten mixture is characterized by a dense network of lithium-carbonate complexes, with K+ ions loosely embedded within this network...Moreover, our work highlights the importance of including polarization for the simulations of dense liquid carbonates. It also acts as a foundational step towards more advanced theoretical studies for elucidating the role of the electrolyte in these devices.
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Biomarker, Journal: Lithium-Associated Kidney Failure: Predictors and Outcomes. (Pubmed Central) - May 6, 2024
Despite this, there are no differences in survival. Given the lower rate of transplantation, barriers to transplantation need further exploration.
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Journal: Prevention of Suicidal Behavior in Bipolar Disorder. (Pubmed Central) - May 2, 2024
Improved understanding of risk and protective factors combined with knowledge and close follow-up of BD patients should limit suicidal risk. Ethically appropriate and scientifically sound studies of plausible medicinal, physical, and psychosocial treatments aimed at suicide prevention specifically for BD patients are urgently needed.Reprinted from Bipolar Disord 2021; 23:14-23, with permission from John Wiley and Sons.
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Journal: Bipolar Disorder Among Older Adults: Newer Evidence to Guide Clinical Practice. (Pubmed Central) - May 2, 2024
Clinicians and health care systems need to be prepared to provide care and services to individuals with bipolar disorder throughout the life span. Although older adults have typically been excluded from bipolar disorder RCTs, emerging efforts organized by global advocates and harnessing teams of clinicians and scientists have the potential to advance care.
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Review, Journal: Treatment of Bipolar Disorders in Older Adults: A Review. (Pubmed Central) - May 2, 2024
There is an obvious need of further research for all treatment modalities of BD in old age. The focus should be pharmacological and psychosocial approaches, as well as their combination, and the role of physical treatment modalities such as ECT.Appeared originally in Ann Gen Psychiatry 2021; 20:1.
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Review, Journal: New pharmacotherapies to tackle the unmet needs in bipolar disorder: a focus on acute suicidality. (Pubmed Central) - Apr 28, 2024
To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results...This may be achieved through prompt remodulation of glutamate activity. The correct use of glutamatergic modulators could reduce acute suicidality and mortality in patients with BD.
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Journal: Sensitivity to light in bipolar disorder: implications for research and clinical practice. (Pubmed Central) - Apr 23, 2024
Circadian dysfunction is a core feature of bipolar disorder and may be due, at least in part, to abnormalities of non-visual photoreception. We critically review the evidence for light hypersensitivity in bipolar disorder and discuss how this may shape future research and clinical innovation, with a focus on a possible novel mechanism of action for lithium.
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Journal: Cognition in older age bipolar disorder: An analysis of archival data across the globe. (Pubmed Central) - Apr 22, 2024
We critically review the evidence for light hypersensitivity in bipolar disorder and discuss how this may shape future research and clinical innovation, with a focus on a possible novel mechanism of action for lithium. More research is needed to understand heterogenous longitudinal patterns of cognitive change in BD and understand whether particular cognitive domains might be affected in OABD in order to develop new therapeutic efforts for cognitive dysfunction OABD.
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