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- || lithium carbonate ER / Generic mfg., tranylcypromine / Generic mfg.
New P2/3 trial, Head-to-Head: Efficacy of Tranylcypromine (TCP) in daily doses up to 60mg and the combination of lithium and antidepressants (Li.-Aug.) in the acute treatmet of therapy-resistant Depression. In this study the assignment to the treatment groups (TCP or Li.-Aug.) is made by chance. Physicians and participants know which treatment is applicated. If a planned interim-analysis reveals no superiority of TCP the study will be terminated previously. Wirksamkeit von Tranylcypromin (TCP) (bis 60mg/Tag) und der Kombination von Lithium und Antidepressiva (Li.-Aug.) in der Behandlung der unipolaren Depression. Die Zuordnung zu den Behandlungsgruppen (TCP oder Li.-Aug.) erfolgt zuf (EUDRACT) - Sep 16, 2013
P2/3, N=71, Ongoing, Sponsor: Charit
- lithium carbonate ER / Generic mfg.
New P4 trial: Longitudinal Study on the Neuroprotective and Neurotrophic Effects of Lithium (clinicaltrials.gov) - Aug 7, 2013
P4, N=30, Completed, Sponsor: University of Sao Paulo
- lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
Enrollment open: Ketamine Plus Lithium in Treatment-Resistant Depression (clinicaltrials.gov) - Jul 17, 2013
P2, N=45, Recruiting, Sponsor: Mount Sinai School of Medicine
Not yet recruiting --> Recruiting
- | New P4 trial: Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania (clinicaltrials.gov) - Jul 4, 2013
P4, N=120, Recruiting, Sponsor: Guiyun Xu
- lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
New P2 trial: Ketamine Plus Lithium in Treatment-Resistant Depression (clinicaltrials.gov) - Jun 17, 2013
P2, N=45, Recruiting, Sponsor: Mount Sinai School of Medicine
- lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
Enrollment closed: Continuation Ketamine in Major Depression (clinicaltrials.gov) - Jun 17, 2013
P1, N=36, Active, not recruiting, Sponsor: James Murrough
Not yet recruiting --> Recruiting Enrolling by invitation --> Active, not recruiting
- lithium carbonate ER / Generic mfg.
Trial completion: Indicated Prevention of Psychotic Disorders With Low-dose Lithium (clinicaltrials.gov) - May 27, 2013
P4, N=30, Completed, Sponsor: Melbourne Health
Enrolling by invitation --> Active, not recruiting Recruiting --> Completed
- | lithium carbonate ER / Generic mfg.
New P2 trial: Study to Evaluate the Efficacy of Lithium Carbonate in Spinal Cord Injury Patients With Neuropathic Pain (clinicaltrials.gov) - May 14, 2013
P2, N=60, Recruiting, Sponsor: China Spinal Cord Injury Network
- | lithium carbonate ER / Generic mfg.
Enrollment change: Bipolar II Depression: Lithium, SSRI, or the Combination (clinicaltrials.gov) - May 7, 2013
P3, N=139, Completed, Sponsor: Lindner Center of HOPE
Recruiting --> Completed N=70 --> 139
- | lithium carbonate ER / Generic mfg.
Trial completion: Bipolar II Depression: Lithium, SSRI, or the Combination (clinicaltrials.gov) - May 7, 2013
P3, N=139, Completed, Sponsor: Lindner Center of HOPE
N=70 --> 139 Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
Enrollment open: Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (clinicaltrials.gov) - May 1, 2013
P1, N=24, Recruiting, Sponsor: Paolo Caimi, MD
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- lithium carbonate ER / Generic mfg.
New P1 trial: Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (clinicaltrials.gov) - Mar 27, 2013
P1, N=24, Recruiting, Sponsor: Paolo Caimi, MD
- lithium carbonate ER / Generic mfg.
Enrollment closed: FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder (clinicaltrials.gov) - Mar 3, 2013
P4, N=120, Active, not recruiting, Sponsor: Indiana University
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- lithium carbonate ER / Generic mfg., paroxetine / Generic mfg.
Trial termination: Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide (clinicaltrials.gov) - Feb 25, 2013
P3, N=2, Terminated, Sponsor: Capital District Health Authority, Canada
Recruiting --> Active, not recruiting Recruiting --> Terminated; Recruitment difficulties
- lithium carbonate ER / Generic mfg., paroxetine / Generic mfg.
Enrollment change: Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide (clinicaltrials.gov) - Feb 25, 2013
P3, N=2, Terminated, Sponsor: Capital District Health Authority, Canada
Recruiting --> Terminated; Recruitment difficulties N=20 --> 2
- | lithium carbonate ER / Generic mfg.
Trial completion: Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 (clinicaltrials.gov) - Jan 28, 2013
P2/3, N=62, Completed, Sponsor: Hospital de Clinicas de Porto Alegre
N=20 --> 2 Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
New P2 trial, Adverse events: Trial of Ketamine and Lithium Therapy in Bipolar Depression (clinicaltrials.gov) - Jan 13, 2013
P2, N=0, Withdrawn, Sponsor: Yale University
- lithium carbonate ER / Generic mfg.
Trial completion: LISCA2: Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2) (clinicaltrials.gov) - Jan 6, 2013
P2, N=20, Completed, Sponsor: Federico II University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
New P1 trial: Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study (clinicaltrials.gov) - Dec 19, 2012
P1, N=50, Recruiting, Sponsor: VA Eastern Colorado Health Care System
- lithium carbonate ER / Generic mfg.
Enrollment change: LISLA: Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis (clinicaltrials.gov) - Oct 29, 2012
P2, N=23, Completed, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed N=200 --> 23
- lithium carbonate ER / Generic mfg.
Trial completion: LISLA: Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis (clinicaltrials.gov) - Oct 29, 2012
P2, N=23, Completed, Sponsor: Assistance Publique - H
N=200 --> 23 Not yet recruiting --> Completed
- | lithium carbonate ER / Generic mfg.
New P4 trial: Li2CO3: Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma (clinicaltrials.gov) - Aug 19, 2012
P4, N=400, Not yet recruiting, Sponsor: Sun Yat-sen University
- simvastatin / Generic mfg., lithium carbonate ER / Generic mfg.
Enrollment open: Simvastatin Augmentation of Lithium Treatment in Bipolar Depression (clinicaltrials.gov) - Aug 16, 2012
P2, N=30, Recruiting, Sponsor: Massachusetts General Hospital
Not yet recruiting --> Completed Not yet recruiting --> Recruiting
- simvastatin / Generic mfg., lithium carbonate ER / Generic mfg.
New P2 trial: Simvastatin Augmentation of Lithium Treatment in Bipolar Depression (clinicaltrials.gov) - Aug 14, 2012
P2, N=30, Recruiting, Sponsor: Massachusetts General Hospital
- ||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Trial completion: PREVAIL3: Lurasidone HCI - A 6-week Phase 3 Study of Patients With Bipolar I Depression (clinicaltrials.gov) - Aug 12, 2012
P3, N=356, Completed, Sponsor: Sunovion
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
Enrollment open: In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects (clinicaltrials.gov) - Jun 20, 2012
P1, N=20, Recruiting, Sponsor: Capital District Health Authority, Canada
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- lithium carbonate ER / Generic mfg.
Enrollment open: Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain (clinicaltrials.gov) - May 1, 2012
P1/2, N=26, Recruiting, Sponsor: Washington University School of Medicine
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- | lithium carbonate ER / Generic mfg.
New P4 trial: SMART: Sequential Multiple Assignment Treatment for Bipolar Disorder (clinicaltrials.gov) - Apr 29, 2012
P4, N=200, Recruiting, Sponsor: The University of Texas Health Science Center at San Antonio
- | lithium carbonate ER / Generic mfg., divalproex sodium XR / Generic mfg., quetiapine / Generic mfg.
Enrollment change: Treatment of Mania Symptoms With Drug Therapy (clinicaltrials.gov) - Apr 24, 2012
P3, N=75, Completed, Sponsor: Palo Alto Institute for Research and Education, Inc
Not yet recruiting --> Recruiting N=105 --> 75
- lithium carbonate ER / Generic mfg.
New P1 trial: In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects (clinicaltrials.gov) - Mar 27, 2012
P1, N=20, Recruiting, Sponsor: Capital District Health Authority, Canada
- lithium carbonate ER / Generic mfg.
New P1/2 trial: Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain (clinicaltrials.gov) - Mar 12, 2012
P1/2, N=26, Recruiting, Sponsor: Washington University School of Medicine
- lithium carbonate ER / Generic mfg.
New P4 trial: Neural Correlates for Therapeutic Mechanisms of Lithium in Bipolar Disorder (clinicaltrials.gov) - Feb 27, 2012
P4, N=50, Recruiting, Sponsor: Seoul National University Hospital
- lithium carbonate ER / Generic mfg.
Trial termination: Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases (clinicaltrials.gov) - Feb 25, 2012
P1, N=9, Terminated, Sponsor: Vanderbilt-Ingram Cancer Center
N=105 --> 75 Completed --> Terminated; low accrual
- | lithium carbonate ER / Generic mfg., quetiapine / Generic mfg.
New P4 trial: Gao Bipolar Spectrum Lithium/Quetiapine Study (clinicaltrials.gov) - Feb 1, 2012
P4, N=60, Recruiting, Sponsor: University Hospital Case Medical Center
- ||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Trial completion: Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on) (clinicaltrials.gov) - Jan 19, 2012
P3, N=348, Completed, Sponsor: Sunovion
Completed --> Terminated; low accrual Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
Trial completion: Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury (clinicaltrials.gov) - Jan 12, 2012
P1, N=20, Completed, Sponsor: The University of Hong Kong
Active, not recruiting --> Completed Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
Trial completion: Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer (clinicaltrials.gov) - Jan 3, 2012
P2, N=34, Completed, Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting --> Completed Active, not recruiting --> Completed
- lithium carbonate ER / Generic mfg.
Trial termination: LAMU: Lithium in Multiple System Atrophy (clinicaltrials.gov) - Dec 18, 2011
P2, N=10, Terminated, Sponsor: Federico II University
Active, not recruiting --> Completed Active, not recruiting --> Terminated; Data Monitoring Committee decision on 22nd August 2011 for safety issues
- lithium carbonate ER / Generic mfg.
Enrollment change: LAMU: Lithium in Multiple System Atrophy (clinicaltrials.gov) - Dec 18, 2011
P2, N=10, Terminated, Sponsor: Federico II University
Active, not recruiting --> Terminated; Data Monitoring Committee decision on 22nd August 2011 for safety issues N=40 --> 10
- lithium carbonate ER / Generic mfg.
New P1/2 trial: Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury (clinicaltrials.gov) - Nov 13, 2011
P1/2, N=16, Completed, Sponsor: China Spinal Cord Injury Network
- lithium carbonate ER / Generic mfg.
Trial completion: Functional Connectivity in Mood Regulating Circuit In Bipolar Depression and Mania (clinicaltrials.gov) - Sep 26, 2011
P4, N=60, Completed, Sponsor: Indiana University School of Medicine
N=40 --> 10 Active, not recruiting --> Completed
- | lithium carbonate ER / Generic mfg., paroxetine / Generic mfg.
New P4 trial: Lithium Versus Paroxetine in Major Depression (clinicaltrials.gov) - Aug 10, 2011
P4, N=76, Not yet recruiting, Sponsor: Capital District Health Authority, Canada