- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Lithium - past, present, future. (Pubmed Central) - Aug 18, 2021
Despite the evidence for the efficacy and added favourable properties, lithium is greatly underutilised in mood disorders. Challenging a scepticism about the use of lithium and optimising its long-term administration can make more patients with mood disorders the beneficiaries of lithium's therapeutic action.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Trinuclear Calcium Site in the C2 Domain of PKCα/γ Is Prone to Lithium Attack. (Pubmed Central) - Aug 17, 2021
Here, using density functional theory calculations combined with continuum dielectric methods, we show that Li may displace the native dication from the positively charged trinuclear site in the C2 domain of cytosolic PKCα/γ. This would affect the membrane-docking ability of cytosolic PKCα/γ and reduce the abnormally high membrane-associated active PKCα/γ levels, thus downregulating the PKC hyperactivity found in bipolar patients.
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Review, Journal: Epigenetics in bipolar disorder: a critical review of the literature. (Pubmed Central) - Aug 15, 2021
This would affect the membrane-docking ability of cytosolic PKCα/γ and reduce the abnormally high membrane-associated active PKCα/γ levels, thus downregulating the PKC hyperactivity found in bipolar patients. Epigenetic is a growing and promising field in BD that may shed light on its pathophysiology or be useful as biomarkers of response to mood-stabilizer.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: FROZEN! Intracellular multi-electrolyte analysis measures millimolar lithium in mammalian cells. (Pubmed Central) - Aug 13, 2021
will greatly facilitate research in intracellular electrolyte balance during drug treatment, or other physiological stresses. In particular, the cell isolation and preservation steps can be easily performed by many laboratories worldwide, after which the samples are sent to an analytical laboratory for electrolyte analysis.
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Clinical, Journal: Pre-diagnostic and post-diagnostic psychopharmacological treatment of 16,288 patients with bipolar disorder. (Pubmed Central) - Aug 11, 2021
The increased use of two or more antidepressants suggests more focus on bipolar disorder as a differential diagnosis to treatment-resistant unipolar depression. The decreased use of lithium (consistent with international trends) and the prevalent use of antidepressants without overlapping treatment with a drug with mood-stabilizing properties is concerning.
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Clinical, Journal: Tolerability of lithium: a naturalistic discontinuation study in older inpatients (≥60 years). (Pubmed Central) - Aug 11, 2021
In terms of clinical guidelines evidence, there is a need for more efficacious treatment strategies for the prevention of bipolar depression. - We found a frequency of 36.3% lithium discontinuation after follow-up of median 18 month in our cohort of older inpatients (≥60 years), well within the range of frequencies reported in younger patients - Not adverse effects but other reasons (e.g. lack of effectiveness, non-compliance) were most commonly mentioned for discontinuation of lithium in our cohort; - Older age itself should not be a reason to withhold treatment with lithium; - Education and reframing of both doctors and patients might improve adherence and thereby reduce potentially unnecessary discontinuations.
- |||||||||| lithium carbonate ER / Generic mfg., risperidone / Generic mfg., amisulpride / Generic mfg.
Journal: Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia. (Pubmed Central) - Aug 8, 2021
In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h. Genome-wide mRNA expression was quantified and analyzed using gene set enrichment analysis (GSEA), with genes belonging to Hippo, Wnt, Notch, TGF- β, and Hedgehog retrieved from the KEGG database...Thirty-six compounds were identified. The presence of antidepressants and antipsychotics validates our approach and reveals possible new targets for drug repurposing.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome. (Pubmed Central) - Aug 7, 2021
We examined the associations between staging and predominant polarity with measures of illness burden and treatment outcome utilizing data from a six-month comparative effectiveness trial of lithium and quetiapine in bipolar disorder (Bipolar CHOICE)...In conclusion, though staging and predominant episode polarity correlated with several measures of illness burden, they were not associated with differential treatment outcomes. This could be because many of our patients presented for treatment at advanced stages of illness and further highlights the need for early intervention in bipolar disorder.
- |||||||||| lurasidone / Generic mfg.
Clinical, Journal: Lurasidone in the long-term treatment of Japanese patients with bipolar I disorder: a 52 week open label study. (Pubmed Central) - Aug 4, 2021
P3
Long-term treatment with lurasidone 20-120 mg/day for Japanese patients with bipolar disorder maintained improvements in depressive symptoms for depressed patients who were treated in a prior 6 week trial and led to improvements in manic symptoms among a newly recruited subgroup of patients with a recent/current manic, hypomanic, or mixed episode. Few changes in weight or metabolic parameters were evident.
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Clinical, Journal: Bipolar disorder: Treatment strategies for women of childbearing age. (Pubmed Central) - Aug 4, 2021
Few changes in weight or metabolic parameters were evident. Caring for patients with bipolar disorder, particularly women of childbearing age, requires careful differentiation of bipolar disorder from other mental health problems, and prudent consideration of pharmacotherapeutic options.
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Preclinical, Journal: The P2X7 receptor in activated microglia promotes depression- and anxiety- like behaviors in lithium -pilocarpine induced epileptic rats. (Pubmed Central) - Aug 1, 2021
More importantly, direct anti-depressive and anti-anxiety effects were produced by the P2X7R antagonist Brilliant Blue G (BBG) is in this study, and the effect was similar to that of the classic anti-depressant and anti-anxiety drug fluoxetine...Thus, our data provide evidence that the P2X7R in activated microglia promotes depression- and anxiety-like behaviors in lithium-pilocarpine induced epileptic rats. Since previous studies have indicated that some anti-depression and anti-anxiety drugs may exacerbate seizures, our data support that the P2X7R is a promising therapeutic target for epilepsy associated with depression and anxiety.
- |||||||||| risperidone / Generic mfg., clozapine / Generic mfg.
Clinical, Review, Journal: Use of N-Acetylcysteine for Clozapine-Induced Acute Liver Injury: A Case Report and Literature Review. (Pubmed Central) - Jul 22, 2021
Purpose: To report a case of clozapine-induced hepatotoxicity managed with intravenous (IV) N-acetylcysteine (NAC) and summarize the available literature...The patient had been initiated on risperidone, clozapine, and lithium approximately 1 month prior to admission...NAC was used in our patient after considering the potential benefit and limited adverse effects. The role of NAC in non-acetaminophen-induced acute liver failure remains promising, but more research is warranted.
- |||||||||| ebselen (SPI-1005) / Sound Pharma
Journal: Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase. (Pubmed Central) - Jul 11, 2021
IMPase is a dimeric enzyme and in the crystal structure two adjacent dimers share four ebselen molecules, creating a tetramer with approximate 222 symmetry. In the crystal structure presented in this publication, the active site in the tetramer is still accessible, suggesting that ebselen may function as an allosteric inhibitor or may block the binding of partner proteins.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Advances in the psychopharmacotherapy of bipolar disorder type I. (Pubmed Central) - Jul 11, 2021
There are new indications for the use of cariprazine, for bipolar mania and depression, and a long-acting injectable formulation of aripiprazole has also been approved for relapse prevention in bipolar illness...Over the same time period (1990 - 2017), disability-adjusted life years (DALYs) increased by 54.4%, from 6.02 million in 1990 to 9.29 million in 2017 which is greater than the 47.74% increase in incidence of the disease, suggesting that the changes in prescribing patterns have not been helpful for our patients. Furthermore, recent effectiveness studies continue to confirm the superiority of lithium and other mood stabilizers in the management of bipolar illness for both psychiatric and medical outcomes, reaffirming their role as foundational treatments in the management of type I bipolar disorder.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Review, Journal: Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment. (Pubmed Central) - Jul 11, 2021
Lamotrigine and lurasidone could be considered in bipolar depression...Combined psychosocial and pharmacological treatments also appear to be a treatment of choice for OABD. More research is needed on the optimal pharmacological and psychosocial approaches to OABD, as well as their combination and ranking in an evidence-based therapy algorithm.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Review, Journal: The Challenges of Children with Bipolar Disorder. (Pubmed Central) - Jul 11, 2021
Lithium and atypical antipsychotics are effective in mania, but treatment of depression remains obscure, with the exception of lurasidone, for children ages 10-17...Cognitive dysfunction after a first manic hospitalization improves over the next year only on the condition that no further episodes occur. Yet comprehensive expert treatment after an initial manic hospitalization results in many fewer relapses than traditional treatment as usual, emphasizing the need for combined pharmacological, psychosocial, and psycho-educational approaches to this difficult and highly recurrent illness.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis. (Pubmed Central) - Jul 10, 2021
In addition to her stable mood, there has been no symptomatic progression or relapse of her MS, and her daughter continues to develop normally.The case supports consideration of balancing lithium's mood-stabilizing benefit with its known teratogenic risk during pregnancy. The case also supports exploration of possible additional benefit in the context of MS co-occurring with bipolar disorder.
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Trial completion date, Trial primary completion date: LATTICE: Lithium As a Treatment to Prevent Impairment of Cognition in Elders (clinicaltrials.gov) - Jul 9, 2021
P4, N=80, Recruiting,
The case also supports exploration of possible additional benefit in the context of MS co-occurring with bipolar disorder. Trial completion date: May 2023 --> May 2024 | Trial primary completion date: May 2023 --> May 2024
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Similarities and Differences Across Bipolar Disorder Subtypes Among Adolescents. (Pubmed Central) - Jul 9, 2021
Present findings support and extend knowledge regarding the course and outcome of bipolar youth study operationalized definition of BD-NOS. Further research is warranted to evaluate intermediate phenotypes and treatment strategies that address these subtype-related differences.
- |||||||||| lithium carbonate ER / Generic mfg.
Trial completion date, Trial primary completion date: Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder (clinicaltrials.gov) - Jul 6, 2021
P=N/A, N=120, Recruiting,
This strategy showed an innovative potential for evaluating mood disorders at the proteomic level, making it possible to identify proteins related to mood disorders and BD. Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Aug 2021 --> Aug 2024
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Spray Flame Synthesis (SFS) of Lithium Lanthanum Zirconate (LLZO) Solid Electrolyte. (Pubmed Central) - Jul 4, 2021
The resulting materials were all tetragonal LLZO (I4/acd) instead of the intended cubic phase, suggesting that an intimate intermixing of the Li precursor during the spray-flame synthesis is mandatory to form a nanoscale product. Based on these results, we propose a model to describe the spray-flame based synthesis process, considering the precipitation of LZO and the subsequent condensation of lithium carbonate on the particles' surface.
- |||||||||| lithium carbonate ER / Generic mfg., lorazepam / Generic mfg.
Clinical, Journal: Case of refractory delirious mania responsive to lithium. (Pubmed Central) - Jun 30, 2021
We present a case of delirious mania refractory to high doses of lorazepam, several antipsychotics and valproic acid, which responded dramatically to therapy with lithium after 26 days of minimal improvement with the other medications. The pathophysiology of delirious mania is reviewed, and the unique actions of lithium are discussed, highlighting possible reasons as to why lithium might offer advantages in the treatment of this disease.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Using mitochondrial respiration inhibitors to design a novel model of bipolar disorder-like phenotype with construct, face and predictive validity. (Pubmed Central) - Jun 30, 2021
Our model is among the very few BD-like animal models exhibiting construct (mild mitochondrial dysfunction), face (decreased/increased immobility time in the forced-swim test, increased/decreased consumption of sweet solution, increased/decreased time spent in the open arms of the elevated plus maze) and predictive (reversal of rotenone-induced behavioral changes by lithium treatment) validity. Our rotenone regime, employing doses that, to the best of our knowledge, have never been used before, differs from those inducing Parkinson's-like models by not affecting ROS-levels and cell-viability in vitro nor motor activity in vivo.
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