- |||||||||| lithium carbonate ER / Generic mfg.
Lithium severe poisoning due to urinary tract infection : a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4552;
She was medicated by irbesartan and cyamemazine...Serum lithium levels should be closely monitored in patients taking this drug. Besides, delayed neurological effects in lithium intoxication must be watched out for .
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium severe poisoning due to urinary tract infection : a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4551;
She was medicated by irbesartan and cyamemazine...Serum lithium levels should be closely monitored in patients taking this drug. Besides, delayed neurological effects in lithium intoxication must be watched out for .
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium severe poisoning due to urinary tract infection : a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4550;
She was medicated by irbesartan and cyamemazine...Serum lithium levels should be closely monitored in patients taking this drug. Besides, delayed neurological effects in lithium intoxication must be watched out for .
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Lithium treatment - the state of the art for 2020. (Pubmed Central) - Oct 1, 2021
The necessity of overcoming negative perceptions of lithium was pointed out to increase the number of possible beneficiaries of lithium treatment. Both introduction of lithium into modern psychiatry and its therapeutic effects have been reflected in literature and art.
- |||||||||| lithium carbonate ER / Generic mfg.
[VIRTUAL] Cerebellar atrophy secondary to lithium intoxication : about 2 cases () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_577;
Its toxic drug origin due to lithium in a context of encephalopathy, is potentially serious and causes irreversible sequelae. In its use, it is important to think about the complications and to intensify the monitoring of these patients and finally to detect them at the beginning stage to avoid permanent sequelae.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Journal: Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone. (Pubmed Central) - Sep 25, 2021
Carbamazepine may sometimes be the best or only viable treatment option for patients with bipolar illness or other conditions. When its use is complicated by syndrome of inappropriate ADH, dose reduction and fluid restriction are the simplest options but, if ineffective, addition of lithium may be a feasible, albeit somewhat complicated, alternative.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Lithium orotate: A superior option for lithium therapy? (Pubmed Central) - Sep 24, 2021
Unfortunately, the most frequently employed lithium salt, lithium carbonate (Li CO ), is associated with a host of adverse health outcomes following chronic use: these unwanted effects range from relatively minor inconveniences (e.g., polydipsia and polyuria) to potentially major complications (e.g., hypothyroidism and/or renal impairment)...LiOr is proposed to cross the blood-brain barrier and enter cells more readily than Li CO , which will theoretically allow for reduced dosage requirements and ameliorated toxicity concerns. This review addresses the controversial history of LiOr, complete with discussions of experimental and clinical efficacy, putative mechanisms of action, adverse effects, and its potential future in therapy.
- |||||||||| lithium carbonate ER / Generic mfg.
Retrospective data, Journal: Lithium concentration and recurrence risk during maintenance treatment of bipolar disorder: multicenter cohort and meta-analysis. (Pubmed Central) - Sep 24, 2021
This review addresses the controversial history of LiOr, complete with discussions of experimental and clinical efficacy, putative mechanisms of action, adverse effects, and its potential future in therapy. Although confounding by indication cannot be excluded, the combined results suggest a significant preventative effect on the recurrence of major affective episodes among those with serum levels of 0.4-0.8 mmol/l.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Review, Journal: Treatment of bipolar disorders in older adults: a review. (Pubmed Central) - Sep 23, 2021
There is an obvious need of further research for all treatment modalities of BD in old age. The focus should be pharmacological and psychosocial approaches, as well as their combination, and the role of physical treatment modalities such as ECT.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: The Role of the UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder. (Pubmed Central) - Sep 18, 2021
In this review, we outline a new perspective wherein mood stabilizers exert their therapeutic mechanism by activating the UPR. Furthermore, we discuss UPR abnormalities in BD patients and suggest future research directions to resolve discrepancies in the literature.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Lithium use in women with bipolar disorder during peripartum (Pubmed Central) - Sep 16, 2021
Risk and benefits of lithium use during the peripartum should be carefully considered, if possible prior to conception. Close monitoring of maternal lithium levels and renal function is necessary due to significant fluctuations during peripartum.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase. (Pubmed Central) - Sep 16, 2021
Furthermore, we report the INPP1/inositol 1,4-bisphosphate complex which illuminates key features of the enzyme active site. Our results provide insights into a structural basis for uncompetitive lithium inhibition, substrate recognition and define a sequence motif for metal binding within this family of regulatory phosphatases.
- |||||||||| verapamil / Generic mfg.
Retrospective data, Review, Journal: Systematic literature review and Bayesian network meta-analysis of episodic cluster headache drugs. (Pubmed Central) - Sep 16, 2021
The results suggest that galcanezumab is more effective compared to verapamil as a prophylaxis treatment for reducing eCH attacks in adults. Further, head-to-head RCTs of galcanezumab vs. treatments using in clinical practice are needed to better assess its comparative efficacy and benefit-risk profile.
- |||||||||| lithium carbonate ER / Generic mfg.
Retrospective data, Review, Journal: Effect of lithium on circadian rhythm in bipolar disorder: a systematic review and meta-analysis. (Pubmed Central) - Sep 12, 2021
However, we found that chronotype can be a potential target for further exploration of biomarkers or biosignatures of lithium treatment in patients with bipolar disorder. Further studies with prospective and longitudinal study design, adopting actigraphy to monitor daily circadian rest-activity changes are needed.
- |||||||||| ebselen (SPI-1005) / Sound Pharma
Journal: Cysteine modification by ebselen reduces the stability and cellular levels of 14-3-3 proteins. (Pubmed Central) - Sep 12, 2021
Significance Statement There is currently great interest in the repurposing of established drugs for new indications and therapeutic targets. This study shows that ebselen, which is a promising drug candidate against cancer, bipolar disorder and the virus infection Covid-19, covalently bonds to cysteine residues in 14-3-3 adaptor proteins, triggering 14-3-3 destabilization and degradation in cells and intact brain tissue when used in therapeutic concentrations, potentially explaining the behavioral and anti-neoplastic effects of this drug.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Stabilizing Lithium Metal Anodes by a Self-Healable and Li-Regulating Interlayer. (Pubmed Central) - Sep 11, 2021
A lithium sulfur (Li-S) cell that uses anodes shows a retention rate of 91% after 100 cycles with a high sulfur loading (5 mg cm). This study provides a novel strategy to concern the intrinsic drawbacks of a lithium metal anode, which can be extended to other light-metal electrodes aiming for high energy-density batteries.
- |||||||||| lithium carbonate ER / Generic mfg.
[VIRTUAL] Mesencephalic astrocyte derived neurotrophic factor mediates lithium induced neuroprotection () - Sep 10, 2021 - Abstract #CANACN2021CAN_ACN_220;
Our results show; (1) Protracted lithium treatment provides neuroprotection against thapsigargin-induced cell death...Taken together, these data suggest that lithium's neuroprotective mechanisms involve the modulation of pro-survival ER-resident proteins such as MANF through the AP-1 transcription factor. Knockout studies using the CRISPR-Cas9 system will determine the extent of MANF's involvement in lithium neuroprotection.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Lithium-associated hyperparathyroidism. (Pubmed Central) - Sep 10, 2021
Hence, regular monitoring of calcium levels in patients on lithium therapy is of paramount importance as early recognition of lithium-associated hyperparathyroidism can improve outcomes. This review focuses on the definition, pathophysiology, presentation, investigations and management of lithium-associated hyperparathyroidism.
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium severe poisoning due to urinary tract infection : a case report (Posters) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_844;
She was medicated by irbesartan and cyamemazine...Serum lithium levels should be closely monitored in patients taking this drug. Besides, delayed neurological effects in lithium intoxication must be watched out for .
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Ultra-long-term lithium therapy: all-important matters and a case of successful 50-year lithium treatment. (Pubmed Central) - Sep 5, 2021
In this patient, apart from maintaining a euthymic state, long-term lithium treatment also exerted a favorable effect on general health, especially the elimination of viral and other respiratory infections. It is concluded that ultra-long term lithium therapy can enable good professional and psychosocial functioning for many patients, and the possible somatic side effects are manageable.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Lithiation of white button mushrooms (Agaricus bisporus) using lithium-fortified substrate: effect of fortification levels on Li uptake and on other trace elements. (Pubmed Central) - Sep 5, 2021
The fortification showed some effects on the uptake of other trace minerals, but concentrations of co-accumulated Ag, Al, As, Ba, Cd, Co, Cr, Cs, Cu, Hg, Mn, Ni, Pb, Rb, Sr, Tl, U, V and Zn were similar or lower than values reported in the literature for commercial A. bisporus. These lithiated mushrooms could be considered as a pro-medicinal alternative to treatments that use Li salts.
- |||||||||| tamoxifen / Generic mfg.
Clinical, Journal: Switch to Hypomania After Discontinuation of Tamoxifen: A Case Report. (Pubmed Central) - Sep 4, 2021
This case highlights the risk of misdiagnosing unipolar depression in breast cancer patients with undiagnosed bipolar disorder who are being treated with tamoxifen and subsequently started on antidepressants. The use of antidepressants in this population should be carefully monitored to avoid the development of manic, hypomanic, or mixed symptoms in patients with underlying bipolar disorder once tamoxifen is discontinued.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Lithium Prescribing and Therapeutic Drug Monitoring in Bipolar Disorder: A Survey of Current Practices and Perspectives. (Pubmed Central) - Sep 3, 2021
The use of antidepressants in this population should be carefully monitored to avoid the development of manic, hypomanic, or mixed symptoms in patients with underlying bipolar disorder once tamoxifen is discontinued. Shifts in prescribing practices, inconsistent interpretation of lithium levels, and concerns about safety and therapeutic drug monitoring highlight the need for evidence-informed guidelines reflective of current practice.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Discontinuity in the Realization of the Vienna Peedee Belemnite Carbon Isotope Ratio Scale. (Pubmed Central) - Sep 2, 2021
1994, 66, 273-276.] To improve the realization of the VPDB scale, a second fixed point (lithium carbonate, LSVEC) was introduced in 2006 [T...Mass Spectrosc. 2021, 35, e9006.] Here, we report the analysis of 25 reference materials using isotope ratio combustion mass spectrometry, show the discontinuity between the values measured against the new IAEA reference materials and the values currently assigned to these reference materials on the VPDB2006, and provide a link bringing these materials onto the new VPDB2020.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Psychotropic drug use in perinatal women with bipolar disorder. (Pubmed Central) - Sep 1, 2021
The elimination clearance trajectory across pregnancy for psychotropics dictates the frequency of laboratory monitoring and dose adjustment. The literature on the pharmacokinetics of lithium, lamotrigine, carbamazepine and atypical antipsychotics during pregnancy and postpartum are reviewed, recommendations for symptom and laboratory monitoring are proposed and recommendations for dose adjustments are presented.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect. (Pubmed Central) - Aug 29, 2021
These findings suggest that BD is associated with minimal changes in whole blood gene expression independent of medication use but emphasize the importance of accounting for medication use and cell type heterogeneity in psychiatric transcriptomic studies. The results of this study add to mounting evidence of lithium's cell signaling and immune-related mechanisms.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials. (Pubmed Central) - Aug 28, 2021
Analysis of the final product included differential scanning calorimetry, thermogravimetric analysis, gas chromatography-mass spectrometry, H and C nuclear magnetic resonance spectroscopy, high-performance liquid chromatography, residual solvent analysis by gas chromatography headspace sampling, X-ray powder diffraction analysis, and residual lithium analysis by inductively coupled plasma-mass spectrometry. The DMT hemifumarate was minimally 99.9% pure, with no significant impurities or residual solvents, thus meeting regulatory standards for administration to humans.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Journal: Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model. (Pubmed Central) - Aug 26, 2021
Here we investigated the impact of lacosamide alone and in combination with other drugs (pregabalin, piracetam and scopolamine) on spontaneous recurrent seizures (SRSs) and behavioral parameters during the time frame of 6 weeks after SE...Furthermore, superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in the L/P group were significantly (P < 0.05) improved. Overall, our findings support the use of a combination of drugs (L/P and L/Pi) in lithium-pilocarpine model which remarkably ameliorated SRSs, reduced anxiety-related behaviors, retention of spatial/reference memory and lowered oxidative stress in a time-course evaluation 6 weeks post- SE insult.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Editorial: Neurobiological Underpinnings of Bipolar Disorder and Its Treatment. (Pubmed Central) - Aug 24, 2021
Overall, our findings support the use of a combination of drugs (L/P and L/Pi) in lithium-pilocarpine model which remarkably ameliorated SRSs, reduced anxiety-related behaviors, retention of spatial/reference memory and lowered oxidative stress in a time-course evaluation 6 weeks post- SE insult. No abstract available
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: When and how to use Lithium. (Pubmed Central) - Aug 20, 2021
It is effective not only for bipolar illness but for prevention of suicide, episodes of unipolar depression, mood temperaments, and possibly dementia. Its many benefits need better appreciation, while lowered dosing can reduce risks.
- |||||||||| ketamine / Generic mfg.
Journal: The Effects of Ketamine on Typical and Atypical Depressive Symptoms. (Pubmed Central) - Aug 20, 2021
Its many benefits need better appreciation, while lowered dosing can reduce risks. Ketamine appears to effectively treat both the typical/melancholic and atypical symptoms of depression, but may have early preferential effects for the former.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Combining machine-learning algorithms for prediction of antidepressant treatment response. (Pubmed Central) - Aug 20, 2021
Especially predictors related to duration of illness, baseline depression severity, anxiety and somatic symptoms, and personality traits moderate treatment success. However, prospectives application of machine learning models will be necessary to prove their value for the clinic.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Performance of a double-slope solar still for the concentration of lithium rich brines with concomitant fresh water recovery. (Pubmed Central) - Aug 20, 2021
The current evaporitic technology is slow, and serious environmental concern has been raised regarding the large volumes of water used, relating both to brine concentration through evaporation, and intensive pumping of fresh water needed in the fine chemical processing to produce high purity lithium carbonate...While the performance of the Solar Still for brine concentration was below that of open air evaporation, the Solar Still allowed for the production of an average of 2 L day m of distilled water, in marked contrast with current practice. Numerical simulations allowed us to quantify heat exchanges in both the Solar Still and the open air system.
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