- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka, Metopirone (metyrapone) / HRA Pharma
Review, Journal: Augmentative Pharmacological Strategies in Treatment-Resistant Major Depression: A Comprehensive Review. (Pubmed Central) - Jan 7, 2022
Studies on lamotrigine and pindolol reported negative results...Reliable conclusions about the other molecules cannot be drawn. Further controlled comparative studies, standardized in terms of design, doses, and duration of the augmentative treatments, are needed to formulate definitive conclusions.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Review, Journal: Effects of lithium use on the white matter of patients with bipolar disorder - a systematic review. (Pubmed Central) - Jan 5, 2022
Lithium appears to positively influence the evolution of the white matter abnormalities described in bipolar disorder patients. Should this information be confirmed in future research, and given its important mood stabilizer effect, it could further reinforce the use of lithium in the treatment of bipolar disorder.
- |||||||||| lithium carbonate ER / Generic mfg., sevoflurane / Generic mfg.
Preclinical, Journal: Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. (Pubmed Central) - Jan 4, 2022
In addition, lithium chloride reduced hippocampal neuron apoptosis and oxidative stress induced by sevoflurane anesthesia. These results suggest that lithium chloride may have potential for development into a therapeutic agent for treatment of sevoflurane anesthesia-induced cognitive dysfunction.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Mini-review: The anti-aging effects of lithium. (Pubmed Central) - Jan 4, 2022
This mini review summarizes findings of anti-aging mechanisms associated with lithium use and provides a discussion of the clinical implications and perspectives of this evolving field. Despite many promising results, more studies are warranted in order to elucidate the exact mechanism by which lithium may act as an anti-aging agent and the extent to which these mechanisms are relevant to its mood stabilizing properties in BD.
- |||||||||| sertraline / Generic mfg., duloxetine / Generic mfg.
Biomarker, Journal: Use of a Consultation Service Following Pharmacogenomic Testing in Psychiatry. (Pubmed Central) - Dec 30, 2021
Consultation with experts in PGx provides additional useful information that may improve outcomes and decrease healthcare resource utilization. This database may provide future opportunities for machine learning algorithms to further inform implications of included gene variants.
- |||||||||| lithium carbonate ER / Generic mfg., risperidone / Generic mfg.
Clinical, Journal: Bipolar disorder and Susac syndrome: a case report. (Pubmed Central) - Dec 29, 2021
Upon admission, corticosteroid treatment was suspended, and the patient was started on lithium and risperidone...Many medical conditions share CNS involvement and/or high-dose/prolonged corticosteroid treatment. In such cases, psychiatric manifestations such as mania or depression should be regarded as secondary and studied to determine the existence of medical complications before considering primary psychiatric conditions.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Bipolar disorder prevalence and psychotropic medication utilisation in Hong Kong and the United Kingdom. (Pubmed Central) - Dec 28, 2021
The disparity in prescribing patterns of BPD maintenance treatment in two regions reflected three major issues in clinical practice: 1) under-prescribing of lithium in both regions, 2) antidepressant monotherapy in the UK and 3) overprescribing of valproate to women of childbearing age in HK. Review of current clinical treatment guidelines and regulations of prescribing practice by local clinicians should be immediately implemented to ensure the safe use of medications in patients with BPD.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Genome-Wide Association Study of Lithium-Induced Dry Mouth in Bipolar I Disorder. (Pubmed Central) - Dec 27, 2021
The SNP rs10135918, located in the immunoglobulin heavy chain locus (IGH), showed the strongest associations in the GWAS (p = 2.12 × 10) and replication groups (p = 6.36 × 10) (dominant model) for dry mouth with a sensitivity of 84.9% in predicting dry mouth induced by lithium. Our results may be translated into clinical recommendation to help identify at-risk individuals for early identification and management of dry mouth, which will improve medication adherence.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: The importance of monitoring renal function and concomitant medication to avoid toxicity in patients taking lithium. (Pubmed Central) - Dec 25, 2021
Tremor and dysarthria occurred only in the not overdose-related group, and duration of hospitalization was significantly longer in the not overdose-related than overdose-related group (P = 0.01). Clinicians must monitor the renal function of patients taking lithium, even when in compliance with the prescribed dosage, because they are at long-term risk of lithium toxicity.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Journal: Effect of Lurasidone on Manic Symptoms and Treatment-Emergent Mania in Adult and Pediatric Populations with Bipolar Depression. (Pubmed Central) - Dec 25, 2021
In addition to presumed neuroprotective effects of lithium, it can produce neurotoxic symptoms at therapeutic doses and levels. Short-term and long-term treatment with lurasidone demonstrated significant improvement in manic symptoms and was not associated with an increased risk of TEM in either adult or pediatric patient populations compared to rates reported in clinical populations of patients.
- |||||||||| lithium carbonate ER / Generic mfg.
Preclinical, Journal: Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats. (Pubmed Central) - Dec 23, 2021
Male rats (24 days old, Sprague Dawley) sequentially received i.p. injections of lithium-carbonate, MSO, methyl-scopolamine, and pilocarpine (Pilo)...The results indicate that MSO impairs an aspect of glutamatergic transmission involved in the transition from the first cholinergic stimulus to the onset of seizures. A continuous rise of extracellular Glu lasting 60 min was insignificantly affected by MSO, leaving the nature of the Glu pool(s) involved in altered glutamatergic transmission undefined.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: The utility of daily mood ratings in clinical trials of patients with bipolar II disorder. (Pubmed Central) - Dec 23, 2021
A daily rating strategy appeared to provide additional and differing data compared to standard monthly measures. We therefore argue for the inclusion of daily mood ratings in clinical trials evaluating mood stabilisers and their use by clinicians in managing those with a bipolar II disorder.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity. (Pubmed Central) - Dec 23, 2021
However, no specific essential function in the animal kingdom has been found for either of the two elements so far. Here, we summarize the current knowledge of Li and B bioactivity in D. melanogaster in the context of health and disease prevention.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Treatment of Electroconvulsive Therapy-Emergent Hypomania and Mania: A Systematic Review of the Literature. (Pubmed Central) - Dec 23, 2021
There were 4 primary treatment courses identified: continuing ECT alone, continuing ECT in conjunction with lithium, discontinuing ECT with no medication treatment, or discontinuing ECT and starting a medication. The available data are insufficient to support definitive conclusions; however, potential treatment guidelines are suggested within the review to providers based on the limited data available.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Journal: Astrocytes in Bipolar Disorder. (Pubmed Central) - Dec 21, 2021
Furthermore, the beneficial therapeutic effects of the frontline treatments for BD are due at least in part to their positive actions on astrocytes, notably lithium, valproic acid (VPA) and carbamazepine (CBZ), as well as antidepressants and antipsychotics that are used in the management of this disorder. Treatments for BD are ineffective in a large proportion of cases, and astrocytes represent new therapeutic targets that can also serve as biomarkers of illness progression and treatment responsiveness in BD.
- |||||||||| lithium carbonate ER / Generic mfg.
Feeding behavior is modulated by an inhibitory pathway from the Substantia Nigra pars reticulata to the Dorsal Raphe (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_7271;
Next day, we measured food intake in response to DR photostimulation of SNr GABA terminals and found that food intake did not change in ChR2-eYFP mice, but significantly decreased in eYFP mice. We conclude that GABAergic neurotransmission from the SNr to DR neurons plays a role in feeding behavior, throughout a mechanism that involves the regulation of DR glutamatergic neurons.; Grant Support: This study was supported by the Intramural Research Program of the National Institute on Drug Abuse
- |||||||||| lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
Early prenatal exposure to homocysteic acid leads to alterations in behavior and gene expression that are consistent with bipolar disorder (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_7072;
The manic behaviors are effectively reversed by lithium treatment, and the depressive behaviors are reversed by acute ketamine treatment...We confirmed several of these alterations in gene expression using qPCR. Collectively, these results suggest that HCA treatment leads to changes in gene expression that mirror those previously identified in GWAS and microarray studies in post-mortem BD patients.; Grant Support: A. Paul and Carol Schaap; Hope College Biology, Chemistry and Neuroscience Program
- |||||||||| lithium carbonate ER / Generic mfg., amphetamine / Generic mfg.
Lithium Orotate: A Superior Option for Lithium Therapy? (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_6898;
Lithium carbonate (Li 2 CO 3 ) is a mainstay treatment option for the prevention of mood-episode recurrences in bipolar disorder (BD)...As a first step in exploring LiOr as a replacement for traditional lithium compounds in therapy, we established dose response curves for a range of LiOr, Li 2 CO 3 , and lithium chloride (LiCl) concentrations (0, 1, 1.5, 2.5, 5, 10 and 15 mg/kg for LiOr; 0, 1, 5, 10, 15, 20 and 25 mg/kg for Li 2 CO 3 /LiCl; all concentrations represent elemental lithium) following a single injection in both male and female wild-type mice using an amphetamine-induced hyperlocomotion (AIH) model (3 mg/kg d -amphetamine)...In contrast, a complete blockade was observed for LiOr concentrations equal to or exceeding 2.5 mg/kg or 1.5 mg/kg in males and females, respectively, indicating both improved efficacy and potency relative to LiCl/Li 2 CO 3 . In sum, LiOr demonstrates superior efficacy to LiCl and Li 2 CO 3 in the attenuation of the mania-mimetic AIH in both male and female wild-type mice, as evidenced by reduced dosage requirements and an enhanced strength of blockade at equivalent concentrations.; Grant Support: CoMRAD - 422467; CoMRAD - 424223
- |||||||||| lithium carbonate ER / Generic mfg.
Common genetic variation modulates lithium-induced neural progenitor proliferation (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_476;
Our results demonstrate how a proliferation response GWAS can identify loci where genetic variation alters stimulus-specific regulation of gene expression within a key cell-type and developmental time period. Colocalization of this lithium-responsive proliferation locus and GWAS loci for complex traits like Bipolar disorder suggests a shared genetic basis for fetal neural progenitor proliferation responses and neuropsychiatric disorder risk and invites exploration into the role of GNL3 modulating responses to lithium treatment in adult neural progenitor cells.; Grant Support: NIH Grant 5R01MH120125-02; Foundation of Hope; NIH Grant 5 T32 GM 67553-15
- |||||||||| lithium carbonate ER / Generic mfg.
Prevalence And Correlates Of Eating Disorders Among Canadian Youth With Bipolar Disorder () - Dec 18, 2021 - Abstract #AACAP2021AACAP_720;
In the multivariate analysis, the most robust predictors of lifetime ED were female sex (OR = 4.39; p = 0.004), greater lifetime depression severity (OR = 1.06; p = 0.03), cigarette smoking (OR = 2.82; p = 0.01), and more severe borderline personality traits (OR = 1.01; p = 0.04).Conclusions EDs are common among youth with BD and associated with several adverse clinical correlates. Future studies evaluating correlates of specific ED subtypes are warranted, as are treatment studies targeting constructs that comprise shared liabilities toward EDs and related adverse clinical correlates of comorbid EDs in youth with BD.BRD, EA, ADOL
- |||||||||| lithium carbonate ER / Generic mfg.
Preclinical, Journal: The Effect of Organic Lithium Salts on Plasma 8-Hydroxy-2'-Deoxyguanosine in Bipolar Patients In Vitro. (Pubmed Central) - Dec 16, 2021
We investigated the effects of lithium salts containing different organic anionic components (lithium carbonate (Li-CAR), pyruvate (Li-PYR), succinate (Li-SUC), fumarate (Li-FUM) and ascorbate (Li-ASC)) on levels of the oxidative damage product of DNA-8-hydroxy-2'-deoxyguanosine (8-OH-dG) in blood plasma after incubation of blood samples from healthy individuals (healthy group) and patients with bipolar disorder (BD-group) with these chemical compounds...In BD patients, Li-PYR significantly reduced levels of plasma 8-OH-dG, while other compounds did not have a noticeable effect. Lithium pyruvate reduces oxidative DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector.
- |||||||||| lithium carbonate ER / Generic mfg.
Preclinical, Journal, IO biomarker: Neuroprotective Effect of Intravitreal Single-Dose Lithium Chloride after Optic Nerve Injury in Rats. (Pubmed Central) - Dec 16, 2021
Adjunctive lamotrigine and quetiapine to either one was well-tolerated and equally effective in reducing bipolar symptomatology, but adjunctive therapy should be initiated as early as possible when depression symptoms are present. It seems intravitreally lithium has optic nerve neuroprotective effects by various mechanisms like overexpression of antiapoptotic proteins, suppressing proinflammatory molecules and proapoptotic factors, and decreasing nitric oxide.
- |||||||||| ketamine / Generic mfg.
Review, Journal: Neurobiological Basis of Increased Risk for Suicidal Behaviour. (Pubmed Central) - Dec 16, 2021
Suicide risk could be attenuated by appropriate psychological treatment, electroconvulsive treatment, and drugs: lithium, ketamine, esketamine, clozapine. In this review, we present the etiopathogenesis of suicide behaviour and explore the mechanisms of action of anti-suicidal treatments, pinpointing similarities among them.
- |||||||||| lithium carbonate ER / Generic mfg.
On the Mental Status of Stargazer Mice () - Dec 12, 2021 - Abstract #AES2021AES_1637;
By applying an objective, automated and experimenter-free assessment of spontaneous behavior, we report that Stargazer mutant mice display features of amotivation and disrupted rest and activity rhythms that may not be fully explained by spike/wave burden: ongoing experiments with wireless EEG seek to clarify this matter further. These results shed light on the pleiotropic effects of AMPA-receptor mis-trafficking and may provide additional behavioral endpoints for the development of novel antiseizure medications designed to address refractory epilepsy syndromes of generalized onset.
- |||||||||| Procoralan (ivabradine) / Amgen, Servier, Ono Pharma
Treatment of a Transgender Individual with Migraine with Aura and Psychogenic Non-Epileptic Seizures () - Dec 12, 2021 - Abstract #AES2021AES_1094;
Unfortunately, there is a paucity of data to guide clinicians about balancing the risk of interactions between ASMs and hormonal treatment with anti-seizure benefits. A multidisciplinary approach is warranted prior to starting medications that may interfere with gender-affirming treatments.
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