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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients. (Pubmed Central) -  Feb 5, 2022   
    AA and AG genotypes were more frequent in both the responder and semi-responder groups compared to the non-responder group in dominant model of analysis. Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Trial completion, Trial completion date, Surgery:  Effect of Lithium Carbonate on Postoperative Sleep in Patients Undergoing Videoassisted Thoracic Surgery (clinicaltrials.gov) -  Feb 4, 2022   
    P4,  N=51, Completed, 
    Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population. Recruiting --> Completed | Trial completion date: Sep 2022 --> Jan 2022
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Clinical, Journal:  Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium. (Pubmed Central) -  Feb 3, 2022   
    Individually, aripiprazole, olanzapine+fluoxetine, risperidone, and ziprasidone all were more effective (all NNT < 10) than quetiapine (NNT = 13), brexpiprazole (16), or cariprazine (16), with overlapping NNT CIs...Several modern antipsychotics and esketamine appeared to be useful adjuncts to antidepressants for acute major depressive episodes, but lithium was somewhat more effective and better tolerated. Most trials of adding lithium involved older, mainly tricyclic, antidepressants, and the dosing of adjunctive treatments were not optimized.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium treatment and human hippocampal neurogenesis. (Pubmed Central) -  Feb 1, 2022   
    We observed that high-dose lithium treatment in human hippocampal progenitors increased the generation of neuroblasts (P ≤ 0.01), neurons (P ≤ 0.01), and glia (P ≤ 0.001), alongside the expression of genes, which regulate the volume of the molecular layer of the dentate gyrus. This study provides empirical support that adult hippocampal neurogenesis and gliogenesis are mechanisms that could contribute to the effects of lithium on human hippocampal volume.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  De novo variation in bipolar disorder. (Pubmed Central) -  Jan 28, 2022   
    In addition, while we found overall evidence for transmission of common variant polygenic risk of BD in our full sample (pTDT p = 2.21 × 10), specific trios with LoF variants showed no evidence of polygenic transmission. In sum, our findings support the de novo paradigm as a contributor to the genetic architecture of BD and provide evidence that constrained genes, as well as genes within the PSD and PI pathway harbor rare variation associated with BD.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Analysis of sex difference in the tubular reabsorption of lithium in rats. (Pubmed Central) -  Jan 28, 2022   
    Among the candidate transporters mediating lithium reabsorption examined herein, the mRNA expression of only PiT2, a sodium-dependent phosphate transporter, exhibited sexual dimorphism. The present results demonstrated sex differences in the tubular reabsorption of lithium with low affinity in rats.
  • ||||||||||  Review, Journal:  Candidate Psychotropics against SARS - CoV - 2: A Narrative Review. (Pubmed Central) -  Jan 28, 2022   
    According to the author's analysis of the currently available evidence, there is significant support for psychotropics as complementary interventions during SARS-CoV-2 infection. However, further studies need to be carried out to assess the effects of the above psychotropic drugs in vitro and clinical settings.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder. (Pubmed Central) -  Jan 27, 2022   
    Understanding the broader gene regulatory effects of VPA in this serotonergic cell model should provide insights into how this drug works and whether other HDAC inhibitor compounds may have similar gene regulatory effects, as well as highlighting molecular processes that may underlie regulation of mood. In BD patients, CM did not influence the clinical response to anticonvulsant mood stabilizers whereas it was associated with a poorer response to lithium with childhood physical abuse playing a major role in this effect.
  • ||||||||||  lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
    Review, Journal:  Long-Term Treatment of Bipolar Disorder with Valproate: Updated Systematic Review and Meta-analyses. (Pubmed Central) -  Jan 27, 2022   
    Valproate was more effective than placebo in preventing new BD episodes of mania or depression, and not significantly different from lithium, second-generation antipsychotics, or other anticonvulsants. Overall benefits were nonsignificantly greater versus mania than bipolar depression.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  A case of dose-dependent lithium-induced tardive dyskinesia. (Pubmed Central) -  Jan 27, 2022   
    TD mainly due to antipsychotics is known as irreversible. This case suggests that lithium-induced TD may be reversible in a dose-dependent manner.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium and endocrine dysfunction. (Pubmed Central) -  Jan 25, 2022   
    Lithium carbonate is a commonly prescribed drug for bipolar disorders...This adverse effect is usually reversible after drug withdrawal. However, some patients may present irreversible kidney damage due to chronic interstitial nephropathy.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    UNRECOGNIZED ACUTE LITHIUM TOXICITY COMPLICATED BY CHRONIC INTERSTITIAL NEPHRITIS: A CASE REPORT (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_589;    
    This difficulty is further compounded by the need of people suffering from bipolar disorder to take chronic therapy in order to prevent their risk of relapse. There remains no firm decision making algorithm to assist clinicians in the question of when to cease or if to cease lithium therapy in a patient with CKD.
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    Preclinical, Journal:  Chronic lithium administration in a mouse model for Krabbe disease. (Pubmed Central) -  Jan 15, 2022   
    Here, we test lithium carbonate in-vivo, in the spontaneous mouse model for KD, the Twitcher (TWI) mouse...We also show that lithium, with this administration protocol, is unable to stimulate autophagy in the TWI mice central nervous system, whereas results suggest that it can restore the β-catenin activation status in the TWI sciatic nerve. Overall, these data provide intriguing inputs for further evaluations of lithium treatment in TWI mice.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice. (Pubmed Central) -  Jan 14, 2022   
    It was already shown that microdoses of lithium carbonate (LiCO) promoted memory stabilization in humans and mice...In addition, 2 µM and 20 µM LiCO were also effective in reducing the activation of NFkB and inflammatory cytokines densities, as evaluated by ELISA. It is concluded that very low doses of LiCO can play an important role in neuroprotection as it can reduce neuronal loss and neuroinflammation in older individuals.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Mini review: Recent advances on epigenetic effects of lithium. (Pubmed Central) -  Jan 13, 2022   
    Recent results in this field of research have provided new insights into the molecular processes involved in Li effects. In this review, we examined the literature investigating the involvement of three epigenetic mechanisms (DNA methylation, noncoding RNAs and histone modifications) in Li clinical efficacy in bipolar disorder.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    PK/PD data, Review, Journal:  The role of brain barriers in the neurokinetics and pharmacodynamics of lithium. (Pubmed Central) -  Jan 12, 2022   
    Moreover, alteration in the functionality and integrity of brain barriers is reported in various CNS diseases, as a cause or a consequence and in this regard, Li by itself is known to modulate BBB properties such as the expression and activity of various transporters, metabolizing enzymes, and the specialized tight junction proteins on BBB. In this review, we will focus on recent knowledge into the role of the brain barriers as key-element in the Li neuropharmacokinetics which might improve the understanding of PK-PD of Li and its interindividual variability in drug response.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Trial completion date, Trial primary completion date:  Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (clinicaltrials.gov) -  Jan 11, 2022   
    P2,  N=160, Recruiting, 
    Therefore, we conclude that PREP deletion or inhibition blocks the intracellular effects of lithium on GSK3b and Akt via PP2A activation. Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Clinical guideline, Journal:  Lithium: Current Clinical Guidelines for Nurse Practitioners. (Pubmed Central) -  Jan 11, 2022   
    The purpose of the current article is to review evidence for lithium's neurotrophic and neuroprotective actions and clinical guidelines for safe and effective use. [Journal of Psychosocial Nursing and Mental Health Services, 60(1), 6-9.].
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Journal:  Plasma circulating cell-free mitochondrial DNA in depressive disorders. (Pubmed Central) -  Jan 7, 2022   
    Decreased plasma ccf-mtDNA in difficult-to-treat depression may be partly explained by concurrent psychotropic medications and co-morbidity. Our findings suggest that ccf-mtDNA may be differentially regulated in different subtypes of depression, and this hypothesis should be pursued in future studies.