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- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case-based systematic analysis. (Pubmed Central) - Feb 5, 2022
Despite the progress made in treating bipolar and unipolar affective disorders, lithium carbonate is still a common drug in psychiatric practice...However, the multiple regression analysis for CKD as the dependent variable showed that the decisive factor was focal segmental glomerulosclerosis (FSGS) as the underlying pathology (the β coefficient = 0.7866 with a confidence interval ranging from 0.600 to 0.9704 and the p value < 0.0001). Thus, we conclude that in lithium-induced NS/AKI, serum lithium levels contribute to these complications, while FSGS lesions are responsible for CKD's disease progression.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients. (Pubmed Central) - Feb 5, 2022
AA and AG genotypes were more frequent in both the responder and semi-responder groups compared to the non-responder group in dominant model of analysis. Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population.
- | lithium carbonate ER / Generic mfg.
Trial completion, Trial completion date, Surgery: Effect of Lithium Carbonate on Postoperative Sleep in Patients Undergoing Videoassisted Thoracic Surgery (clinicaltrials.gov) - Feb 4, 2022
P4, N=51, Completed, Sponsor: China Medical University, China
Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population. Recruiting --> Completed | Trial completion date: Sep 2022 --> Jan 2022
- || Rexulti (brexpiprazole) / Lundbeck, Otsuka
Clinical, Journal: Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium. (Pubmed Central) - Feb 3, 2022
Individually, aripiprazole, olanzapine+fluoxetine, risperidone, and ziprasidone all were more effective (all NNT < 10) than quetiapine (NNT = 13), brexpiprazole (16), or cariprazine (16), with overlapping NNT CIs...Several modern antipsychotics and esketamine appeared to be useful adjuncts to antidepressants for acute major depressive episodes, but lithium was somewhat more effective and better tolerated. Most trials of adding lithium involved older, mainly tricyclic, antidepressants, and the dosing of adjunctive treatments were not optimized.
- | lithium carbonate ER / Generic mfg.
New P3 trial: Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients (clinicaltrials.gov) - Feb 2, 2022
P3, N=50, Recruiting, Sponsor: Al-Azhar University
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. (Pubmed Central) - Feb 1, 2022
Thus, chronomodulatory compounds offer a promising route to a novel treatment paradigm. These findings, upon larger-scale validation, could facilitate the implementation of a personalized approach for mood stabilization.
- | lithium carbonate ER / Generic mfg.
Journal: Lithium treatment and human hippocampal neurogenesis. (Pubmed Central) - Feb 1, 2022
We observed that high-dose lithium treatment in human hippocampal progenitors increased the generation of neuroblasts (P ≤ 0.01), neurons (P ≤ 0.01), and glia (P ≤ 0.001), alongside the expression of genes, which regulate the volume of the molecular layer of the dentate gyrus. This study provides empirical support that adult hippocampal neurogenesis and gliogenesis are mechanisms that could contribute to the effects of lithium on human hippocampal volume.
- | lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
Preclinical, Journal: Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. (Pubmed Central) - Feb 1, 2022
In contrast, pmTOR/mTOR levels were reduced in the PL of ketamine+lithium treated animals, while pERK/ERK expression levels were elevated. Taken together, these data demonstrate that lithium augmentation of ketamine in antidepressant nonresponsive animals improves antidepressant-like behavioral responses under stress, together with peripheral insulin efflux and region-specific PFC insulin signaling.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. (Pubmed Central) - Feb 1, 2022
An exploratory functional pathway analysis of top MET2-PRS variants was conducted. Findings may inform the development of future testing strategies for personalized lithium prescribing in BD.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder. (Pubmed Central) - Feb 1, 2022
Furthermore, circCCNT2 expression was reduced in response to lithium treatment in vitro. Together, our study is the first to associate circCCNT2 to bipolar disorder and lithium treatment.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Enriched environment ameliorates chronic temporal lobe epilepsy-induced behavioral hyperexcitability and restores synaptic plasticity in CA3-CA1 synapses in male Wistar rats. (Pubmed Central) - Jan 29, 2022
Our results reaffirm the beneficial effects of EE on behavior in chronic epilepsy and establishes some of the putative cellular mechanisms. Since drug resistance and comorbidities are a major concern in TLE, we propose EE as a potent non-pharmacological treatment modality to mitigate these changes in chronic epilepsy.
- |||| lithium carbonate ER / Generic mfg.
Video: Why has lithium decreased in use as a treatment for #bipolar disorder? @StanfordPSY's Michael Ostacher (@RecoveryDoctor), @HopkinsPsych's Kay Jamison & @DellMedSchool's Stephen Strakowski discuss in a @Medscape video. https://t.co/WMScGQjInP (Twitter) - Jan 28, 2022
- | lithium carbonate ER / Generic mfg.
Journal: De novo variation in bipolar disorder. (Pubmed Central) - Jan 28, 2022
In addition, while we found overall evidence for transmission of common variant polygenic risk of BD in our full sample (pTDT p = 2.21 × 10), specific trios with LoF variants showed no evidence of polygenic transmission. In sum, our findings support the de novo paradigm as a contributor to the genetic architecture of BD and provide evidence that constrained genes, as well as genes within the PSD and PI pathway harbor rare variation associated with BD.
- || Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
Retrospective data, Review, Journal: Recurrence rates in stable bipolar disorder patients after drug discontinuation v. drug maintenance: a systematic review and meta-analysis. (Pubmed Central) - Jan 28, 2022
Discontinuation of medications for ⩾1 month significantly increased recurrence risk. However, 47.3% of patients who discontinued drugs for 6 months did not experience recurrence.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Analysis of sex difference in the tubular reabsorption of lithium in rats. (Pubmed Central) - Jan 28, 2022
Among the candidate transporters mediating lithium reabsorption examined herein, the mRNA expression of only PiT2, a sodium-dependent phosphate transporter, exhibited sexual dimorphism. The present results demonstrated sex differences in the tubular reabsorption of lithium with low affinity in rats.
- || Review, Journal: Candidate Psychotropics against SARS - CoV - 2: A Narrative Review. (Pubmed Central) - Jan 28, 2022
According to the author's analysis of the currently available evidence, there is significant support for psychotropics as complementary interventions during SARS-CoV-2 infection. However, further studies need to be carried out to assess the effects of the above psychotropic drugs in vitro and clinical settings.
- | lithium carbonate ER / Generic mfg., olanzapine / Generic mfg., haloperidol / Generic mfg.
Preclinical, Journal: Effects of chronic exposure to haloperidol, olanzapine or lithium on SV2A and NLGN synaptic puncta in the rat frontal cortex. (Pubmed Central) - Jan 27, 2022
In contrast, chronic lithium exposure significantly increased NLGN puncta density relative to vehicle, with no effect on either SV2A or total synaptic puncta. Future studies are required to understand the functional consequences of these changes.
- | sodium valproate / Generic mfg.
Preclinical, Journal: Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms. (Pubmed Central) - Jan 27, 2022
These results suggest VPA may regulate genes through both HDAC-dependent and independent mechanisms. Understanding the broader gene regulatory effects of VPA in this serotonergic cell model should provide insights into how this drug works and whether other HDAC inhibitor compounds may have similar gene regulatory effects, as well as highlighting molecular processes that may underlie regulation of mood.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder. (Pubmed Central) - Jan 27, 2022
Understanding the broader gene regulatory effects of VPA in this serotonergic cell model should provide insights into how this drug works and whether other HDAC inhibitor compounds may have similar gene regulatory effects, as well as highlighting molecular processes that may underlie regulation of mood. In BD patients, CM did not influence the clinical response to anticonvulsant mood stabilizers whereas it was associated with a poorer response to lithium with childhood physical abuse playing a major role in this effect.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. (Pubmed Central) - Jan 27, 2022
We conclude that neuronal circadian rhythm abnormalities are present in BD and most pronounced in Li-NR. Rhythm deficits in BD may be partly reversible through stimulation of entrainment pathways.
- || lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: Long-Term Treatment of Bipolar Disorder with Valproate: Updated Systematic Review and Meta-analyses. (Pubmed Central) - Jan 27, 2022
Valproate was more effective than placebo in preventing new BD episodes of mania or depression, and not significantly different from lithium, second-generation antipsychotics, or other anticonvulsants. Overall benefits were nonsignificantly greater versus mania than bipolar depression.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Chronic lithium treatment alters the excitatory/ inhibitory balance of synaptic networks and reduces mGluR5-PKC signalling in mouse cortical neurons. (Pubmed Central) - Jan 27, 2022
Together, the results revealed how lithium dampens neuronal excitability and the activity of the glutamatergic network, both of which are predicted to be overactive in the manic phase of bipolar disorder. Our working model of lithium action enables the development of targeted strategies to restore the balance of overactive networks, mimicking the therapeutic benefits of lithium but with reduced toxicity.
- || lithium carbonate ER / Generic mfg.
Clinical, Observational data, Journal: Response to antidepressants among patients with unipolar depression with and without comorbid epilepsy-a nation-wide population-based longitudinal study. (Pubmed Central) - Jan 27, 2022
Response to antidepressants was decreased in patients with comorbid epilepsy versus without comorbid epilepsy at all time points during a ten-year follow-up period. The study highlights the need for closely clinical monitoring and psychological support for patients with depression and comorbid epilepsy and emphasize the need for further long-term studies of effect of interventions.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: A case of dose-dependent lithium-induced tardive dyskinesia. (Pubmed Central) - Jan 27, 2022
TD mainly due to antipsychotics is known as irreversible. This case suggests that lithium-induced TD may be reversible in a dose-dependent manner.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal, Real-world evidence: Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data. (Pubmed Central) - Jan 27, 2022
There was a large amount of variability and polypharmacy in the treatments received by MDD patients with SI/SA, and is much more complex than what has been previously observed in the general MDD population. Within one-year, many patients received four or more unique class-based regimens and most patients received treatments from multiple classes simultaneously, indicating the high unmet medical need and therapy refractoriness of this patient population.
- |||| lithium carbonate ER / Generic mfg.
Clinical, Video: Despite its proven efficacy & safety, clinicians continue to move away from using #lithium to treat bipolar disorder. @StanfordPSY's Michael Ostacher (@RecoveryDoctor) discusses the topic with colleagues in this @Medscape video. https://t.co/WMScGQjInP (Twitter) - Jan 27, 2022
- || lithium carbonate ER / Generic mfg.
Lithium Works for #BipolarDisorder. Why Aren't We Using It? https://t.co/33nQXpXkdq via @medscape (Twitter) - Jan 27, 2022
- | lithium carbonate ER / Generic mfg.
Journal: A 5-Year Study of Lithium and Valproic Acid Drug Monitoring in Patients with Bipolar Disorders in an Italian Clinical Center. (Pubmed Central) - Jan 26, 2022
No differences were reported when analyzing the distribution of Cp values in males and females. In conclusion, this present study suggests that TDM is widely used by many specialists, but there is still a window of improvement for optimizing pharmacological treatments in clinical practice.
- | lithium carbonate ER / Generic mfg.
Journal: Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder. (Pubmed Central) - Jan 26, 2022
Lithium treatment duration and hypothyroidism strongly impacted mGFR independently of age, especially in patients with microcysts. MRI might help detect early lithium-induced kidney damage and inform preventive strategies.
- | lithium carbonate ER / Generic mfg.
Journal: Lithium and endocrine dysfunction. (Pubmed Central) - Jan 25, 2022
Lithium carbonate is a commonly prescribed drug for bipolar disorders...This adverse effect is usually reversible after drug withdrawal. However, some patients may present irreversible kidney damage due to chronic interstitial nephropathy.
- | lithium carbonate ER / Generic mfg.
Journal: The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression. (Pubmed Central) - Jan 21, 2022
Results from CASA showed that sperm parameters like count, motility and viability significantly decreased in lithium treated group (p < 0.001). It is clear that lithium carbonate induce severe damage on male reproductive system and histopathological damages via generation oxidative stress but supplementation with Ganoderma lucidum extract exhibited prevention effects and repaired induced damages.
- lithium carbonate ER / Generic mfg.
UNRECOGNIZED ACUTE LITHIUM TOXICITY COMPLICATED BY CHRONIC INTERSTITIAL NEPHRITIS: A CASE REPORT (Poster Area (Virtual)) - Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_589;
This difficulty is further compounded by the need of people suffering from bipolar disorder to take chronic therapy in order to prevent their risk of relapse. There remains no firm decision making algorithm to assist clinicians in the question of when to cease or if to cease lithium therapy in a patient with CKD.
- | lithium carbonate ER / Generic mfg.
Trial completion: Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder (clinicaltrials.gov) - Jan 19, 2022
P4, N=60, Completed, Sponsor: All India Institute of Medical Sciences, Bhubaneswar
There remains no firm decision making algorithm to assist clinicians in the question of when to cease or if to cease lithium therapy in a patient with CKD. Recruiting --> Completed
- ||| lithium carbonate ER / Generic mfg.
I have never really heard anti-lithium - but I do definitely hear a pro-AAP for bipolar disorder and more recently bipolar depression. (Twitter) - Jan 19, 2022
- |||| lithium carbonate ER / Generic mfg., trazodone ER / Generic mfg.
FDA event: Definitely not the whole story, which is why I said "possible additional". Agree there's an anti-lithium narrative. Speaking of trazodone, in the US, it's used almost exclusively for insomnia, and few people realize it's FDA-approved only for depression. (Twitter) - Jan 19, 2022
- | lithium carbonate ER / Generic mfg., dextroamphetamine immediate release / Generic mfg., doxycycline / Generic mfg.
Preclinical, Journal: Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment? (Pubmed Central) - Jan 18, 2022
Tetracyclines present neuroprotective actions based on their anti-inflammatory and microglia suppressant effects...This study points to DOXY as a promising adjunctive tool for bipolar disorder treatment focused on cognition and neuroimmune changes. Our data provide the first rationale for clinical trials investigating DOXY therapeutic actions in bipolar disorder mania.
- | Germanin (suramin) / Optimum Therap
Preclinical, Journal: Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice. (Pubmed Central) - Jan 18, 2022
These results support the mania-like profile of DAT KD mice, which may be partially remediated by nAChR agonists via restoration of disrupted catecholaminergic/cholinergic equilibrium. Delineating the precise mechanism of action of nicotine could identify more selective therapeutic targets.
- |||| lithium carbonate ER / Generic mfg.
Clinical: Lithium can be very effective for people with bipolar disorder, especially for suicidality. So why it its use declining? https://t.co/0kN5lhqIqV @RecoveryDoctor @tylerblack32 @MarlonDanMD @rjelefante @ashleypmiller (Twitter) - Jan 18, 2022
- ||| lithium carbonate ER / Generic mfg.
I got a chance to speak with Kay Redfield Jamison and Steve Strakowski about how well lithium works, why we’re not using it more, and how to do better. @StanfordPSY @NNDC_official Lithium Works for Bipolar Disorder. Why Aren't We Using It? https://t.co/lyv8rvPQf8 via @medscape (Twitter) - Jan 18, 2022
- || lithium carbonate ER / Generic mfg.
Lithium Works for Bipolar Disorder. Why Aren't We Using It? https://t.co/mzfC88LMzY via @medscape (Twitter) - Jan 15, 2022
- | lithium carbonate ER / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Chronic lithium administration in a mouse model for Krabbe disease. (Pubmed Central) - Jan 15, 2022
Here, we test lithium carbonate in-vivo, in the spontaneous mouse model for KD, the Twitcher (TWI) mouse...We also show that lithium, with this administration protocol, is unable to stimulate autophagy in the TWI mice central nervous system, whereas results suggest that it can restore the β-catenin activation status in the TWI sciatic nerve. Overall, these data provide intriguing inputs for further evaluations of lithium treatment in TWI mice.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice. (Pubmed Central) - Jan 14, 2022
It was already shown that microdoses of lithium carbonate (LiCO) promoted memory stabilization in humans and mice...In addition, 2 µM and 20 µM LiCO were also effective in reducing the activation of NFkB and inflammatory cytokines densities, as evaluated by ELISA. It is concluded that very low doses of LiCO can play an important role in neuroprotection as it can reduce neuronal loss and neuroinflammation in older individuals.
- || lithium carbonate ER / Generic mfg.
Clinical, Journal: Decreased leukocyte telomere length in male patients with chronic bipolar disorder: lack of effect of long-term lithium-treatment. (Pubmed Central) - Jan 14, 2022
The study did not confirm the lithium effect on TL in bipolar patients. TL showed gender differences, being shorter in BD males, compared to control males, and longer in healthy males, compared to control females.
- | lithium carbonate ER / Generic mfg.
Enrollment open: A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction (clinicaltrials.gov) - Jan 13, 2022
P3, N=500, Recruiting, Sponsor: Negovsky Reanimatology Research Institute
TL showed gender differences, being shorter in BD males, compared to control males, and longer in healthy males, compared to control females. Not yet recruiting --> Recruiting
- || lithium carbonate ER / Generic mfg.
Review, Journal: Mini review: Recent advances on epigenetic effects of lithium. (Pubmed Central) - Jan 13, 2022
Recent results in this field of research have provided new insights into the molecular processes involved in Li effects. In this review, we examined the literature investigating the involvement of three epigenetic mechanisms (DNA methylation, noncoding RNAs and histone modifications) in Li clinical efficacy in bipolar disorder.
- | lithium carbonate ER / Generic mfg.
Trial completion date: Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder (clinicaltrials.gov) - Jan 13, 2022
P4, N=72, Recruiting, Sponsor: All India Institute of Medical Sciences, Bhubaneswar
In this review, we examined the literature investigating the involvement of three epigenetic mechanisms (DNA methylation, noncoding RNAs and histone modifications) in Li clinical efficacy in bipolar disorder. Trial completion date: Dec 2022 --> Feb 2022
- || lithium carbonate ER / Generic mfg.
PK/PD data, Review, Journal: The role of brain barriers in the neurokinetics and pharmacodynamics of lithium. (Pubmed Central) - Jan 12, 2022
Moreover, alteration in the functionality and integrity of brain barriers is reported in various CNS diseases, as a cause or a consequence and in this regard, Li by itself is known to modulate BBB properties such as the expression and activity of various transporters, metabolizing enzymes, and the specialized tight junction proteins on BBB. In this review, we will focus on recent knowledge into the role of the brain barriers as key-element in the Li neuropharmacokinetics which might improve the understanding of PK-PD of Li and its interindividual variability in drug response.
- | lithium carbonate ER / Generic mfg.
Journal: Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A. (Pubmed Central) - Jan 11, 2022
When lithium exposure was combined with okadaic acid, a PP2A inhibitor, KYP-2047 did not have effect on lithium-induced GSK3b and Akt phosphorylation. Therefore, we conclude that PREP deletion or inhibition blocks the intracellular effects of lithium on GSK3b and Akt via PP2A activation.
- | lithium carbonate ER / Generic mfg.
Trial completion date, Trial primary completion date: Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (clinicaltrials.gov) - Jan 11, 2022
P2, N=160, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
Therefore, we conclude that PREP deletion or inhibition blocks the intracellular effects of lithium on GSK3b and Akt via PP2A activation. Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Dec 2021 --> Dec 2022
- ||| lithium carbonate ER / Generic mfg.
Clinical, Clinical guideline, Journal: Lithium: Current Clinical Guidelines for Nurse Practitioners. (Pubmed Central) - Jan 11, 2022
The purpose of the current article is to review evidence for lithium's neurotrophic and neuroprotective actions and clinical guidelines for safe and effective use. [Journal of Psychosocial Nursing and Mental Health Services, 60(1), 6-9.].