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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders. (Pubmed Central) -  Mar 15, 2022   
    Li improved OCR levels only in Li-R NPCs by enhancing maximal respiration and reserve capacity, while VPA enhanced maximal respiration and reserve capacity in Li-N NPCs. Overall, our findings further support the involvement of mitochondrial functions in the molecular mechanisms of mood stabilizers and suggest novel mechanisms related to the spliceosome, which warrant further investigation.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar disorder. (Pubmed Central) -  Mar 15, 2022   
    The reported proteins are involved in neuronal cell-cell and cell-matrix interactions, particularly in the developing brain, and in pathways of importance for lithium's mechanism of action. In summary, we report four novel CSF protein associations with bipolar disorder that replicated in two independent case-control cohorts, shedding new light on the central nervous system processes implicated in bipolar disorder.
  • ||||||||||  Journal:  Personality disorder among youth with first episode psychotic mania: An important target for specific treatment? (Pubmed Central) -  Mar 12, 2022   
    In the early phase of bipolar disorder, patients with personality disorder comorbidity display delayed symptomatic and functional recovery and increased likelihood to need hospital readmissions. These observations suggest that routine assessment for personality disorder and specific interventions are important in order to improve short-term treatment efficacy in this subgroup.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Effects of lithium administration on vertebral bone disease in mucopolysaccharidosis I dogs. (Pubmed Central) -  Mar 12, 2022   
    The objective of this study was to examine whether lithium, a glycogen synthase kinase-3 inhibitor and stimulator of Wnt/beta-catenin signaling, administered during postnatal growth could attenuate progression of vertebral trabecular bone disease in MPS I. MPS I dogs were treated orally with therapeutic levels of lithium carbonate from 14 days to 6 months-of-age...Growth plates from lithium-treated animals exhibited increased numbers of hypertrophic chondrocytes relative to both untreated MPS I and heterozygous animals. These findings suggest that bone and cartilage cells in MPS I are still capable of responding to exogenous osteogenic signals even in the presence of significant lysosomal storage, and that targeted osteogenic therapies may represent a promising approach for attenuating bone disease progression in MPS I.
  • ||||||||||  lithium carbonate ER / Generic mfg., sodium valproate / Generic mfg.
    Journal:  Personality profile and therapeutic response to lithium carbonate and sodium valproate in mania with psychotic features. (Pubmed Central) -  Mar 11, 2022   
    The responders to sodium valproate had significantly higher scores in novelty seeking, harm avoidance (P = 0.003 and 0.004, respectively) and lower scores in persistence (P = 0.006) than the non-responders, but the responders to lithium carbonate did not have significantly different personality profiles. The results of the present study revealed that the personality profiles in the inpatients with psychotic mania are related to the responses to sodium valproate, but are irrelevant to the responses to lithium carbonate.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Review, Journal:  Genetic and Epigenetic Markers of Lithium Response. (Pubmed Central) -  Mar 11, 2022   
    Next, we describe results from studies investigating epigenetic mechanisms, such as changes in methylation or noncoding RNA levels, which play a relevant role as regulators of gene expression. Finally, we discuss challenges related to the search for the molecular determinants of lithium response and potential future research directions to pave the path towards a biomarker guided approach in lithium treatment.
  • ||||||||||  lithium carbonate ER / Generic mfg., risperidone / Generic mfg.
    Review, Journal:  Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress-Induced Damage in Patients with Bipolar Disorder. (Pubmed Central) -  Mar 11, 2022   
    Furthermore, it reviews the efficacy of the most used therapies for BD, such as cognitive-behavioral therapy, bright light therapy, imagery-focused cognitive therapy, and electroconvulsive therapy. A better understanding of the roles of OS, mitochondrial dysfunction, and inflammation in the pathogenesis of bipolar disorder, along with a stronger elucidation of the therapeutic functions of antioxidants, antipsychotics, anti-inflammatory agents, lithium therapy, and light therapies, may lead to improved strategies for the treatment and prevention of bipolar disorder.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain. (Pubmed Central) -  Mar 4, 2022   
    The administration of lithium carbonate or antidepressants might be recommended, especially to male schizophrenia patients with depression. Information obtained on the distribution of lithium in developing brain provides a basis for studying possible deleterious effects on brain development and behaviour in offspring of mothers undergoing lithium therapy.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Lithium and Erectile Dysfunction: An Overview. (Pubmed Central) -  Mar 4, 2022   
    Here, we had an overview of the epidemiology of lithium-related sexual and erectile dysfunction in previous clinical studies as well as possible pathologic pathways that could be involved in this adverse effect of lithium based on the previous preclinical studies. Understanding such mechanisms could potentially open a new avenue for therapies that can overcome lithium-related sexual dysfunction and improve patients' adherence to the medication intake.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Beyond its psychiatric use: the benefits of low dose lithium supplementation. (Pubmed Central) -  Mar 4, 2022   
    Although lithium's actions have been widely studied in the brain, the study of the potential benefits of lithium, particularly at a low dose is still relatively novel. Therefore, this review aims to provide possible mechanistic insights for future research in this field.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Lithium intoxication induced pyroptosis via ROS/NF-κB/NLRP3 inflammasome regulatory networks in kidney of mice. (Pubmed Central) -  Mar 3, 2022   
    The results of histopathology staining and TdT-mediated dUTP nick-end labeling assay showed that high Li condition (Lithium carbonate, 20 mg/kg/twice a day, i.e., for 30 consecutive days) caused inflammatory damage and apoptosis in kidney tissue cells...Moreover, excessive Li activated nuclear factor kappa-B (NF-κB) signaling pathway and nucleotide-binding oligomerization domain-like receptors domains-containing protein 3 (NLRP3) inflammasome, resulting in activation of inflammatory factors tumor necrosis factor-α and IL-1β in the kidney of mice. In the vitro study, ROS as an upstream signal phosphorylated IκBα and NF-κB, up-regulated the NLRP3 inflammasome, increased caspase3, 6, 7, and 9 to exaggerate inflammation response, finally inducing pyroptosis in renal cells.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Journal:  Methylomic Biomarkers of Lithium Response in Bipolar Disorder: A Proof of Transferability Study. (Pubmed Central) -  Feb 27, 2022   
    Classification tree analyses further suggested that the MS-HRM-measured DMRs correctly classified up to 84% of individuals as good or non-responders. This study suggested that epigenetic biomarkers, identified in a retrospective sample, accurately discriminate non-responders from responders to Li and may be transferrable to routine practice.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder. (Pubmed Central) -  Feb 22, 2022   
    Furthermore, the current techniques for lithium monitoring require highly qualified personnel and expensive equipment; hence, it is crucial to develop low-cost and easy-to-use devices for decentralized monitoring of lithium. The current paper seeks to review the pertinent literature rigorously and critically with a focus on different lithium-monitoring techniques which could lead towards the development of automatic and point-of-care analytical devices for lithium determination.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Plus ça change? Switching lithium preparations. (Pubmed Central) -  Feb 19, 2022   
    For comparable pre- and post-switch doses in adherent patients, the most common brands of lithium carbonate appear to produce similar plasma lithium levels. British National Formulary guidance relating to switching lithium brands may be unnecessarily complex.
  • ||||||||||  A Unique Case of Serotonin Syndrome of Unknown Etiology (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1180;    
    We are still unsure of the etiology or the diagnosis but we are inclined towards the diagnosis of SS, which may be atypical given the timeline of onset of symptoms. Here, we present a unique case of AMS with resolution likely SS or SS-like syndrome in a patient with no prior usage of serotonergic/MAOI agents but responsive to Cyproheptadine.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes. (Pubmed Central) -  Feb 16, 2022   
    Among 379 outpatients (57% female, mean age 38 years, mean Clinical Global Impression 4.4), users of Li+AP (N = 50, primarily quetiapine and aripiprazole) improved to a similar degree (mean Clinical Global Impression improvement = 1.6, standard deviation = 1.5) as those using lithium-only (i.e. without adjunctive antipsychotics or anticonvulsants, N = 149, mean Clinical Global Impression improvement = 1.7, standard deviation = 1.4) (p = 0.59)...When comparing Li+AP to Li+AC, users of Li+AP improved slightly better on general (p = 0.05) and manic symptoms (p = 0.01), but showed a worse development of glucose, triglycerides, and metabolic syndrome. Despite treatment-by-indication confounding, these findings are relevant for real-world treatment settings and emphasize the need for randomized trials on this clinically important topic.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model. (Pubmed Central) -  Feb 9, 2022   
    Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-induced NTDs. Providing evidence to further understand the molecular mechanisms of lithium-induced NTDs and enhancing its primary prevention.
  • ||||||||||  trazodone ER / Generic mfg., amitriptyline / Generic mfg., tranylcypromine / Generic mfg.
    Review, Journal:  60 Years of Combining Tranylcypromine: A Systematic Review of Available Evidence. (Pubmed Central) -  Feb 9, 2022   
    Any combination of a psychotropic with TCP should be preceded by an evaluation of drug-to-drug interaction and an informed consent process and followed by close monitoring. Before any combination strategy, doctors should reevaluate factors of pseudo-treatment resistance, such as rapid-metabolizing status, noncompliance, trauma, alternative diagnosis, or drug abuse.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  CME: Light Therapy: Why, What, for Whom, How, and When (And a Postscript about Darkness). (Pubmed Central) -  Feb 9, 2022   
    We specify criteria for choice of treatment devices: optimum dose (10,000 lux), spectrum (white light), exposure duration (30-60 minutes) and timing (early morning). Protocol adjustment requires continual monitoring with attention to rate of improvement and management of potential side effects.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case-based systematic analysis. (Pubmed Central) -  Feb 5, 2022   
    Despite the progress made in treating bipolar and unipolar affective disorders, lithium carbonate is still a common drug in psychiatric practice...However, the multiple regression analysis for CKD as the dependent variable showed that the decisive factor was focal segmental glomerulosclerosis (FSGS) as the underlying pathology (the β coefficient = 0.7866 with a confidence interval ranging from 0.600 to 0.9704 and the p value < 0.0001). Thus, we conclude that in lithium-induced NS/AKI, serum lithium levels contribute to these complications, while FSGS lesions are responsible for CKD's disease progression.