- |||||||||| lithium carbonate ER / Generic mfg., Ryanodex (dantrolene) / Eagle Pharma
Journal: Drug Development. (Pubmed Central) - Jan 12, 2025
Intranasal LiCl in RFV ameliorates memory loss and depressive behavior in 5XFAD mice without side effects or organ toxicity, with chronic use. Intranasal LiCl in RFV effectively inhibited, oxidative stress, inflammation and pyroptosis in aged 5XFAD brains.
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Preclinical, Journal, Immunomodulating: Immunomodulatory effect of lithium treatment on in vitro model of neuroinflammation. (Pubmed Central) - Jan 6, 2025
We observed that lithium treatment reduces inflammasome activity, which may attenuate the inflammatory state. Interestingly, the lithium pretreatment resulted in significantly elevated inflammasome activity, suggesting that lithium does not impair the immune response to additional stimuli.
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Preclinical, Journal: Lithium Coupled with C6-Carboxyl Improves the Efficacy of Oligoguluronate in DSS-Induced Ulcerative Colitis in C57BL/6J Mice. (Pubmed Central) - Dec 27, 2024
The therapeutic effects of OGLi on dextran sulfate (DSS)-induced UC mice were investigated, and oligoguluronate sodium (OGNa) and lithium carbonate (LC) were used as contrasts...The OGLi could significantly increase the diversity of intestinal microorganisms in the short term. All of these discoveries demonstrate that lithium collaboratively enhances the anti-UC efficacy of OG, which will help to create OG-based drugs for the treatment of UC.
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Review, Journal: Agitated Depression and the Potential Response to Gama-Amino Butyric Acid Agonist: A Case Series and Literature Review. (Pubmed Central) - Dec 23, 2024
Both patients had worsening symptoms with the use of various antidepressants but improved with the use of lorazepam and olanzapine...2024;15:1372136), might help recognize this variant of depressive disorder. These patients might have a poor response or worsen with the use of antidepressants while responding to options like gamma-amino butyric acid (GABA) agonists, antipsychotics, and ECT.
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Journal: Lithium Intoxication After Sleeve Gastrectomy: A Case Report and Differential Diagnosis. (Pubmed Central) - Dec 16, 2024
During the toxicity treatment, elevated mood were also observed. We aimed to emphasize the importance of post-bariatric surgery follow-up for patients undergoing psychiatric treatments, especially those using lithium, focusing on both medication management and monitoring of clinical symptoms.
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Review, Journal: A physical perspective on lithium therapy. (Pubmed Central) - Dec 11, 2024
This review investigates how lithium ions affect lipid membrane composition and function, and how lithium response might in fact be the body's attempt to counteract the physical presence of lithium ions at cell level. Ideas for further research in microbiology and drug development are discussed.
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Journal: Early diagnosis of nonconvulsive status epilepticus due to lithium intoxication using 6-channel electroencephalography. (Pubmed Central) - Dec 9, 2024
The ability of emergency physicians to apply and interpret simplified EEG enabled timely intervention and prevention of neurological complications. While further research is needed to validate interpretation protocols by non-EEG specialists, simplified EEG shows promise as an accessible tool for rapid assessment of neurotoxicity in lithium intoxication, potentially improving patient outcomes through earlier intervention.
- |||||||||| lithium carbonate ER / Generic mfg., olanzapine / Generic mfg.
Preclinical, Journal: Vitamin D3 and zinc supplements augment the antimanic efficacy of lithium and olanzapine treatments in an animal model of mania. (Pubmed Central) - Dec 2, 2024
Mania was induced in C57BL/6 mice by administering methylphenidate (MPH) for 14 consecutive days...The VitD3/Zn/Oln, C50, and C100 treatment regimens reversed most of the behavioral and pathophysiological alterations; however, the C50 treatment regimen was the most efficient. This study emphasizes the importance of combining different antimanic medications like Li and Oln with nutraceutical supplements to increase their antimanic efficacy, reduce their adverse effects, and, ideally, improve the BD patient's quality of life.
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Review, Journal: Lithium: current state of the art and future directions. (Pubmed Central) - Nov 29, 2024
Lithium continues to be the mainstay treatment of mood disorders in general and in bipolar disorder specifically. Other potential clinical uses for lithium in psychiatry have re-invigorated excitement for research in other areas such as suicide, preventing cognitive impairment and possibly preventing viral infections and diminishing cancer risk.
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Journal: High-Voltage NMC for LIBs via Ternary MOF-Lithium Carbonate System. (Pubmed Central) - Nov 28, 2024
Owing in part to the higher stability of lithium carbonate at lower temperatures, short-range ordered surface presence was seen during the high voltage cycling process. Nevertheless, the sample that produced with lithium carbonate (S6) exhibited stable cycling performance under high voltage conditions compared to the sample (R) produced with lithium acetate.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
Review, Journal: Cariprazine in Bipolar Disorder and Substance Use: A Dual Approach to Treatment? (Pubmed Central) - Nov 27, 2024
However, evidence on the role of cariprazine in the treatment of SUDs remains limited, based primarily on case reports and animal studies. Further research, including large-scale clinical trials, is needed to determine its full efficacy in this dual diagnosis.
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Journal, Real-world evidence, Real-world: Insights into the Incidence, Course, and Management of Lithium-Induced Hypothyroidism in Real-World Psychiatric Practice in Italy. (Pubmed Central) - Nov 27, 2024
Clinicians should be prepared to initiate thyroid replacement therapy, when necessary, as timely management can prevent the interruption of lithium treatment and ensure ongoing symptomatic improvement in BD patients. Future studies could include larger and more diverse populations to validate these findings further, extending the follow-up period beyond 12 months to better observe long-term thyroid function trends and management outcomes.
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Journal, Gold standard: Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies. (Pubmed Central) - Nov 21, 2024
Lithium was superior to aripiprazole, valproic acid, and quetiapine in terms of improving manic symptoms...Only the add-on therapy with sertraline led to a higher rate of study discontinuations than lithium-monotherapy...However, risperidone and quetiapine were superior to lithium in some aspects, which is why these drugs should be considered as an alternative treatment option for children. Collectively, current clinical studies highlight the relevance of lithium in the treatment of bipolar disorder.
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Journal: Uncommon Drug-Induced Hidradenitis Suppurativa: A Case Report of A Patient on Lithium Therapy. (Pubmed Central) - Nov 21, 2024
Here, we present a case report of HS after the initiation of lithium therapy, focusing on the underlying pathological process of this skin condition. Despite limited data on this topic, clinical features, management of the condition, and possible disease development prevention methods will be emphasized.
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Review, Journal: Endocrinological Effects of Lithium: Pathophysiological Mechanisms and Clinical Implications (Pubmed Central) - Oct 25, 2024
Lithium carbonate has a narrow therapeutic range capable of producing various adverse effects; despite this fact, it is used as first-line therapy in patients with bipolar disorder (BD) thanks to its high effectiveness...The adherence to current guidelines for monitoring those events is low. The objective of this review is to provide insight into the pathophysiological mechanisms of the endocrine effects of lithium and give recommendations based on the current literature for the monitoring and treatment of these conditions.
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Review, Journal: What is the effect of lithium use on the amygdalar volume of adult patients diagnosed with bipolar disorder: a scoping review. (Pubmed Central) - Oct 25, 2024
The objective of this review is to provide insight into the pathophysiological mechanisms of the endocrine effects of lithium and give recommendations based on the current literature for the monitoring and treatment of these conditions. The present review may be used to influence future work concerning neurobiological changes in the amygdala as a result of lithium treatment for bipolar patients by summarizing patterns in the current literature.
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Preclinical, Journal: NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. (Pubmed Central) - Oct 25, 2024
We then perform phosphoproteomic analyses to demonstrate that the diurnal and nocturnal phosphoproteomic profiles of male control and NEK4 overexpressing mice are different. These results suggest that male mice with different NEK4 expression levels may recapitulate some of the core features observed in patients with bipolar disorder, indicating that interruption of the homeostatic dynamics of synapses may underlie the emotional swings in bipolar disorder.
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Journal: Prolonged transcranial magnetic stimulation in a pregnant patient with treatment-resistant depression: a case report. (Pubmed Central) - Oct 23, 2024
To our knowledge, this is the first published case of a pregnant individual with perinatal depression who received and tolerated a prolonged transcranial magnetic stimulation course with two distinct protocols (repetitive transcranial magnetic stimulation and intermittent theta burst stimulation) with clinically significant response. Transcranial magnetic stimulation is a well-tolerated and effective intervention that warrants further investigation for use in treatment-resistant perinatal depression.
- |||||||||| Preclinical, Journal: Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice. (Pubmed Central) - Oct 19, 2024
Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression...Significance Statement This study used a novel set of mu opioid receptor (MOR)-selective opioids with graded MOR efficacies to examine the lower boundary of MOR efficacy sufficient to relieve pain-related behavioral depression in mice. Two novel low-efficacy opioids (JL-2-39, DC-1-76.1) produced effective antinociception with improved safety relative to higher- or lower-efficacy opioids, and results support further consideration of these and other low-efficacy opioids as candidate analgesics.
- |||||||||| Horizant (gabapentin enacarbil XR) / Azurity Pharma, Astellas, GSK
Journal: Leveraging the Genetics of Psychiatric Disorders to Prioritize Potential Drug Targets and Compounds. (Pubmed Central) - Oct 14, 2024
Opportunities for drug repurposing were revealed such as cholinergic drugs for ADHD, estrogens for depression, and gabapentin enacarbil for schizophrenia...Here we present a series of complimentary and comprehensive analyses that highlight the utility of genetics for informing drug development and repurposing for psychiatric disorders. Our findings present novel opportunities for refining psychiatric treatment.
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Lithium-Induced Nephrotic Syndrome: A Rare Complication of a Known Kidney Offender () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5259;
She was started on Lithium Carbonate 4 months prior...However, if the symptoms persist beyond 6 weeks, a kidney biopsy to exclude other causes and treatment with prednisone have been done in the case reports. Kidney biopsy usually shows minimal change disease.This case provides an example of a rare renal side effect of Lithium that occurs after relative short duration of treatment..
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Journal: Acute kidney injury induced lithium toxicity with concomitant neuroleptic malignant syndrome. (Pubmed Central) - Oct 10, 2024
He also developed NMS which could either be triggered independently by olanzapine; lithium toxicity; or attributed by a synergistic combination from lithium and olanzapine which led to an enhanced neurotoxicity in an already unstable dopaminergic pathway. Fluid therapy and supportive care allowed the patient to recover, and he was discharged well with a lower potency neuroleptic with slow dose titration.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Modulation of Neuronal Excitability and Plasticity by BHLHE41 Conveys Lithium Non-Responsiveness. (Pubmed Central) - Oct 7, 2024
Single-cell RNA sequencing identified that lithium deregulated mitochondrial respiration, cation channel and postsynapse associated gene-sets specifically in upper layer excitatory neurons. Our findings show that lithium acts in a highly cell-specific way on neuronal metabolism and excitability and modulates synaptic plasticity depending on BHLHE40/41.
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Trial completion, Trial completion date, Trial primary completion date: Lithium in FAP: The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis (clinicaltrials.gov) - Oct 3, 2024
P2, N=12, Completed,
Our findings show that lithium acts in a highly cell-specific way on neuronal metabolism and excitability and modulates synaptic plasticity depending on BHLHE40/41. Active, not recruiting --> Completed | Trial completion date: Apr 2025 --> Sep 2024 | Trial primary completion date: Apr 2025 --> Sep 2024
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Journal: Agitated Depression Associated With Flurazepam Discontinuation. (Pubmed Central) - Sep 30, 2024
She finally had a complete resolution of these symptoms with a combination of alprazolam, zopiclone, and olanzapine. This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management.
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Preclinical, Journal: Intranasal Lithium Chloride Nanoparticles Inhibit Inflammatory Pyroptosis in Brains and Ameliorate Memory Loss and Depression Behavior in 5xFAD mice. (Pubmed Central) - Sep 30, 2024
This study compares the changes in lithium concentrations in the brain and blood following the administration of intranasal or oral lithium chloride (LiCl) dissolved in either Ryanodex Formulation Vehicle (RFV) or water, as well as the therapeutic effectiveness and side effects of intranasal versus oral lithium chloride (LiCl) in RFV, and their mechanisms for inhibiting inflammation and pyroptosis in 5xFAD Alzheimer's Disease (AD) mice brains...This lithium mediated neuroprotection was associated with its potent effects on the inhibition of InsP3R-1 Ca 2+ channel receptor increase, ameliorating pathological inflammation and activation of the pyroptosis pathway, and the associated loss of synapse proteins. Intranasal LiCl in RFV could become an effective and potent inhibitor of pathological inflammation/pyroptosis in the CNS and treat both dementia and depression with no or minimal side effects/organ toxicity, particular in AD.
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