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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  Elderly bipolar disorder with hyperthyroidism during long-term lithium treatment: a case report. (Pubmed Central) -  Apr 20, 2022   
    Chronic lithium-the first-line drug for treating bipolar disorders-treatment has been associated with various endocrine disorders including thyroid dysfunction, diabetes insipidus, and hyperparathyroidism. Despite its suppressive effect on thyroid function, hyperthyroidism rarely occurs in elderly patients with bipolar disorders after long-term lithium treatment.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium Ascorbate as a Promising Neuroprotector: Fundamental and Experimental Studies of an Organic Lithium Salt. (Pubmed Central) -  Apr 19, 2022   
    Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts...Lithium ascorbate is characterized by extremely low acute and chronic toxicity (LD50 > 5000 mg/kg) and also shows a moderate antitumor effect when used in doses studied (5 or 10 mg/kg). Studies on the model of alcohol intoxication in rats have shown that intake of lithium ascorbate in doses either 5, 10 or 30 mg/kg did not only reduced brain damage due to ischemia, but also improved the preservation of myelin sheaths of neurons.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  MRI based Kidney Radiomics analysis during chronic lithium treatment. (Pubmed Central) -  Apr 15, 2022   
    A renal texture index was developed among patients treated with lithium associated with a decreased mGFR. This index might be relevant in the diagnosis of lithium-induced renal toxicity.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Correlates of clinical variables on early-stage visual processing in schizophrenia and bipolar disorder. (Pubmed Central) -  Apr 13, 2022   
    Fifty-six healthy controls (HCs; mean age = 31.04 years), 42 BPD patients (mean age = 32.84 years) who took only lithium, and 39 SCZ patients who took only olanzapine (mean age = 32.80 years) were recruited for this study...These findings may aid investigations of other clinical variables and the role of state- and trait-like effects on visual and cognitive processing in these patient populations. This study underscores the need for visual remediation interventions.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Studies on lithium in the environment and its effects on the central nervous system (Pubmed Central) -  Apr 13, 2022   
    However, the safe dose range of lithium is narrow, and the health effects of drinking high concentrations of lithium water in high-lithium areas are unclear. It is necessary to study the health effects and mechanisms of different doses of lithium, especially high concentrations of lithium in the environment.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Review, Journal:  Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses. (Pubmed Central) -  Apr 12, 2022   
    It is equaly efficacious in rapid and non-rapid cycling patients, in concomitant obsessive-compulsive symptoms, alcohol and substance abuse, the neurocognitive deficit, suicidal ideation and fatigue The current systematic review provided support for the usefulness of lithium against a broad spectrum of clinical issues in Bipolar disorder. Its efficacy is comparable to that of more recently developed agents.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Review, Journal:  Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review. (Pubmed Central) -  Apr 12, 2022   
    Strengths and limitations of available studies are presented and discussed in light of the specific designs, methodology and clinical characterization of included patients for transcriptomic compared to DNA-based studies. Finally, future directions of transcriptomics of psychopharmacological interventions in psychiatric disorders are discussed.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Antiviral, immunomodulatory, and neuroprotective effect of lithium. (Pubmed Central) -  Apr 9, 2022   
    Despite promising results of lithium obtained in animal models of Huntington's disease and amyotrophic lateral sclerosis, they have not been confirmed in clinical studies. A suggestion for common mechanisms of antiviral, immunomodulatory, and neuroprotective effects of lithium is advanced.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Suicide death over the first year of lithium versus valproate treatment in cohorts with and without bipolar disorder. (Pubmed Central) -  Apr 8, 2022   
    If it were possible to correct for this potential confounding, then the suicide-related risks associated with among individuals discontinuing lithium would be expected to be less, and the suicide-related benefits associated with actively receiving lithium (already statistically significant in some analyses among individuals without bipolar disorder) would be expected to increase. Further research is needed.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Retrospective data, Journal:  Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study. (Pubmed Central) -  Apr 8, 2022   
    We observed an association between lithium use and a decreased risk of developing dementia. This lends further support to the idea that lithium may be a disease-modifying treatment for dementia and that this is a promising treatment to take forwards to larger randomised controlled trials (RCTs) for this indication.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19. (Pubmed Central) -  Apr 8, 2022   
    This narrative review aims at exploring the underlying mechanism by which lithium, a first line drug for the treatment of bipolar disorder, inhibits Ca2+ dysregulation and associated downstream pathology in both AD and COVID-19. It is suggested that lithium can be repurposed to treat AD patients, especially those afflicted with COVID-19.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Mini-review: Anomalous association between lithium data and lithium use. (Pubmed Central) -  Apr 6, 2022   
    They show the data on lithium superiority over other mood stabilizers and point to the proper management of the lithium-induced side effects. This endeavor aims to allow a larger number of mood disorder patients to become beneficiaries of lithium use.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Journal:  A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder. (Pubmed Central) -  Apr 5, 2022   
    Finally, we used machine learning to evaluate the classification performance of the studied biomarkers but the average performance in unseen data was fair to moderate (area under the receiver operating curve = 0.72). Taken together, our serum biomarker findings provide novel insight to the etiopathology of bipolar disorder, and we present a suggestive biomarker for lithium-induced nephropathy.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal, HEOR:  Chronic Kidney Disease and Severe Mental Illness: Addressing Disparities in Access to Health Care and Health Outcomes. (Pubmed Central) -  Apr 2, 2022   
    Limited research suggests that care might be improved through educating kidney health care staff regarding the needs of patients with severe mental illness and by facilitating closer collaboration with psychiatry. Further research investigating the rates of severe mental illness in patients with CKD, as well as the barriers and facilitators to effective care for this population, is clearly required to inform the provision of appropriate supports and to improve health outcomes for individuals with CKD and co-occurring severe mental illness.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Lithium as a Neuroprotective Agent for Bipolar Disorder: An Overview. (Pubmed Central) -  Apr 1, 2022   
    It is expected that in a nearby future, precision medicine approaches will improve diagnosis and expand treatment options. This will certainly contribute to ameliorating the medical and economic burden created by this devastating mood disorder.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium treatment in the era of personalized medicine. (Pubmed Central) -  Mar 29, 2022   
    In 1949, an Australian psychiatrist, John Cade, reported on the antimanic efficacy of lithium carbonate, which is regarded as an introduction of lithium into contemporary psychiatry...However, it seems that the more important indication would be the augmentation of antidepressant drugs in treatment-resistant depression. The factors connected with the efficacy of lithium in these conditions are reviewed.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  ESR dosimetry with lithium, potassium, and sodium compounds. (Pubmed Central) -  Mar 29, 2022   
    Among them, lithium carbonate, lithium phosphate, sodium formate, sodium acetate, sodium citrate, sodium dithionite, sodium carbonate, showed eligible characteristics...Sodium citrate also presents radiological properties close to soft tissue. Therefore, considering all properties, in the set of the new materials studied in this work, sodium citrate is a promising material for ESR dosimetry.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Age-related GSK3β overexpression drives podocyte senescence and glomerular aging. (Pubmed Central) -  Mar 29, 2022   
    Furthermore, in psychiatric patients, lithium carbonate therapy inhibited GSK3β activity and mitigated senescence signaling in urinary exfoliated podocytes and was associated with preservation of kidney function. Thus, GSK3β appears to play a key role in podocyte senescence by modulating senescence signaling and may be an actionable senostatic target to delay kidney aging.
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    Preclinical, Journal:  Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction. (Pubmed Central) -  Mar 26, 2022   
    Amiodarone possessed an anti-convulsive potential, protected the cardiac muscle and preserved its histological architecture. Therefore, amiodarone could be recommended as a protective therapy against cardiac dysfunction during epileptic seizures with favorable effect on seizure activity.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  The neuroprotective mechanism of lithium after ischaemic stroke. (Pubmed Central) -  Mar 25, 2022   
    Using immunocytochemstry, MRI imaging, and cell sorting with subsequent mRNA and protein quantification, we demonstrate that Li decreases the infarct volume, improves motor function, and alleviates associated cognitive and depressive impairments. In conclusion, this study reveals molecular mechanisms of Li neuroprotection during brain ischaemia, thus providing the theoretical background to extend clinical applications of Li for treatment of ischemic stroke.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Effect of antipsychotics on serum lithium levels and white blood cell counts. (Pubmed Central) -  Mar 24, 2022   
    Lithium carbonate is used to increase white blood cell counts as a means of counteracting leukopenia caused by the administration of antipsychotic drugs...Chlorpromazine equivalent values were used as an indicator of the antipsychotic dose...Because of the large variety of antipsychotic drugs used in combination with lithium and the various doses used, it was difficult to evaluate the effects of lithium, with or without antipsychotic administration, on leukocyte count enhancement. We are planning to study a larger number of patients and, since renal function could not be assessed in this study, we will also focus on renal function, including urine output.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Risk Factors for Early Recurrence After Discontinuing Lithium in Bipolar Disorder. (Pubmed Central) -  Mar 24, 2022   
    We are planning to study a larger number of patients and, since renal function could not be assessed in this study, we will also focus on renal function, including urine output. Early recurrence risk was again much greater after rapid discontinuation of lithium and discontinuing for medical reasons, somewhat greater with BD-I than BD-II, and following greater morbidity during lithium-treatment, but not related to dose or duration of preceding treatment-exposure.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Synapto-protective effect of lithium on HIV-1 Tat-induced synapse loss in rat hippocampal cultures. (Pubmed Central) -  Mar 23, 2022   
    This synaptic protection was prevented by both the activation of NMDA receptor leading to intracellular signaling and the regulatory pathway of lithium including inositol depletion and glycogen synthase kinase-3β (GSK-3β). These results suggest that mood stabilizers might be effective drugs to treat neurodegenerative disorders including HAND.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Association of Lithium and Second-Generation Antipsychotics with Neurocognition in Youth with Bipolar Disorder. (Pubmed Central) -  Mar 18, 2022   
    This study adds to the limited body of literature examining medication use in relation to neurocognition in youth with BD. While the current study cannot rule out associations of smaller effect size, present findings suggest that leading mood-stabilizing medications are not associated with frank neurocognitive impairments in youth with BD.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Observational data, Journal:  Genetic polymorphisms influencing response to lithium in early-onset Bipolar disorder from south India. (Pubmed Central) -  Mar 16, 2022   
    While the current study cannot rule out associations of smaller effect size, present findings suggest that leading mood-stabilizing medications are not associated with frank neurocognitive impairments in youth with BD. Although conducting pharmaco-genomic studies with large sample size is a challenge for low and middle-income countries, future studies can help improve the long-term outcome of youth with EOBD.