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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Retrospective data, Journal:  Unintentional Pediatric Lithium Exposure: A 15-Year Retrospective Analysis. (Pubmed Central) -  Jul 9, 2022   
    Unintentional exposures appear to be benign, even with detectable lithium levels. Further study is needed to better risk stratify for home care versus health care facility evaluation.
  • ||||||||||  Journal:  Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. (Pubmed Central) -  Jul 8, 2022   
    When KO mice were treated with methylphenidate, lithium, or fluoxetine, the mood stabilizer lithium showed a genotype-dependent effect. Taken together, Slitrk2 deficiency causes aberrant neural network activity, synaptic integrity, vestibular function, and serotonergic function, providing molecular-neurophysiological insight into the brain dysregulation in bipolar disorders.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium increases cortical and subcortical volumes in subjects with bipolar disorder. (Pubmed Central) -  Jun 29, 2022   
    This cohort also includes underrepresented demographics in the literature (young adult patients, mostly bipolar II, and exclusively in the depressed phase). These findings bolster the extensive body of evidence in support of long-term lithium therapy in BD, furthering the possibility of its expanded use to wider demographics.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Trial completion:  PET and MRI Brain Imaging of Bipolar Disorder (clinicaltrials.gov) -  Jun 29, 2022   
    P=N/A,  N=76, Completed, 
    These findings bolster the extensive body of evidence in support of long-term lithium therapy in BD, furthering the possibility of its expanded use to wider demographics. Unknown status --> Completed
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium use associated with symptom severity in comorbid bipolar disorder I and migraine. (Pubmed Central) -  Jun 28, 2022   
    Herein, we replicate the relatively worse outcome in BD with comorbid migraine. We find evidence to suggest that lithium use is associated with more severe symptoms of mania among those with BD and a history of migraine and conclude that lithium is contraindicated in BD comorbid with migraine.
  • ||||||||||  thyroxine / Generic mfg.
    Journal:  "Block and replace" of sodium levothyroxine therapy (Pubmed Central) -  Jun 28, 2022   
    A "block and replace" therapeutic regimen was then started with reduced methimazole doses in combination with levothyroxine, which resulted in a short time in normalization of the hormonal profile and significant improvement of the clinical picture. Therefore, the "block and replace" regimen represents a valid therapeutic alternative to anti-thyroid drugs monotherapy in the treatment of hyperthyroidism due to Graves disease in selected cases.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    The potentially protective effect of lithium on the risk of osteoporosis () -  Jun 26, 2022 - Abstract #CINP2022CINP_260;    
    These results have two implications. I) Bone health should be a priority in the clinical management of bipolar disorder, and II) The potentially beneficial effects of lithium on bone-structure should be further investigated.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. (Pubmed Central) -  Jun 25, 2022   
    While there was a significant association of SLC35B2 with SCZ (SNP rs2233437), its expression was not changed in SCZ. These findings indicate that SLC35B2 might be differentially involved in the pathophysiology of BD and SCZ by influencing the sulfation process and/or glutamate system in the central nervous system.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Association between serum lithium level and incidence of COVID-19 infection. (Pubmed Central) -  Jun 22, 2022   
    Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, we show that the 6-month COVID-19 infection incidence was lower among matched patients with 'therapeutic' (0.50-1.00) versus 'subtherapeutic' (0.05-0.50) lithium levels (hazard ratio (HR) = 0.82, 95% CI 0.69-0.97, P = 0.017) and among patients with 'therapeutic' lithium levels versus matched patients using valproate (HR = 0.79, 95% CI 0.67-0.92, P = 0.0023). Lower rates of infection were observed for both new COVID-19 diagnoses and positive polymerase chain reaction tests, regardless of underlying psychiatric diagnosis and vaccination status.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Evidence-based treatment strategies for rapid cycling bipolar disorder, a systematic review. (Pubmed Central) -  Jun 22, 2022   
    Evidence supports the use of aripiprazole, olanzapine, and valproate for acute manic or mixed episodes, quetiapine for acute depressive episodes and aripiprazole and lamotrigine for relapse prevention. Given the paucity of available evidence, and the burden that accompanies rapid cycling, future research is warranted.
  • ||||||||||  lithium carbonate ER / Generic mfg., sirolimus / Generic mfg.
    Journal:  Unbalanced regulation of Sec22b and Ykt6 blocks autophagosome axonal retrograde flux in neuronal ischemia-reperfusion injury. (Pubmed Central) -  Jun 8, 2022   
    Ischemia-reperfusion-induced excess Sec22b and loss of Ykt6 in neurons lead to axonal autophagosome retrograde trafficking failure, autophagic flux damage, and finally neuronal injury. Facilitated axonal autophagosome retrograde transport by Sec22b knockdown and Ykt6 overexpression may reduce ischemia-reperfusion-induced neuron injury and extend the therapeutic window of pharmacological autophagy induction for neuroprotection.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Enrollment closed:  LATTICE: Lithium As a Treatment to Prevent Impairment of Cognition in Elders (clinicaltrials.gov) -  Jun 7, 2022   
    P4,  N=80, Active, not recruiting, 
    Facilitated axonal autophagosome retrograde transport by Sec22b knockdown and Ykt6 overexpression may reduce ischemia-reperfusion-induced neuron injury and extend the therapeutic window of pharmacological autophagy induction for neuroprotection. Recruiting --> Active, not recruiting
  • ||||||||||  RECLAIMING HER LIFE: SUCCESSFUL TREATMENT OF KLEINE-LEVIN SYNDROME WITH TRANSDERMAL FLUMAZENIL () -  Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1232;    
    Reduction in episodes of sleepiness with flumazenil ultimately led to discontinuing stimulant, mood stabilizer, and clarithromycin use. Early trials of transdermal flumazenil and continued research regarding the use of this medication for patients with KLS may prove to be a promising intervention.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  The effect of prenatal lithium exposure on the neuropsychological development of the child. (Pubmed Central) -  Jun 4, 2022   
    Early trials of transdermal flumazenil and continued research regarding the use of this medication for patients with KLS may prove to be a promising intervention. In this study, we found no evidence for significantly altered neuropsychological functioning of lithium-exposed children at the age of 6-14 years, when compared to non-lithium-exposed controls.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Journal:  Identifying medical mimics for late-life mania: A case of prion disease. (Pubmed Central) -  May 29, 2022   
    Approximately 2 years later, the patient met the Center for Disease Control (CDC) diagnostic criteria for prion disease following a rapid decline in cognition. This case provides an example of a medical mimic of bipolar disorder in the geriatric population.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Clinical, Review, Journal:  Lithium therapy in patients on dialysis: A systematic review. (Pubmed Central) -  May 29, 2022   
    This case provides an example of a medical mimic of bipolar disorder in the geriatric population. Lithium may be used in patients on dialysis, with close monitoring of pre-dialysis serum lithium concentrations for at least two weeks after treatment initiation, followed by a lower frequency after stabilization to ensure therapeutic concentrations and reduce toxicity risk.
  • ||||||||||  FT03 - Racial/Ethnic Differences in Pharmacogenetics () -  May 27, 2022 - Abstract #CINP2022CINP_222;    
    There was no difference in remoxipride, olanzapine, paliperidone and lurasidone...Frye’s group compared lithium and mood stabilizing anticonvulsants (MSA) treatment patterns in more contemporary cohorts including the Mayo Clinic Bipolar Disorder Biobank, University of Mississippi Medical Center (UMMC), and the NIH funded All of Us (AoU) Research Program. While study designs differed, the AA vs EA lithium utilization was less (Mayo: OR=0.30, p=0.06; UMMC: RR=0.56 (0.43-0.72)
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Retrospective data, Review, Journal:  Lithium in the treatment of acute bipolar depression: A systematic review and meta-analysis. (Pubmed Central) -  May 26, 2022   
    However, the bipolar vs. unipolar sensitivity analysis and the modest, though non-significant advantage over placebo suggest lithium may still be a viable treatment option. Larger and more rigorously-designed studies are needed to determine lithium's full range of efficacy relative to placebo and other psychotropics.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides. (Pubmed Central) -  May 25, 2022   
    This vinylic C-H functionalization proceeds in high yields of up to 94% and (Z/E)-ratios of up to 99:1, tolerating a wide range of functional groups. Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Trial completion, Enrollment change, Trial completion date:  OPTIMUM: Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (clinicaltrials.gov) -  May 24, 2022   
    P4,  N=742, Completed, 
    Mechanistic studies indicate that the vinylic C-H activation proceeds via base-assisted cyclometalation rather than via a Heck-type mechanism, which explains its orthogonal stereoselectivity. Recruiting --> Completed | N=1500 --> 742 | Trial completion date: Dec 2021 --> Sep 2021
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Common effects of bipolar disorder medications on expression quantitative trait loci genes. (Pubmed Central) -  May 18, 2022   
    We pinpointed potential genes involved in the beneficial effects of drugs used for BD and their main associated biological pathways. CHDH, which encodes a mitochondrial protein, had a significant dose-responsive downregulation following treatment with increasing doses of quetiapine and lamotrigine, which in combination with the enriched mitochondrial pathways suggests potential therapeutic roles and demand more studies on mitochondrial involvement in BD to identify novel treatment targets.