- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Lithium bidirectionally regulates depression- and mania-related brain functional alterations without worsening cognitive function in patients with bipolar disorder. (Pubmed Central) - Oct 4, 2022
We enrolled 149 drug-naïve patients with BP; 99 patients experiencing first depressive episodes were allocated randomly to four treatment groups [lithium (DP/Li), lithium with lamotrigine (LTG; DP/Li+LTG), LTG (DP/LTG), and valproate (VPA) with LTG (DP/VPA+LTG)], and 50 experiencing first hypo-manic episodes were allocated to two treatment groups (MA/Li and MA/VPA)...Our results showed that lithium bidirectionally regulates depression- and mania-associated brain functional abnormalities in patients with BP. Lithium monotherapy has a better antimanic effect than VPA, is superior to other tested treatments in improving cognition during the course of BP, and has satisfactory antidepressant effects in patients with BP.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Carbonate-superstructured solid fuel cells with hydrocarbon fuels. (Pubmed Central) - Oct 4, 2022
Furthermore, the CSSFC exhibits a high peak power density of 215 mW⋅cm with dry methane fuel at 550 °C, which is higher than all reported values of electrolyte-supported SOFCs. This provides a different approach for the development of efficient solid fuel cells.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: MicroRNAs, Stem Cells in Bipolar Disorder, and Lithium Therapeutic Approach. (Pubmed Central) - Oct 1, 2022
This review aimed to evaluate the most reliable scientific evidence on miRNAs as biomarkers for the diagnosis of BD and assess their implications in response to mood stabilizers, such as lithium. Neural stem cell distribution, regulation, and dysfunction in the etiology of BD are also dissected.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Therapeutic Application of Lithium in Bipolar Disorders: A Brief Review. (Pubmed Central) - Sep 29, 2022
Along with medication provision, psychotherapy is of great significance for BD patients. The review was conducted on recent available scientific literature through the electronic database like Embase, ScienceDirect, Google Scholar, and PubMed using keywords like 'Bipolar Disease,' 'Bipolar Disease Therapeutics,' 'Bipolar Disease and Psychotherapy' to highlight the possible effective means of management of this disease of mood instability.
- |||||||||| lithium carbonate ER / Generic mfg., aripiprazole / Generic mfg., quetiapine / Generic mfg.
Retrospective data, Review: Is aripiprazole similar to quetiapine for treatment of bipolar depression? Results from meta-analysis of Chinese data. (Pubmed Central) - Sep 29, 2022
As an atypical antipsychotic, aripiprazole may be similar to quetiapine for treating bipolar depression with similar drop-out and higher remission rates when combined with lithium carbonate. However, the results of this study need to be read with caution given the poor quality of collected/analyzed literature.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Diagnostic trap: Lithium neurotoxicity with normal lithemia (Pubmed Central) - Sep 29, 2022
We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness caused by a supposed mismanagement of her treatment...The patient has been transferred to our nephrology department where she got two hemodialysis sessions conducting to clinical and biological improvement, confirming the diagnosis of lithium poisoning despite the normal blood levels. Later, she was transferred to the psychiatry department for follow-up and for treatment adjustment.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: An ecological study of objective rest-activity markers of lithium response in bipolar-I-disorder. (Pubmed Central) - Sep 29, 2022
However, associations were modest and future research must determine whether these objectively measured parameters, singly or together, represent robust treatment response biomarkers. Actigraphy may offer an adjunct to multi-platform approaches aimed at developing personalized treatments or stratification of individuals with BD-I into treatment-relevant subgroups.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical, Journal: Decreased cortical gyrification in patients with bipolar disorder. (Pubmed Central) - Sep 29, 2022
BD appears to be characterized by a significant regionally localized hypogyria, in various cortical areas. This abnormality may be a structural and developmental endophenotype marking the risk for BD, and it might help to clarify the etiology of BD.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Isotopic Signatures of Lithium Carbonate and Lithium Hydroxide Monohydrate Measured Using Raman Spectroscopy. (Pubmed Central) - Sep 25, 2022
Principal Component Regression was used to evaluate the sensitivity to isotopic content of small Raman peak shifts in Li2CO3 and indicates differences greater than 2 atom-% could be reliably determined. These measurements add to the body of work on lithium isotope Raman spectroscopy for these two compounds and increases the number of Raman bands which could be used for lithium isotope content analysis.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, Heterogeneity: Recovery of Lithium Carbonate from Dilute Li-Rich Brine via Homogenous and Heterogeneous Precipitation. (Pubmed Central) - Sep 22, 2022
The present work investigates two separation routes to extract Li from synthetic solutions, mimicking those obtained from low-content Li sources through selective Li separation and further concentration steps: (i) addition of NaCO solution and (ii) addition of NaOH solution + CO insufflation. A Li recovery up to 80% and purities up to 99% at 80 °C and with high-ionic strength solutions was achieved employing NaOH solution + CO insufflation and an ethanol washing step.
- |||||||||| lithium carbonate ER / Generic mfg.
Atypical parkinsonism related to a rare variant in the PLA2G6 gene (Poster Station: 4) - Sep 22, 2022 - Abstract #MDSCongress2022MDR_Congress_1114;
Our findings support that heterozygous variants in the PLA2G6 gene could be associated with atypical adult-onset parkinsonism. Genetic testing of patients with atypical parkinsonian syndromes, especially when some radiological signs are present could help to a better characterization of the PLAN clinical spectrum.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, Adverse events: Lithium-induced nephropathy; One medication with multiple side effects: a case report. (Pubmed Central) - Sep 18, 2022
This case provides an example of a rare side effect of lithium-induced minimal change nephropathy with chronic tubulointerstitial nephropathy in addition to its well-known complication of interstitial nephritis or diabetes insipidus. In our opinion, these patients likely have much worse clinical outcome.
- |||||||||| olanzapine / Generic mfg.
Review, Journal: Opioid antagonists to prevent olanzapine-induced weight gain: A systematic review. (Pubmed Central) - Sep 11, 2022
Six studies met inclusion criteria, 5 of which assessed OLZ and samidorphan (SAM) and 1 of which assessed OLZ and naltrexone compared with OLZ monotherapy...Naltrexone did not reduce OLZ-induced increases in weight or BMI. However, there is a paucity of data on other opioid antagonists as adjuncts to OLZ treatment to prevent increases in weight or BMI.
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Journal: Controversies In The Pharmacotherapy Of Adolescent Depression. (Pubmed Central) - Sep 10, 2022
Although no response to pharmacotherapy and psychotherapy may occur in up to 40% of depressed adolescents, possible predictors or mediators of poorer response in adolescents are uncertain, and only a few studies support possible treatment strategies. Finally, studies exploring the efficacy of antidepressants in specific depression subtypes, i.e., based on prevalent psychopathological dimensions (apathy, withdrawal, impulsivity), are warranted.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
Retrospective data, Journal: A cumulative Bayesian network meta-analysis on the comparative efficacy of pharmacotherapies for mania over the last 40 years. (Pubmed Central) - Sep 7, 2022
Overall, tamoxifen appears to be the most effective of the currently known pharmaceutical therapy available to treat acute mania or manic episodes; however, this conclusion is restricted by the scale of RCTs conducted, and risperidone was found to be the most effective medication among antipsychotics. Carbamazepine, haloperidol, ziprasidone, cariprazine, olanzapine, quetiapine, aripiprazole, lithium, paliperidone, asenapine, and divalproex were noticeably effective in treating acute mania or manic episodes.
- |||||||||| lithium carbonate ER / Generic mfg.
Retrospective data, Journal: Hemodialysis Treatment for Patients with Lithium Poisoning. (Pubmed Central) - Sep 3, 2022
The analytical results revealed zero mortality rate and low hemodialysis rate (1.9%). Compared with patients without hemodialysis, patients receiving hemodialysis suffered severer lithium-associated complications and needed a more intensive care unit admission and longer hospital stay.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Neuroprotective substances: are they able to protect the pancreatic beta-cells too? (Pubmed Central) - Aug 31, 2022
The presented data indicate that the neuroprotective substances attenuating the damaging effect of oxidative stress and neurotrophins deficit cannot only protect neurons but also exert their cytoprotective effect towards pancreatic β-cells. These data may provide a theoretical basis for the further study of neuroprotective drugs as potential therapeutic options for T2D prevention and treatment.
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Journal: Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D receptor dependent mechanism. (Pubmed Central) - Aug 31, 2022
Our results demonstrate that lumateperone; i) significantly suppressed CAR in rats, indicating an antipsychotic-like effect, ii) facilitated NMDA and AMPA receptor-mediated currents in the mPFC, in a dopamine D-dependent manner, and iii) significantly increased dopamine and glutamate release in the rat mPFC. To the extent that these findings can be translated to humans, the ability of lumateperone to activate these pathways may contribute to its demonstrated effectiveness in safely improving symptoms related to neuropsychiatric disorder including mood alterations.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Insulin signaling as a therapeutic mechanism of lithium in bipolar disorder. (Pubmed Central) - Aug 31, 2022
It may also provide context for the significant co-morbidity between bipolar disorder, type 2 diabetes, and other forms of metabolic illness characterized by impaired glucose metabolism. It is suggested that developments in assessing neuronal insulin signaling using extracellular vesicles would allow for this hypothesis to be tested in bipolar disorder patients.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, IO biomarker: Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder. (Pubmed Central) - Aug 27, 2022
Mitochondrial-ETC complex enzymes, including complex-I, II, IV, V, and CoQ10, were also restored following long-term SNL treatment...Histological examinations also validated Solanesol's protective effect. As a result, our findings suggest that SNL, as a SIRT-1 signalling activator, may be a promising therapeutic approach for BD-like neurological dysfunctions.
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Review, Journal: Lumateperone for the Treatment of Adults With Schizophrenia: a Systematic Review. (Pubmed Central) - Aug 27, 2022
LUM also exhibits a favorable tolerability and safety profile with placebo level rates of weight gain, metabolic disruption, akathisia, extrapyramidal side effects (excluding akathisia), and prolactin elevation. Lumateperone should be conceptualized as a first-line treatment strategy for adults with SCZ.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Effect of valproate and lithium on dementia onset risk in bipolar disorder patients. (Pubmed Central) - Aug 24, 2022
However, the dementia risk associated with lithium is unclear. Therefore, we concluded that lithium has the potential to be the safer choice as a mood stabilizer over valproate for elderly bipolar disorder patients considering the risk of dementia.
- |||||||||| lithium carbonate ER / Generic mfg., dextroamphetamine immediate release / Generic mfg.
Preclinical, Review, Journal: Measuring Mania-like Elevated Mood through Amphetamine-induced 50-kHz Ultrasonic Vocalizations in Rats. (Pubmed Central) - Aug 24, 2022
Exaggerated 50-kHz USV emission evoked by d-amphetamine is modulated by dopamine, noradrenaline and 5-hydroxytyrptamine receptor ligands and inhibited by the mood stabilizer lithium, the gold standard anti-manic drug for treating bipolar disorder...This indicates that exaggerated 50-kHz USV emission can serve as a reliable and valid measure for assessing mania-like elevated mood in rats with sufficient translational power for gaining a better understanding of relevant pathophysiological mechanisms and the identification of new therapeutic targets. The improved capacity to study the effects of anti-manic pharmacological interventions on a broader range of behaviors by including exaggerated 50-kHz USV emission as preclinical outcome measure complementary to locomotor hyperactivity will refine rodent models for mania.
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